SIMILAR PATTERNS OF AMINO ACIDS FOR 5VEU_H_RITH602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 LEU A  97
PHE A 160
GLY A  69
ILE A 147
GLY A   5
 None
 1.06A 5veuH-1ao0A:
0.0		 5veuH-1ao0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174) 		PF01374
(Glyco_hydro_46) 		5 LEU A  81
GLY A  47
PHE A  97
ALA A  88
GLY A  50
 None
 1.07A 5veuH-1chkA:
0.0		 5veuH-1chkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		6 LEU A  22
GLY A  44
ILE A 123
ALA A 127
THR A  33
GLY A  41
 None
 1.28A 5veuH-1cliA:
0.0		 5veuH-1cliA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		5 LEU B 400
GLY B 360
PHE B 414
ILE B 423
THR B 430
 None
 0.96A 5veuH-1cp9B:
0.0		 5veuH-1cp9B:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		5 LEU A  65
ILE A  72
ALA A  76
THR A  80
GLY A 144
 None
 0.83A 5veuH-1eyyA:
0.0		 5veuH-1eyyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		5 LEU A  65
ILE A  72
ALA A  76
THR A  80
GLY A 173
 None
 1.07A 5veuH-1eyyA:
0.0		 5veuH-1eyyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A 431
GLY A 469
ILE A 458
ALA A 487
GLY A 396
 None
 1.07A 5veuH-1i2dA:
0.0		 5veuH-1i2dA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ARG A 173
GLY A 186
PHE A 405
ALA A 404
GLY A 164
 None
 1.03A 5veuH-1j3nA:
0.0		 5veuH-1j3nA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A 327
PHE A 255
GLY A 252
ILE A 259
ALA A  83
 None
 0.89A 5veuH-1kyiA:
0.0		 5veuH-1kyiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		5 SER A 620
LEU A 624
PHE A 678
ILE A 674
ALA A 667
 None
 1.03A 5veuH-1nd7A:
0.0		 5veuH-1nd7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		5 SER A 620
LEU A 624
PHE A 678
ILE A 674
GLY A 779
 None
 1.03A 5veuH-1nd7A:
0.0		 5veuH-1nd7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A 327
PHE A 255
GLY A 252
ILE A 259
ALA A  83
 None
 0.90A 5veuH-1ofhA:
undetectable		 5veuH-1ofhA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		5 LEU A  90
GLY A  52
PHE A  20
ILE A  31
ALA A  16
 None
 1.07A 5veuH-1pzsA:
undetectable		 5veuH-1pzsA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76

(Thermotoga
maritima) 		PF03641
(Lysine_decarbox) 		5 SER A  90
LEU A  93
GLY A  46
GLU A  70
GLY A  11
 None
 1.02A 5veuH-1rcuA:
undetectable		 5veuH-1rcuA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		5 PHE A  93
PHE A 673
ILE A 662
ALA A 109
GLY A  70
 None
 1.06A 5veuH-1w8jA:
0.0		 5veuH-1w8jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 194
PHE A 360
GLY A 235
PHE A 353
ALA A 354
 LEU  A 194 ( 0.6A)
PHE  A 360 ( 1.3A)
GLY  A 235 ( 0.0A)
PHE  A 353 ( 1.3A)
ALA  A 354 ( 0.0A)
 0.95A 5veuH-1wqaA:
undetectable		 5veuH-1wqaA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 LEU A 181
PHE A 228
GLY A 223
GLU A 196
GLY A 225
 None
 1.03A 5veuH-1wytA:
undetectable		 5veuH-1wytA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 GLY A 402
ILE A 272
ALA A 261
THR A 231
GLY A 239
 None
 0.99A 5veuH-2bwsA:
0.9		 5veuH-2bwsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 PHE A  93
PHE A 673
ILE A 662
ALA A 109
GLY A  70
 None
 1.06A 5veuH-2dfsA:
0.0		 5veuH-2dfsA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF08442
(ATP-grasp_2) 		5 LEU B 322
GLY B 327
ILE B 282
ALA A 290
GLY B 358
 None
 1.04A 5veuH-2fpgB:
undetectable		 5veuH-2fpgB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		5 LEU A 175
GLY A 393
ILE A 135
PHE A  97
GLU A 201
 None
URP  A 604 (-3.4A)
KCX  A 167 ( 4.4A)
KCX  A 167 ( 4.5A)
None
 1.03A 5veuH-2fvmA:
undetectable		 5veuH-2fvmA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		5 LEU A 229
PHE A 167
PHE A 194
ALA A 193
GLY A 159
 None
None
None
TUX  A 901 ( 3.9A)
None
 1.00A 5veuH-2go4A:
undetectable		 5veuH-2go4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hay PUTATIVE
NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Streptococcus
pyogenes) 		PF00881
(Nitroreductase) 		6 ARG A 104
SER A 101
LEU A 102
ILE A  98
ALA A  91
THR A 141
 None
 1.46A 5veuH-2hayA:
undetectable		 5veuH-2hayA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 LEU A  92
GLY A 383
ILE A 119
THR A 147
GLY A 380
 None
 1.07A 5veuH-2hg4A:
undetectable		 5veuH-2hg4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iph THIOL PROTEASE P3C

