SIMILAR PATTERNS OF AMINO ACIDS FOR 5VEU_A_RITA602_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1at3 | HERPES SIMPLEX VIRUSTYPE II PROTEASE (Humanalphaherpesvirus2) |
PF00716(Peptidase_S21) | 5 | ARG A 156SER A 127ILE A 161ALA A 237GLY A 33 | None | 1.14A | 5veuA-1at3A:0.0 | 5veuA-1at3A:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8u | ACYL-COATHIOESTERASE II (Escherichiacoli) |
PF13622(4HBT_3) | 5 | PHE A 235ALA A 274THR A 276ALA A 202GLY A 41 | None | 1.12A | 5veuA-1c8uA:0.0 | 5veuA-1c8uA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eyy | ALDEHYDEDEHYDROGENASE (Vibrio harveyi) |
PF00171(Aldedh) | 5 | LEU A 65ILE A 72ALA A 76THR A 80GLY A 144 | None | 0.88A | 5veuA-1eyyA:0.0 | 5veuA-1eyyA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 5 | ARG A 318ILE A 201ALA A 220THR A 266GLY A 334 | None | 1.09A | 5veuA-1k9aA:0.0 | 5veuA-1k9aA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9b | ADENYLOSUCCINATESYNTHETASE (Plasmodiumfalciparum) |
PF00709(Adenylsucc_synt) | 5 | SER A 258PHE A 240THR A 247ALA A 231GLY A 21 | NoneNoneIMO A1601 (-3.7A)IMO A1601 (-4.2A)None | 1.09A | 5veuA-1p9bA:0.0 | 5veuA-1p9bA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r66 | TDP-GLUCOSE-4,6-DEHYDRATASE (Streptomycesvenezuelae) |
PF16363(GDP_Man_Dehyd) | 5 | LEU A 231PHE A 83PHE A 16THR A 107ALA A 114 | None | 1.13A | 5veuA-1r66A:0.0 | 5veuA-1r66A:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t5j | HYPOTHETICAL PROTEINMJ1187 (Methanocaldococcusjannaschii) |
PF03747(ADP_ribosyl_GH) | 5 | ILE A 80PHE A 83ALA A 84ALA A 105GLY A 123 | None | 0.94A | 5veuA-1t5jA:0.0 | 5veuA-1t5jA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w8j | MYOSIN VA (Gallus gallus) |
PF00063(Myosin_head) | 5 | PHE A 93PHE A 673ILE A 662ALA A 109GLY A 70 | None | 1.05A | 5veuA-1w8jA:0.4 | 5veuA-1w8jA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xg2 | PECTINESTERASEINHIBITOR (Actinidiachinensis) |
PF04043(PMEI) | 5 | ARG B 13LEU B 17ILE B 43ALA B 104GLY B 110 | None | 1.11A | 5veuA-1xg2B:undetectable | 5veuA-1xg2B:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xp8 | RECA PROTEIN (Deinococcusradiodurans) |
PF00154(RecA) | 5 | LEU A 138PHE A 203ILE A 105ALA A 103GLY A 71 | None | 0.94A | 5veuA-1xp8A:0.0 | 5veuA-1xp8A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zbs | HYPOTHETICAL PROTEINPG1100 (Porphyromonasgingivalis) |
PF01869(BcrAD_BadFG) | 5 | LEU A 261ILE A 112ALA A 113ALA A 245GLY A 145 | None | 1.11A | 5veuA-1zbsA:undetectable | 5veuA-1zbsA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dfs | MYOSIN-5A (Gallus gallus) |
PF00063(Myosin_head)PF00612(IQ) | 5 | PHE A 93PHE A 673ILE A 662ALA A 109GLY A 70 | None | 1.02A | 5veuA-2dfsA:undetectable | 5veuA-2dfsA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e11 | HYDROLASE (Xanthomonascampestris) |
PF00795(CN_hydrolase) | 5 | ARG A 179PHE A 171PHE A 113ALA A 218ALA A 214 | NoneNoneCAC A1266 (-3.6A)NoneNone | 1.04A | 5veuA-2e11A:undetectable | 5veuA-2e11A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f07 | YVDT (Bacillussubtilis) |
