SIMILAR PATTERNS OF AMINO ACIDS FOR 5VEU_H_RITH602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 LEU A  97
PHE A 160
GLY A  69
ILE A 147
GLY A   5
 None
 1.06A 5veuH-1ao0A:
0.0		 5veuH-1ao0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174) 		PF01374
(Glyco_hydro_46) 		5 LEU A  81
GLY A  47
PHE A  97
ALA A  88
GLY A  50
 None
 1.07A 5veuH-1chkA:
0.0		 5veuH-1chkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		6 LEU A  22
GLY A  44
ILE A 123
ALA A 127
THR A  33
GLY A  41
 None
 1.28A 5veuH-1cliA:
0.0		 5veuH-1cliA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		5 LEU B 400
GLY B 360
PHE B 414
ILE B 423
THR B 430
 None
 0.96A 5veuH-1cp9B:
0.0		 5veuH-1cp9B:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		5 LEU A  65
ILE A  72
ALA A  76
THR A  80
GLY A 144
 None
 0.83A 5veuH-1eyyA:
0.0		 5veuH-1eyyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		5 LEU A  65
ILE A  72
ALA A  76
THR A  80
GLY A 173
 None
 1.07A 5veuH-1eyyA:
0.0		 5veuH-1eyyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A 431
GLY A 469
ILE A 458
ALA A 487
GLY A 396
 None
 1.07A 5veuH-1i2dA:
0.0		 5veuH-1i2dA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ARG A 173
GLY A 186
PHE A 405
ALA A 404
GLY A 164
 None
 1.03A 5veuH-1j3nA:
0.0		 5veuH-1j3nA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A 327
PHE A 255
GLY A 252
ILE A 259
ALA A  83
 None
 0.89A 5veuH-1kyiA:
0.0		 5veuH-1kyiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		5 SER A 620
LEU A 624
PHE A 678
ILE A 674
ALA A 667
 None
 1.03A 5veuH-1nd7A:
0.0		 5veuH-1nd7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		5 SER A 620
LEU A 624
PHE A 678
ILE A 674
GLY A 779
 None
 1.03A 5veuH-1nd7A:
0.0		 5veuH-1nd7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A 327
PHE A 255
GLY A 252
ILE A 259
ALA A  83
 None
 0.90A 5veuH-1ofhA:
undetectable		 5veuH-1ofhA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		5 LEU A  90
GLY A  52
PHE A  20
ILE A  31
ALA A  16
 None
 1.07A 5veuH-1pzsA:
undetectable		 5veuH-1pzsA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76

(Thermotoga
maritima) 		PF03641
(Lysine_decarbox) 		5 SER A  90
LEU A  93
GLY A  46
GLU A  70
GLY A  11
 None
 1.02A 5veuH-1rcuA:
undetectable		 5veuH-1rcuA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		5 PHE A  93
PHE A 673
ILE A 662
ALA A 109
GLY A  70
 None
 1.06A 5veuH-1w8jA:
0.0		 5veuH-1w8jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 194
PHE A 360
GLY A 235
PHE A 353
ALA A 354
 LEU  A 194 ( 0.6A)
PHE  A 360 ( 1.3A)
GLY  A 235 ( 0.0A)
PHE  A 353 ( 1.3A)
ALA  A 354 ( 0.0A)
 0.95A 5veuH-1wqaA:
undetectable		 5veuH-1wqaA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 LEU A 181
PHE A 228
GLY A 223
GLU A 196
GLY A 225
 None
 1.03A 5veuH-1wytA:
undetectable		 5veuH-1wytA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 GLY A 402
ILE A 272
ALA A 261
THR A 231
GLY A 239
 None
 0.99A 5veuH-2bwsA:
0.9		 5veuH-2bwsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 PHE A  93
PHE A 673
ILE A 662
ALA A 109
GLY A  70
 None
 1.06A 5veuH-2dfsA:
0.0		 5veuH-2dfsA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF08442
(ATP-grasp_2) 		5 LEU B 322
GLY B 327
ILE B 282
ALA A 290
GLY B 358
 None
 1.04A 5veuH-2fpgB:
undetectable		 5veuH-2fpgB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		5 LEU A 175
GLY A 393
ILE A 135
PHE A  97
GLU A 201
 None
URP  A 604 (-3.4A)
KCX  A 167 ( 4.4A)
KCX  A 167 ( 4.5A)
None
 1.03A 5veuH-2fvmA:
undetectable		 5veuH-2fvmA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		5 LEU A 229
PHE A 167
PHE A 194
ALA A 193
GLY A 159
 None
None
None
TUX  A 901 ( 3.9A)
None
 1.00A 5veuH-2go4A:
undetectable		 5veuH-2go4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hay PUTATIVE
NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Streptococcus
pyogenes) 		PF00881
(Nitroreductase) 		6 ARG A 104
SER A 101
LEU A 102
ILE A  98
ALA A  91
THR A 141
 None
 1.46A 5veuH-2hayA:
undetectable		 5veuH-2hayA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 LEU A  92
GLY A 383
ILE A 119
THR A 147
GLY A 380
 None
 1.07A 5veuH-2hg4A:
undetectable		 5veuH-2hg4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iph THIOL PROTEASE P3C

