SIMILAR PATTERNS OF AMINO ACIDS FOR 5VEU_A_RITA602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		3 ARG A 142
PHE A 125
LEU A 128
 None
 0.81A 5veuA-1al8A:
0.0		 5veuA-1al8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)

(Homo sapiens) 		PF00258
(Flavodoxin_1) 		3 ARG A 160
PHE A  75
LEU A 113
 None
None
FMN  A 190 (-4.2A)
 0.84A 5veuA-1b1cA:
0.0		 5veuA-1b1cA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 ARG A 107
PHE A  44
LEU A 696
 None
 0.87A 5veuA-1br2A:
0.4		 5veuA-1br2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		3 ARG A 316
PHE A 275
LEU A 351
 None
 0.86A 5veuA-1c3rA:
0.0		 5veuA-1c3rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c6v PROTEIN (SIU89134)

(Simian
immunodeficiency
virus) 		PF00552
(IN_DBD_C) 		3 ARG X 228
PHE X 223
LEU X 251
 None
 0.85A 5veuA-1c6vX:
undetectable		 5veuA-1c6vX:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		3 ARG A 275
PHE A 436
LEU A 442
 None
 0.85A 5veuA-1ecgA:
0.0		 5veuA-1ecgA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ARG A 274
PHE A 378
LEU A 219
 CAA  A 600 (-3.1A)
None
CAA  A 600 ( 4.8A)
 0.81A 5veuA-1ee0A:
0.0		 5veuA-1ee0A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		3 ARG A 470
PHE A 265
LEU A 311
 None
 0.87A 5veuA-1ek2A:
0.0		 5veuA-1ek2A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gak FERTILIZATION
PROTEIN

(Haliotis
fulgens) 		PF01303
(Egg_lysin) 		3 ARG A  99
PHE A  46
LEU A  40
 None
 0.85A 5veuA-1gakA:
2.2		 5veuA-1gakA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mus musculus) 		PF00268
(Ribonuc_red_sm) 		3 ARG A 125
PHE A 135
LEU A 194
 None
 0.44A 5veuA-1h0nA:
0.0		 5veuA-1h0nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		3 ARG B 266
PHE B 305
LEU B 163
 None
 0.86A 5veuA-1h4vB:
undetectable		 5veuA-1h4vB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		3 ARG A 722
PHE A 707
LEU A 710
 None
 0.85A 5veuA-1h7wA:
undetectable		 5veuA-1h7wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica) 		PF00905
(Transpeptidase) 		3 ARG A  84
PHE A 180
LEU A 187
 None
 0.71A 5veuA-1k38A:
undetectable		 5veuA-1k38A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI

(Pantoea
stewartii) 		PF00765
(Autoind_synth) 		3 ARG A 144
PHE A 101
LEU A 174
 None
 0.80A 5veuA-1k4jA:
undetectable		 5veuA-1k4jA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kdu PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00051
(Kringle) 		3 ARG A  57
PHE A   8
LEU A  46
 None
 0.73A 5veuA-1kduA:
undetectable		 5veuA-1kduA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		3 ARG A  53
PHE A   2
LEU A 155
 None
 0.80A 5veuA-1lnzA:
undetectable		 5veuA-1lnzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A  62
PHE A  96
LEU A 176
 None
 0.72A 5veuA-1mdfA:
undetectable		 5veuA-1mdfA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvh CRYPTIC LOCI
REGULATOR 4

(Schizosaccharomyces
pombe) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 ARG A 295
PHE A 435
LEU A 328
 None
 0.77A 5veuA-1mvhA:
undetectable		 5veuA-1mvhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naf ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF03127
(GAT) 		3 ARG A 258
PHE A 264
LEU A 287
 None
 0.77A 5veuA-1nafA:
undetectable		 5veuA-1nafA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		3 ARG A 137
PHE A 329
LEU A 288
 None
 0.51A 5veuA-1ndfA:
undetectable		 5veuA-1ndfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg6 HYPOTHETICAL PROTEIN
SPYM3_0169