PF00440(TetR_N) | 5 | LEU A 13PHE A 48ILE A 33ALA A 28GLY A 108 | None | 1.11A | 5veuA-2f07A:undetectable | 5veuA-2f07A:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gl5 | PUTATIVE DEHYDRATASEPROTEIN (Salmonellaenterica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ARG A 275ILE A 310ALA A 314THR A 319ALA A 271 | None | 1.13A | 5veuA-2gl5A:undetectable | 5veuA-2gl5A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2go4 | UDP-3-O-[3-HYDROXYMYRISTOYL]N-ACETYLGLUCOSAMINEDEACETYLASE (Aquifexaeolicus) |
PF03331(LpxC) | 5 | LEU A 229PHE A 167PHE A 194ALA A 193GLY A 159 | NoneNoneNoneTUX A 901 ( 3.9A)None | 1.00A | 5veuA-2go4A:undetectable | 5veuA-2go4A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ox4 | PUTATIVE MANDELATERACEMASE (Zymomonasmobilis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 60PHE A 100ILE A 6ALA A 49GLY A 290 | None | 1.13A | 5veuA-2ox4A:undetectable | 5veuA-2ox4A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ptz | ENOLASE (Trypanosomabrucei) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | SER A 113ILE A 350ALA A 353THR A 323ALA A 46 | None | 1.09A | 5veuA-2ptzA:undetectable | 5veuA-2ptzA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q27 | OXALYL-COADECARBOXYLASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ARG A 414LEU A 383ILE A 530ALA A 433GLY A 426 | None | 1.08A | 5veuA-2q27A:undetectable | 5veuA-2q27A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2v | BETA-D-HYDROXYBUTYRATE DEHYDROGENASE (Pseudomonasputida) |
PF00106(adh_short) | 5 | ARG A 133ILE A 137ALA A 138ALA A 245GLY A 167 | None | 1.11A | 5veuA-2q2vA:undetectable | 5veuA-2q2vA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qw8 | EUGENOL SYNTHASE 1 (Ocimumbasilicum) |
PF05368(NmrA) | 5 | PHE A 266PHE A 125PHE A 314ALA A 313ALA A 310 | NoneNO3 A 902 (-4.9A)PEG A 901 (-4.8A)NAP A 401 ( 4.1A)None | 1.03A | 5veuA-2qw8A:undetectable | 5veuA-2qw8A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2reb | REC A (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A 126PHE A 191ILE A 93ALA A 91GLY A 59 | None | 1.04A | 5veuA-2rebA:undetectable | 5veuA-2rebA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vob | TRYPANOTHIONESYNTHETASE (Leishmaniamajor) |
PF03738(GSP_synth)PF05257(CHAP) | 5 | LEU A 516PHE A 287ILE A 529ALA A 332GLY A 599 | None | 0.79A | 5veuA-2vobA:undetectable | 5veuA-2vobA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4g | MYOSIN HEAVY CHAIN,SKELETAL MUSCLE,ADULTMYOSIN LIGHT CHAIN3, SKELETAL MUSCLEISOFORM (Gallus gallus) |
PF00063(Myosin_head)PF02736(Myosin_N)no annotation | 5 | LEU M 775PHE C 87ILE M 786ALA M 729ALA M 743 | None | 1.13A | 5veuA-2w4gM:undetectable | 5veuA-2w4gM:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8z | 6-PHOSPHOGLUCONATEDEHYDROGENASE,DECARBOXYLATING (Geobacillusstearothermophilus) |
PF00393(6PGD)PF03446(NAD_binding_2) | 5 | LEU A 388PHE A 361PHE A 371ALA A 425GLY A 187 | None | 1.11A | 5veuA-2w8zA:undetectable | 5veuA-2w8zA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wuq | BETA-LACTAMASEREGULATORY PROTEINBLAB (Streptomycescacaoi) |