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 LEU A1180
GLY A1015
PHE A1039
ILE A1049
GLY A1140
 None
 1.00A 5veuH-2iphA:
undetectable		 5veuH-2iphA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 LEU A 126
GLY A  26
ILE A  56
THR A 361
GLY A 376
 None
 0.90A 5veuH-2p50A:
undetectable		 5veuH-2p50A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg7 ETHANOLAMINE KINASE
PV091845

(Plasmodium
vivax) 		PF01633
(Choline_kinase) 		5 GLY A 442
ILE A 149
THR A 239
GLU A 370
GLY A 422
 None
SO4  A 600 (-4.8A)
None
None
None
 0.84A 5veuH-2qg7A:
undetectable		 5veuH-2qg7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		5 ARG A 541
PHE A 610
PHE A 580
ILE A 590
GLY A 564
 None
 1.06A 5veuH-2qv3A:
undetectable		 5veuH-2qv3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		5 PHE A 351
GLY A 194
PHE A 338
ILE A 284
THR A 295
 None
 0.95A 5veuH-2rmpA:
undetectable		 5veuH-2rmpA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		5 SER A 177
GLY A 123
ILE A 171
PHE A 168
GLY A 125
 None
 1.05A 5veuH-2uz0A:
undetectable		 5veuH-2uz0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuq BETA-LACTAMASE
REGULATORY PROTEIN
BLAB

(Streptomyces
cacaoi) 		PF13354
(Beta-lactamase2) 		5 LEU A 219
PHE A 135
ALA A  54
THR A 106
GLY A 266
 None
 0.98A 5veuH-2wuqA:
undetectable		 5veuH-2wuqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10

(Schizosaccharomyces
pombe) 		PF13519
(VWA_2) 		5 ARG A 109
ILE A 157
PHE A 156
ALA A 160
GLY A  90
 None
 1.06A 5veuH-2x5nA:
undetectable		 5veuH-2x5nA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLY A 174
PHE A 150
THR A 390
GLU A 414
GLY A 425
 None
 1.01A 5veuH-2xsxA:
undetectable		 5veuH-2xsxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 LEU A 972
GLY A 893
ALA A 913
THR A 925
GLY A 941
 None
 1.00A 5veuH-2xt6A:
undetectable		 5veuH-2xt6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 PHE A 378
GLY A  14
THR A 382
GLU A 178
GLY A  16
 None
FAD  A 618 (-3.3A)
FAD  A 618 (-3.5A)
None
FAD  A 618 (-3.0A)
 1.03A 5veuH-2zxhA:
undetectable		 5veuH-2zxhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		5 SER A  62
GLY A 163
ILE A  70
THR A 154
GLY A 147
 None
None
None
1PG  A 964 ( 3.9A)
None
 1.05A 5veuH-3a21A:
undetectable		 5veuH-3a21A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A 126
PHE A 191
ILE A  93
ALA A  91
GLY A  59
 None
 1.02A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A1126
PHE A1191
ILE A1093
ALA A1091
GLY A1059
 None
 1.02A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A2126
PHE A2191
ILE A2093
ALA A2091
GLY A2059
 None
 1.02A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A3126
PHE A3191
ILE A3093
ALA A3091
GLY A3059
 None
 1.03A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A4126
PHE A4191
ILE A4093
ALA A4091
GLY A4059
 None
 1.02A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A5126
PHE A5191
ILE A5093
ALA A5091
GLY A5059
 None
 1.03A 5veuH-3cmuA:
undetectable		 5veuH-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A 126
PHE A 191
ILE A  93
ALA A  91
GLY A  59
 None
 1.03A 5veuH-3cmvA:
undetectable		 5veuH-3cmvA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 LEU A 257
PHE A 272
GLY A 380
ILE A 191
GLU A 369
 None
None
None
None
MN  A 429 ( 3.0A)
 1.07A 5veuH-3ig4A:
undetectable		 5veuH-3ig4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luy PROBABLE CHORISMATE
MUTASE

(Bifidobacterium
adolescentis) 		PF00800
(PDT) 		5 LEU A  76
GLY A  53
PHE A  85
ALA A  86
GLY A  55
 None
 1.01A 5veuH-3luyA:
undetectable		 5veuH-3luyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qit POLYKETIDE SYNTHASE

(Moorea
producens) 		PF00561
(Abhydrolase_1) 		5 SER A  64
GLY A  98
ILE A  13
THR A  77
GLY A 102
 None
 1.02A 5veuH-3qitA:
undetectable		 5veuH-3qitA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		5 LEU A 523
PHE A 552
ILE A 491
PHE A 493
GLU A 535
 None
 1.00A 5veuH-3texA:
undetectable		 5veuH-3texA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 SER A 145
GLY A 214
PHE A 153
ALA A 196
THR A 194
 NAP  A 601 (-3.3A)
None
None
NAP  A 601 (-3.2A)
NAP  A 601 (-2.8A)
 1.02A 5veuH-3toxA:
undetectable		 5veuH-3toxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		5 LEU A 139
PHE A 180
ILE A 208
THR A 149
GLY A 129
 None
 1.06A 5veuH-3u4yA:
undetectable		 5veuH-3u4yA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uem PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		5 PHE A 445
GLY A 477
ILE A 420
PHE A 389
GLY A 459
 None
 0.99A 5veuH-3uemA:
undetectable		 5veuH-3uemA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 LEU A 972
GLY A 893
ALA A 913
THR A 925
GLY A 941
 None
 1.02A 5veuH-3zhrA:
undetectable		 5veuH-3zhrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A 165
GLY A 310
PHE A 377
ILE A 161
GLY A 313
 None
 1.07A 5veuH-4ak9A:
undetectable		 5veuH-4ak9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)

