SIMILAR PATTERNS OF AMINO ACIDS FOR 5VEU_A_RITA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE

(Human
alphaherpesvirus
2) 		PF00716
(Peptidase_S21) 		5 ARG A 156
SER A 127
ILE A 161
ALA A 237
GLY A  33
 None
 1.14A 5veuA-1at3A:
0.0		 5veuA-1at3A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		5 PHE A 235
ALA A 274
THR A 276
ALA A 202
GLY A  41
 None
 1.12A 5veuA-1c8uA:
0.0		 5veuA-1c8uA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		5 LEU A  65
ILE A  72
ALA A  76
THR A  80
GLY A 144
 None
 0.88A 5veuA-1eyyA:
0.0		 5veuA-1eyyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ARG A 318
ILE A 201
ALA A 220
THR A 266
GLY A 334
 None
 1.09A 5veuA-1k9aA:
0.0		 5veuA-1k9aA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		5 SER A 258
PHE A 240
THR A 247
ALA A 231
GLY A  21
 None
None
IMO  A1601 (-3.7A)
IMO  A1601 (-4.2A)
None
 1.09A 5veuA-1p9bA:
0.0		 5veuA-1p9bA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE

(Streptomyces
venezuelae) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 231
PHE A  83
PHE A  16
THR A 107
ALA A 114
 None
 1.13A 5veuA-1r66A:
0.0		 5veuA-1r66A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5j HYPOTHETICAL PROTEIN
MJ1187

(Methanocaldococcus
jannaschii) 		PF03747
(ADP_ribosyl_GH) 		5 ILE A  80
PHE A  83
ALA A  84
ALA A 105
GLY A 123
 None
 0.94A 5veuA-1t5jA:
0.0		 5veuA-1t5jA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		5 PHE A  93
PHE A 673
ILE A 662
ALA A 109
GLY A  70
 None
 1.05A 5veuA-1w8jA:
0.4		 5veuA-1w8jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE
INHIBITOR

(Actinidia
chinensis) 		PF04043
(PMEI) 		5 ARG B  13
LEU B  17
ILE B  43
ALA B 104
GLY B 110
 None
 1.11A 5veuA-1xg2B:
undetectable		 5veuA-1xg2B:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans) 		PF00154
(RecA) 		5 LEU A 138
PHE A 203
ILE A 105
ALA A 103
GLY A  71
 None
 0.94A 5veuA-1xp8A:
0.0		 5veuA-1xp8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		5 LEU A 261
ILE A 112
ALA A 113
ALA A 245
GLY A 145
 None
 1.11A 5veuA-1zbsA:
undetectable		 5veuA-1zbsA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 PHE A  93
PHE A 673
ILE A 662
ALA A 109
GLY A  70
 None
 1.02A 5veuA-2dfsA:
undetectable		 5veuA-2dfsA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e11 HYDROLASE

(Xanthomonas
campestris) 		PF00795
(CN_hydrolase) 		5 ARG A 179
PHE A 171
PHE A 113
ALA A 218
ALA A 214
 None
None
CAC  A1266 (-3.6A)
None
None
 1.04A 5veuA-2e11A:
undetectable		 5veuA-2e11A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f07 YVDT

(Bacillus
subtilis) 		PF00440
(TetR_N) 		5 LEU A  13
PHE A  48
ILE A  33
ALA A  28
GLY A 108
 None
 1.11A 5veuA-2f07A:
undetectable		 5veuA-2f07A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gl5 PUTATIVE DEHYDRATASE
PROTEIN

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ARG A 275
ILE A 310
ALA A 314
THR A 319
ALA A 271
 None
 1.13A 5veuA-2gl5A:
undetectable		 5veuA-2gl5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		5 LEU A 229
PHE A 167
PHE A 194
ALA A 193
GLY A 159
 None
None
None
TUX  A 901 ( 3.9A)
None
 1.00A 5veuA-2go4A:
undetectable		 5veuA-2go4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  60
PHE A 100
ILE A   6
ALA A  49
GLY A 290
 None
 1.13A 5veuA-2ox4A:
undetectable		 5veuA-2ox4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 SER A 113
ILE A 350
ALA A 353
THR A 323
ALA A  46
 None
 1.09A 5veuA-2ptzA:
undetectable		 5veuA-2ptzA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ARG A 414
LEU A 383
ILE A 530
ALA A 433
GLY A 426
 None
 1.08A 5veuA-2q27A:
undetectable		 5veuA-2q27A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
putida) 		PF00106
(adh_short) 		5 ARG A 133
ILE A 137
ALA A 138
ALA A 245
GLY A 167
 None
 1.11A 5veuA-2q2vA:
undetectable		 5veuA-2q2vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum) 		PF05368
(NmrA) 		5 PHE A 266
PHE A 125
PHE A 314
ALA A 313
ALA A 310
 None
NO3  A 902 (-4.9A)
PEG  A 901 (-4.8A)
NAP  A 401 ( 4.1A)
None
 1.03A 5veuA-2qw8A:
undetectable		 5veuA-2qw8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A 126
PHE A 191
ILE A  93
ALA A  91
GLY A  59
 None
 1.04A 5veuA-2rebA:
undetectable		 5veuA-2rebA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		5 LEU A 516
PHE A 287
ILE A 529
ALA A 332
GLY A 599
 None
 0.79A 5veuA-2vobA:
undetectable		 5veuA-2vobA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT
MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N)
no annotation 		5 LEU M 775
PHE C  87
ILE M 786
ALA M 729
ALA M 743
 None
 1.13A 5veuA-2w4gM:
undetectable		 5veuA-2w4gM:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Geobacillus
stearothermophilus) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 LEU A 388
PHE A 361
PHE A 371
ALA A 425
GLY A 187
 None
 1.11A 5veuA-2w8zA:
undetectable		 5veuA-2w8zA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuq BETA-LACTAMASE
REGULATORY PROTEIN
BLAB

