SIMILAR PATTERNS OF AMINO ACIDS FOR 5VEU_B_RITB602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		5 SER A  53
LEU A  55
ILE A 188
PHE A 190
ALA A 347
 None
None
None
None
ACT  B 600 (-3.6A)
 1.07A 5veuB-1as4A:
undetectable		 5veuB-1as4A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		5 LEU A  65
ILE A  72
ALA A  76
ALA A 145
GLY A 173
 None
 0.97A 5veuB-1eyyA:
0.0		 5veuB-1eyyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		5 LEU A  65
ILE A  72
ALA A  76
THR A  80
GLY A 144
 None
 0.79A 5veuB-1eyyA:
0.0		 5veuB-1eyyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0p ANTIGEN 85-B

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		5 LEU A 271
ILE A 123
ALA A 121
ALA A 284
GLY A  29
 None
 0.95A 5veuB-1f0pA:
undetectable		 5veuB-1f0pA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE B 534
ALA B 578
ALA B 585
ILE B 588
GLY B 637
 None
 0.87A 5veuB-1ffvB:
0.0		 5veuB-1ffvB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		5 PHE B 426
ILE B 532
PHE B 535
ALA B 496
GLY B 449
 None
 1.07A 5veuB-1gh6B:
0.8		 5veuB-1gh6B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13561
(adh_short_C2) 		5 PHE A 116
ALA A  72
ALA A 124
ILE A 123
GLY A 118
 None
 0.83A 5veuB-1hxhA:
0.0		 5veuB-1hxhA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A 252
ILE A 261
ALA A 429
ILE A 468
GLY A 450
 None
 1.03A 5veuB-1i1qA:
0.0		 5veuB-1i1qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE B 540
ALA B 584
ALA B 591
ILE B 594
GLY B 643
 None
 0.86A 5veuB-1n60B:
0.5		 5veuB-1n60B:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 LEU A  69
ILE A  45
ALA A  47
ILE A 229
GLY A 209
 None
 1.04A 5veuB-1nr6A:
37.8		 5veuB-1nr6A:
30.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzj HYPOTHETICAL PROTEIN
YADB

(Escherichia
coli) 		PF00749
(tRNA-synt_1c) 		5 LEU A  18
PHE A  10
ALA A 221
ALA A 249
ILE A 248
 None
 1.03A 5veuB-1nzjA:
undetectable		 5veuB-1nzjA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		5 LEU A 101
PHE A 193
ALA A 251
ILE A 185
GLY A 188
 1PE  A2712 (-4.8A)
None
AKA  A 600 ( 3.8A)
None
None
 0.88A 5veuB-1q0zA:
undetectable		 5veuB-1q0zA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F
CYTOCHROME B6

(Chlamydomonas
reinhardtii) 		PF00033
(Cytochrome_B)
PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 PHE A 259
ILE B  82
PHE B  78
ILE A 252
GLY A 254
 None
None
LFA  B 960 ( 4.8A)
None
LFA  B 960 ( 4.0A)
 1.07A 5veuB-1q90A:
undetectable		 5veuB-1q90A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjs HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		5 PHE A 113
ILE A  88
ALA A  77
THR A  37
GLY A  81
 None
None
NA  A 513 ( 4.9A)
None
None
 1.07A 5veuB-1qjsA:
undetectable		 5veuB-1qjsA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 ILE A 420
PHE A 400
ALA A 417
ILE A 375
GLY A 353
 None
 0.92A 5veuB-1rp1A:
undetectable		 5veuB-1rp1A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7u H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, D-B ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 LEU A 114
PHE A  74
ALA A 117
ALA A 140
ILE A 142
 None
 0.97A 5veuB-1s7uA:
undetectable		 5veuB-1s7uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5j HYPOTHETICAL PROTEIN
MJ1187