(Legionella
pneumophila) 		PF00351
(Biopterin_H) 		5 LEU A  54
GLY A 181
PHE A 100
ALA A 102
GLY A 183
 None
 1.04A 5veuH-4bptA:
undetectable		 5veuH-4bptA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvt CYANURIC ACID
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF09663
(Amido_AtzD_TrzD) 		5 PHE A 293
ILE A 257
THR A 274
GLU A 207
GLY A 355
 None
None
None
None
MG  A1364 ( 4.6A)
 0.92A 5veuH-4bvtA:
undetectable		 5veuH-4bvtA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 LEU A 397
ILE A 393
ALA A 236
THR A 210
GLY A 218
 None
None
None
BGC  A1001 (-4.0A)
None
 1.07A 5veuH-4f9oA:
undetectable		 5veuH-4f9oA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN

(Thermotoga
maritima;
Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		5 ARG A 210
PHE A 127
PHE A 171
ILE A 146
THR A  97
 None
 1.02A 5veuH-4gxpA:
undetectable		 5veuH-4gxpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		5 ARG A 221
GLY A 231
ILE A 214
ALA A 189
GLY A 228
 None
 0.90A 5veuH-4hyvA:
undetectable		 5veuH-4hyvA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij3 HEAVY CHAIN OF FAB
FRAGMENT
SULFHYDRYL OXIDASE 1

(Homo sapiens;
Mus musculus) 		PF00085
(Thioredoxin)
PF07654
(C1-set)
PF07686
(V-set) 		5 LEU C   4
GLY C 101
PHE C  27
THR C  57
GLY A 117
 None
 0.93A 5veuH-4ij3C:
undetectable		 5veuH-4ij3C:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 5 LEU H  84
PHE H  69
GLY H 227
ILE H 188
ALA H 190
 None
 0.95A 5veuH-4l0oH:
undetectable		 5veuH-4l0oH:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 5 LEU H  84
PHE H  69
ILE H 188
ALA H 190
GLY H 228
 None
 0.92A 5veuH-4l0oH:
undetectable		 5veuH-4l0oH:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 SER A 236
GLY A 334
ALA A  38
GLU A 187
GLY A 196
 None
 1.04A 5veuH-4lr2A:
undetectable		 5veuH-4lr2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 LEU A 123
GLY A 197
ILE A  58
ALA A  54
GLY A 194
 None
 1.06A 5veuH-4lz6A:
undetectable		 5veuH-4lz6A:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 105
ALA A 305
THR A 309
GLU A 374
GLY A 481
 HEM  A 601 ( 2.8A)
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 4.8A)
None
 0.89A 5veuH-4ny4A:
51.8		 5veuH-4ny4A:
83.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 105
SER A 119
ALA A 305
THR A 309
GLU A 374
 HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 4.8A)
 0.65A 5veuH-4ny4A:
51.8		 5veuH-4ny4A:
83.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		6 ARG A 105
SER A 119
PHE A 241
ILE A 301
ALA A 305
THR A 309
 HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
2QH  A 602 (-4.5A)
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
 0.66A 5veuH-4ny4A:
51.8		 5veuH-4ny4A:
83.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		5 LEU A 127
PHE A 192
ILE A  94
ALA A  92
GLY A  60
 None
 1.05A 5veuH-4oqfA:
undetectable		 5veuH-4oqfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 GLY A 401
ILE A 270
ALA A 259
THR A 229
GLY A 237
 None
 1.00A 5veuH-4pv4A:
0.8		 5veuH-4pv4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		5 SER A 479
GLY A 420
ILE A 736
ALA A 756
GLY A 417
 None
 1.04A 5veuH-4qi4A:
undetectable		 5veuH-4qi4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 LEU A 156
GLY A  30
ILE A 106
GLU A  70
GLY A  33
 ANP  A 402 (-4.6A)
ANP  A 402 (-3.4A)
ANP  A 402 (-4.6A)
ANP  A 402 (-3.0A)
None
 0.96A 5veuH-4qnyA:
undetectable		 5veuH-4qnyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4i CU/ZN SUPEROXIDE
DISMUTASE

(Megavirus
chiliensis) 		PF00080
(Sod_Cu) 		5 LEU A  92
GLY A 122
PHE A  30
ALA A 153
GLY A  59
 None
 1.00A 5veuH-4u4iA:
undetectable		 5veuH-4u4iA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 177
GLY A  27
ILE A 129
ALA A 212
GLY A 258
 None
 1.05A 5veuH-4wkyA:
undetectable		 5veuH-4wkyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ARG A 136
LEU A 139
GLY A 284
ILE A 171
GLY A 281
 None
 0.87A 5veuH-4xgiA:
undetectable		 5veuH-4xgiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xw3 ATP-DEPENDENT RNA
HELICASE DDX1