(Streptomyces
cacaoi) 		PF13354
(Beta-lactamase2) 		5 LEU A 219
PHE A 135
ALA A  54
THR A 106
GLY A 266
 None
 1.04A 5veuA-2wuqA:
undetectable		 5veuA-2wuqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 PHE A 276
PHE A 377
THR A 270
ALA A 250
GLY A 256
 None
 1.12A 5veuA-2xvgA:
undetectable		 5veuA-2xvgA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 PHE A 450
ILE A 417
ALA A 431
ALA A 484
GLY A 222
 None
None
None
GOL  A1721 (-4.1A)
None
 1.07A 5veuA-2yfnA:
undetectable		 5veuA-2yfnA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5m UNCHARACTERIZED
PROTEIN

(Rhodopirellula
baltica) 		PF04289
(DUF447) 		5 ARG A 187
ILE A 159
ALA A 147
ALA A  69
GLY A  74
 None
 0.83A 5veuA-3b5mA:
undetectable		 5veuA-3b5mA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		5 LEU A 271
PHE A 341
ALA A 275
ALA A 404
GLY A 380
 None
None
None
None
294  A 801 (-3.5A)
 1.02A 5veuA-3b8zA:
undetectable		 5veuA-3b8zA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A 126
PHE A 191
ILE A  93
ALA A  91
GLY A  59
 None
 1.04A 5veuA-3cmtA:
undetectable		 5veuA-3cmtA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A1126
PHE A1191
ILE A1093
ALA A1091
GLY A1059
 None
 1.04A 5veuA-3cmtA:
undetectable		 5veuA-3cmtA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A2126
PHE A2191
ILE A2093
ALA A2091
GLY A2059
 None
 1.04A 5veuA-3cmtA:
undetectable		 5veuA-3cmtA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A3126
PHE A3191
ILE A3093
ALA A3091
GLY A3059
 None
 1.04A 5veuA-3cmtA:
undetectable		 5veuA-3cmtA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A4126
PHE A4191
ILE A4093
ALA A4091
GLY A4059
 None
 1.04A 5veuA-3cmtA:
undetectable		 5veuA-3cmtA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A 126
PHE A 191
ILE A  93
ALA A  91
GLY A  59
 None
 1.02A 5veuA-3cmuA:
undetectable		 5veuA-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A1126
PHE A1191
ILE A1093
ALA A1091
GLY A1059
 None
 1.02A 5veuA-3cmuA:
undetectable		 5veuA-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A2126
PHE A2191
ILE A2093
ALA A2091
GLY A2059
 None
 1.02A 5veuA-3cmuA:
undetectable		 5veuA-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A3126
PHE A3191
ILE A3093
ALA A3091
GLY A3059
 None
 1.02A 5veuA-3cmuA:
undetectable		 5veuA-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A4126
PHE A4191
ILE A4093
ALA A4091
GLY A4059
 None
 1.02A 5veuA-3cmuA:
undetectable		 5veuA-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A5126
PHE A5191
ILE A5093
ALA A5091
GLY A5059
 None
 1.03A 5veuA-3cmuA:
undetectable		 5veuA-3cmuA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A 126
PHE A 191
ILE A  93
ALA A  91
GLY A  59
 None
 1.02A 5veuA-3cmvA:
undetectable		 5veuA-3cmvA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A2126
PHE A2191
ILE A2093
ALA A2091
GLY A2059
 None
 1.03A 5veuA-3cmvA:
undetectable		 5veuA-3cmvA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A3126
PHE A3191
ILE A3093
ALA A3091
GLY A3059
 None
 1.11A 5veuA-3cmvA:
undetectable		 5veuA-3cmvA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ARG A 318
ILE A 201
ALA A 220
THR A 266
GLY A 334
 None
 1.09A 5veuA-3d7uA:
undetectable		 5veuA-3d7uA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 LEU A  44
ILE A  46
ALA A 120
THR A 142
ALA A 364
 None
 1.07A 5veuA-3eafA:
undetectable		 5veuA-3eafA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		5 PHE A  31
PHE A  86
ALA A  26
ALA A  54
GLY A  60
 None
 0.84A 5veuA-3gafA:
undetectable		 5veuA-3gafA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm4 CHEMOTAXIS PROTEIN
CHEX

(Desulfovibrio
alaskensis) 		PF13690
(CheX) 		5 ILE A 121
ALA A  47
THR A  95
ALA A 116
GLY A  57
 None
None
None
UNL  A 156 (-3.1A)
None
 1.10A 5veuA-3hm4A:
undetectable		 5veuA-3hm4A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr8 PROTEIN RECA

(Thermotoga
maritima) 		PF00154
(RecA) 		5 LEU A 128
PHE A 193
ILE A  95
ALA A  93
GLY A  61
 None
 1.04A 5veuA-3hr8A:
undetectable		 5veuA-3hr8A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1c DIISOPROPYL-FLUOROPH
OSPHATASE