(Streptococcus
pyogenes) 		PF01987
(AIM24) 		3 ARG A 181
PHE A 141
LEU A 108
 None
 0.80A 5veuA-1pg6A:
undetectable		 5veuA-1pg6A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		3 ARG A 301
PHE A 284
LEU A 278
 None
 0.86A 5veuA-1qd1A:
undetectable		 5veuA-1qd1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		3 ARG A 109
PHE A 291
LEU A 466
 None
 0.87A 5veuA-1qhbA:
undetectable		 5veuA-1qhbA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjs HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		3 ARG A 262
PHE A  78
LEU A  45
 None
 0.76A 5veuA-1qjsA:
undetectable		 5veuA-1qjsA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		3 ARG A 120
PHE A 237
LEU A 291
 None
ADP  A 401 (-4.1A)
None
 0.80A 5veuA-1rfvA:
undetectable		 5veuA-1rfvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		3 ARG A 284
PHE A 211
LEU A 274
 None
 0.67A 5veuA-1ru4A:
undetectable		 5veuA-1ru4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		3 ARG A 278
PHE A 235
LEU A 258
 None
 0.84A 5veuA-1sr8A:
undetectable		 5veuA-1sr8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus) 		PF00079
(Serpin) 		3 ARG A 359
PHE A 366
LEU A 230
 None
 0.67A 5veuA-1uhgA:
undetectable		 5veuA-1uhgA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukv GTP-BINDING PROTEIN
YPT1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		3 ARG Y  79
PHE Y   9
LEU Y  12
 None
 0.82A 5veuA-1ukvY:
undetectable		 5veuA-1ukvY:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		3 ARG A 321
PHE A 399
LEU A 219
 None
 0.70A 5veuA-1uz5A:
undetectable		 5veuA-1uz5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		3 ARG A 262
PHE A 282
LEU A 275
 None
 0.65A 5veuA-1v4aA:
undetectable		 5veuA-1v4aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		3 ARG A 326
PHE A 279
LEU A 272
 None
 0.79A 5veuA-1v5cA:
undetectable		 5veuA-1v5cA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464

(Thermotoga
maritima) 		PF04227
(Indigoidine_A) 		3 ARG A 184
PHE A 177
LEU A 214
 None
 0.65A 5veuA-1vkmA:
undetectable		 5veuA-1vkmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkw PUTATIVE
NITROREDUCTASE

(Thermotoga
maritima) 		PF14512
(TM1586_NiRdase) 		3 ARG A 195
PHE A  36
LEU A 175
 None
 0.85A 5veuA-1vkwA:
undetectable		 5veuA-1vkwA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjc MOBB PROTEIN HOMOLOG

(Geobacillus
stearothermophilus) 		PF03205
(MobB) 		3 ARG A 114
PHE A 146
LEU A 137
 None
 0.73A 5veuA-1xjcA:
undetectable		 5veuA-1xjcA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B) 		3 ARG A  45
PHE A  71
LEU A 390
 None
 0.86A 5veuA-1yewA:
undetectable		 5veuA-1yewA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1x PHYTANOYL-COA
DIOXYGENASE

(Homo sapiens) 		PF05721
(PhyH) 		3 ARG A 184
PHE A 282
LEU A 338
 None
 0.87A 5veuA-2a1xA:
undetectable		 5veuA-2a1xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auw HYPOTHETICAL PROTEIN
NE0471

(Nitrosomonas
europaea) 		PF10387
(DUF2442) 		3 ARG A  21
PHE A  72
LEU A   9
 None
 0.84A 5veuA-2auwA:
undetectable		 5veuA-2auwA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 ARG A1253
PHE A1275
LEU A1236
 None
 0.68A 5veuA-2b39A:
undetectable		 5veuA-2b39A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjk NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
4

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		3 ARG A 176
PHE A 202
LEU A 223
 None
U  B   5 ( 3.0A)
None
 0.82A 5veuA-2cjkA:
undetectable		 5veuA-2cjkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqj U3 SMALL NUCLEOLAR
RIBONUCLEOPROTEIN
PROTEIN IMP3 HOMOLOG