(Methanocaldococcus
jannaschii) 		PF03747
(ADP_ribosyl_GH) 		5 ILE A  80
PHE A  83
ALA A  84
ALA A 105
GLY A 123
 None
 0.98A 5veuB-1t5jA:
undetectable		 5veuB-1t5jA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		5 SER A  55
THR A  15
ALA A  20
ILE A  23
GLY A 285
 None
 1.02A 5veuB-1to6A:
undetectable		 5veuB-1to6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuz DIACYLGLYCEROL
KINASE ALPHA

(Homo sapiens) 		PF14513
(DAG_kinase_N) 		5 SER A  77
LEU A  74
ILE A   8
PHE A  13
GLY A 108
 None
 1.08A 5veuB-1tuzA:
undetectable		 5veuB-1tuzA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvc METHANE
MONOOXYGENASE
COMPONENT C

(Methylococcus
capsulatus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A 170
ILE A 151
PHE A 123
ALA A 125
GLY A  48
 None
 1.06A 5veuB-1tvcA:
undetectable		 5veuB-1tvcA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Sulfurisphaera
tokodaii) 		PF00294
(PfkB) 		5 LEU A 306
PHE A 270
ILE A 302
ALA A 230
ILE A 231
 None
 1.05A 5veuB-1wyeA:
undetectable		 5veuB-1wyeA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xaj 3-DEHYDROQUINATE
SYNTHASE

(Staphylococcus
aureus) 		PF01761
(DHQ_synthase) 		5 PHE A 163
PHE A 119
ALA A 110
ILE A  38
GLY A  98
 None
None
None
None
NAD  A 400 ( 4.8A)
 1.07A 5veuB-1xajA:
undetectable		 5veuB-1xajA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		5 LEU A 142
ILE A 137
ALA A 117
ALA A 275
GLY A  21
 None
 1.07A 5veuB-1xc3A:
undetectable		 5veuB-1xc3A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		5 LEU A 215
PHE A 171
ILE A 203
PHE A 202
GLY A 166
 None
 0.96A 5veuB-1zbsA:
undetectable		 5veuB-1zbsA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF10433
(MMS1_N) 		5 LEU A 666
ILE A 659
ALA A 651
THR A 636
ALA A 610
 None
 1.00A 5veuB-2b5nA:
undetectable		 5veuB-2b5nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		5 LEU A 377
ALA A 396
THR A  13
ALA A 350
GLY A 346
 None
 0.99A 5veuB-2bwmA:
undetectable		 5veuB-2bwmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 LEU A 558
PHE A 612
ILE A 599
ALA A 300
ILE A 299
 None
 0.96A 5veuB-2ddhA:
undetectable		 5veuB-2ddhA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		5 LEU A 229
PHE A 167
PHE A 194
ALA A 193
GLY A 159
 None
None
None
TUX  A 901 ( 3.9A)
None
 1.01A 5veuB-2go4A:
undetectable		 5veuB-2go4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1
TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 4

(Homo sapiens;
Mus musculus) 		PF04099
(Sybindin) 		5 SER D   5
LEU D 158
PHE C  48
ILE D  16
GLY D  14
 None
 1.06A 5veuB-2j3tD:
undetectable		 5veuB-2j3tD:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onk MOLYBDATE/TUNGSTATE
ABC TRANSPORTER,
PERMEASE PROTEIN

(Archaeoglobus
fulgidus) 		PF00528
(BPD_transp_1) 		5 LEU C 178
PHE C 151
ILE C 185
ALA C 189
THR C  62
 None
 1.06A 5veuB-2onkC:
undetectable		 5veuB-2onkC:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		6 LEU A  60
PHE A 100
ILE A   6
ALA A  49
ILE A  40
GLY A 290
 None
 1.35A 5veuB-2ox4A:
undetectable		 5veuB-2ox4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		5 SER A1113
LEU A1203
THR A1095
ILE A1069
GLY A1026
 None
 0.99A 5veuB-2oxfA:
undetectable		 5veuB-2oxfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		5 LEU A 115
PHE A  23
ILE A  62
THR A   2
GLY A  32
 None
 1.08A 5veuB-2pfzA:
undetectable		 5veuB-2pfzA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmw PREPHENATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF00800
(PDT) 		5 SER A 131
LEU A 132
ALA A 107
THR A 111
ILE A  95
 None
 1.00A 5veuB-2qmwA:
undetectable		 5veuB-2qmwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 SER A  94
LEU A 131
ILE A  60
ALA A 366
GLY A 363
 None
 1.04A 5veuB-2vhlA:
undetectable		 5veuB-2vhlA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuq BETA-LACTAMASE
REGULATORY PROTEIN
BLAB