PF13354(Beta-lactamase2) | 5 | LEU A 219PHE A 135ALA A 54THR A 106GLY A 266 | None | 1.04A | 5veuA-2wuqA:undetectable | 5veuA-2wuqA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 5 | PHE A 276PHE A 377THR A 270ALA A 250GLY A 256 | None | 1.12A | 5veuA-2xvgA:undetectable | 5veuA-2xvgA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfn | ALPHA-GALACTOSIDASE-SUCROSE KINASE AGASK ([Ruminococcus]gnavus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 5 | PHE A 450ILE A 417ALA A 431ALA A 484GLY A 222 | NoneNoneNoneGOL A1721 (-4.1A)None | 1.07A | 5veuA-2yfnA:undetectable | 5veuA-2yfnA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b5m | UNCHARACTERIZEDPROTEIN (Rhodopirellulabaltica) |
PF04289(DUF447) | 5 | ARG A 187ILE A 159ALA A 147ALA A 69GLY A 74 | None | 0.83A | 5veuA-3b5mA:undetectable | 5veuA-3b5mA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b8z | PROTEIN ADAMTS-5 (Homo sapiens) |
PF01421(Reprolysin) | 5 | LEU A 271PHE A 341ALA A 275ALA A 404GLY A 380 | NoneNoneNoneNone294 A 801 (-3.5A) | 1.02A | 5veuA-3b8zA:undetectable | 5veuA-3b8zA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A 126PHE A 191ILE A 93ALA A 91GLY A 59 | None | 1.04A | 5veuA-3cmtA:undetectable | 5veuA-3cmtA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A1126PHE A1191ILE A1093ALA A1091GLY A1059 | None | 1.04A | 5veuA-3cmtA:undetectable | 5veuA-3cmtA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A2126PHE A2191ILE A2093ALA A2091GLY A2059 | None | 1.04A | 5veuA-3cmtA:undetectable | 5veuA-3cmtA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A3126PHE A3191ILE A3093ALA A3091GLY A3059 | None | 1.04A | 5veuA-3cmtA:undetectable | 5veuA-3cmtA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmt | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A4126PHE A4191ILE A4093ALA A4091GLY A4059 | None | 1.04A | 5veuA-3cmtA:undetectable | 5veuA-3cmtA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A 126PHE A 191ILE A 93ALA A 91GLY A 59 | None | 1.02A | 5veuA-3cmuA:undetectable | 5veuA-3cmuA:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A1126PHE A1191ILE A1093ALA A1091GLY A1059 | None | 1.02A | 5veuA-3cmuA:undetectable | 5veuA-3cmuA:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A2126PHE A2191ILE A2093ALA A2091GLY A2059 | None | 1.02A | 5veuA-3cmuA:undetectable | 5veuA-3cmuA:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A3126PHE A3191ILE A3093ALA A3091GLY A3059 | None | 1.02A | 5veuA-3cmuA:undetectable | 5veuA-3cmuA:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A4126PHE A4191ILE A4093ALA A4091GLY A4059 | None | 1.02A | 5veuA-3cmuA:undetectable | 5veuA-3cmuA:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmu | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A5126PHE A5191ILE A5093ALA A5091GLY A5059 | None | 1.03A | 5veuA-3cmuA:undetectable | 5veuA-3cmuA:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmv | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A 126PHE A 191ILE A 93ALA A 91GLY A 59 | None | 1.02A | 5veuA-3cmvA:undetectable | 5veuA-3cmvA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmv | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A2126PHE A2191ILE A2093ALA A2091GLY A2059 | None | 1.03A | 5veuA-3cmvA:undetectable | 5veuA-3cmvA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmv | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 5 | LEU A3126PHE A3191ILE A3093ALA A3091GLY A3059 | None | 1.11A | 5veuA-3cmvA:undetectable | 5veuA-3cmvA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ARG A 318ILE A 201ALA A 220THR A 266GLY A 334 | None | 1.09A | 5veuA-3d7uA:undetectable | 5veuA-3d7uA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eaf | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (Aeropyrumpernix) |