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 LEU A1180
GLY A1015
PHE A1039
ILE A1049
GLY A1140
 None
 1.00A 5veuH-2iphA:
undetectable		 5veuH-2iphA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 LEU A 126
GLY A  26
ILE A  56
THR A 361
GLY A 376
 None
 0.90A 5veuH-2p50A:
undetectable		 5veuH-2p50A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg7 ETHANOLAMINE KINASE
PV091845

(Plasmodium
vivax) 		PF01633
(Choline_kinase) 		5 GLY A 442
ILE A 149
THR A 239
GLU A 370
GLY A 422
 None
SO4  A 600 (-4.8A)
None
None
None
 0.84A 5veuH-2qg7A:
undetectable		 5veuH-2qg7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		5 ARG A 541
PHE A 610
PHE A 580
ILE A 590
GLY A 564
 None
 1.06A 5veuH-2qv3A:
undetectable		 5veuH-2qv3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		5 PHE A 351
GLY A 194
PHE A 338
ILE A 284
THR A 295
 None
 0.95A 5veuH-2rmpA:
undetectable		 5veuH-2rmpA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		5 SER A 177
GLY A 123
ILE A 171
PHE A 168
GLY A 125
 None
 1.05A 5veuH-2uz0A:
undetectable		 5veuH-2uz0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuq BETA-LACTAMASE
REGULATORY PROTEIN
BLAB

(Streptomyces
cacaoi) 		PF13354
(Beta-lactamase2) 		5 LEU A 219
PHE A 135
ALA A  54
THR A 106
GLY A 266
 None
 0.98A 5veuH-2wuqA:
undetectable		 5veuH-2wuqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10

(Schizosaccharomyces
pombe) 		PF13519
(VWA_2) 		5 ARG A 109
ILE A 157
PHE A 156
ALA A 160
GLY A  90
 None
 1.06A 5veuH-2x5nA:
undetectable		 5veuH-2x5nA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLY A 174
PHE A 150
THR A 390
GLU A 414
GLY A 425
 None
 1.01A 5veuH-2xsxA:
undetectable		 5veuH-2xsxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 LEU A 972
GLY A 893
ALA A 913
THR A 925
GLY A 941
 None
 1.00A 5veuH-2xt6A:
undetectable		 5veuH-2xt6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 PHE A 378
GLY A  14
THR A 382
GLU A 178
GLY A  16
 None
FAD  A 618 (-3.3A)
FAD  A 618 (-3.5A)
None
FAD  A 618 (-3.0A)
 1.03A 5veuH-2zxhA:
undetectable		 5veuH-2zxhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		5 SER A  62
GLY A 163
ILE A  70
THR A 154
GLY A 147
 None
None
None
1PG  A 964 ( 3.9A)
None
 1.05A 5veuH-3a21A:
undetectable		 5veuH-3a21A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A 126
PHE A 191
ILE A  93
ALA A  91
GLY A  59
 None
 1.02A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A1126
PHE A1191
ILE A1093
ALA A1091
GLY A1059
 None
 1.02A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A2126
PHE A2191
ILE A2093
ALA A2091
GLY A2059
 None
 1.02A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A3126
PHE A3191
ILE A3093
ALA A3091
GLY A3059
 None
 1.03A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A4126
PHE A4191
ILE A4093
ALA A4091
GLY A4059
 None
 1.02A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A5126
PHE A5191
ILE A5093
ALA A5091
GLY A5059
 None
 1.03A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A 126
PHE A 191
ILE A  93
ALA A  91
GLY A  59
 None
 1.03A 5veuH-3cmvA:
undetectable		 5veuH-3cmvA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 LEU A 257
PHE A 272
GLY A 380
ILE A 191
GLU A 369
 None
None
None
None
MN  A 429 ( 3.0A)
 1.07A 5veuH-3ig4A:
undetectable		 5veuH-3ig4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luy PROBABLE CHORISMATE
MUTASE

