SIMILAR PATTERNS OF AMINO ACIDS FOR 5VCY_A_DB8A401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
THR A 334
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
 0.59A 5vcyA-1opkA:
22.8		 5vcyA-1opkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
 0.80A 5vcyA-1q8yA:
25.5		 5vcyA-1q8yA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
ALA A 642
GLU A 661
LEU A 689
CYH A 694
 None
 0.70A 5vcyA-1rjbA:
21.6		 5vcyA-1rjbA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
LEU A 689
 None
 0.93A 5vcyA-1rjbA:
21.6		 5vcyA-1rjbA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
CYH A 673
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
 0.66A 5vcyA-1t46A:
22.4		 5vcyA-1t46A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
LEU A 412
GLY A 418
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 ( 4.7A)
 0.79A 5vcyA-1u59A:
24.7		 5vcyA-1u59A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 352
ALA A 367
LYS A 369
GLU A 386
LEU A 412
GLY A 420
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-3.5A)
 0.78A 5vcyA-1u59A:
24.7		 5vcyA-1u59A:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A 103
CYH A 108
GLY A 110
 None
 1.10A 5vcyA-1u5qA:
27.3		 5vcyA-1u5qA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
GLU A  55
CYH A  87
GLY A  89
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
 0.80A 5vcyA-1zltA:
25.2		 5vcyA-1zltA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
GLU A  55
LEU A  82
CYH A  87
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
None
HYM  A 400 (-4.2A)
 0.58A 5vcyA-1zltA:
25.2		 5vcyA-1zltA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  89
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
 0.92A 5vcyA-1zltA:
25.2		 5vcyA-1zltA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  82
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
 0.69A 5vcyA-1zltA:
25.2		 5vcyA-1zltA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  91
 None
 0.69A 5vcyA-1zwsA:
25.4		 5vcyA-1zwsA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 605
VAL A 613
ALA A 626
LYS A 628
CYH A 791
PHE A 842
 None
None
GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
 0.90A 5vcyA-1zy4A:
23.8		 5vcyA-1zy4A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  91
 None
None
GOL  A3001 (-3.5A)
None
None
None
 0.54A 5vcyA-2a2aA:
25.4		 5vcyA-2a2aA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  60
LEU A  87
 None
 0.74A 5vcyA-2bdwA:
23.6		 5vcyA-2bdwA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
LEU A  96
GLY A 104
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
STU  A1301 ( 4.0A)
 0.81A 5vcyA-2bujA:
25.2		 5vcyA-2bujA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLU X  54
THR X  82
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.1A)
 0.40A 5vcyA-2dq7X:
25.8		 5vcyA-2dq7X:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 162
VAL A 170
ALA A 184
LYS A 186
GLU A 201
GLY A 240
 None
 0.58A 5vcyA-2eu9A:
26.7		 5vcyA-2eu9A:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-4.0A)
STU  A 400 (-3.4A)
 0.98A 5vcyA-2gcdA:
28.1		 5vcyA-2gcdA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
THR A 316
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
 0.46A 5vcyA-2hk5A:
25.1		 5vcyA-2hk5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  55
VAL A  63
ALA A  76
LYS A  78
LEU A 122
GLY A 129
 None
 0.79A 5vcyA-2hw6A:
24.3		 5vcyA-2hw6A:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
VAL A 256
ALA A 269
LYS A 271
GLU A 286
THR A 315
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
 0.69A 5vcyA-2hz0A:
24.7		 5vcyA-2hz0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LYS A 454
GLU A 471
CYH A 502
GLY A 505
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
 0.96A 5vcyA-2j0jA:
23.4		 5vcyA-2j0jA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
ALA A 271
GLU A 288
THR A 316
GLY A 322
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
 0.77A 5vcyA-2og8A:
22.1		 5vcyA-2og8A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
THR A 316
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
 0.86A 5vcyA-2og8A:
22.1		 5vcyA-2og8A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
VAL A 596
ALA A 614
GLU A 633
THR A 663
CYH A 666
 None
 0.68A 5vcyA-2ogvA:
21.7		 5vcyA-2ogvA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
LEU A 101
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
 0.61A 5vcyA-2phkA:
27.1		 5vcyA-2phkA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
LYS A 217
GLU A 230
LEU A 263
THR A 265
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
ADE  A 488 (-4.3A)
 0.80A 5vcyA-2qluA:
22.9		 5vcyA-2qluA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		6 VAL A 498
ALA A 509
GLU A 535
LEU A 603
GLY A 609
GLN A 614
 5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
None
None
5ID  A1800 (-4.7A)
5ID  A1800 ( 4.9A)
 0.84A 5vcyA-2vuwA:
18.6		 5vcyA-2vuwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		6 VAL A 498
ALA A 509
LYS A 511
GLU A 535
LEU A 603
GLN A 614
 5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
None
None
5ID  A1800 ( 4.9A)
 0.81A 5vcyA-2vuwA:
18.6		 5vcyA-2vuwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  91
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
 0.50A 5vcyA-2w4kA:
25.4		 5vcyA-2w4kA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU C  55
VAL C  63
ALA C  76
LYS C  78
GLU C  98
CYH C 132
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
ANP  C   2 (-4.5A)
 0.76A 5vcyA-2wtkC:
24.6		 5vcyA-2wtkC:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  91
GLY A  98
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
None
 0.92A 5vcyA-2yabA:
25.5		 5vcyA-2yabA:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 313
ALA A 326
LYS A 328
GLU A 346
CYH A 379
PHE A 433
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
 0.56A 5vcyA-2z2wA:
31.8		 5vcyA-2z2wA:
30.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 313
ALA A 326
LYS A 328
GLU A 346
GLY A 382
PHE A 433
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
 0.93A 5vcyA-2z2wA:
31.8		 5vcyA-2z2wA:
30.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 253
VAL A 261
ALA A 273
LYS A 275
GLU A 290
THR A 319
 None
 0.80A 5vcyA-2zv7A:
25.4		 5vcyA-2zv7A:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
LEU A 170
GLY A 177
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
None
 0.84A 5vcyA-3a62A:
22.5		 5vcyA-3a62A:
30.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
LEU A 170
GLY A 178
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
STU  A 400 ( 4.4A)
 0.95A 5vcyA-3a62A:
22.5		 5vcyA-3a62A:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  91
 4RB  A 401 ( 3.9A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
GOL  A 503 (-2.8A)
None
 0.66A 5vcyA-3bqrA:
23.9		 5vcyA-3bqrA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  44
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A 118
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
 0.68A 5vcyA-3f2aA:
24.9		 5vcyA-3f2aA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
GLU A  71
LEU A 104
THR A 106
GLY A 110
 NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.3A)
NIL  A   1 (-3.3A)
None
 0.73A 5vcyA-3gp0A:
22.6		 5vcyA-3gp0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
LYS A  53
GLU A  71
THR A 106
GLY A 110
 NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
None
 0.84A 5vcyA-3gp0A:
22.6		 5vcyA-3gp0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
CYH A 912
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
 0.64A 5vcyA-3hngA:
22.1		 5vcyA-3hngA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A 566
ALA A 579
GLU A 596
LEU A 628
GLY A 634
PRO A 635
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.66A 5vcyA-3lltA:
25.5		 5vcyA-3lltA:
24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  39
VAL A  47
ALA A  60
LYS A  62
LEU A 108
GLY A 115
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
 0.96A 5vcyA-3lm5A:
26.2		 5vcyA-3lm5A:
31.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
ALA A 229
LYS A 231
GLU A 244
LEU A 277
THR A 279
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
 0.57A 5vcyA-3mdyA:
22.7		 5vcyA-3mdyA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 268
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
 0.79A 5vcyA-3nyoA:
24.4		 5vcyA-3nyoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		7 VAL A  39
ALA A  52
LYS A  54
GLU A  72
LEU A 105
THR A 107
GLY A 111
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.2A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
 0.66A 5vcyA-3ohtA:
17.9		 5vcyA-3ohtA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 363
ALA A 373
LYS A 375
GLU A 393
THR A 421
CYH A 424
PHE A 475
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
 0.98A 5vcyA-3omvA:
23.1		 5vcyA-3omvA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 726
VAL A 734
ALA A 751
LYS A 753
LEU A 796
THR A 798
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
 0.59A 5vcyA-3pp0A:
23.4		 5vcyA-3pp0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
 0.76A 5vcyA-3q5iA:
23.9		 5vcyA-3q5iA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 438
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
 0.62A 5vcyA-3txoA:
21.3		 5vcyA-3txoA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 439
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
 0.94A 5vcyA-3txoA:
21.3		 5vcyA-3txoA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
 0.60A 5vcyA-3vidA:
21.4		 5vcyA-3vidA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
 1.17A 5vcyA-3wzdA:
22.2		 5vcyA-3wzdA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
LYS A  33
GLU A  51
LEU A  78
CYH A  83
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
None
D15  A 500 (-4.3A)
 0.70A 5vcyA-4aguA:
26.8		 5vcyA-4aguA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A  91
ALA A 104
LYS A 106
GLU A 125
LEU A 152
GLY A 160
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
 0.96A 5vcyA-4aw2A:
23.3		 5vcyA-4aw2A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 653
LYS A 655
GLU A 672
THR A 701
GLY A 707
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
None
 0.85A 5vcyA-4ckrA:
21.5		 5vcyA-4ckrA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  84
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 1.12A 5vcyA-4eutA:
20.7		 5vcyA-4eutA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  84
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 1.07A 5vcyA-4euuA:
23.3		 5vcyA-4euuA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
LEU A 446
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
 0.81A 5vcyA-4f4pA:
24.8		 5vcyA-4f4pA:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 598
VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 943
 924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
 0.36A 5vcyA-4g34A:
23.4		 5vcyA-4g34A:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 156
VAL A 164
ALA A 177
LYS A 179
GLU A 198
GLY A 232
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
None
 0.70A 5vcyA-4gv1A:
24.5		 5vcyA-4gv1A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLU A 871
LEU A 900
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
 0.90A 5vcyA-4hviA:
24.4		 5vcyA-4hviA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
CYH A  89
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
None
SU6  A 701 (-3.8A)
 0.57A 5vcyA-4jlcA:
17.5		 5vcyA-4jlcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
GLY A  92
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
None
SU6  A 701 (-3.8A)
 0.92A 5vcyA-4jlcA:
17.5		 5vcyA-4jlcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		6 LEU A 258
VAL A 266
ALA A 279
LYS A 281
GLU A 300
LEU A 354
 ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
None
None
 0.57A 5vcyA-4jrnA:
21.3		 5vcyA-4jrnA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  18
VAL A  26
ALA A  39
LYS A  41
LEU A  87
CYH A  92
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 (-4.5A)
 0.68A 5vcyA-4jxfA:
18.4		 5vcyA-4jxfA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  50
ALA A  61
LYS A  63
GLU A  77
LEU A 102
GLY A 109
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 ( 4.7A)