PF13458(Peripla_BP_6) | 5 | LEU A 44ILE A 46ALA A 120THR A 142ALA A 364 | None | 1.07A | 5veuA-3eafA:undetectable | 5veuA-3eafA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gaf | 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Brucellaabortus) |
PF13561(adh_short_C2) | 5 | PHE A 31PHE A 86ALA A 26ALA A 54GLY A 60 | None | 0.84A | 5veuA-3gafA:undetectable | 5veuA-3gafA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hm4 | CHEMOTAXIS PROTEINCHEX (Desulfovibrioalaskensis) |
PF13690(CheX) | 5 | ILE A 121ALA A 47THR A 95ALA A 116GLY A 57 | NoneNoneNoneUNL A 156 (-3.1A)None | 1.10A | 5veuA-3hm4A:undetectable | 5veuA-3hm4A:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hr8 | PROTEIN RECA (Thermotogamaritima) |
PF00154(RecA) | 5 | LEU A 128PHE A 193ILE A 95ALA A 93GLY A 61 | None | 1.04A | 5veuA-3hr8A:undetectable | 5veuA-3hr8A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i1c | DIISOPROPYL-FLUOROPHOSPHATASE (Loligo vulgaris) |
PF08450(SGL) | 5 | ILE A 74ALA A 21THR A 285ALA A 242GLY A 245 | None | 0.87A | 5veuA-3i1cA:undetectable | 5veuA-3i1cA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jcx | FAB E LIGHT CHAIN (Rattusnorvegicus) |
PF07686(V-set) | 5 | LEU L 45PHE L 71ALA L 82ALA L 78GLY L 14 | None | 1.10A | 5veuA-3jcxL:undetectable | 5veuA-3jcxL:11.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ndo | DEOXYRIBOSE-PHOSPHATE ALDOLASE (Mycolicibacteriumsmegmatis) |
PF01791(DeoC) | 5 | LEU A 205ILE A 195THR A 16ALA A 41GLY A 38 | NoneNoneUNL A 301 ( 3.3A)NoneNone | 1.13A | 5veuA-3ndoA:undetectable | 5veuA-3ndoA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3niz | RHODANESE FAMILYPROTEIN (Cryptosporidiumparvum) |
PF00069(Pkinase) | 5 | LEU A 252PHE A 233PHE A 258ALA A 187GLY A 222 | None | 1.09A | 5veuA-3nizA:undetectable | 5veuA-3nizA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pl2 | SUGAR KINASE,RIBOKINASE FAMILY (Corynebacteriumglutamicum) |
PF00294(PfkB) | 5 | LEU A 158PHE A 145ILE A 13ALA A 43GLY A 200 | None | 1.01A | 5veuA-3pl2A:undetectable | 5veuA-3pl2A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q58 | N-ACETYLMANNOSAMINE-6-PHOSPHATE2-EPIMERASE (Salmonellaenterica) |
PF04131(NanE) | 5 | LEU A 3ILE A 101THR A 205ALA A 47GLY A 15 | PEG A 241 (-4.2A)NoneNoneNoneNone | 1.04A | 5veuA-3q58A:undetectable | 5veuA-3q58A:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r4q | LACTOYLGLUTATHIONELYASE (Agrobacteriumfabrum) |
PF00903(Glyoxalase) | 5 | LEU A 32PHE A 82ALA A 13ALA A 16GLY A 124 | None | 1.01A | 5veuA-3r4qA:undetectable | 5veuA-3r4qA:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ruy | ORNITHINEAMINOTRANSFERASE (Bacillusanthracis) |
PF00202(Aminotran_3) | 5 | LEU A 84ALA A 92THR A 95ALA A 267GLY A 254 | NoneNoneNoneNoneLLP A 255 ( 2.4A) | 1.13A | 5veuA-3ruyA:undetectable | 5veuA-3ruyA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tox | SHORT CHAINDEHYDROGENASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | SER A 145PHE A 153ALA A 196THR A 194ALA A 222 | NAP A 601 (-3.3A)NoneNAP A 601 (-3.2A)NAP A 601 (-2.8A)None | 1.11A | 5veuA-3toxA:undetectable | 5veuA-3toxA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u44 | ATP-DEPENDENTHELICASE/DEOXYRIBONUCLEASE SUBUNIT B (Bacillussubtilis) |