(Bifidobacterium
adolescentis) 		PF00800
(PDT) 		5 LEU A  76
GLY A  53
PHE A  85
ALA A  86
GLY A  55
 None
 1.01A 5veuH-3luyA:
undetectable		 5veuH-3luyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qit POLYKETIDE SYNTHASE

(Moorea
producens) 		PF00561
(Abhydrolase_1) 		5 SER A  64
GLY A  98
ILE A  13
THR A  77
GLY A 102
 None
 1.02A 5veuH-3qitA:
undetectable		 5veuH-3qitA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		5 LEU A 523
PHE A 552
ILE A 491
PHE A 493
GLU A 535
 None
 1.00A 5veuH-3texA:
undetectable		 5veuH-3texA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 SER A 145
GLY A 214
PHE A 153
ALA A 196
THR A 194
 NAP  A 601 (-3.3A)
None
None
NAP  A 601 (-3.2A)
NAP  A 601 (-2.8A)
 1.02A 5veuH-3toxA:
undetectable		 5veuH-3toxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		5 LEU A 139
PHE A 180
ILE A 208
THR A 149
GLY A 129
 None
 1.06A 5veuH-3u4yA:
undetectable		 5veuH-3u4yA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uem PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		5 PHE A 445
GLY A 477
ILE A 420
PHE A 389
GLY A 459
 None
 0.99A 5veuH-3uemA:
undetectable		 5veuH-3uemA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 LEU A 972
GLY A 893
ALA A 913
THR A 925
GLY A 941
 None
 1.02A 5veuH-3zhrA:
undetectable		 5veuH-3zhrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A 165
GLY A 310
PHE A 377
ILE A 161
GLY A 313
 None
 1.07A 5veuH-4ak9A:
undetectable		 5veuH-4ak9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)

(Legionella
pneumophila) 		PF00351
(Biopterin_H) 		5 LEU A  54
GLY A 181
PHE A 100
ALA A 102
GLY A 183
 None
 1.04A 5veuH-4bptA:
undetectable		 5veuH-4bptA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvt CYANURIC ACID
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF09663
(Amido_AtzD_TrzD) 		5 PHE A 293
ILE A 257
THR A 274
GLU A 207
GLY A 355
 None
None
None
None
MG  A1364 ( 4.6A)
 0.92A 5veuH-4bvtA:
undetectable		 5veuH-4bvtA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 LEU A 397
ILE A 393
ALA A 236
THR A 210
GLY A 218
 None
None
None
BGC  A1001 (-4.0A)
None
 1.07A 5veuH-4f9oA:
undetectable		 5veuH-4f9oA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN

(Thermotoga
maritima;
Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		5 ARG A 210
PHE A 127
PHE A 171
ILE A 146
THR A  97
 None
 1.02A 5veuH-4gxpA:
undetectable		 5veuH-4gxpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		5 ARG A 221
GLY A 231
ILE A 214
ALA A 189
GLY A 228
 None
 0.90A 5veuH-4hyvA:
undetectable		 5veuH-4hyvA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij3 HEAVY CHAIN OF FAB
FRAGMENT
SULFHYDRYL OXIDASE 1