 0.85A 5vcyA-4l52A:
21.9		 5vcyA-4l52A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
VAL A  41
ALA A  54
GLU A  70
CYH A 102
GLY A 103
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
GOL  A 403 (-4.0A)
None
 0.87A 5vcyA-4lg4A:
24.1		 5vcyA-4lg4A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
VAL A  41
ALA A  54
LYS A  56
GLU A  70
GLY A 103
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
 0.94A 5vcyA-4lg4A:
24.1		 5vcyA-4lg4A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  78
VAL A  86
ALA A  99
LYS A 101
GLU A 117
LEU A 144
CYH A 149
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-4.2A)
 0.66A 5vcyA-4mvfA:
22.2		 5vcyA-4mvfA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
LEU A 121
THR A 123
CYH A 126
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-4.3A)
 0.78A 5vcyA-4o38A:
21.6		 5vcyA-4o38A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
LEU A 689
CYH A 694
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
 0.83A 5vcyA-4rt7A:
22.1		 5vcyA-4rt7A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 268
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 0.97A 5vcyA-4tnbA:
20.2		 5vcyA-4tnbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
THR A  81
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
 0.78A 5vcyA-4ueuA:
25.2		 5vcyA-4ueuA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
GLY A 269
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
 0.77A 5vcyA-4wboA:
24.9		 5vcyA-4wboA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 262
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
 0.73A 5vcyA-4wboA:
24.9		 5vcyA-4wboA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
ALA A  72
LYS A  74
CYH A 129
GLY A 131
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
None
 0.80A 5vcyA-4wsqA:
26.2		 5vcyA-4wsqA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
LEU A 689
CYH A 694
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.2A)
 0.74A 5vcyA-4xufA:
22.2		 5vcyA-4xufA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 262
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
 0.62A 5vcyA-4yhjA:
22.7		 5vcyA-4yhjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 0.63A 5vcyA-4ysjA:
27.6		 5vcyA-4ysjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 258
ALA A 275
LYS A 277
GLU A 290
LEU A 323
THR A 325
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
None
STU  A 601 ( 3.7A)
 0.62A 5vcyA-5e8yA:
23.3		 5vcyA-5e8yA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 471
ALA A 481
LYS A 483
THR A 529
CYH A 532
PHE A 583
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-4.3A)
 0.65A 5vcyA-5fd2A:
23.1		 5vcyA-5fd2A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
THR A 674
CYH A 677
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
 0.61A 5vcyA-5grnA:
22.1		 5vcyA-5grnA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  95
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
 0.88A 5vcyA-5hu3A:
28.2		 5vcyA-5hu3A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
LEU A  88
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
 0.45A 5vcyA-5hu3A:
28.2		 5vcyA-5hu3A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		6 VAL A 344
ALA A 356
LYS A 358
GLU A 411
LEU A 443
THR A 445
 ANP  A 700 (-4.7A)
ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
None
None
ANP  A 700 (-4.1A)
 0.69A 5vcyA-5i35A:
9.8		 5vcyA-5i35A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  94
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
TPO  A 145 ( 4.9A)
 0.85A 5vcyA-5j5tA:
22.7		 5vcyA-5j5tA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLU A 762
LEU A 788
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.6A)
 0.49A 5vcyA-5j9zA:
23.5		 5vcyA-5j9zA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 6 LEU A  44
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A 118
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
 0.64A 5vcyA-5turA:
24.6		 5vcyA-5turA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 6 LEU A  17
VAL A  25
ALA A  38
LYS A  40
GLU A  59
GLY A  97
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
GOL  A 305 ( 4.3A)
 0.89A 5vcyA-5u94A:
27.0		 5vcyA-5u94A:
15.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 185
THR A 187
CYH A 190
GLY A 191
PRO A 192
GLN A 196
PHE A 240
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
H8H  A 401 ( 4.1A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
 0.53A 5vcyA-5vcxA:
42.4		 5vcyA-5vcxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 226
ALA A 239
LYS A 241
CYH A 292
GLY A 294
PHE A 346
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.6A)
8X7  A 501 (-3.8A)
None
8X7  A 501 (-3.7A)
 0.76A 5vcyA-5vdkA:
30.3		 5vcyA-5vdkA:
31.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 226
ALA A 239
LYS A 241
GLU A 259
CYH A 292
PHE A 346
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.6A)
PO4  A 502 (-3.8A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
 0.64A 5vcyA-5vdkA:
30.3		 5vcyA-5vdkA:
31.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 LEU A 366
VAL A 374
ALA A 388
LYS A 390
GLU A 409
CYH A 441
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 4.2A)
EE4  A 701 (-4.6A)
 0.47A 5vcyA-6c0tA:
24.3		 5vcyA-6c0tA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A 954
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
 0.77A 5vcyA-6c7yA:
24.2		 5vcyA-6c7yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 7 LEU U  20
VAL U  28
ALA U  42
LYS U  44
LEU U  89
CYH U  94
GLY U  96
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.2A)
None
 0.80A 5vcyA-6fdyU:
24.4		 5vcyA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 LEU U  20
VAL U  28
ALA U  42
LYS U  44
LEU U  89
GLY U  97
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 ( 4.1A)
 0.99A 5vcyA-6fdyU:
24.4		 5vcyA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		4 VAL A 136
LEU A 100
ASN A 120
ASP A 133
 None
 1.13A 5vcyA-1b2hA:
undetectable		 5vcyA-1b2hA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek0 PROTEIN (GTP-BINDING
PROTEIN YPT51)