(Homo sapiens) 		PF00622
(SPRY) 		5 LEU A 238
PHE A 167
GLY A 159
PHE A 205
GLY A 164
 None
 0.93A 5veuH-4xw3A:
undetectable		 5veuH-4xw3A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		6 GLY A 265
PHE A 528
ILE A 503
THR A 535
GLU A 331
GLY A 307
 None
None
None
None
CA  A 604 (-2.2A)
None
 1.14A 5veuH-4z2aA:
undetectable		 5veuH-4z2aA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY A 478
ILE A 453
PHE A 450
ALA A 449
GLY A 480
 None
None
None
MCN  A 801 (-3.1A)
None
 0.95A 5veuH-4zohA:
undetectable		 5veuH-4zohA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		5 ARG A 367
PHE A 196
GLY A 219
ILE A 260
GLY A 202
 T6T  A 501 (-3.0A)
None
None
None
None
 1.06A 5veuH-5ci5A:
undetectable		 5veuH-5ci5A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus) 		PF00604
(Flu_PB2) 		5 PHE C 337
GLY C 377
PHE C 416
ILE C 529
ALA C 531
 None
 0.98A 5veuH-5d9aC:
undetectable		 5veuH-5d9aC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dth MULTIPLE PDZ DOMAIN
PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU A1385
GLY A1374
ILE A1388
ALA A1408
GLY A1371
 None
 0.91A 5veuH-5dthA:
undetectable		 5veuH-5dthA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE

(Hirschia
baltica) 		PF00160
(Pro_isomerase) 		5 LEU A  51
PHE A 166
GLY A 162
ILE A  49
THR A 169
 None
 1.06A 5veuH-5ex1A:
undetectable		 5veuH-5ex1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		5 SER A 136
GLY A 227
PHE A 291
ALA A 292
THR A 296
 GWM  A 502 ( 2.5A)
None
GWM  A 502 (-4.7A)
GWM  A 502 ( 3.6A)
HEM  A 501 (-3.6A)
 0.77A 5veuH-5gweA:
29.4		 5veuH-5gweA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 PHE A 280
ILE A 337
ALA A 185
THR A 194
GLY A 293
 None
 1.03A 5veuH-5hc4A:
undetectable		 5veuH-5hc4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 SER A 330
GLY A 190
ILE A 126
ALA A 122
GLY A 107
 None
None
None
None
TRS  A 402 ( 3.8A)
 1.05A 5veuH-5hc4A:
undetectable		 5veuH-5hc4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		5 PHE A  91
PHE A 661
ILE A 650
ALA A 107
GLY A  68
 None
 0.92A 5veuH-5hmpA:
undetectable		 5veuH-5hmpA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 LEU B  93
GLY B 216
ILE B 170
PHE B 154
GLY B  36
 None
 1.06A 5veuH-5i70B:
undetectable		 5veuH-5i70B:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkq PFVFT1

(Plasmodium
falciparum) 		no annotation 5 LEU A  51
GLY A 119
ILE A 192
ALA A 296
GLU A 130
 None
 1.05A 5veuH-5jkqA:
undetectable		 5veuH-5jkqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		5 GLY A 504
PHE A 355
ALA A 352
GLU A  56
GLY A 384
 None
 1.01A 5veuH-5jozA:
undetectable		 5veuH-5jozA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		5 LEU A 133
PHE A 198
ILE A 100
ALA A  98
GLY A  66
 None
 1.02A 5veuH-5jrjA:
undetectable		 5veuH-5jrjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY

(Thermomonospora
curvata) 		PF04261
(Dyp_perox) 		5 ARG A 246
GLY A  54
ALA A 353
THR A 250
GLY A 390
 None
 1.02A 5veuH-5jxuA:
undetectable		 5veuH-5jxuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A 326
PHE A 254
GLY A 251
ILE A 258
ALA A  83
 None
 0.88A 5veuH-5txvA:
undetectable		 5veuH-5txvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		5 LEU A 286
PHE A 254
ILE A 289
ALA A 196
GLY A 202
 None
 1.01A 5veuH-5usdA:
undetectable		 5veuH-5usdA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		5 ARG A  45
LEU A 255
GLY A 285
ILE A 240
ALA A 265
 None
 1.06A 5veuH-5w1uA:
undetectable		 5veuH-5w1uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01058
(Oxidored_q6) 		5 SER C  30
GLY C  99
ILE C 166
THR C  18
GLY C  69
 None
 0.98A 5veuH-5xfaC:
undetectable		 5veuH-5xfaC:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		5 SER A 109
GLY A 200
PHE A 264
ALA A 265
THR A 269
 88L  A 501 ( 2.4A)
None
88L  A 501 (-4.2A)
88L  A 501 ( 3.1A)
HEM  A 502 (-3.5A)
 0.65A 5veuH-5xjnA:
30.1		 5veuH-5xjnA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh1 -

(-) 		no annotation 5 ARG A 507
GLY A 367
ILE A 340
ALA A 344
GLY A 371
 None
 0.98A 5veuH-5yh1A:
undetectable		 5veuH-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 ARG A 202
GLY A 170
ILE A  68
PHE A  88
GLY A 173
 None
SO4  A 403 ( 4.7A)
None
None
None
 1.03A 5veuH-6blgA:
undetectable		 5veuH-6blgA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Mus musculus) 		no annotation 5 LEU A 206
ILE A 367
PHE A 366
ALA A 370
GLY A 339
 None
 1.04A 5veuH-6brkA:
undetectable		 5veuH-6brkA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 5 LEU A 432
GLY A 311
ILE A 424
ALA A 422
THR A 420
 None
 0.85A 5veuH-6ei1A:
undetectable		 5veuH-6ei1A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 5 ARG D 196
GLY D 126
ALA D 193
THR D 190
GLY D 119
 None
 0.96A 5veuH-6f45D:
undetectable		 5veuH-6f45D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 PHE S 929
PHE S 930
LEU S 934
LEU S 919
 None
 1.35A 5veuH-1bkdS:
0.0		 5veuH-1bkdS:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 ARG A 166
PHE A 282
LEU A 281
LEU A 333
 None
 1.18A 5veuH-1cj2A:
undetectable		 5veuH-1cj2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej8 LYS7