(Homo sapiens;
Mus musculus) 		PF00085
(Thioredoxin)
PF07654
(C1-set)
PF07686
(V-set) 		5 LEU C   4
GLY C 101
PHE C  27
THR C  57
GLY A 117
 None
 0.93A 5veuH-4ij3C:
undetectable		 5veuH-4ij3C:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 5 LEU H  84
PHE H  69
GLY H 227
ILE H 188
ALA H 190
 None
 0.95A 5veuH-4l0oH:
undetectable		 5veuH-4l0oH:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 5 LEU H  84
PHE H  69
ILE H 188
ALA H 190
GLY H 228
 None
 0.92A 5veuH-4l0oH:
undetectable		 5veuH-4l0oH:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 SER A 236
GLY A 334
ALA A  38
GLU A 187
GLY A 196
 None
 1.04A 5veuH-4lr2A:
undetectable		 5veuH-4lr2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 LEU A 123
GLY A 197
ILE A  58
ALA A  54
GLY A 194
 None
 1.06A 5veuH-4lz6A:
undetectable		 5veuH-4lz6A:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 105
ALA A 305
THR A 309
GLU A 374
GLY A 481
 HEM  A 601 ( 2.8A)
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 4.8A)
None
 0.89A 5veuH-4ny4A:
51.8		 5veuH-4ny4A:
83.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 105
SER A 119
ALA A 305
THR A 309
GLU A 374
 HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 4.8A)
 0.65A 5veuH-4ny4A:
51.8		 5veuH-4ny4A:
83.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		6 ARG A 105
SER A 119
PHE A 241
ILE A 301
ALA A 305
THR A 309
 HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
2QH  A 602 (-4.5A)
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
 0.66A 5veuH-4ny4A:
51.8		 5veuH-4ny4A:
83.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		5 LEU A 127
PHE A 192
ILE A  94
ALA A  92
GLY A  60
 None
 1.05A 5veuH-4oqfA:
undetectable		 5veuH-4oqfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 GLY A 401
ILE A 270
ALA A 259
THR A 229
GLY A 237
 None
 1.00A 5veuH-4pv4A:
0.8		 5veuH-4pv4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		5 SER A 479
GLY A 420
ILE A 736
ALA A 756
GLY A 417
 None
 1.04A 5veuH-4qi4A:
undetectable		 5veuH-4qi4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 LEU A 156
GLY A  30
ILE A 106
GLU A  70
GLY A  33
 ANP  A 402 (-4.6A)
ANP  A 402 (-3.4A)
ANP  A 402 (-4.6A)
ANP  A 402 (-3.0A)
None
 0.96A 5veuH-4qnyA:
undetectable		 5veuH-4qnyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4i CU/ZN SUPEROXIDE
DISMUTASE

(Megavirus
chiliensis) 		PF00080
(Sod_Cu) 		5 LEU A  92
GLY A 122
PHE A  30
ALA A 153
GLY A  59
 None
 1.00A 5veuH-4u4iA:
undetectable		 5veuH-4u4iA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 177
GLY A  27
ILE A 129
ALA A 212
GLY A 258
 None
 1.05A 5veuH-4wkyA:
undetectable		 5veuH-4wkyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ARG A 136
LEU A 139
GLY A 284
ILE A 171
GLY A 281
 None
 0.87A 5veuH-4xgiA:
undetectable		 5veuH-4xgiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xw3 ATP-DEPENDENT RNA
HELICASE DDX1

(Homo sapiens) 		PF00622
(SPRY) 		5 LEU A 238
PHE A 167
GLY A 159
PHE A 205
GLY A 164
 None
 0.93A 5veuH-4xw3A:
undetectable		 5veuH-4xw3A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		6 GLY A 265
PHE A 528
ILE A 503
THR A 535
GLU A 331
GLY A 307
 None
None
None
None
CA  A 604 (-2.2A)
None
 1.14A 5veuH-4z2aA:
undetectable		 5veuH-4z2aA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY A 478
ILE A 453
PHE A 450
ALA A 449
GLY A 480
 None
None
None
MCN  A 801 (-3.1A)
None
 0.95A 5veuH-4zohA:
undetectable		 5veuH-4zohA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		5 ARG A 367
PHE A 196
GLY A 219
ILE A 260
GLY A 202
 T6T  A 501 (-3.0A)
None
None
None
None
 1.06A 5veuH-5ci5A:
undetectable		 5veuH-5ci5A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus) 		PF00604
(Flu_PB2) 		5 PHE C 337
GLY C 377
PHE C 416
ILE C 529
ALA C 531
 None
 0.98A 5veuH-5d9aC:
undetectable		 5veuH-5d9aC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dth MULTIPLE PDZ DOMAIN
PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU A1385
GLY A1374
ILE A1388
ALA A1408
GLY A1371
 None
 0.91A 5veuH-5dthA:
undetectable		 5veuH-5dthA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE

(Hirschia
baltica) 		PF00160
(Pro_isomerase) 		5 LEU A  51
PHE A 166
GLY A 162
ILE A  49
THR A 169
 None
 1.06A 5veuH-5ex1A:
undetectable		 5veuH-5ex1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		5 SER A 136
GLY A 227
PHE A 291
ALA A 292
THR A 296
 GWM  A 502 ( 2.5A)
None
GWM  A 502 (-4.7A)
GWM  A 502 ( 3.6A)
HEM  A 501 (-3.6A)
 0.77A 5veuH-5gweA:
29.4		 5veuH-5gweA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 PHE A 280
ILE A 337
ALA A 185
THR A 194
GLY A 293
 None
 1.03A 5veuH-5hc4A:
undetectable		 5veuH-5hc4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 SER A 330
GLY A 190
ILE A 126
ALA A 122
GLY A 107
 None
None
None
None
TRS  A 402 ( 3.8A)
 1.05A 5veuH-5hc4A:
undetectable		 5veuH-5hc4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		5 PHE A  91
PHE A 661
ILE A 650
ALA A 107
GLY A  68
 None
 0.92A 5veuH-5hmpA:
undetectable		 5veuH-5hmpA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 LEU B  93
GLY B 216
ILE B 170
PHE B 154
GLY B  36
 None
 1.06A 5veuH-5i70B:
undetectable		 5veuH-5i70B:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkq PFVFT1

(Plasmodium
falciparum) 		no annotation 5 LEU A  51
GLY A 119
ILE A 192
ALA A 296
GLU A 130
 None
 1.05A 5veuH-5jkqA:
undetectable		 5veuH-5jkqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		5 GLY A 504
PHE A 355
ALA A 352
GLU A  56
GLY A 384
 None
 1.01A 5veuH-5jozA:
undetectable		 5veuH-5jozA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		5 LEU A 133
PHE A 198
ILE A 100
ALA A  98
GLY A  66
 None
 1.02A 5veuH-5jrjA:
undetectable		 5veuH-5jrjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY

(Thermomonospora
curvata) 		PF04261
(Dyp_perox) 		5 ARG A 246
GLY A  54
ALA A 353
THR A 250
GLY A 390
 None
 1.02A 5veuH-5jxuA:
undetectable		 5veuH-5jxuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A 326
PHE A 254
GLY A 251
ILE A 258
ALA A  83
 None
 0.88A 5veuH-5txvA:
undetectable		 5veuH-5txvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		5 LEU A 286
PHE A 254
ILE A 289
ALA A 196
GLY A 202
 None
 1.01A 5veuH-5usdA:
undetectable		 5veuH-5usdA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		5 ARG A  45
LEU A 255
GLY A 285
ILE A 240
ALA A 265
 None
 1.06A 5veuH-5w1uA:
undetectable		 5veuH-5w1uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01058
(Oxidored_q6) 		5 SER C  30
GLY C  99
ILE C 166
THR C  18
GLY C  69
 None
 0.98A 5veuH-5xfaC:
undetectable		 5veuH-5xfaC:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		5 SER A 109
GLY A 200
PHE A 264
ALA A 265
THR A 269
 88L  A 501 ( 2.4A)
None
88L  A 501 (-4.2A)
88L  A 501 ( 3.1A)
HEM  A 502 (-3.5A)
 0.65A 5veuH-5xjnA:
30.1		 5veuH-5xjnA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh1 -

(-) 		no annotation 5 ARG A 507
GLY A 367
ILE A 340
ALA A 344
GLY A 371
 None
 0.98A 5veuH-5yh1A:
undetectable		 5veuH-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 ARG A 202
GLY A 170
ILE A  68
PHE A  88
GLY A 173
 None
SO4  A 403 ( 4.7A)
None
None
None
 1.03A 5veuH-6blgA:
undetectable		 5veuH-6blgA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Mus musculus) 		no annotation 5 LEU A 206
ILE A 367
PHE A 366
ALA A 370
GLY A 339
 None
 1.04A 5veuH-6brkA:
undetectable		 5veuH-6brkA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 5 LEU A 432
GLY A 311
ILE A 424
ALA A 422
THR A 420
 None
 0.85A 5veuH-6ei1A:
undetectable		 5veuH-6ei1A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 5 ARG D 196
GLY D 126
ALA D 193
THR D 190
GLY D 119
 None
 0.96A 5veuH-6f45D:
undetectable		 5veuH-6f45D:
undetectable