PF12705(PDDEXK_1) | 5 | SER B 897LEU B 900ILE B 837ALA B 863GLY B 827 | None | 1.07A | 5veuA-3u44B:undetectable | 5veuA-3u44B:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wst | PROTEIN ARGININEN-METHYLTRANSFERASE7 (Caenorhabditiselegans) |
PF13649(Methyltransf_25) | 5 | ARG A 522LEU A 28PHE A 513ALA A 103GLY A 504 | None | 1.13A | 5veuA-3wstA:undetectable | 5veuA-3wstA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4akd | MANNOSE-SPECIFICLECTIN KM+ (Artocarpusinteger) |
PF01419(Jacalin) | 5 | LEU A 77PHE A 121ALA A 149THR A 5GLY A 9 | None | 1.13A | 5veuA-4akdA:undetectable | 5veuA-4akdA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evw | NUCLEOSIDE-DIPHOSPHATE-SUGARPYROPHOSPHORYLASE (Vibrio cholerae) |
no annotation | 5 | PHE A 62ILE A 114PHE A 51ALA A 41GLY A 71 | None | 0.99A | 5veuA-4evwA:undetectable | 5veuA-4evwA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ief | GINGIPAIN R2PRO-DOMAIN (Porphyromonasgingivalis) |
PF08126(Propeptide_C25) | 5 | PHE A 49ILE A 151PHE A 170ALA A 152ALA A 191 | None | 1.03A | 5veuA-4iefA:undetectable | 5veuA-4iefA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igi | COLLAGEN ALPHA3(VI) (Mus musculus) |
PF00092(VWA) | 5 | ARG A1093LEU A1095PHE A1077ILE A1031PHE A1029 | None | 1.09A | 5veuA-4igiA:undetectable | 5veuA-4igiA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ij4 | CHITINASE A (Gemmabryumcoronatum) |
PF00182(Glyco_hydro_19) | 6 | SER A 62PHE A 12ILE A 58ALA A 136THR A 135ALA A 126 | None | 1.26A | 5veuA-4ij4A:undetectable | 5veuA-4ij4A:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kna | N-SUCCINYLGLUTAMATE5-SEMIALDEHYDEDEHYDROGENASE (Burkholderiathailandensis) |
PF00171(Aldedh) | 5 | SER A 46ILE A 6PHE A 5ALA A 9GLY A 189 | None | 1.06A | 5veuA-4knaA:undetectable | 5veuA-4knaA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l0o | CYSTATHIONINEGAMMA-SYNTHASE (Helicobacterpylori) |
no annotation | 5 | LEU H 84PHE H 69ILE H 188ALA H 190GLY H 228 | None | 1.02A | 5veuA-4l0oH:undetectable | 5veuA-4l0oH:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nbt | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Acholeplasmalaidlawii) |
PF13561(adh_short_C2) | 5 | PHE A 218ILE A 232ALA A 175ALA A 161GLY A 126 | None | 1.08A | 5veuA-4nbtA:undetectable | 5veuA-4nbtA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnq | PUTATIVE ENOYL-COAHYDRATASE (Streptomycesatroolivaceus) |
PF00378(ECH_1) | 5 | LEU A 59PHE A 100ALA A 43ALA A 36GLY A 89 | None | 1.09A | 5veuA-4nnqA:undetectable | 5veuA-4nnqA:20.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 5 | ARG A 106ALA A 305THR A 309ALA A 370GLY A 481 | None2QH A 602 ( 3.6A)2QH A 602 ( 3.7A)2QH A 602 ( 3.1A)None | 0.86A | 5veuA-4ny4A:51.5 | 5veuA-4ny4A:83.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 5 | SER A 119PHE A 213ALA A 305THR A 309ALA A 370 | 2QH A 602 (-3.9A)2QH A 602 (-4.2A)2QH A 602 ( 3.6A)2QH A 602 ( 3.7A)2QH A 602 ( 3.1A) | 1.11A | 5veuA-4ny4A:51.5 | 5veuA-4ny4A:83.