(Saccharomyces
cerevisiae) 		PF00080
(Sod_Cu) 		4 PHE A 116
PHE A 175
LEU A 115
LEU A 103
 None
 0.88A 5veuH-1ej8A:
0.0		 5veuH-1ej8A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		4 ARG A 355
PHE A 256
LEU A 260
LEU A 497
 None
 1.10A 5veuH-1gk2A:
1.3		 5veuH-1gk2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ARG A 430
PHE A  43
LEU A 433
LEU A  34
 None
 1.11A 5veuH-1hkwA:
0.0		 5veuH-1hkwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdp ATRIAL NATRIURETIC
PEPTIDE CLEARANCE
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 PHE A 371
PHE A 391
LEU A 280
LEU A 146
 None
 1.30A 5veuH-1jdpA:
0.0		 5veuH-1jdpA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 ARG A 861
PHE A 742
LEU A 788
LEU A 848
 None
 1.04A 5veuH-1jqoA:
0.0		 5veuH-1jqoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6u NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		4 PHE A 310
PHE A 153
LEU A 279
LEU A 148
 None
 1.30A 5veuH-1m6uA:
undetectable		 5veuH-1m6uA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		4 PHE A 310
PHE A 153
LEU A 279
LEU A 148
 None
 1.37A 5veuH-1mnnA:
0.0		 5veuH-1mnnA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ARG B 563
PHE B 443
LEU B 446
LEU B 570
 None
 1.32A 5veuH-1ovlB:
undetectable		 5veuH-1ovlB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 ARG A 799
PHE A 682
LEU A 728
LEU A 786
 None
 0.95A 5veuH-1qb4A:
undetectable		 5veuH-1qb4A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3k HU3S193 FAB
FRAGMENT, HEAVY
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H  95
PHE H 106
LEU H  45
LEU H  81
 None
 0.99A 5veuH-1s3kH:
undetectable		 5veuH-1s3kH:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		4 PHE A 101
PHE A  71
LEU A  84
LEU A 121
 None
 1.28A 5veuH-1smrA:
undetectable		 5veuH-1smrA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A

(Rattus
norvegicus) 		PF00625
(Guanylate_kin) 		4 PHE B 250
PHE B 252
LEU B 249
LEU B 315
 None
 1.37A 5veuH-1t0hB:
undetectable		 5veuH-1t0hB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 PHE A 282
PHE A 280
LEU A 283
LEU A   7
 None
 0.94A 5veuH-1tz7A:
undetectable		 5veuH-1tz7A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uan HYPOTHETICAL PROTEIN
TT1542

(Thermus
thermophilus) 		PF02585
(PIG-L) 		4 ARG A  93
PHE A  66
LEU A   2
LEU A  37
 None
 1.18A 5veuH-1uanA:
undetectable		 5veuH-1uanA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 PHE A 132
PHE A  60
LEU A 131
LEU A 155
 None
 1.07A 5veuH-1ulvA:
undetectable		 5veuH-1ulvA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 PHE A 929
PHE A 930
LEU A 934
LEU A 919
 None
 1.35A 5veuH-1xdvA:
undetectable		 5veuH-1xdvA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		4 PHE A 138
PHE A 109
LEU A 154
LEU A  36
 None
 1.27A 5veuH-1y5eA:
undetectable		 5veuH-1y5eA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7l UBIQUITIN-ACTIVATING
ENZYME E1 1

(Mus musculus) 		PF10585
(UBA_e1_thiolCys) 		4 PHE A 861
PHE A 857
LEU A 771
LEU A 762
 None
 1.28A 5veuH-1z7lA:
undetectable		 5veuH-1z7lA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a38 TITIN

(Homo sapiens) 		PF07679
(I-set) 		4 ARG A 139
PHE A 150
LEU A 161
LEU A 192
 None
 1.30A 5veuH-2a38A:
undetectable		 5veuH-2a38A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8g HYPOTHETICAL PROTEIN
PH0536

(Pyrococcus
horikoshii) 		PF01588
(tRNA_bind) 		4 PHE A  20
PHE A 112
LEU A  19
LEU A  71
 None
 1.13A 5veuH-2e8gA:
undetectable		 5veuH-2e8gA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 PHE A  89
PHE A  90
LEU A  85
LEU A 129
 None
 1.30A 5veuH-2fvlA:
undetectable		 5veuH-2fvlA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 ARG A  96
PHE A  72
PHE A  92
LEU A  89
 None
 1.35A 5veuH-2hz7A:
undetectable		 5veuH-2hz7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00497
(SBP_bac_3) 		4 ARG A  77
PHE A  52
LEU A  55
LEU A  87
 None
 1.31A 5veuH-2laoA:
undetectable		 5veuH-2laoA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llg UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF16729
(DUF5067) 		4 ARG A  15
PHE A  64
PHE A 124
LEU A  17
 None
 1.31A 5veuH-2llgA:
undetectable		 5veuH-2llgA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 ARG A 442
PHE A 371
LEU A 373
LEU A 397
 None
 1.36A 5veuH-2r66A:
undetectable		 5veuH-2r66A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE

(Streptomyces
avermitilis) 		PF05721
(PhyH) 		4 ARG A 150
PHE A  32
LEU A 218
LEU A  15
 None
 0.95A 5veuH-2rdsA:
undetectable		 5veuH-2rdsA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2stt ETS1

(Homo sapiens) 		PF00178
(Ets) 		4 ARG A  64
PHE A  30
LEU A  31
LEU A  16
 None
 1.28A 5veuH-2sttA:
undetectable		 5veuH-2sttA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 PHE C  98
PHE C  33
LEU C  97
LEU C  19
 None
None
None
SF4  C1413 (-4.3A)
 1.01A 5veuH-2ynmC:
undetectable		 5veuH-2ynmC:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 ARG A 295
PHE A 300
PHE A 237
LEU A 384
 None
 1.26A 5veuH-2zq5A:
undetectable		 5veuH-2zq5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 PHE A  37
PHE A 351
LEU A 386
LEU A  28
 None
 1.24A 5veuH-2zyjA:
undetectable		 5veuH-2zyjA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 PHE A 107
PHE A  42
LEU A 106
LEU A  28
 None
None
None
SF4  A 425 (-4.1A)
 1.09A 5veuH-3aeuA:
undetectable		 5veuH-3aeuA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d00 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT E

(Syntrophus
aciditrophicus) 		PF02663
(FmdE) 		4 PHE A 100
PHE A  84
LEU A 101
LEU A  88
 None
 1.37A 5veuH-3d00A:
undetectable		 5veuH-3d00A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsh INTERFERON
REGULATORY FACTOR 5

(Homo sapiens) 		PF10401
(IRF-3) 		4 PHE A 420
PHE A 372
LEU A 417
LEU A 424
 None
 1.00A 5veuH-3dshA:
undetectable		 5veuH-3dshA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg7 VILLIN-1

(Homo sapiens) 		PF00626
(Gelsolin) 		4 PHE A 622
PHE A 650
LEU A 621
LEU A 632
 None
 1.22A 5veuH-3fg7A:
undetectable		 5veuH-3fg7A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm8 HEXOKINASE-3

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ARG A 644
PHE A 608
LEU A 642
LEU A 604
 None
 1.26A 5veuH-3hm8A:
1.4		 5veuH-3hm8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		4 ARG A 382
PHE A 427
LEU A 376
LEU A 168
 None
 1.26A 5veuH-3hoaA:
undetectable		 5veuH-3hoaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcu PROBABLE FORMATE
TRANSPORTER 1

(Escherichia
coli) 		PF01226
(Form_Nir_trans) 		4 PHE A  75
PHE A  51
LEU A  77
LEU A  69
 None
 0.83A 5veuH-3kcuA:
1.8		 5veuH-3kcuA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kly PUTATIVE FORMATE
TRANSPORTER 1

(Vibrio cholerae) 		PF01226
(Form_Nir_trans) 		4 PHE A  74
PHE A  50
LEU A  76
LEU A  68
 None
 0.93A 5veuH-3klyA:
1.8		 5veuH-3klyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		4 ARG A 537
PHE A 277
LEU A 278
LEU A 334
 None
 1.29A 5veuH-3ky9A:
undetectable		 5veuH-3ky9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 628
PHE A 627
LEU A 489
LEU A 592
 None
 1.15A 5veuH-3ldrA:
undetectable		 5veuH-3ldrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ARG A  88
PHE A 127
LEU A 124
LEU A  58
 None
 1.33A 5veuH-3lijA:
undetectable		 5veuH-3lijA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 ARG A1066
PHE A1056
LEU A1037
LEU A1016
 None
 1.10A 5veuH-3psfA:
undetectable		 5veuH-3psfA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh6 CT296

(Chlamydia
trachomatis) 		PF16802
(DUF5070) 		4 PHE A 125
PHE A 126
LEU A 124
LEU A  90
 None
 1.11A 5veuH-3qh6A:
undetectable		 5veuH-3qh6A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 ARG A 756
PHE A 614
LEU A 611
LEU A 319
 None
 1.36A 5veuH-3qr1A:
undetectable		 5veuH-3qr1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re1 UROPORPHYRINOGEN-III
SYNTHETASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02602
(HEM4) 		4 ARG A 121
PHE A  87
LEU A 116
LEU A  98
 None
 1.29A 5veuH-3re1A:
undetectable		 5veuH-3re1A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tig TTL PROTEIN

(Xenopus
tropicalis) 		PF03133
(TTL) 		4 PHE A 263
PHE A 264
LEU A 221
LEU A 346
 None
 1.26A 5veuH-3tigA:
undetectable		 5veuH-3tigA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta) 		PF04261
(Dyp_perox) 		4 PHE A 429
PHE A 428
LEU A 430
LEU A  79
 None
 1.08A 5veuH-3vxiA:
undetectable		 5veuH-3vxiA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 ARG A 485
PHE A 539
LEU A 444
LEU A 684
 None
 0.97A 5veuH-3wfzA:
undetectable		 5veuH-3wfzA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 418
PHE A 473
LEU A 475
LEU A 392
 None
 1.36A 5veuH-3wpeA:
undetectable		 5veuH-3wpeA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		4 ARG A 855
PHE A 736
LEU A 782
LEU A 842
 None
 1.05A 5veuH-3zgbA:
1.3		 5veuH-3zgbA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ARG A 376
PHE A 391
LEU A 380
LEU A 473
 None
 1.36A 5veuH-3zo9A:
undetectable		 5veuH-3zo9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 ARG A 165
PHE A 226
LEU A 183
LEU A 220
 None
 1.21A 5veuH-4cgrA:
undetectable		 5veuH-4cgrA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e45 FANCONI ANEMIA GROUP
M PROTEIN

