SIMILAR PATTERNS OF AMINO ACIDS FOR 5VCY_A_DB8A401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		4 VAL A 136
LEU A 100
ASN A 120
ASP A 133
 None
 1.13A 5vcyA-1b2hA:
undetectable		 5vcyA-1b2hA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek0 PROTEIN (GTP-BINDING
PROTEIN YPT51)

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 VAL A 118
LEU A  12
ASN A 159
ASP A 162
 None
 1.24A 5vcyA-1ek0A:
undetectable		 5vcyA-1ek0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epv ALANINE RACEMASE

(Geobacillus
stearothermophilus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A  64
LEU A  67
ASN A  41
ASP A  47
 None
 1.32A 5vcyA-1epvA:
undetectable		 5vcyA-1epvA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gu1 3-DEHYDROQUINATE
DEHYDRATASE

(Streptomyces
coelicolor) 		PF01220
(DHquinase_II) 		4 VAL A 122
LEU A  12
ASN A  95
ASP A  92
 None
 1.35A 5vcyA-1gu1A:
undetectable		 5vcyA-1gu1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 VAL C 139
LEU C  93
ASN C 136
ASP C 133
 None
 1.34A 5vcyA-1h2tC:
undetectable		 5vcyA-1h2tC:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 VAL A 568
LEU A 580
ASN A 584
ASP A 588
 None
 1.34A 5vcyA-1ji6A:
undetectable		 5vcyA-1ji6A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 VAL A 503
LEU A 344
ASN A 470
ASP A 471
 None
 1.16A 5vcyA-1k25A:
undetectable		 5vcyA-1k25A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ky3 GTP-BINDING PROTEIN
YPT7P

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 VAL A 137
LEU A 145
ASN A  93
ASP A  90
 None
 1.15A 5vcyA-1ky3A:
undetectable		 5vcyA-1ky3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		4 VAL A 233
LEU A  31
ASN A 227
ASP A 229
 None
 1.04A 5vcyA-1tcsA:
undetectable		 5vcyA-1tcsA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 VAL A   2
LEU A  29
ASN A  21
ASP A  16
 None
 1.31A 5vcyA-1uiyA:
undetectable		 5vcyA-1uiyA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 VAL A   2
LEU A  32
ASN A  21
ASP A  16
 None
 0.98A 5vcyA-1uiyA:
undetectable		 5vcyA-1uiyA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 VAL A 493
LEU A 500
ASN A 453
ASP A 454
 None
 1.39A 5vcyA-1upxA:
undetectable		 5vcyA-1upxA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 VAL A 323
LEU A 272
ASN A 319
ASP A 292
 None
 1.27A 5vcyA-1v5cA:
undetectable		 5vcyA-1v5cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 4 VAL B  68
LEU B 200
ASN B 210
ASP B 208
 None
 1.26A 5vcyA-1xnjB:
undetectable		 5vcyA-1xnjB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cnd NADH-DEPENDENT
NITRATE REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 VAL A 268
LEU A 139
ASN A 265
ASP A 262
 None
 1.39A 5vcyA-2cndA:
undetectable		 5vcyA-2cndA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 220
LEU A 238
ASN A 288
ASP A 320
 None
 0.90A 5vcyA-2eu9A:
26.7		 5vcyA-2eu9A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6b RAS-RELATED PROTEIN
RAB-26

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 187
LEU A 195
ASN A 148
ASP A 145
 None
 1.17A 5vcyA-2g6bA:
undetectable		 5vcyA-2g6bA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf9 RAS-RELATED PROTEIN
RAB-3D

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 145
LEU A 153
ASN A 106
ASP A 103
 None
 1.16A 5vcyA-2gf9A:
undetectable		 5vcyA-2gf9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 VAL A  91
LEU A 112
ASN A   5
ASP A  89
 None
 1.28A 5vcyA-2i80A:
undetectable		 5vcyA-2i80A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 VAL A 484
LEU A 501
ASN A 551
ASP A 564
 None
4ST  A1687 (-4.3A)
None
4ST  A1687 (-4.7A)
 1.08A 5vcyA-2j0jA:
23.4		 5vcyA-2j0jA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  82
LEU A 100
ASN A 149
ASP A 165
 J60  A1305 ( 4.7A)
J60  A1305 (-4.4A)
None
J60  A1305 ( 3.6A)
 1.16A 5vcyA-2jamA:
19.1		 5vcyA-2jamA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2s MICRONEMAL PROTEIN 1