(Loligo vulgaris) 		PF08450
(SGL) 		5 ILE A  74
ALA A  21
THR A 285
ALA A 242
GLY A 245
 None
 0.87A 5veuA-3i1cA:
undetectable		 5veuA-3i1cA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcx FAB E LIGHT CHAIN

(Rattus
norvegicus) 		PF07686
(V-set) 		5 LEU L  45
PHE L  71
ALA L  82
ALA L  78
GLY L  14
 None
 1.10A 5veuA-3jcxL:
undetectable		 5veuA-3jcxL:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndo DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Mycolicibacterium
smegmatis) 		PF01791
(DeoC) 		5 LEU A 205
ILE A 195
THR A  16
ALA A  41
GLY A  38
 None
None
UNL  A 301 ( 3.3A)
None
None
 1.13A 5veuA-3ndoA:
undetectable		 5veuA-3ndoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 LEU A 252
PHE A 233
PHE A 258
ALA A 187
GLY A 222
 None
 1.09A 5veuA-3nizA:
undetectable		 5veuA-3nizA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 LEU A 158
PHE A 145
ILE A  13
ALA A  43
GLY A 200
 None
 1.01A 5veuA-3pl2A:
undetectable		 5veuA-3pl2A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Salmonella
enterica) 		PF04131
(NanE) 		5 LEU A   3
ILE A 101
THR A 205
ALA A  47
GLY A  15
 PEG  A 241 (-4.2A)
None
None
None
None
 1.04A 5veuA-3q58A:
undetectable		 5veuA-3q58A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4q LACTOYLGLUTATHIONE
LYASE

(Agrobacterium
fabrum) 		PF00903
(Glyoxalase) 		5 LEU A  32
PHE A  82
ALA A  13
ALA A  16
GLY A 124
 None
 1.01A 5veuA-3r4qA:
undetectable		 5veuA-3r4qA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruy ORNITHINE
AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 LEU A  84
ALA A  92
THR A  95
ALA A 267
GLY A 254
 None
None
None
None
LLP  A 255 ( 2.4A)
 1.13A 5veuA-3ruyA:
undetectable		 5veuA-3ruyA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 SER A 145
PHE A 153
ALA A 196
THR A 194
ALA A 222
 NAP  A 601 (-3.3A)
None
NAP  A 601 (-3.2A)
NAP  A 601 (-2.8A)
None
 1.11A 5veuA-3toxA:
undetectable		 5veuA-3toxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis) 		PF12705
(PDDEXK_1) 		5 SER B 897
LEU B 900
ILE B 837
ALA B 863
GLY B 827
 None
 1.07A 5veuA-3u44B:
undetectable		 5veuA-3u44B:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		5 ARG A 522
LEU A  28
PHE A 513
ALA A 103
GLY A 504
 None
 1.13A 5veuA-3wstA:
undetectable		 5veuA-3wstA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akd MANNOSE-SPECIFIC
LECTIN KM+

(Artocarpus
integer) 		PF01419
(Jacalin) 		5 LEU A  77
PHE A 121
ALA A 149
THR A   5
GLY A   9
 None
 1.13A 5veuA-4akdA:
undetectable		 5veuA-4akdA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE

(Vibrio cholerae) 		no annotation 5 PHE A  62
ILE A 114
PHE A  51
ALA A  41
GLY A  71
 None
 0.99A 5veuA-4evwA:
undetectable		 5veuA-4evwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ief GINGIPAIN R2
PRO-DOMAIN

(Porphyromonas
gingivalis) 		PF08126
(Propeptide_C25) 		5 PHE A  49
ILE A 151
PHE A 170
ALA A 152
ALA A 191
 None
 1.03A 5veuA-4iefA:
undetectable		 5veuA-4iefA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		5 ARG A1093
LEU A1095
PHE A1077
ILE A1031
PHE A1029
 None
 1.09A 5veuA-4igiA:
undetectable		 5veuA-4igiA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij4 CHITINASE A

(Gemmabryum
coronatum) 		PF00182
(Glyco_hydro_19) 		6 SER A  62
PHE A  12
ILE A  58
ALA A 136
THR A 135
ALA A 126
 None
 1.26A 5veuA-4ij4A:
undetectable		 5veuA-4ij4A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 SER A  46
ILE A   6
PHE A   5
ALA A   9
GLY A 189
 None
 1.06A 5veuA-4knaA:
undetectable		 5veuA-4knaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 5 LEU H  84
PHE H  69
ILE H 188
ALA H 190
GLY H 228
 None
 1.02A 5veuA-4l0oH:
undetectable		 5veuA-4l0oH:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Acholeplasma
laidlawii) 		PF13561
(adh_short_C2) 		5 PHE A 218
ILE A 232
ALA A 175
ALA A 161
GLY A 126
 None
 1.08A 5veuA-4nbtA:
undetectable		 5veuA-4nbtA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnq PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
atroolivaceus) 		PF00378
(ECH_1) 		5 LEU A  59
PHE A 100
ALA A  43
ALA A  36
GLY A  89
 None
 1.09A 5veuA-4nnqA:
undetectable		 5veuA-4nnqA:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 106
ALA A 305
THR A 309
ALA A 370
GLY A 481
 None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 3.1A)
None
 0.86A 5veuA-4ny4A:
51.5		 5veuA-4ny4A:
83.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 SER A 119
PHE A 213
ALA A 305
THR A 309
ALA A 370
 2QH  A 602 (-3.9A)
2QH  A 602 (-4.2A)
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 3.1A)
 1.11A 5veuA-4ny4A:
51.5		 5veuA-4ny4A:
83.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		6 SER A 119
PHE A 241
ILE A 301
ALA A 305
THR A 309
ALA A 370
 2QH  A 602 (-3.9A)
2QH  A 602 (-4.5A)
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 3.1A)
 0.84A 5veuA-4ny4A:
51.5		 5veuA-4ny4A:
83.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh1 L-IDITOL
2-DEHYDROGENASE