(Streptomyces
cacaoi) 		PF13354
(Beta-lactamase2) 		5 LEU A 219
PHE A 135
ALA A  54
THR A 106
GLY A 266
 None
 0.97A 5veuB-2wuqA:
undetectable		 5veuB-2wuqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		5 ILE A  68
ALA A   9
ALA A  44
ILE A  43
GLY A 132
 None
None
None
None
NAD  A1001 (-3.5A)
 1.01A 5veuB-3b1fA:
undetectable		 5veuB-3b1fA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		5 LEU A 271
PHE A 341
ALA A 275
ALA A 404
GLY A 380
 None
None
None
None
294  A 801 (-3.5A)
 1.04A 5veuB-3b8zA:
undetectable		 5veuB-3b8zA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 ALA A 113
THR A 114
ALA A 168
ILE A 167
GLY A 328
 None
 1.03A 5veuB-3b9yA:
undetectable		 5veuB-3b9yA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE A  43
PHE A 141
ALA A 140
ALA A 133
ILE A 130
 None
 1.05A 5veuB-3dd6A:
undetectable		 5veuB-3dd6A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlt ESTERASE D

(Lactobacillus
rhamnosus) 		PF12146
(Hydrolase_4) 		5 PHE A  99
ILE A 162
ALA A 166
ILE A 182
GLY A 114
 None
 0.90A 5veuB-3dltA:
undetectable		 5veuB-3dltA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 117
PHE A  75
ILE A 363
THR A 347
GLY A 108
 None
 1.08A 5veuB-3dtyA:
undetectable		 5veuB-3dtyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 PHE A 286
PHE A 287
ILE A  71
PHE A  94
ILE A 276
 None
 1.02A 5veuB-3ec7A:
undetectable		 5veuB-3ec7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eea GAF DOMAIN/HD DOMAIN
PROTEIN

(Geobacter
sulfurreducens) 		PF13492
(GAF_3) 		5 LEU A  96
PHE A 135
ILE A  72
ALA A  35
ILE A  34
 None
None
PG6  A 163 (-4.4A)
PG6  A 163 ( 4.3A)
None
 0.72A 5veuB-3eeaA:
undetectable		 5veuB-3eeaA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi1 NA(+)/H(+)
ANTIPORTER NHAA

(Escherichia
coli) 		PF06965
(Na_H_antiport_1) 		5 LEU A 152
PHE A 307
ALA A 100
ALA A 160
GLY A 336
 None
 1.05A 5veuB-3fi1A:
undetectable		 5veuB-3fi1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 LEU A 381
ALA A  82
THR A  80
ILE A 162
GLY A 157
 None
 0.91A 5veuB-3fiiA:
undetectable		 5veuB-3fiiA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 LEU A  44
PHE A 167
ALA A 166
ALA A 160
ILE A 158
 None
 0.91A 5veuB-3fydA:
undetectable		 5veuB-3fydA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 LEU A  44
PHE A 167
ALA A 166
ALA A 160
ILE A 158
 SAM  A 300 ( 4.7A)
None
None
None
None
 0.93A 5veuB-3gryA:
1.3		 5veuB-3gryA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		5 ALA A 248
THR A 252
ALA A 227
ILE A 278
GLY A 197
 None
 0.94A 5veuB-3hdjA:
undetectable		 5veuB-3hdjA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1c DIISOPROPYL-FLUOROPH
OSPHATASE