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 VAL A 118
LEU A  12
ASN A 159
ASP A 162
 None
 1.24A 5vcyA-1ek0A:
undetectable		 5vcyA-1ek0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epv ALANINE RACEMASE

(Geobacillus
stearothermophilus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A  64
LEU A  67
ASN A  41
ASP A  47
 None
 1.32A 5vcyA-1epvA:
undetectable		 5vcyA-1epvA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gu1 3-DEHYDROQUINATE
DEHYDRATASE

(Streptomyces
coelicolor) 		PF01220
(DHquinase_II) 		4 VAL A 122
LEU A  12
ASN A  95
ASP A  92
 None
 1.35A 5vcyA-1gu1A:
undetectable		 5vcyA-1gu1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 VAL C 139
LEU C  93
ASN C 136
ASP C 133
 None
 1.34A 5vcyA-1h2tC:
undetectable		 5vcyA-1h2tC:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 VAL A 568
LEU A 580
ASN A 584
ASP A 588
 None
 1.34A 5vcyA-1ji6A:
undetectable		 5vcyA-1ji6A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 VAL A 503
LEU A 344
ASN A 470
ASP A 471
 None
 1.16A 5vcyA-1k25A:
undetectable		 5vcyA-1k25A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ky3 GTP-BINDING PROTEIN
YPT7P