([Clostridium]
scindens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A 224
PHE A 270
ILE A 205
ALA A 213
GLY A 183
 None
 1.11A 5veuA-4oh1A:
undetectable		 5veuA-4oh1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		5 LEU A 127
PHE A 192
ILE A  94
ALA A  92
GLY A  60
 None
 1.03A 5veuA-4oqfA:
undetectable		 5veuA-4oqfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Acidothermus
cellulolyticus) 		PF13407
(Peripla_BP_4) 		5 SER A 292
LEU A 293
THR A 311
ALA A 308
GLY A 139
 None
 1.14A 5veuA-4ru1A:
undetectable		 5veuA-4ru1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 LEU A 371
PHE A 440
ILE A 369
ALA A 575
GLY A 579
 None
 0.96A 5veuA-4xgtA:
1.9		 5veuA-4xgtA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycz FUSION PROTEIN OF
SEC13 AND NUP145C

(Thermothelomyces
thermophila) 		PF00400
(WD40)
PF12110
(Nup96) 		5 ARG A 100
ILE A  44
ALA A  34
ALA A  80
GLY A  83
 None
 1.09A 5veuA-4yczA:
undetectable		 5veuA-4yczA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzg PROTEIN PHOSPHATASE
2C 57

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 ARG A 169
ILE A 291
ALA A 183
THR A 195
ALA A 176
 None
 1.10A 5veuA-4yzgA:
undetectable		 5veuA-4yzgA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 LEU A 371
PHE A 440
ILE A 369
ALA A 575
GLY A 579
 None
 1.03A 5veuA-5e02A:
1.6		 5veuA-5e02A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi5 TETRAHYDROALSTONINE
SYNTHASE

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ARG A 182
PHE A 202
ILE A 248
ALA A 195
ALA A 225
 None
 1.13A 5veuA-5fi5A:
undetectable		 5veuA-5fi5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 PHE A 347
PHE A 406
ILE A 415
ALA A 419
ALA A 518
 None
 1.06A 5veuA-5fkuA:
undetectable		 5veuA-5fkuA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpl PUTATIVE NUCLEOSOME
ASSEMBLY PROTEIN
C36B7.08C

(Schizosaccharomyces
pombe) 		PF00956
(NAP) 		5 LEU A  96
PHE A 161
ILE A  94
ALA A 186
ALA A 193
 None
 1.12A 5veuA-5gplA:
undetectable		 5veuA-5gplA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 ARG A 398
SER A 535
ILE A 521
PHE A 523
GLY A  47
 None
 1.12A 5veuA-5h42A:
undetectable		 5veuA-5h42A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 PHE A 280
ILE A 337
ALA A 185
THR A 194
GLY A 293
 None
 1.10A 5veuA-5hc4A:
undetectable		 5veuA-5hc4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		5 PHE A  91
PHE A 661
ILE A 650
ALA A 107
GLY A  68
 None
 0.91A 5veuA-5hmpA:
undetectable		 5veuA-5hmpA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		5 LEU A 133
PHE A 198
ILE A 100
ALA A  98
GLY A  66
 None
 1.00A 5veuA-5jrjA:
undetectable		 5veuA-5jrjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 LEU A 313
ILE A 278
ALA A 138
ALA A 226
GLY A 233
 None
 1.14A 5veuA-5kgnA:
undetectable		 5veuA-5kgnA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb4 GLCNAC SPECIFIC
LECTIN

(Psathyrella) 		PF13517
(VCBS) 		5 LEU A 377
ALA A 396
THR A  13
ALA A 350
GLY A 346
 None
 1.05A 5veuA-5mb4A:
undetectable		 5veuA-5mb4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 SER A 114
ILE A 164
ALA A  94
ALA A 118
GLY A 121
 None
 1.00A 5veuA-5n9xA:
undetectable		 5veuA-5n9xA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 SER A 191
PHE A 160
ILE A 166
ALA A 165
GLY A 154
 None
None
EPE  A 526 (-4.5A)
None
None
 1.11A 5veuA-5v36A:
undetectable		 5veuA-5v36A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 5 ILE A 294
ALA A 288
THR A  49
ALA A 285
GLY A 237
 None
 1.11A 5veuA-5yy8A:
undetectable		 5veuA-5yy8A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Mus musculus) 		no annotation 5 LEU A 206
ILE A 367
PHE A 366
ALA A 370
GLY A 339
 None
 1.02A 5veuA-6brkA:
undetectable		 5veuA-6brkA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 5 ILE A 366
ALA A 362
THR A 359
ALA A 356
GLY A 230
 None
 1.03A 5veuA-6d0nA:
1.9		 5veuA-6d0nA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 ARG A  45
ILE A  20
ALA A 121
ALA A  95
GLY A  89
 None
 1.06A 5veuA-6e85A:
undetectable		 5veuA-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 5 LEU A 756
PHE A1002
ILE A 748
ALA A 926
GLY A 939
 None
 1.13A 5veuA-6etzA:
undetectable		 5veuA-6etzA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 8