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 6 | SER A 119PHE A 241ILE A 301ALA A 305THR A 309ALA A 370 | 2QH A 602 (-3.9A)2QH A 602 (-4.5A)None2QH A 602 ( 3.6A)2QH A 602 ( 3.7A)2QH A 602 ( 3.1A) | 0.84A | 5veuA-4ny4A:51.5 | 5veuA-4ny4A:83.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oh1 | L-IDITOL2-DEHYDROGENASE ([Clostridium]scindens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | SER A 224PHE A 270ILE A 205ALA A 213GLY A 183 | None | 1.11A | 5veuA-4oh1A:undetectable | 5veuA-4oh1A:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqf | PROTEIN RECA (Mycobacteriumtuberculosis) |
PF00154(RecA) | 5 | LEU A 127PHE A 192ILE A 94ALA A 92GLY A 60 | None | 1.03A | 5veuA-4oqfA:undetectable | 5veuA-4oqfA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ru1 | MONOSACCHARIDE ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN, CUT2 FAMILY (Acidothermuscellulolyticus) |
PF13407(Peripla_BP_4) | 5 | SER A 292LEU A 293THR A 311ALA A 308GLY A 139 | None | 1.14A | 5veuA-4ru1A:undetectable | 5veuA-4ru1A:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgt | FRQ-INTERACTING RNAHELICASE (Neurosporacrassa) |
PF00270(DEAD)PF00271(Helicase_C)PF08148(DSHCT)PF13234(rRNA_proc-arch) | 5 | LEU A 371PHE A 440ILE A 369ALA A 575GLY A 579 | None | 0.96A | 5veuA-4xgtA:1.9 | 5veuA-4xgtA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ycz | FUSION PROTEIN OFSEC13 AND NUP145C (Thermothelomycesthermophila) |
PF00400(WD40)PF12110(Nup96) | 5 | ARG A 100ILE A 44ALA A 34ALA A 80GLY A 83 | None | 1.09A | 5veuA-4yczA:undetectable | 5veuA-4yczA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzg | PROTEIN PHOSPHATASE2C 57 (Arabidopsisthaliana) |
PF00481(PP2C) | 5 | ARG A 169ILE A 291ALA A 183THR A 195ALA A 176 | None | 1.10A | 5veuA-4yzgA:undetectable | 5veuA-4yzgA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e02 | FRQ-INTERACTING RNAHELICASE (Neurosporacrassa) |
PF00270(DEAD)PF00271(Helicase_C)PF08148(DSHCT)PF13234(rRNA_proc-arch) | 5 | LEU A 371PHE A 440ILE A 369ALA A 575GLY A 579 | None | 1.03A | 5veuA-5e02A:1.6 | 5veuA-5e02A:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fi5 | TETRAHYDROALSTONINESYNTHASE (Catharanthusroseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ARG A 182PHE A 202ILE A 248ALA A 195ALA A 225 | None | 1.13A | 5veuA-5fi5A:undetectable | 5veuA-5fi5A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fku | DNA POLYMERASE IIISUBUNIT ALPHA (Escherichiacoli) |
PF01336(tRNA_anti-codon)PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 5 | PHE A 347PHE A 406ILE A 415ALA A 419ALA A 518 | None | 1.06A | 5veuA-5fkuA:undetectable | 5veuA-5fkuA:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gpl | PUTATIVE NUCLEOSOMEASSEMBLY PROTEINC36B7.08C (Schizosaccharomycespombe) |
PF00956(NAP) | 5 | LEU A 96PHE A 161ILE A 94ALA A 186ALA A 193 | None | 1.12A | 5veuA-5gplA:undetectable | 5veuA-5gplA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h42 | UNCHARACTERIZEDPROTEIN (Lachnoclostridiumphytofermentans) |