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 VAL A 137
LEU A 145
ASN A  93
ASP A  90
 None
 1.15A 5vcyA-1ky3A:
undetectable		 5vcyA-1ky3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		4 VAL A 233
LEU A  31
ASN A 227
ASP A 229
 None
 1.04A 5vcyA-1tcsA:
undetectable		 5vcyA-1tcsA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 VAL A   2
LEU A  29
ASN A  21
ASP A  16
 None
 1.31A 5vcyA-1uiyA:
undetectable		 5vcyA-1uiyA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 VAL A   2
LEU A  32
ASN A  21
ASP A  16
 None
 0.98A 5vcyA-1uiyA:
undetectable		 5vcyA-1uiyA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 VAL A 493
LEU A 500
ASN A 453
ASP A 454
 None
 1.39A 5vcyA-1upxA:
undetectable		 5vcyA-1upxA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 VAL A 323
LEU A 272
ASN A 319
ASP A 292
 None
 1.27A 5vcyA-1v5cA:
undetectable		 5vcyA-1v5cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 4 VAL B  68
LEU B 200
ASN B 210
ASP B 208
 None
 1.26A 5vcyA-1xnjB:
undetectable		 5vcyA-1xnjB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cnd NADH-DEPENDENT
NITRATE REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 VAL A 268
LEU A 139
ASN A 265
ASP A 262
 None
 1.39A 5vcyA-2cndA:
undetectable		 5vcyA-2cndA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 220
LEU A 238
ASN A 288
ASP A 320
 None
 0.90A 5vcyA-2eu9A:
26.7		 5vcyA-2eu9A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6b RAS-RELATED PROTEIN
RAB-26

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 187
LEU A 195
ASN A 148
ASP A 145
 None
 1.17A 5vcyA-2g6bA:
undetectable		 5vcyA-2g6bA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf9 RAS-RELATED PROTEIN
RAB-3D

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 145
LEU A 153
ASN A 106
ASP A 103
 None
 1.16A 5vcyA-2gf9A:
undetectable		 5vcyA-2gf9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 VAL A  91
LEU A 112
ASN A   5
ASP A  89
 None
 1.28A 5vcyA-2i80A:
undetectable		 5vcyA-2i80A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 VAL A 484
LEU A 501
ASN A 551
ASP A 564
 None
4ST  A1687 (-4.3A)
None
4ST  A1687 (-4.7A)
 1.08A 5vcyA-2j0jA:
23.4		 5vcyA-2j0jA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  82
LEU A 100
ASN A 149
ASP A 165
 J60  A1305 ( 4.7A)
J60  A1305 (-4.4A)
None
J60  A1305 ( 3.6A)
 1.16A 5vcyA-2jamA:
19.1		 5vcyA-2jamA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2s MICRONEMAL PROTEIN 1

(Toxoplasma
gondii) 		PF11476
(TgMIC1) 		4 VAL A  62
LEU A  90
ASN A  41
ASP A  44
 None
 1.36A 5vcyA-2k2sA:
undetectable		 5vcyA-2k2sA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nuh PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN

(Xylella
fastidiosa) 		PF03091
(CutA1) 		4 VAL A  90
LEU A  94
ASN A  63
ASP A   4
 None
 1.38A 5vcyA-2nuhA:
undetectable		 5vcyA-2nuhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 4 VAL A 148
LEU A 215
ASN A 170
ASP A 171
 None
None
None
FEO  A 701 ( 2.5A)
 1.02A 5vcyA-2q9uA:
undetectable		 5vcyA-2q9uA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 781
LEU A 798
ASN A 848
ASP A 861
 GW7  A   1 ( 4.7A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-4.1A)
 1.10A 5vcyA-2r4bA:
22.2		 5vcyA-2r4bA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1060
LEU A1078
ASN A1137
ASP A1150
 None
S91  A   1 (-4.7A)
None
None
 0.90A 5vcyA-2z8cA:
24.3		 5vcyA-2z8cA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zjs FAB56 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H 127
LEU H 130
ASN H 202
ASP H 213
 None
 1.32A 5vcyA-2zjsH:
undetectable		 5vcyA-2zjsH:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztb CRYSTAL PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 VAL A  73
LEU A  66
ASN A 263
ASP A 267
 None
 1.27A 5vcyA-2ztbA:
undetectable		 5vcyA-2ztbA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		4 VAL A 812
LEU A 768
ASN A 773
ASP A 772
 None
 1.25A 5vcyA-3aibA:
undetectable		 5vcyA-3aibA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  74
LEU A  92
ASN A 141
ASP A 157
 5CP  A 600 ( 4.7A)
5CP  A 600 (-4.6A)
None
5CP  A 600 (-3.5A)
 0.86A 5vcyA-3bhhA:
25.3		 5vcyA-3bhhA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		4 VAL A  86
LEU A 105
ASN A  94
ASP A  97
 None
 1.32A 5vcyA-3c3jA:
undetectable		 5vcyA-3c3jA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		4 VAL A  86
LEU A 107
ASN A  94
ASP A  97
 None
 1.17A 5vcyA-3c3jA:
undetectable		 5vcyA-3c3jA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE

(Eubacterium
barkeri) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 VAL A  43
LEU A  23
ASN A  39
ASP A  34
 None
 1.34A 5vcyA-3ckyA:
undetectable		 5vcyA-3ckyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 VAL A 423
LEU A 351
ASN A 419
ASP A 358
 None
 1.36A 5vcyA-3cmmA:
undetectable		 5vcyA-3cmmA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  76
LEU A  94
ASN A 151
ASP A 164
 None
None
ANP  A   1 ( 3.4A)
ANP  A   1 (-3.8A)
 1.19A 5vcyA-3dakA:
21.5		 5vcyA-3dakA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dz8 RAS-RELATED PROTEIN
RAB-3B

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 145
LEU A 153
ASN A 106
ASP A 103
 None
 1.10A 5vcyA-3dz8A:
undetectable		 5vcyA-3dz8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		4 VAL A 243
LEU A 188
ASN A 123
ASP A 217
 None
 1.39A 5vcyA-3e9zA:
undetectable		 5vcyA-3e9zA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 VAL A 468
LEU A  58
ASN A 463
ASP A 439
 EDO  A8005 (-4.6A)
None
None
None
 1.35A 5vcyA-3gbdA:
2.4		 5vcyA-3gbdA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE

(Francisella
tularensis) 		PF00834
(Ribul_P_3_epim) 		4 VAL A 197
LEU A  11
ASN A  32
ASP A  66
 None
 1.38A 5vcyA-3inpA:
undetectable		 5vcyA-3inpA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 368
LEU A 387
ASN A 458
ASP A 457
 None
 1.31A 5vcyA-3iwaA:
undetectable		 5vcyA-3iwaA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9j TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus) 		PF00520
(Ion_trans) 		4 VAL A  35
LEU A  42
ASN A  28
ASP A  31
 None
 1.22A 5vcyA-3j9jA:
undetectable		 5vcyA-3j9jA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		4 VAL G  67
LEU F  79
ASN G  65
ASP G  61
 None
None
U  C 101 ( 3.2A)
None
 1.17A 5vcyA-3jb9G:
undetectable		 5vcyA-3jb9G:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz3 SENSOR PROTEIN QSEC

(Escherichia
coli) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		4 VAL A 308
LEU A 352
ASN A 304
ASP A 303
 None
 1.02A 5vcyA-3jz3A:
undetectable		 5vcyA-3jz3A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9h PF-32 PROTEIN

(Borreliella
burgdorferi) 		PF13614
(AAA_31) 		4 VAL A  37
LEU A  27
ASN A  87
ASP A  86
 None
 1.35A 5vcyA-3k9hA:
undetectable		 5vcyA-3k9hA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 482
LEU A 500
ASN A 549
ASP A 565
 None
ANP  A 400 (-4.6A)
ANP  A 400 ( 4.4A)
None
 1.00A 5vcyA-3kn5A:
21.2		 5vcyA-3kn5A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		4 VAL A  52
LEU A 340
ASN A  65
ASP A  64
 None
 1.25A 5vcyA-3l7gA:
undetectable		 5vcyA-3l7gA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lr0 SENSOR PROTEIN