(Toxoplasma
gondii) 		PF11476
(TgMIC1) 		4 VAL A  62
LEU A  90
ASN A  41
ASP A  44
 None
 1.36A 5vcyA-2k2sA:
undetectable		 5vcyA-2k2sA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nuh PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN

(Xylella
fastidiosa) 		PF03091
(CutA1) 		4 VAL A  90
LEU A  94
ASN A  63
ASP A   4
 None
 1.38A 5vcyA-2nuhA:
undetectable		 5vcyA-2nuhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 4 VAL A 148
LEU A 215
ASN A 170
ASP A 171
 None
None
None
FEO  A 701 ( 2.5A)
 1.02A 5vcyA-2q9uA:
undetectable		 5vcyA-2q9uA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 781
LEU A 798
ASN A 848
ASP A 861
 GW7  A   1 ( 4.7A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-4.1A)
 1.10A 5vcyA-2r4bA:
22.2		 5vcyA-2r4bA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1060
LEU A1078
ASN A1137
ASP A1150
 None
S91  A   1 (-4.7A)
None
None
 0.90A 5vcyA-2z8cA:
24.3		 5vcyA-2z8cA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zjs FAB56 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H 127
LEU H 130
ASN H 202
ASP H 213
 None
 1.32A 5vcyA-2zjsH:
undetectable		 5vcyA-2zjsH:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztb CRYSTAL PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 VAL A  73
LEU A  66
ASN A 263
ASP A 267
 None
 1.27A 5vcyA-2ztbA:
undetectable		 5vcyA-2ztbA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		4 VAL A 812
LEU A 768
ASN A 773
ASP A 772
 None
 1.25A 5vcyA-3aibA:
undetectable		 5vcyA-3aibA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  74
LEU A  92
ASN A 141
ASP A 157
 5CP  A 600 ( 4.7A)
5CP  A 600 (-4.6A)
None
5CP  A 600 (-3.5A)
 0.86A 5vcyA-3bhhA:
25.3		 5vcyA-3bhhA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		4 VAL A  86
LEU A 105
ASN A  94
ASP A  97
 None
 1.32A 5vcyA-3c3jA:
undetectable		 5vcyA-3c3jA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		4 VAL A  86
LEU A 107
ASN A  94
ASP A  97
 None
 1.17A 5vcyA-3c3jA:
undetectable		 5vcyA-3c3jA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE

(Eubacterium
barkeri) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 VAL A  43
LEU A  23
ASN A  39
ASP A  34
 None
 1.34A 5vcyA-3ckyA:
undetectable		 5vcyA-3ckyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 VAL A 423
LEU A 351
ASN A 419
ASP A 358
 None
 1.36A 5vcyA-3cmmA:
undetectable		 5vcyA-3cmmA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  76
LEU A  94
ASN A 151
ASP A 164
 None
None
ANP  A   1 ( 3.4A)
ANP  A   1 (-3.8A)
 1.19A 5vcyA-3dakA:
21.5		 5vcyA-3dakA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dz8 RAS-RELATED PROTEIN
RAB-3B

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 145
LEU A 153
ASN A 106
ASP A 103
 None
 1.10A 5vcyA-3dz8A:
undetectable		 5vcyA-3dz8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		4 VAL A 243
LEU A 188
ASN A 123
ASP A 217
 None
 1.39A 5vcyA-3e9zA:
undetectable		 5vcyA-3e9zA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 VAL A 468
LEU A  58
ASN A 463
ASP A 439
 EDO  A8005 (-4.6A)
None
None
None
 1.35A 5vcyA-3gbdA:
2.4		 5vcyA-3gbdA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE

(Francisella
tularensis) 		PF00834
(Ribul_P_3_epim) 		4 VAL A 197
LEU A  11
ASN A  32
ASP A  66
 None
 1.38A 5vcyA-3inpA:
undetectable		 5vcyA-3inpA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 368
LEU A 387
ASN A 458
ASP A 457
 None
 1.31A 5vcyA-3iwaA:
undetectable		 5vcyA-3iwaA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9j TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus) 		PF00520
(Ion_trans) 		4 VAL A  35
LEU A  42
ASN A  28
ASP A  31
 None
 1.22A 5vcyA-3j9jA:
undetectable		 5vcyA-3j9jA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		4 VAL G  67
LEU F  79
ASN G  65
ASP G  61
 None
None
U  C 101 ( 3.2A)
None
 1.17A 5vcyA-3jb9G:
undetectable		 5vcyA-3jb9G:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz3 SENSOR PROTEIN QSEC