(Homo sapiens) 		PF01479
(S4) 		3 ARG A 109
PHE A 157
LEU A 118
 None
 0.83A 5veuA-2cqjA:
undetectable		 5veuA-2cqjA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		3 ARG X 365
PHE X 456
LEU X 463
 None
 0.87A 5veuA-2de0X:
undetectable		 5veuA-2de0X:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ds2 SWEET PROTEIN
MABINLIN-2 CHAIN A
SWEET PROTEIN
MABINLIN-2 CHAIN B

(Capparis
masaikai) 		PF00234
(Tryp_alpha_amyl)
no annotation 		3 ARG A  24
PHE B  49
LEU B  55
 None
 0.62A 5veuA-2ds2A:
undetectable		 5veuA-2ds2A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0z VIRUS-LIKE PARTICLE

(Pyrococcus
furiosus) 		PF04454
(Linocin_M18) 		3 ARG A 255
PHE A 247
LEU A 274
 None
 0.82A 5veuA-2e0zA:
undetectable		 5veuA-2e0zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2c UBIQUITIN
CONJUGATING ENZYME

(Spisula
solidissima) 		PF00179
(UQ_con) 		3 ARG A  34
PHE A  53
LEU A  59
 None
 0.65A 5veuA-2e2cA:
undetectable		 5veuA-2e2cA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		3 ARG A 307
PHE A 310
LEU A   7
 None
 0.86A 5veuA-2ejaA:
undetectable		 5veuA-2ejaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2el8 SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 2

(Homo sapiens) 		PF00017
(SH2) 		3 ARG A  73
PHE A 115
LEU A 112
 None
 0.38A 5veuA-2el8A:
undetectable		 5veuA-2el8A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2enp B/K PROTEIN

(Homo sapiens) 		PF00168
(C2) 		3 ARG A  98
PHE A  89
LEU A 129
 None
 0.85A 5veuA-2enpA:
undetectable		 5veuA-2enpA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		3 ARG A 231
PHE A 260
LEU A 240
 None
 0.80A 5veuA-2epjA:
undetectable		 5veuA-2epjA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		3 ARG X 569
PHE X 539
LEU X 532
 None
 0.81A 5veuA-2epkX:
2.3		 5veuA-2epkX:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		3 ARG A 554
PHE A 579
LEU A 601
 None
 0.77A 5veuA-2f5vA:
undetectable		 5veuA-2f5vA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flh CYTOKININ-SPECIFIC
BINDING PROTEIN

(Vigna radiata) 		PF00407
(Bet_v_1) 		3 ARG A 144
PHE A  26
LEU A  34
 None
ZEA  A 701 (-3.5A)
ZEA  A 702 (-4.9A)
 0.85A 5veuA-2flhA:
undetectable		 5veuA-2flhA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fml MUTT/NUDIX FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00293
(NUDIX) 		3 ARG A 153
PHE A 149
LEU A  47
 None
 0.55A 5veuA-2fmlA:
undetectable		 5veuA-2fmlA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		3 ARG A 292
PHE A 199
LEU A 397
 BSC  A   2 (-3.9A)
None
None
 0.83A 5veuA-2gwcA:
undetectable		 5veuA-2gwcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		3 ARG A 204
PHE A 180
LEU A 185
 None
GOL  A 406 ( 4.6A)
None
 0.72A 5veuA-2hekA:
undetectable		 5veuA-2hekA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig8 HYPOTHETICAL PROTEIN
PA3499

(Pseudomonas
aeruginosa) 		PF01042
(Ribonuc_L-PSP) 		3 ARG A  47
PHE A 121
LEU A  51
 None
 0.67A 5veuA-2ig8A:
undetectable		 5veuA-2ig8A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		3 ARG A 368
PHE A 377
LEU A 392
 None
 0.85A 5veuA-2j3zA:
undetectable		 5veuA-2j3zA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		3 ARG A  21
PHE A 109
LEU A 239
 None
 0.86A 5veuA-2jfnA:
undetectable		 5veuA-2jfnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khz C-MYC-RESPONSIVE
PROTEIN RCL