PF17167(Glyco_hydro_36) | 5 | ARG A 398SER A 535ILE A 521PHE A 523GLY A 47 | None | 1.12A | 5veuA-5h42A:undetectable | 5veuA-5h42A:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hc4 | LIPOLYTIC ENZYME (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | PHE A 280ILE A 337ALA A 185THR A 194GLY A 293 | None | 1.10A | 5veuA-5hc4A:undetectable | 5veuA-5hc4A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hmp | UNCONVENTIONALMYOSIN-VC (Homo sapiens) |
PF00063(Myosin_head) | 5 | PHE A 91PHE A 661ILE A 650ALA A 107GLY A 68 | None | 0.91A | 5veuA-5hmpA:undetectable | 5veuA-5hmpA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jrj | PROTEIN RECA (Herbaspirillumseropedicae) |
PF00154(RecA) | 5 | LEU A 133PHE A 198ILE A 100ALA A 98GLY A 66 | None | 1.00A | 5veuA-5jrjA:undetectable | 5veuA-5jrjA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kgn | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Caenorhabditiselegans) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 5 | LEU A 313ILE A 278ALA A 138ALA A 226GLY A 233 | None | 1.14A | 5veuA-5kgnA:undetectable | 5veuA-5kgnA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mb4 | GLCNAC SPECIFICLECTIN (Psathyrella) |
PF13517(VCBS) | 5 | LEU A 377ALA A 396THR A 13ALA A 350GLY A 346 | None | 1.05A | 5veuA-5mb4A:undetectable | 5veuA-5mb4A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9x | ADENYLATION DOMAIN (Streptomycessp.) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | SER A 114ILE A 164ALA A 94ALA A 118GLY A 121 | None | 1.00A | 5veuA-5n9xA:undetectable | 5veuA-5n9xA:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v36 | GLUTATHIONEREDUCTASE (Streptococcusmutans) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | SER A 191PHE A 160ILE A 166ALA A 165GLY A 154 | NoneNoneEPE A 526 (-4.5A)NoneNone | 1.11A | 5veuA-5v36A:undetectable | 5veuA-5v36A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yy8 | INFLUENZA VIRUSNS1A-BINDING PROTEIN (Homo sapiens) |
no annotation | 5 | ILE A 294ALA A 288THR A 49ALA A 285GLY A 237 | None | 1.11A | 5veuA-5yy8A:undetectable | 5veuA-5yy8A:8.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brk | DEOXYNUCLEOSIDETRIPHOSPHATETRIPHOSPHOHYDROLASESAMHD1 (Mus musculus) |
no annotation | 5 | LEU A 206ILE A 367PHE A 366ALA A 370GLY A 339 | None | 1.02A | 5veuA-6brkA:undetectable | 5veuA-6brkA:10.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) |
no annotation | 5 | ILE A 366ALA A 362THR A 359ALA A 356GLY A 230 | None | 1.03A | 5veuA-6d0nA:1.9 | 5veuA-6d0nA:11.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e85 | - (-) |
no annotation | 5 | ARG A 45ILE A 20ALA A 121ALA A 95GLY A 89 | None | 1.06A | 5veuA-6e85A:undetectable | 5veuA-6e85A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6etz | BETA-GALACTOSIDASE (Arthrobactersp. 32cB) |
no annotation | 5 | LEU A 756PHE A1002ILE A 748ALA A 926GLY A 939 | None | 1.13A | 5veuA-6etzA:undetectable | 5veuA-6etzA:9.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g72 | NADH DEHYDROGENASE[UBIQUINONE] 1 ALPHASUBCOMPLEX SUBUNIT 8 (Mus musculus) |
no annotation | 5 | ARG X 118PHE X 96ILE X 73PHE X 70ALA X 33 | None | 1.08A | 5veuA-6g72X:undetectable | 5veuA-6g72X:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gne | - (-) |
no annotation | 5 | LEU A 341PHE A 458ILE A 406THR A 417GLY A 434 | NoneNoneNoneADP A 601 (-3.7A)None | 1.06A | 5veuA-6gneA:undetectable | 5veuA-6gneA:undetectable |