(Escherichia
coli) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		4 VAL A 308
LEU A 352
ASN A 304
ASP A 303
 None
 1.02A 5vcyA-3jz3A:
undetectable		 5vcyA-3jz3A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9h PF-32 PROTEIN

(Borreliella
burgdorferi) 		PF13614
(AAA_31) 		4 VAL A  37
LEU A  27
ASN A  87
ASP A  86
 None
 1.35A 5vcyA-3k9hA:
undetectable		 5vcyA-3k9hA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 482
LEU A 500
ASN A 549
ASP A 565
 None
ANP  A 400 (-4.6A)
ANP  A 400 ( 4.4A)
None
 1.00A 5vcyA-3kn5A:
21.2		 5vcyA-3kn5A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		4 VAL A  52
LEU A 340
ASN A  65
ASP A  64
 None
 1.25A 5vcyA-3l7gA:
undetectable		 5vcyA-3l7gA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lr0 SENSOR PROTEIN

(Burkholderia
pseudomallei) 		PF16524
(RisS_PPD) 		4 VAL A  79
LEU A  53
ASN A  76
ASP A  72
 None
 1.26A 5vcyA-3lr0A:
undetectable		 5vcyA-3lr0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2n ANTHRAX TOXIN
RECEPTOR 1

(Homo sapiens) 		no annotation 4 VAL F 178
LEU F  69
ASN F 202
ASP F 203
 None
 1.37A 5vcyA-3n2nF:
undetectable		 5vcyA-3n2nF:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		4 VAL A  55
LEU A  62
ASN A 176
ASP A 149
 SO4  A 233 (-4.2A)
None
None
None
 1.37A 5vcyA-3ntvA:
undetectable		 5vcyA-3ntvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 247
LEU A 265
ASN A 316
ASP A 329
 None
AMP  A 577 ( 4.9A)
AMP  A 577 (-4.2A)
AMP  A 577 (-4.0A)
 0.85A 5vcyA-3nyoA:
24.4		 5vcyA-3nyoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 VAL A 174
LEU A  43
ASN A 134
ASP A 133
 None
 1.30A 5vcyA-3ob8A:
undetectable		 5vcyA-3ob8A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		4 VAL A  90
LEU A 138
ASN A  84
ASP A  87
 None
 0.98A 5vcyA-3p2cA:
undetectable		 5vcyA-3p2cA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbt RAS-RELATED PROTEIN
RAB-8A

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 131
LEU A 139
ASN A  92
ASP A  89
 None
 1.15A 5vcyA-3qbtA:
undetectable		 5vcyA-3qbtA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up3 ACEDAF-12

(Ancylostoma
ceylanicum) 		PF00104
(Hormone_recep) 		4 VAL A 669
LEU A 664
ASN A 490
ASP A 487
 EDO  A 400 ( 3.7A)
XCA  A 100 (-4.8A)
None
None
 1.37A 5vcyA-3up3A:
undetectable		 5vcyA-3up3A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 113
LEU A 131
ASN A 184
ASP A 197
 None
None
ANK  A 401 ( 2.7A)
MG  A 402 ( 2.8A)
 1.19A 5vcyA-3vn9A:
22.4		 5vcyA-3vn9A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9r ABSCISIC ACID
RECEPTOR PYL9

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		4 VAL A 146
LEU A  28
ASN A 121
ASP A 148
 None
 1.33A 5vcyA-3w9rA:
undetectable		 5vcyA-3w9rA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdb PROTEIN XNI

(Escherichia
coli) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		4 VAL A  48
LEU A  11
ASN A 101
ASP A 105
 None
 1.29A 5vcyA-3zdbA:
undetectable		 5vcyA-3zdbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 114
LEU A 132
ASN A 181
ASP A 194
 None
939  A1331 (-4.4A)
None
939  A1331 (-3.1A)
 0.80A 5vcyA-4a4lA:
26.0		 5vcyA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 123
LEU A 141
ASN A 190
ASP A 203
 9ZP  A1333 (-4.4A)
9ZP  A1333 (-4.7A)
None
None
 0.79A 5vcyA-4b6lA:
26.9		 5vcyA-4b6lA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e13 DIKETOREDUCTASE

(Acinetobacter
baylyi) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A  89
LEU A 110
ASN A   6
ASP A  87
 None
None
GOL  A 305 ( 4.7A)
None
 1.30A 5vcyA-4e13A:
undetectable		 5vcyA-4e13A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 VAL A 620
LEU A 638
ASN A 688
ASP A 701
 None
GUI  A 901 (-4.4A)
GUI  A 901 (-4.6A)
GUI  A 901 ( 4.1A)
 0.84A 5vcyA-4e93A:
25.0		 5vcyA-4e93A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  84
LEU A 102
ASN A 151
ASP A 164
 None
STU  A 401 (-4.4A)
STU  A 401 ( 4.8A)
STU  A 401 ( 3.9A)
 0.86A 5vcyA-4fr4A:
24.9		 5vcyA-4fr4A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE

(Coffea
canephora) 		PF02458
(Transferase) 		4 VAL A  31
LEU A 355
ASN A  24
ASP A  28
 None
 1.29A 5vcyA-4g0bA:
undetectable		 5vcyA-4g0bA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		4 VAL A 455
LEU A 473
ASN A 522
ASP A 536
 None
0WB  A 701 (-4.3A)
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
 0.90A 5vcyA-4g3fA:
25.1		 5vcyA-4g3fA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 453
LEU A 471
ASN A 520
ASP A 534
 None
T28  A 701 ( 4.8A)
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
 0.90A 5vcyA-4idtA:
24.9		 5vcyA-4idtA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		4 VAL A 399
LEU A 428
ASN A 373
ASP A 376
 None
 0.83A 5vcyA-4nscA:
undetectable		 5vcyA-4nscA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 VAL A 416
LEU A 434
ASN A 487
ASP A 500
 None
 0.96A 5vcyA-4o1oA:
16.9		 5vcyA-4o1oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 VAL B 418
LEU B 436
ASN B 490
ASP B 503
 None
ACP  B 801 ( 4.9A)
MG  B 802 ( 2.5A)
MG  B 803 (-1.8A)
 0.88A 5vcyA-4oavB:
18.4		 5vcyA-4oavB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oit LYSM DOMAIN PROTEIN

(Mycolicibacterium
smegmatis) 		PF01453
(B_lectin) 		4 VAL A  53
LEU A  11
ASN A  49
ASP A  31
 None
None
MAN  A 201 (-4.1A)
MAN  A 201 (-3.2A)
 1.32A 5vcyA-4oitA:
undetectable		 5vcyA-4oitA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0j INTERLEUKIN-36
RECEPTOR
ANTAGONIST/INTERLEUK
IN-36 GAMMA CHIMERA
PROTEIN

(Homo sapiens) 		PF00340
(IL1) 		4 VAL A 131
LEU A  59
ASN A 142
ASP A  13
 None
 1.21A 5vcyA-4p0jA:
undetectable		 5vcyA-4p0jA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H 120
LEU H 123
ASN H 195
ASP H 206
 None
 1.34A 5vcyA-4qexH:
undetectable		 5vcyA-4qexH:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		4 VAL A 344
LEU A 374
ASN A 433
ASP A 432
 None
 1.31A 5vcyA-4uf7A:
undetectable		 5vcyA-4uf7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v36 LYSYL-TRNA-DEPENDENT
L-YSYL-PHOSPHATIDYLG
YCEROL SYNTHASE

(Bacillus
licheniformis) 		PF09924
(DUF2156) 		4 VAL A 592
LEU A 619
ASN A 564
ASP A 562
 None
 1.28A 5vcyA-4v36A:
undetectable		 5vcyA-4v36A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmo XEEL PROTEIN

(Xenopus laevis) 		no annotation 4 VAL F 221
LEU F 277
ASN F 145
ASP F 143
 None
 1.33A 5vcyA-4wmoF:
undetectable		 5vcyA-4wmoF:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		4 VAL A 275
LEU A 271
ASN A 250
ASP A 248
 None
 1.26A 5vcyA-4y9wA:
undetectable		 5vcyA-4y9wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 VAL A 269
LEU A 282
ASN A 274
ASP A 250
 None
 1.02A 5vcyA-4ztxA:
undetectable		 5vcyA-4ztxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		4 VAL A  52
LEU A 340
ASN A  65
ASP A  64
 None
 1.31A 5vcyA-4zwoA:
undetectable		 5vcyA-4zwoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyj PUTATIVE PEPTIDASE
C60B, SORTASE B