(Homo sapiens) 		PF16783
(FANCM-MHF_bd) 		4 ARG E 693
PHE E 679
PHE E 685
LEU E 680
 None
 1.36A 5veuH-4e45E:
undetectable		 5veuH-4e45E:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 ARG A 464
PHE A 456
LEU A 482
LEU A 540
 None
 1.22A 5veuH-4ipeA:
undetectable		 5veuH-4ipeA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu2 CELLULOSE-BINDING
PROTEIN

(Ruminococcus
flavefaciens) 		no annotation 4 PHE B  24
PHE B  26
LEU B 179
LEU B 190
 None
 1.12A 5veuH-4iu2B:
undetectable		 5veuH-4iu2B:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 PHE A  77
PHE A  37
LEU A  40
LEU A  82
 None
 1.35A 5veuH-4ntjA:
0.0		 5veuH-4ntjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5y MATERNAL PROTEIN
TUDOR

(Drosophila
melanogaster) 		PF00567
(TUDOR) 		4 ARG A2478
PHE A2501
PHE A2483
LEU A2500
 None
 1.31A 5veuH-4q5yA:
undetectable		 5veuH-4q5yA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 PHE A 415
PHE A 416
LEU A 439
LEU A 528
 None
 1.34A 5veuH-4rt6A:
undetectable		 5veuH-4rt6A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 PHE A  94
PHE A  33
LEU A  35
LEU A 128
 None
 1.20A 5veuH-4ru0A:
undetectable		 5veuH-4ru0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis) 		PF10079
(BshC) 		4 PHE A 285
PHE A 327
LEU A 284
LEU A 307
 None
 1.26A 5veuH-4wbdA:
undetectable		 5veuH-4wbdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whm UDP-GLUCOSE:ANTHOCYA
NIDIN
3-O-GLUCOSYLTRANSFER
ASE

(Clitoria
ternatea) 		PF00201
(UDPGT) 		4 PHE A  50
PHE A  48
LEU A  18
LEU A 246
 None
 1.37A 5veuH-4whmA:
undetectable		 5veuH-4whmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 PHE A  18
PHE A 143
LEU A  21
LEU A 277
 None
 1.35A 5veuH-4wlpA:
undetectable		 5veuH-4wlpA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7o TYPE VI SECRETION
SYSTEM PROTEIN VASD

(Escherichia
coli) 		PF12790
(T6SS-SciN) 		4 PHE C 106
PHE C  60
LEU C  54
LEU C 149
 None
 1.20A 5veuH-4y7oC:
undetectable		 5veuH-4y7oC:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 ARG A 346
PHE A 151
LEU A 152
LEU A 453
 None
 1.05A 5veuH-4y9lA:
undetectable		 5veuH-4y9lA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 PHE A 272
PHE A 273
LEU A 270
LEU A 321
 None
 1.30A 5veuH-4z64A:
undetectable		 5veuH-4z64A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		4 PHE A 230
PHE A 361
LEU A 233
LEU A 334
 None
 1.35A 5veuH-4zowA:
undetectable		 5veuH-4zowA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN

(Zaire
ebolavirus) 		PF02097
(Filo_VP35)
PF05505
(Ebola_NP) 		4 ARG A 240
PHE A 296
LEU A 158
LEU A 245
 None
 1.09A 5veuH-4ztiA:
undetectable		 5veuH-4ztiA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 916
PHE A 892
PHE A 887
LEU A 932
 None
 1.33A 5veuH-5b7iA:
undetectable		 5veuH-5b7iA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE

(Pyrobaculum
ferrireducens) 		PF00171
(Aldedh) 		4 PHE A 363
PHE A 364
LEU A 330
LEU A 314
 None
 1.32A 5veuH-5eebA:
undetectable		 5veuH-5eebA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		4 ARG A 858
PHE A 739
LEU A 785
LEU A 845
 None
 1.10A 5veuH-5fdnA:
1.5		 5veuH-5fdnA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE C 154
PHE C 142
LEU C 153
LEU C  67
 None
 1.26A 5veuH-5fqdC:
undetectable		 5veuH-5fqdC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 ARG A 363
PHE A 378
LEU A 367
LEU A 460
 None
 1.36A 5veuH-5h2tA:
undetectable		 5veuH-5h2tA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilb PROTEASE DO-LIKE 2,
CHLOROPLASTIC,PROTEA
SE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 ARG A 171
PHE A 147
LEU A 154
LEU A 115
 None
 1.28A 5veuH-5ilbA:
undetectable		 5veuH-5ilbA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Aspergillus
fumigatus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ARG A  70
PHE A  22
LEU A  12
LEU A  64
 None
 1.11A 5veuH-5jw6A:
undetectable		 5veuH-5jw6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kz5 FRATAXIN,
MITOCHONDRIAL