(Mus musculus) 		no annotation 5 ARG X 118
PHE X  96
ILE X  73
PHE X  70
ALA X  33
 None
 1.08A 5veuA-6g72X:
undetectable		 5veuA-6g72X:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 5 LEU A 341
PHE A 458
ILE A 406
THR A 417
GLY A 434
 None
None
None
ADP  A 601 (-3.7A)
None
 1.06A 5veuA-6gneA:
undetectable		 5veuA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		3 ARG A 142
PHE A 125
LEU A 128
 None
 0.81A 5veuA-1al8A:
0.0		 5veuA-1al8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)

(Homo sapiens) 		PF00258
(Flavodoxin_1) 		3 ARG A 160
PHE A  75
LEU A 113
 None
None
FMN  A 190 (-4.2A)
 0.84A 5veuA-1b1cA:
0.0		 5veuA-1b1cA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 ARG A 107
PHE A  44
LEU A 696
 None
 0.87A 5veuA-1br2A:
0.4		 5veuA-1br2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		3 ARG A 316
PHE A 275
LEU A 351
 None
 0.86A 5veuA-1c3rA:
0.0		 5veuA-1c3rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c6v PROTEIN (SIU89134)

(Simian
immunodeficiency
virus) 		PF00552
(IN_DBD_C) 		3 ARG X 228
PHE X 223
LEU X 251
 None
 0.85A 5veuA-1c6vX:
undetectable		 5veuA-1c6vX:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		3 ARG A 275
PHE A 436
LEU A 442
 None
 0.85A 5veuA-1ecgA:
0.0		 5veuA-1ecgA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ARG A 274
PHE A 378
LEU A 219
 CAA  A 600 (-3.1A)
None
CAA  A 600 ( 4.8A)
 0.81A 5veuA-1ee0A:
0.0		 5veuA-1ee0A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		3 ARG A 470
PHE A 265
LEU A 311
 None
 0.87A 5veuA-1ek2A:
0.0		 5veuA-1ek2A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gak FERTILIZATION
PROTEIN

(Haliotis
fulgens) 		PF01303
(Egg_lysin) 		3 ARG A  99
PHE A  46
LEU A  40
 None
 0.85A 5veuA-1gakA:
2.2		 5veuA-1gakA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mus musculus) 		PF00268
(Ribonuc_red_sm) 		3 ARG A 125
PHE A 135
LEU A 194
 None
 0.44A 5veuA-1h0nA:
0.0		 5veuA-1h0nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		3 ARG B 266
PHE B 305
LEU B 163
 None
 0.86A 5veuA-1h4vB:
undetectable		 5veuA-1h4vB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		3 ARG A 722
PHE A 707
LEU A 710
 None
 0.85A 5veuA-1h7wA:
undetectable		 5veuA-1h7wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica) 		PF00905
(Transpeptidase) 		3 ARG A  84
PHE A 180
LEU A 187
 None
 0.71A 5veuA-1k38A:
undetectable		 5veuA-1k38A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI

(Pantoea
stewartii) 		PF00765
(Autoind_synth) 		3 ARG A 144
PHE A 101
LEU A 174
 None
 0.80A 5veuA-1k4jA:
undetectable		 5veuA-1k4jA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kdu PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00051
(Kringle) 		3 ARG A  57
PHE A   8
LEU A  46
 None
 0.73A 5veuA-1kduA:
undetectable		 5veuA-1kduA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		3 ARG A  53
PHE A   2
LEU A 155
 None
 0.80A 5veuA-1lnzA:
undetectable		 5veuA-1lnzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A  62
PHE A  96
LEU A 176
 None
 0.72A 5veuA-1mdfA:
undetectable		 5veuA-1mdfA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvh CRYPTIC LOCI
REGULATOR 4

(Schizosaccharomyces
pombe) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 ARG A 295
PHE A 435
LEU A 328
 None
 0.77A 5veuA-1mvhA:
undetectable		 5veuA-1mvhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naf ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF03127
(GAT) 		3 ARG A 258
PHE A 264
LEU A 287
 None
 0.77A 5veuA-1nafA:
undetectable		 5veuA-1nafA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		3 ARG A 137
PHE A 329
LEU A 288
 None
 0.51A 5veuA-1ndfA:
undetectable		 5veuA-1ndfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg6 HYPOTHETICAL PROTEIN
SPYM3_0169