(Loligo vulgaris) 		PF08450
(SGL) 		5 ILE A  74
ALA A  21
THR A 285
ALA A 242
GLY A 245
 None
 1.05A 5veuB-3i1cA:
undetectable		 5veuB-3i1cA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwe MGLL PROTEIN

(Homo sapiens) 		PF12146
(Hydrolase_4) 		5 LEU A  75
ILE A 296
ALA A 138
ILE A 137
GLY A  60
 None
None
None
None
F4P  A 314 ( 3.7A)
 1.03A 5veuB-3jweA:
undetectable		 5veuB-3jweA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Bacillus
cytotoxicus) 		PF13377
(Peripla_BP_3) 		5 LEU A 164
ALA A 119
ALA A 198
ILE A 203
GLY A 139
 None
 1.07A 5veuB-3k4hA:
undetectable		 5veuB-3k4hA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		5 LEU A 226
PHE A  81
ILE A 233
ALA A  96
GLY A 168
 None
 1.05A 5veuB-3n0lA:
undetectable		 5veuB-3n0lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 PHE A 381
PHE A 175
ALA A 178
ILE A 361
GLY A 143
 None
 1.05A 5veuB-3nieA:
undetectable		 5veuB-3nieA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op6 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF04073
(tRNA_edit) 		5 LEU A 135
PHE A 102
ILE A 122
ALA A  43
GLY A 127
 None
 1.01A 5veuB-3op6A:
undetectable		 5veuB-3op6A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruy ORNITHINE
AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		6 LEU A  84
ALA A  92
THR A  95
ALA A 267
ILE A 252
GLY A 254
 None
None
None
None
None
LLP  A 255 ( 2.4A)
 1.35A 5veuB-3ruyA:
undetectable		 5veuB-3ruyA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 PHE A 431
PHE A 415
ALA A 417
ALA A  50
ILE A  51
 None
 1.08A 5veuB-3sm9A:
undetectable		 5veuB-3sm9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 LEU A 131
PHE A 177
ALA A 155
ILE A 313
GLY A 315
 None
 1.00A 5veuB-3tefA:
undetectable		 5veuB-3tefA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcb ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT

(Bartonella
schoenbuchensis) 		PF02661
(Fic) 		5 ILE A  96
ALA A 100
THR A 104
ILE A 150
GLY A 130
 None
 0.90A 5veuB-3zcbA:
undetectable		 5veuB-3zcbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d74 PROTEIN-TYROSINE-PHO
SPHATASE AMSI

(Erwinia
amylovora) 		PF01451
(LMWPc) 		5 LEU A  37
ALA A  65
ALA A  33
ILE A  32
GLY A  19
 None
 1.05A 5veuB-4d74A:
undetectable		 5veuB-4d74A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 PHE A 339
PHE A 372
ALA A 161
ALA A 153
ILE A 150
 None
 1.01A 5veuB-4efcA:
undetectable		 5veuB-4efcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 PHE A 241
PHE A 281
ILE A 339
PHE A 342
ALA A 343
 None
 0.91A 5veuB-4faiA:
undetectable		 5veuB-4faiA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij4 CHITINASE A