(Rattus
norvegicus) 		PF05014
(Nuc_deoxyrib_tr) 		3 ARG A  34
PHE A 108
LEU A 105
 None
 0.73A 5veuA-2khzA:
undetectable		 5veuA-2khzA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 ARG A 143
PHE A  46
LEU A  51
 None
 0.87A 5veuA-2nq5A:
1.8		 5veuA-2nq5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		3 ARG A  77
PHE A 181
LEU A  81
 None
 0.80A 5veuA-2oxtA:
undetectable		 5veuA-2oxtA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbx HEMAGGLUTININ/PROTEA
SE REGULATORY
PROTEIN

(Vibrio cholerae) 		PF00440
(TetR_N) 		3 ARG A  33
PHE A  71
LEU A  64
 None
 0.67A 5veuA-2pbxA:
undetectable		 5veuA-2pbxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		3 ARG A 231
PHE A 210
LEU A 228
 None
 0.79A 5veuA-2pqdA:
undetectable		 5veuA-2pqdA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN

(Desulfotalea
psychrophila) 		PF02634
(FdhD-NarQ) 		3 ARG A  75
PHE A  63
LEU A  39
 None
 0.77A 5veuA-2pw9A:
undetectable		 5veuA-2pw9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE

(Plasmodium
vivax) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		3 ARG B 342
PHE B 319
LEU B 326
 AMP  B 908 (-3.7A)
None
None
 0.84A 5veuA-2qgaB:
undetectable		 5veuA-2qgaB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		3 ARG A 321
PHE A 367
LEU A 372
 None
 0.70A 5veuA-2qveA:
undetectable		 5veuA-2qveA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 ARG B 280
PHE B 343
LEU B 296
 None
 0.63A 5veuA-2uzxB:
undetectable		 5veuA-2uzxB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 ARG A 590
PHE A 639
LEU A 642
 None
 0.81A 5veuA-2vdcA:
undetectable		 5veuA-2vdcA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 ARG A 231
PHE A 227
LEU A 302
 None
 0.79A 5veuA-2vr5A:
undetectable		 5veuA-2vr5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w68 SIALIDASE

(Vibrio cholerae) 		PF09264
(Sial-lect-inser) 		3 ARG A 207
PHE A  37
LEU A  57
 None
 0.55A 5veuA-2w68A:
undetectable		 5veuA-2w68A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 ARG A 538
PHE A 434
LEU A 427
 None
 0.82A 5veuA-2x3kA:
2.0		 5veuA-2x3kA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		3 ARG A 371
PHE A 423
LEU A 406
 None
HG  A1687 (-4.6A)
None
 0.87A 5veuA-2x49A:
undetectable		 5veuA-2x49A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xko GLOBAL NITROGEN
REGULATOR
PIPX

(Synechococcus
elongatus) 		PF00027
(cNMP_binding)
PF12058
(DUF3539)
PF13545
(HTH_Crp_2) 		3 ARG C  35
PHE C  49
LEU A  80
 None
 0.76A 5veuA-2xkoC:
undetectable		 5veuA-2xkoC:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 ARG A 147
PHE A 669
LEU A 655
 None
 0.85A 5veuA-2y3aA:
undetectable		 5veuA-2y3aA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		3 ARG A 298
PHE A 362
LEU A 322
 None
 0.70A 5veuA-2zfuA:
undetectable		 5veuA-2zfuA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 ARG X  65
PHE X  72
LEU X 131
 None
 0.68A 5veuA-2zkmX:
undetectable		 5veuA-2zkmX:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 ARG A  83
PHE A 250
LEU A  62
 None
 0.84A 5veuA-2ztgA:
undetectable		 5veuA-2ztgA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzj GLUCURONAN LYASE A

(Trichoderma
reesei) 		PF14099
(Polysacc_lyase) 		3 ARG A 122
PHE A 172
LEU A 156
 None
 0.79A 5veuA-2zzjA:
undetectable		 5veuA-2zzjA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5x FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		3 ARG A 422
PHE A 131
LEU A 137
 None
 0.80A 5veuA-3a5xA:
undetectable		 5veuA-3a5xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		3 ARG B 357
PHE B 334
LEU B 371
 C  E  61 ( 3.7A)
None
None
 0.70A 5veuA-3al0B:
undetectable		 5veuA-3al0B:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqs BACTERIAL REGULATORY
PROTEINS, TETR
FAMILY