(Streptococcus
pyogenes) 		PF01987
(AIM24) 		3 ARG A 181
PHE A 141
LEU A 108
 None
 0.80A 5veuA-1pg6A:
undetectable		 5veuA-1pg6A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		3 ARG A 301
PHE A 284
LEU A 278
 None
 0.86A 5veuA-1qd1A:
undetectable		 5veuA-1qd1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		3 ARG A 109
PHE A 291
LEU A 466
 None
 0.87A 5veuA-1qhbA:
undetectable		 5veuA-1qhbA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjs HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		3 ARG A 262
PHE A  78
LEU A  45
 None
 0.76A 5veuA-1qjsA:
undetectable		 5veuA-1qjsA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		3 ARG A 120
PHE A 237
LEU A 291
 None
ADP  A 401 (-4.1A)
None
 0.80A 5veuA-1rfvA:
undetectable		 5veuA-1rfvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		3 ARG A 284
PHE A 211
LEU A 274
 None
 0.67A 5veuA-1ru4A:
undetectable		 5veuA-1ru4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		3 ARG A 278
PHE A 235
LEU A 258
 None
 0.84A 5veuA-1sr8A:
undetectable		 5veuA-1sr8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus) 		PF00079
(Serpin) 		3 ARG A 359
PHE A 366
LEU A 230
 None
 0.67A 5veuA-1uhgA:
undetectable		 5veuA-1uhgA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukv GTP-BINDING PROTEIN
YPT1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		3 ARG Y  79
PHE Y   9
LEU Y  12
 None
 0.82A 5veuA-1ukvY:
undetectable		 5veuA-1ukvY:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		3 ARG A 321
PHE A 399
LEU A 219
 None
 0.70A 5veuA-1uz5A:
undetectable		 5veuA-1uz5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		3 ARG A 262
PHE A 282
LEU A 275
 None
 0.65A 5veuA-1v4aA:
undetectable		 5veuA-1v4aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		3 ARG A 326
PHE A 279
LEU A 272
 None
 0.79A 5veuA-1v5cA:
undetectable		 5veuA-1v5cA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464

(Thermotoga
maritima) 		PF04227
(Indigoidine_A) 		3 ARG A 184
PHE A 177
LEU A 214
 None
 0.65A 5veuA-1vkmA:
undetectable		 5veuA-1vkmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkw PUTATIVE
NITROREDUCTASE

(Thermotoga
maritima) 		PF14512
(TM1586_NiRdase) 		3 ARG A 195
PHE A  36
LEU A 175
 None
 0.85A 5veuA-1vkwA:
undetectable		 5veuA-1vkwA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjc MOBB PROTEIN HOMOLOG

(Geobacillus
stearothermophilus) 		PF03205
(MobB) 		3 ARG A 114
PHE A 146
LEU A 137
 None
 0.73A 5veuA-1xjcA:
undetectable		 5veuA-1xjcA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B) 		3 ARG A  45
PHE A  71
LEU A 390
 None
 0.86A 5veuA-1yewA:
undetectable		 5veuA-1yewA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1x PHYTANOYL-COA
DIOXYGENASE

(Homo sapiens) 		PF05721
(PhyH) 		3 ARG A 184
PHE A 282
LEU A 338
 None
 0.87A 5veuA-2a1xA:
undetectable		 5veuA-2a1xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auw HYPOTHETICAL PROTEIN
NE0471

(Nitrosomonas
europaea) 		PF10387
(DUF2442) 		3 ARG A  21
PHE A  72
LEU A   9
 None
 0.84A 5veuA-2auwA:
undetectable		 5veuA-2auwA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 ARG A1253
PHE A1275
LEU A1236
 None
 0.68A 5veuA-2b39A:
undetectable		 5veuA-2b39A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjk NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
4

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		3 ARG A 176
PHE A 202
LEU A 223
 None
U  B   5 ( 3.0A)
None
 0.82A 5veuA-2cjkA:
undetectable		 5veuA-2cjkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqj U3 SMALL NUCLEOLAR
RIBONUCLEOPROTEIN
PROTEIN IMP3 HOMOLOG

(Homo sapiens) 		PF01479
(S4) 		3 ARG A 109
PHE A 157
LEU A 118
 None
 0.83A 5veuA-2cqjA:
undetectable		 5veuA-2cqjA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		3 ARG X 365
PHE X 456
LEU X 463
 None
 0.87A 5veuA-2de0X:
undetectable		 5veuA-2de0X:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ds2 SWEET PROTEIN
MABINLIN-2 CHAIN A
SWEET PROTEIN
MABINLIN-2 CHAIN B

(Capparis
masaikai) 		PF00234
(Tryp_alpha_amyl)
no annotation 		3 ARG A  24
PHE B  49
LEU B  55
 None
 0.62A 5veuA-2ds2A:
undetectable		 5veuA-2ds2A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0z VIRUS-LIKE PARTICLE

(Pyrococcus
furiosus) 		PF04454
(Linocin_M18) 		3 ARG A 255
PHE A 247
LEU A 274
 None
 0.82A 5veuA-2e0zA:
undetectable		 5veuA-2e0zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2c UBIQUITIN
CONJUGATING ENZYME

(Spisula
solidissima) 		PF00179
(UQ_con) 		3 ARG A  34
PHE A  53
LEU A  59
 None
 0.65A 5veuA-2e2cA:
undetectable		 5veuA-2e2cA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		3 ARG A 307
PHE A 310
LEU A   7
 None
 0.86A 5veuA-2ejaA:
undetectable		 5veuA-2ejaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2el8 SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 2

(Homo sapiens) 		PF00017
(SH2) 		3 ARG A  73
PHE A 115
LEU A 112
 None
 0.38A 5veuA-2el8A:
undetectable		 5veuA-2el8A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2enp B/K PROTEIN