(Gemmabryum
coronatum) 		PF00182
(Glyco_hydro_19) 		6 SER A  62
PHE A  12
ILE A  58
ALA A 136
THR A 135
ALA A 126
 None
 1.13A 5veuB-4ij4A:
undetectable		 5veuB-4ij4A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 5 LEU H  84
PHE H  69
ILE H 188
ALA H 190
GLY H 228
 None
 1.00A 5veuB-4l0oH:
undetectable		 5veuB-4l0oH:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome) 		PF00150
(Cellulase) 		5 PHE A 193
ALA A 195
THR A 237
ALA A 288
ILE A 292
 None
 1.01A 5veuB-4m1rA:
undetectable		 5veuB-4m1rA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		5 LEU A  52
PHE A 245
ALA A 216
ILE A 214
GLY A 241
 None
 1.04A 5veuB-4narA:
undetectable		 5veuB-4narA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Acholeplasma
laidlawii) 		PF13561
(adh_short_C2) 		5 PHE A 218
ILE A 232
ALA A 175
ALA A 161
GLY A 126
 None
 1.03A 5veuB-4nbtA:
undetectable		 5veuB-4nbtA:
18.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		6 SER A 119
PHE A 241
ILE A 301
ALA A 305
THR A 309
ALA A 370
 2QH  A 602 (-3.9A)
2QH  A 602 (-4.5A)
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 3.1A)
 0.64A 5veuB-4ny4A:
51.8		 5veuB-4ny4A:
83.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omu SHIKIMATE
DEHYDROGENASE

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 109
PHE A 223
ILE A 185
ALA A 187
GLY A 217
 None
 1.07A 5veuB-4omuA:
undetectable		 5veuB-4omuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qid BACTERIORHODOPSIN-I

(Haloquadratum
walsbyi) 		PF01036
(Bac_rhodopsin) 		5 SER A 152
PHE A 216
ILE A 122
ALA A 191
ILE A 192
 None
 1.02A 5veuB-4qidA:
1.8		 5veuB-4qidA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01) 		PF07859
(Abhydrolase_3) 		5 LEU A 145
PHE A  55
ILE A  67
ALA A 153
ILE A 179
 None
 1.03A 5veuB-4v2iA:
undetectable		 5veuB-4v2iA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcx BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED

(Thermoanaerobacter
italicus) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		5 SER A 331
PHE A 355
ALA A 131
ILE A 121
GLY A 339
 None
 1.01A 5veuB-4wcxA:
undetectable		 5veuB-4wcxA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcx BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED

(Thermoanaerobacter
italicus) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		5 SER A 331
PHE A 355
ALA A 131
ILE A 121
GLY A 340
 None
 0.90A 5veuB-4wcxA:
undetectable		 5veuB-4wcxA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020

(Homo sapiens) 		PF08144
(CPL) 		5 SER A 237
PHE A 222
PHE A 199
ALA A 263
ILE A 264
 None
 1.08A 5veuB-4wzwA:
undetectable		 5veuB-4wzwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 SER A  83
ILE A 423
ALA A 114
ILE A 160
GLY A  89
 None
None
None
None
AKG  A 501 ( 3.9A)
 1.02A 5veuB-4xgiA:
undetectable		 5veuB-4xgiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		5 LEU A 433
ILE A 241
ALA A 235
ILE A  71
GLY A 149
 None
 0.95A 5veuB-4y23A:
undetectable		 5veuB-4y23A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		5 LEU A 394
PHE A 361
PHE A 221
ALA A 341
GLY A 354
 None
 1.08A 5veuB-4zowA:
undetectable		 5veuB-4zowA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 861
ALA A 415
ALA A 393
ILE A 395
GLY A 405
 None
 1.03A 5veuB-5a0zA:
undetectable		 5veuB-5a0zA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A,KTR
SYSTEM POTASSIUM
UPTAKE PROTEIN A

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		5 LEU A 234
PHE A 159
ALA A 197
ALA A 176
GLY A 157
 None
 1.08A 5veuB-5butA:
undetectable		 5veuB-5butA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN B

(Bacillus
subtilis) 		PF02386
(TrkH) 		6 LEU I 212
PHE I  94
ILE I 207
THR I 278
ILE I  84
GLY I  87
 None
 1.46A 5veuB-5butI:
undetectable		 5veuB-5butI:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		5 PHE A 146
PHE A  93
ALA A 242
ILE A 243
GLY A  42
 None
None
DMS  A 607 ( 3.8A)
None
None
 0.95A 5veuB-5ddbA:
undetectable		 5veuB-5ddbA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L18