(Homo sapiens) 		PF01491
(Frataxin_Cyay) 		4 PHE A 127
PHE A 110
LEU A 106
LEU A 136
 None
 1.27A 5veuH-5kz5A:
undetectable		 5veuH-5kz5A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me5 EIF4G
EUKARYOTIC
TRANSCRIPTION
INITIATION FACTOR 4E

(Cucumis melo) 		PF01652
(IF4E)
no annotation 		4 PHE B1067
PHE A  98
LEU B1064
LEU B1072
 None
 1.10A 5veuH-5me5B:
undetectable		 5veuH-5me5B:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mek CYTOSOLIC
SULFOTRANSFERASE 18

(Arabidopsis
thaliana) 		PF00685
(Sulfotransfer_1) 		4 PHE A 152
PHE A  86
LEU A 151
LEU A 161
 EDO  A 404 (-4.5A)
None
None
None
 1.28A 5veuH-5mekA:
undetectable		 5veuH-5mekA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		4 PHE 1 121
PHE 1  90
LEU 1 118
LEU 1 128
 None
 1.23A 5veuH-5mz61:
undetectable		 5veuH-5mz61:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		4 PHE 5 318
PHE 5 107
LEU 5 123
LEU 5 355
 None
 1.07A 5veuH-5ool5:
undetectable		 5veuH-5ool5:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio;
Streptococcus
pyogenes) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 ARG A 464
PHE A 456
LEU A 482
LEU A 540
 None
 1.21A 5veuH-5tthA:
undetectable		 5veuH-5tthA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		4 ARG A1606
PHE A1403
LEU A1264
LEU A1394
 None
 1.17A 5veuH-5u1sA:
undetectable		 5veuH-5u1sA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7z ACID CERAMIDASE

(Homo sapiens) 		no annotation 4 ARG B 254
PHE B 204
LEU B 211
LEU A  65
 NAG  B 404 ( 4.8A)
None
None
None
 1.16A 5veuH-5u7zB:
undetectable		 5veuH-5u7zB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u81 ACID CERAMIDASE
ISOFORM B

(Heterocephalus
glaber) 		no annotation 4 ARG A 254
PHE A 204
LEU A 211
LEU A  65
 NAG  A 408 ( 4.1A)
None
None
None
 1.31A 5veuH-5u81A:
undetectable		 5veuH-5u81A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9m SUPEROXIDE DISMUTASE
1 COPPER CHAPERONE

(Saccharomyces
cerevisiae) 		PF00080
(Sod_Cu)
PF00403
(HMA) 		4 PHE B 116
PHE B 175
LEU B 115
LEU B 103
 None
 0.87A 5veuH-5u9mB:
undetectable		 5veuH-5u9mB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vic FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H  91
PHE H 100
LEU H  45
LEU H  80
 None
 0.99A 5veuH-5vicH:
undetectable		 5veuH-5vicH:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viy 8ANC195 G52K5 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE K  91
PHE K 100
LEU K  45
LEU K  80
 None
 1.08A 5veuH-5viyK:
undetectable		 5veuH-5viyK:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		4 ARG A 477
PHE A 395
LEU A 398
LEU A 390
 None
 1.30A 5veuH-5wu6A:
undetectable		 5veuH-5wu6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xf7 PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS

(Homo sapiens) 		no annotation 4 ARG A  61
PHE A 124
PHE A 125
LEU A 148
 None
 1.35A 5veuH-5xf7A:
undetectable		 5veuH-5xf7A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 601
PHE A 600
LEU A 462
LEU A 565
 None
 1.21A 5veuH-5xh9A:
undetectable		 5veuH-5xh9A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN

(Escherichia
coli) 		no annotation 4 PHE A 494
PHE A 493
LEU A 270
LEU A 510
 None
 1.21A 5veuH-5xnuA:
undetectable		 5veuH-5xnuA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		4 PHE A 785
PHE A1254
LEU A 788
LEU A 746
 None
 1.22A 5veuH-5xsyA:
0.6		 5veuH-5xsyA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR

(Staphylococcus
aureus) 		PF03466
(LysR_substrate) 		4 PHE A 185
PHE A  27
LEU A 188
LEU A 177
 None
 1.26A 5veuH-5y9qA:
undetectable		 5veuH-5y9qA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yrp SENSORY BOX/RESPONSE
REGULATOR

(Mycolicibacterium
smegmatis) 		no annotation 4 ARG A 421
PHE A 427
PHE A 466
LEU A 367
 None
 1.29A 5veuH-5yrpA:
undetectable		 5veuH-5yrpA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 4 PHE A2138
PHE A2142
LEU A2145
LEU A2169
 None
 1.28A 5veuH-5yz0A:
undetectable		 5veuH-5yz0A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		no annotation 4 ARG A 464
PHE A 456
LEU A 482
LEU A 540
 None
 1.25A 5veuH-6d14A:
undetectable		 5veuH-6d14A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Homo sapiens) 		no annotation 4 ARG A 470
PHE A 478
LEU A 475
LEU A 592
 FZ4  A 801 ( 3.7A)
None
None
None
 1.36A 5veuH-6d7tA:
undetectable		 5veuH-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 ARG A 142
PHE A 221
LEU A 220
LEU A 159
 None
 1.25A 5veuH-6f9nA:
undetectable		 5veuH-6f9nA:
9.49