(Homo sapiens) 		PF00168
(C2) 		3 ARG A  98
PHE A  89
LEU A 129
 None
 0.85A 5veuA-2enpA:
undetectable		 5veuA-2enpA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		3 ARG A 231
PHE A 260
LEU A 240
 None
 0.80A 5veuA-2epjA:
undetectable		 5veuA-2epjA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		3 ARG X 569
PHE X 539
LEU X 532
 None
 0.81A 5veuA-2epkX:
2.3		 5veuA-2epkX:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		3 ARG A 554
PHE A 579
LEU A 601
 None
 0.77A 5veuA-2f5vA:
undetectable		 5veuA-2f5vA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flh CYTOKININ-SPECIFIC
BINDING PROTEIN

(Vigna radiata) 		PF00407
(Bet_v_1) 		3 ARG A 144
PHE A  26
LEU A  34
 None
ZEA  A 701 (-3.5A)
ZEA  A 702 (-4.9A)
 0.85A 5veuA-2flhA:
undetectable		 5veuA-2flhA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fml MUTT/NUDIX FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00293
(NUDIX) 		3 ARG A 153
PHE A 149
LEU A  47
 None
 0.55A 5veuA-2fmlA:
undetectable		 5veuA-2fmlA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		3 ARG A 292
PHE A 199
LEU A 397
 BSC  A   2 (-3.9A)
None
None
 0.83A 5veuA-2gwcA:
undetectable		 5veuA-2gwcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		3 ARG A 204
PHE A 180
LEU A 185
 None
GOL  A 406 ( 4.6A)
None
 0.72A 5veuA-2hekA:
undetectable		 5veuA-2hekA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig8 HYPOTHETICAL PROTEIN
PA3499

(Pseudomonas
aeruginosa) 		PF01042
(Ribonuc_L-PSP) 		3 ARG A  47
PHE A 121
LEU A  51
 None
 0.67A 5veuA-2ig8A:
undetectable		 5veuA-2ig8A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		3 ARG A 368
PHE A 377
LEU A 392
 None
 0.85A 5veuA-2j3zA:
undetectable		 5veuA-2j3zA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		3 ARG A  21
PHE A 109
LEU A 239
 None
 0.86A 5veuA-2jfnA:
undetectable		 5veuA-2jfnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khz C-MYC-RESPONSIVE
PROTEIN RCL

(Rattus
norvegicus) 		PF05014
(Nuc_deoxyrib_tr) 		3 ARG A  34
PHE A 108
LEU A 105
 None
 0.73A 5veuA-2khzA:
undetectable		 5veuA-2khzA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 ARG A 143
PHE A  46
LEU A  51
 None
 0.87A 5veuA-2nq5A:
1.8		 5veuA-2nq5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		3 ARG A  77
PHE A 181
LEU A  81
 None
 0.80A 5veuA-2oxtA:
undetectable		 5veuA-2oxtA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbx HEMAGGLUTININ/PROTEA
SE REGULATORY
PROTEIN

(Vibrio cholerae) 		PF00440
(TetR_N) 		3 ARG A  33
PHE A  71
LEU A  64
 None
 0.67A 5veuA-2pbxA:
undetectable		 5veuA-2pbxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		3 ARG A 231
PHE A 210
LEU A 228
 None
 0.79A 5veuA-2pqdA:
undetectable		 5veuA-2pqdA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN

(Desulfotalea
psychrophila) 		PF02634
(FdhD-NarQ) 		3 ARG A  75
PHE A  63
LEU A  39
 None
 0.77A 5veuA-2pw9A:
undetectable		 5veuA-2pw9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE

(Plasmodium
vivax) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		3 ARG B 342
PHE B 319
LEU B 326
 AMP  B 908 (-3.7A)
None
None
 0.84A 5veuA-2qgaB:
undetectable		 5veuA-2qgaB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		3 ARG A 321
PHE A 367
LEU A 372
 None
 0.70A 5veuA-2qveA:
undetectable		 5veuA-2qveA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 ARG B 280
PHE B 343
LEU B 296
 None
 0.63A 5veuA-2uzxB:
undetectable		 5veuA-2uzxB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 ARG A 590
PHE A 639
LEU A 642
 None
 0.81A 5veuA-2vdcA:
undetectable		 5veuA-2vdcA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 ARG A 231
PHE A 227
LEU A 302
 None
 0.79A 5veuA-2vr5A:
undetectable		 5veuA-2vr5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w68 SIALIDASE

(Vibrio cholerae) 		PF09264
(Sial-lect-inser) 		3 ARG A 207
PHE A  37
LEU A  57
 None
 0.55A 5veuA-2w68A:
undetectable		 5veuA-2w68A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 ARG A 538
PHE A 434
LEU A 427
 None
 0.82A 5veuA-2x3kA:
2.0		 5veuA-2x3kA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		3 ARG A 371
PHE A 423
LEU A 406
 None
HG  A1687 (-4.6A)
None
 0.87A 5veuA-2x49A:
undetectable		 5veuA-2x49A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xko GLOBAL NITROGEN
REGULATOR
PIPX