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		3 ARG A 116
PHE A  86
LEU A  93
 None
 0.87A 5veuA-3aqsA:
undetectable		 5veuA-3aqsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		3 ARG A 365
PHE A 301
LEU A 295
 0JO  A 401 (-2.7A)
None
None
 0.85A 5veuA-3b1eA:
undetectable		 5veuA-3b1eA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbj PUTATIVE
THIOESTERASE II

(Thermobifida
fusca) 		PF13622
(4HBT_3) 		3 ARG A  46
PHE A  94
LEU A  25
 None
 0.77A 5veuA-3bbjA:
undetectable		 5veuA-3bbjA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl2 V-BCL-2

(Murid
gammaherpesvirus
4) 		PF15286
(Bcl-2_3) 		3 ARG A  96
PHE A 122
LEU A 115
 None
 0.83A 5veuA-3bl2A:
undetectable		 5veuA-3bl2A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A1166
PHE A1216
LEU A1181
 None
 0.80A 5veuA-3c1xA:
undetectable		 5veuA-3c1xA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A1170
PHE A1216
LEU A1181
 None
 0.79A 5veuA-3c1xA:
undetectable		 5veuA-3c1xA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 ARG A 227
PHE A 216
LEU A 308
 None
 0.85A 5veuA-3cinA:
undetectable		 5veuA-3cinA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs1 FLAGELLAR
CALCIUM-BINDING
PROTEIN

(Trypanosoma
cruzi) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		3 ARG A 120
PHE A 130
LEU A 198
 None
 0.86A 5veuA-3cs1A:
undetectable		 5veuA-3cs1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2
CARBOXYPEPTIDASE
INHIBITOR

(Bos taurus;
Rhipicephalus
bursa) 		PF00246
(Peptidase_M14)
PF10468
(Inhibitor_I68) 		3 ARG A  71
PHE B   8
LEU B  11
 None
 0.82A 5veuA-3d4uA:
undetectable		 5veuA-3d4uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 ARG A 342
PHE A 364
LEU A 357
 None
 0.84A 5veuA-3e77A:
undetectable		 5veuA-3e77A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		3 ARG A 160
PHE A  99
LEU A  91
 None
 0.84A 5veuA-3efsA:
undetectable		 5veuA-3efsA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		3 ARG A  30
PHE A  51
LEU A  35
 None
 0.76A 5veuA-3ek2A:
undetectable		 5veuA-3ek2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyt UNCHARACTERIZED
PROTEIN SPOA0173

(Ruegeria
pomeroyi) 		PF00578
(AhpC-TSA) 		3 ARG A 113
PHE A  33
LEU A 119
 None
 0.82A 5veuA-3eytA:
undetectable		 5veuA-3eytA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		3 ARG A 351
PHE A 288
LEU A 282
 CL  A 379 ( 3.1A)
None
None
 0.81A 5veuA-3fdbA:
undetectable		 5veuA-3fdbA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ARG A 355
PHE A 330
LEU A 372
 None
 0.86A 5veuA-3fxiA:
undetectable		 5veuA-3fxiA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF01095
(Pectinesterase) 		3 ARG A 273
PHE A 226
LEU A 220
 None
 0.78A 5veuA-3grhA:
undetectable		 5veuA-3grhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grp 3-OXOACYL-(ACYL
CARRIERPROTEIN)
REDUCTASE

(Bartonella
henselae) 		PF13561
(adh_short_C2) 		3 ARG A 133
PHE A 218
LEU A 236
 None
 0.83A 5veuA-3grpA:
undetectable		 5veuA-3grpA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h94 CATION EFFLUX SYSTEM
PROTEIN CUSB

(Escherichia
coli) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		3 ARG A 354
PHE A 358
LEU A 332
 None
AG  A 408 ( 3.9A)
None
 0.73A 5veuA-3h94A:
undetectable		 5veuA-3h94A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		3 ARG C  89
PHE C 185
LEU C 192
 None
 0.79A 5veuA-3if6C:
undetectable		 5veuA-3if6C:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu6 PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		3 ARG A 804
PHE A 754
LEU A 749
 None
 0.84A 5veuA-3iu6A:
undetectable		 5veuA-3iu6A:
16.95