(Deinococcus
radiodurans) 		PF00861
(Ribosomal_L18p) 		5 SER L  56
ILE L  38
ALA L  40
ALA L  78
GLY L 110
 None
 1.07A 5veuB-5dm6L:
undetectable		 5veuB-5dm6L:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		5 PHE A  37
ILE A 141
PHE A 142
THR A 116
ALA A  66
 None
 1.07A 5veuB-5gkxA:
undetectable		 5veuB-5gkxA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 LEU B 751
ALA B 736
ALA B 900
ILE B 894
GLY B 812
 None
 1.06A 5veuB-5gztB:
undetectable		 5veuB-5gztB:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 LEU A 751
ALA A 736
ALA A 900
ILE A 894
GLY A 812
 None
 1.06A 5veuB-5gzuA:
undetectable		 5veuB-5gzuA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 LEU A 220
PHE A 114
ILE A 258
ALA A 260
ILE A 170
 None
 1.06A 5veuB-5j3pA:
undetectable		 5veuB-5j3pA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Geoglobus
acetivorans) 		PF00348
(polyprenyl_synt) 		5 LEU A 176
PHE A 117
ALA A 133
ALA A  63
ILE A  64
 None
 0.99A 5veuB-5jfqA:
undetectable		 5veuB-5jfqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 5 LEU B 478
ALA B 661
ALA B 447
ILE B 438
GLY B 656
 None
 1.00A 5veuB-5kisB:
undetectable		 5veuB-5kisB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		5 PHE B 454
PHE B 337
PHE B 486
ALA B 445
ILE B 446
 None
 1.06A 5veuB-5m99B:
undetectable		 5veuB-5m99B:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb4 GLCNAC SPECIFIC
LECTIN

(Psathyrella) 		PF13517
(VCBS) 		5 LEU A 377
ALA A 396
THR A  13
ALA A 350
GLY A 346
 None
 0.93A 5veuB-5mb4A:
undetectable		 5veuB-5mb4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 6 PHE A  79
PHE A 174
PHE A 218
ALA A 266
ILE A 265
GLY A  82
 None
 1.50A 5veuB-5nfgA:
undetectable		 5veuB-5nfgA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 LEU T1107
PHE T1087
ILE T1145
ILE T1216
GLY T1211
 None
 0.89A 5veuB-5ojsT:
undetectable		 5veuB-5ojsT:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr0 SEED LINOLEATE
13S-LIPOXYGENASE-1

(Glycine max) 		no annotation 5 PHE A 785
ILE A 683
ALA A 686
ALA A 692
GLY A 832
 None
 1.08A 5veuB-5tr0A:
undetectable		 5veuB-5tr0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uoh CARBOXYLESTERASE A

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		5 LEU A 508
PHE A 494
ILE A 249
ILE A 213
GLY A 138
 None
 0.96A 5veuB-5uohA:
undetectable		 5veuB-5uohA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3v APOBEC3H

(Macaca
nemestrina) 		no annotation 5 LEU B  92
ILE B 106
ALA B 108
ALA B  28
ILE B  48
 None
 1.08A 5veuB-5w3vB:
undetectable		 5veuB-5w3vB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Enterococcus
faecalis) 		PF01867
(Cas_Cas1) 		5 LEU A 247
PHE A 286
ALA A 265
THR A 269
ALA A 214
 None
 1.05A 5veuB-5xvnA:
undetectable		 5veuB-5xvnA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT C''

(Saccharomyces
cerevisiae) 		no annotation 5 SER D  59
LEU D  60
ILE D  56
ILE C 165
GLY C 167
 None
 1.06A 5veuB-6c6lD:
undetectable		 5veuB-6c6lD:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 SER C 365
ALA C 371
ALA C 156
ILE C 152
GLY C 150
 None
 0.99A 5veuB-6fkhC:
undetectable		 5veuB-6fkhC:
11.34