(Clostridioides
difficile) 		PF04203
(Sortase) 		4 VAL A  73
LEU A 146
ASN A  55
ASP A  57
 None
 1.36A 5vcyA-5gyjA:
undetectable		 5vcyA-5gyjA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 VAL A  74
LEU A  92
ASN A 141
ASP A 157
 None
ADP  A 301 ( 4.8A)
MG  A 302 ( 2.8A)
MG  A 302 ( 3.3A)
 0.93A 5vcyA-5hu3A:
28.2		 5vcyA-5hu3A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
coronavirus
HKU1;
Human
immunodeficiency
virus 1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 VAL A 216
LEU A  46
ASN A 108
ASP A 196
 None
 1.38A 5vcyA-5i08A:
undetectable		 5vcyA-5i08A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 449
LEU A 467
ASN A 516
ASP A 533
 None
GUI  A 701 ( 4.7A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.84A 5vcyA-5jznA:
27.5		 5vcyA-5jznA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL B 723
LEU B 741
ASN B 791
ASP B 803
 None
6U7  B1001 (-4.6A)
None
6U7  B1001 (-4.6A)
 0.84A 5vcyA-5kkrB:
20.1		 5vcyA-5kkrB:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL A 126
LEU A 129
ASN A 202
ASP A 213
 None
 1.30A 5vcyA-5kn5A:
undetectable		 5vcyA-5kn5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		4 VAL A 135
LEU A 146
ASN A 152
ASP A 155
 None
 1.14A 5vcyA-5kztA:
undetectable		 5vcyA-5kztA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9p PERIPLASMIC BINDING
PROTEIN

(Agrobacterium
tumefaciens) 		PF13416
(SBP_bac_8) 		4 VAL A 120
LEU A 105
ASN A 301
ASP A 114
 None
None
SO4  A 403 (-3.6A)
None
 1.33A 5vcyA-5l9pA:
undetectable		 5vcyA-5l9pA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE TLDD

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 VAL A 250
LEU A 260
ASN A 474
ASP A 473
 None
 1.28A 5vcyA-5njfA:
undetectable		 5vcyA-5njfA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szi RAS-RELATED PROTEIN
RAB-8A

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 131
LEU A 139
ASN A  92
ASP A  89
 None
 1.18A 5vcyA-5sziA:
undetectable		 5vcyA-5sziA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 VAL A 500
LEU A 414
ASN A 504
ASP A 463
 None
 1.26A 5vcyA-5tw7A:
undetectable		 5vcyA-5tw7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 VAL A 137
LEU A 128
ASN A  35
ASP A 135
 None
 1.38A 5vcyA-5u3cA:
undetectable		 5vcyA-5u3cA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 255
LEU A 273
ASN A 322
ASP A 335
 None
None
None
QRW  A 601 (-3.7A)
 1.10A 5vcyA-5uuuA:
25.2		 5vcyA-5uuuA:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 171
LEU A 189
ASN A 238
ASP A 251
 None
None
EDO  A 402 (-3.9A)
EDO  A 402 ( 2.9A)
 0.75A 5vcyA-5vcxA:
42.4		 5vcyA-5vcxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wix P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 4 VAL A   9
LEU A 202
ASN A   2
ASP A 207
 None
 1.18A 5vcyA-5wixA:
undetectable		 5vcyA-5wixA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2p -

(-) 		no annotation 4 VAL A 228
LEU A 261
ASN A 226
ASP A 218
 None
 1.38A 5vcyA-5y2pA:
undetectable		 5vcyA-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 4 VAL A  34
LEU A  23
ASN A  45
ASP A  48
 None
 1.36A 5vcyA-6b92A:
undetectable		 5vcyA-6b92A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 4 VAL A 212
LEU A 232
ASN A 280
ASP A 293
 H1N  A 501 (-4.9A)
H1N  A 501 (-4.3A)
H1N  A 501 (-4.5A)
H1N  A 501 (-3.5A)
 0.92A 5vcyA-6ccfA:
24.4		 5vcyA-6ccfA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 4 VAL A 249
LEU A 269
ASN A 317
ASP A 330
 None
F6J  A 501 ( 4.4A)
F6J  A 501 ( 4.7A)
F6J  A 501 (-3.8A)
 0.85A 5vcyA-6cmjA:
24.2		 5vcyA-6cmjA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 HEAVY CHAIN

(Mus musculus) 		no annotation 4 VAL G 128
LEU G 131
ASN G 203
ASP G 214
 None
 1.35A 5vcyA-6cnkG:
undetectable		 5vcyA-6cnkG:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 4 VAL A  94
LEU A 109
ASN A 119
ASP A 121
 None
 1.35A 5vcyA-6czmA:
undetectable		 5vcyA-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 VAL A1083
LEU A1099
ASN A1052
ASP A1048
 None
 1.16A 5vcyA-6en4A:
undetectable		 5vcyA-6en4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 VAL A 225
LEU A 243
ASN A 293
ASP A 325
 None
EAQ  A 501 ( 4.9A)
None
EAQ  A 501 (-4.6A)
 0.95A 5vcyA-6fyoA:
26.7		 5vcyA-6fyoA:
undetectable