(Synechococcus
elongatus) 		PF00027
(cNMP_binding)
PF12058
(DUF3539)
PF13545
(HTH_Crp_2) 		3 ARG C  35
PHE C  49
LEU A  80
 None
 0.76A 5veuA-2xkoC:
undetectable		 5veuA-2xkoC:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 ARG A 147
PHE A 669
LEU A 655
 None
 0.85A 5veuA-2y3aA:
undetectable		 5veuA-2y3aA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		3 ARG A 298
PHE A 362
LEU A 322
 None
 0.70A 5veuA-2zfuA:
undetectable		 5veuA-2zfuA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 ARG X  65
PHE X  72
LEU X 131
 None
 0.68A 5veuA-2zkmX:
undetectable		 5veuA-2zkmX:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 ARG A  83
PHE A 250
LEU A  62
 None
 0.84A 5veuA-2ztgA:
undetectable		 5veuA-2ztgA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzj GLUCURONAN LYASE A

(Trichoderma
reesei) 		PF14099
(Polysacc_lyase) 		3 ARG A 122
PHE A 172
LEU A 156
 None
 0.79A 5veuA-2zzjA:
undetectable		 5veuA-2zzjA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5x FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		3 ARG A 422
PHE A 131
LEU A 137
 None
 0.80A 5veuA-3a5xA:
undetectable		 5veuA-3a5xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		3 ARG B 357
PHE B 334
LEU B 371
 C  E  61 ( 3.7A)
None
None
 0.70A 5veuA-3al0B:
undetectable		 5veuA-3al0B:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqs BACTERIAL REGULATORY
PROTEINS, TETR
FAMILY

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		3 ARG A 116
PHE A  86
LEU A  93
 None
 0.87A 5veuA-3aqsA:
undetectable		 5veuA-3aqsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		3 ARG A 365
PHE A 301
LEU A 295
 0JO  A 401 (-2.7A)
None
None
 0.85A 5veuA-3b1eA:
undetectable		 5veuA-3b1eA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbj PUTATIVE
THIOESTERASE II

(Thermobifida
fusca) 		PF13622
(4HBT_3) 		3 ARG A  46
PHE A  94
LEU A  25
 None
 0.77A 5veuA-3bbjA:
undetectable		 5veuA-3bbjA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl2 V-BCL-2

(Murid
gammaherpesvirus
4) 		PF15286
(Bcl-2_3) 		3 ARG A  96
PHE A 122
LEU A 115
 None
 0.83A 5veuA-3bl2A:
undetectable		 5veuA-3bl2A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A1166
PHE A1216
LEU A1181
 None
 0.80A 5veuA-3c1xA:
undetectable		 5veuA-3c1xA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A1170
PHE A1216
LEU A1181
 None
 0.79A 5veuA-3c1xA:
undetectable		 5veuA-3c1xA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 ARG A 227
PHE A 216
LEU A 308
 None
 0.85A 5veuA-3cinA:
undetectable		 5veuA-3cinA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs1 FLAGELLAR
CALCIUM-BINDING
PROTEIN

(Trypanosoma
cruzi) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		3 ARG A 120
PHE A 130
LEU A 198
 None
 0.86A 5veuA-3cs1A:
undetectable		 5veuA-3cs1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2
CARBOXYPEPTIDASE
INHIBITOR

(Bos taurus;
Rhipicephalus
bursa) 		PF00246
(Peptidase_M14)
PF10468
(Inhibitor_I68) 		3 ARG A  71
PHE B   8
LEU B  11
 None
 0.82A 5veuA-3d4uA:
undetectable		 5veuA-3d4uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 ARG A 342
PHE A 364
LEU A 357
 None
 0.84A 5veuA-3e77A:
undetectable		 5veuA-3e77A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		3 ARG A 160
PHE A  99
LEU A  91
 None
 0.84A 5veuA-3efsA:
undetectable		 5veuA-3efsA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		3 ARG A  30
PHE A  51
LEU A  35
 None
 0.76A 5veuA-3ek2A:
undetectable		 5veuA-3ek2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyt UNCHARACTERIZED
PROTEIN SPOA0173

(Ruegeria
pomeroyi) 		PF00578
(AhpC-TSA) 		3 ARG A 113
PHE A  33
LEU A 119
 None
 0.82A 5veuA-3eytA:
undetectable		 5veuA-3eytA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		3 ARG A 351
PHE A 288
LEU A 282
 CL  A 379 ( 3.1A)
None
None
 0.81A 5veuA-3fdbA:
undetectable		 5veuA-3fdbA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ARG A 355
PHE A 330
LEU A 372
 None
 0.86A 5veuA-3fxiA:
undetectable		 5veuA-3fxiA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF01095
(Pectinesterase) 		3 ARG A 273
PHE A 226
LEU A 220
 None
 0.78A 5veuA-3grhA:
undetectable		 5veuA-3grhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grp 3-OXOACYL-(ACYL
CARRIERPROTEIN)
REDUCTASE

(Bartonella
henselae) 		PF13561
(adh_short_C2) 		3 ARG A 133
PHE A 218
LEU A 236
 None
 0.83A 5veuA-3grpA:
undetectable		 5veuA-3grpA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h94 CATION EFFLUX SYSTEM
PROTEIN CUSB

(Escherichia
coli) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		3 ARG A 354
PHE A 358
LEU A 332
 None
AG  A 408 ( 3.9A)
None
 0.73A 5veuA-3h94A:
undetectable		 5veuA-3h94A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		3 ARG C  89
PHE C 185
LEU C 192
 None
 0.79A 5veuA-3if6C:
undetectable		 5veuA-3if6C:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu6 PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		3 ARG A 804
PHE A 754
LEU A 749
 None
 0.84A 5veuA-3iu6A:
undetectable		 5veuA-3iu6A:
16.95