(Burkholderia
pseudomallei) 		PF16524
(RisS_PPD) 		4 VAL A  79
LEU A  53
ASN A  76
ASP A  72
 None
 1.26A 5vcyA-3lr0A:
undetectable		 5vcyA-3lr0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2n ANTHRAX TOXIN
RECEPTOR 1

(Homo sapiens) 		no annotation 4 VAL F 178
LEU F  69
ASN F 202
ASP F 203
 None
 1.37A 5vcyA-3n2nF:
undetectable		 5vcyA-3n2nF:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		4 VAL A  55
LEU A  62
ASN A 176
ASP A 149
 SO4  A 233 (-4.2A)
None
None
None
 1.37A 5vcyA-3ntvA:
undetectable		 5vcyA-3ntvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 247
LEU A 265
ASN A 316
ASP A 329
 None
AMP  A 577 ( 4.9A)
AMP  A 577 (-4.2A)
AMP  A 577 (-4.0A)
 0.85A 5vcyA-3nyoA:
24.4		 5vcyA-3nyoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 VAL A 174
LEU A  43
ASN A 134
ASP A 133
 None
 1.30A 5vcyA-3ob8A:
undetectable		 5vcyA-3ob8A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		4 VAL A  90
LEU A 138
ASN A  84
ASP A  87
 None
 0.98A 5vcyA-3p2cA:
undetectable		 5vcyA-3p2cA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbt RAS-RELATED PROTEIN
RAB-8A

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 131
LEU A 139
ASN A  92
ASP A  89
 None
 1.15A 5vcyA-3qbtA:
undetectable		 5vcyA-3qbtA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up3 ACEDAF-12

(Ancylostoma
ceylanicum) 		PF00104
(Hormone_recep) 		4 VAL A 669
LEU A 664
ASN A 490
ASP A 487
 EDO  A 400 ( 3.7A)
XCA  A 100 (-4.8A)
None
None
 1.37A 5vcyA-3up3A:
undetectable		 5vcyA-3up3A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 113
LEU A 131
ASN A 184
ASP A 197
 None
None
ANK  A 401 ( 2.7A)
MG  A 402 ( 2.8A)
 1.19A 5vcyA-3vn9A:
22.4		 5vcyA-3vn9A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9r ABSCISIC ACID
RECEPTOR PYL9

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		4 VAL A 146
LEU A  28
ASN A 121
ASP A 148
 None
 1.33A 5vcyA-3w9rA:
undetectable		 5vcyA-3w9rA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdb PROTEIN XNI

(Escherichia
coli) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		4 VAL A  48
LEU A  11
ASN A 101
ASP A 105
 None
 1.29A 5vcyA-3zdbA:
undetectable		 5vcyA-3zdbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 114
LEU A 132
ASN A 181
ASP A 194
 None
939  A1331 (-4.4A)
None
939  A1331 (-3.1A)
 0.80A 5vcyA-4a4lA:
26.0		 5vcyA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 123
LEU A 141
ASN A 190
ASP A 203
 9ZP  A1333 (-4.4A)
9ZP  A1333 (-4.7A)
None
None
 0.79A 5vcyA-4b6lA:
26.9		 5vcyA-4b6lA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e13 DIKETOREDUCTASE

(Acinetobacter
baylyi) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A  89
LEU A 110
ASN A   6
ASP A  87
 None
None
GOL  A 305 ( 4.7A)
None
 1.30A 5vcyA-4e13A:
undetectable		 5vcyA-4e13A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 VAL A 620
LEU A 638
ASN A 688
ASP A 701
 None
GUI  A 901 (-4.4A)
GUI  A 901 (-4.6A)
GUI  A 901 ( 4.1A)
 0.84A 5vcyA-4e93A:
25.0		 5vcyA-4e93A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  84
LEU A 102
ASN A 151
ASP A 164
 None
STU  A 401 (-4.4A)
STU  A 401 ( 4.8A)
STU  A 401 ( 3.9A)
 0.86A 5vcyA-4fr4A:
24.9		 5vcyA-4fr4A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE

(Coffea
canephora) 		PF02458
(Transferase) 		4 VAL A  31
LEU A 355
ASN A  24
ASP A  28
 None
 1.29A 5vcyA-4g0bA:
undetectable		 5vcyA-4g0bA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		4 VAL A 455
LEU A 473
ASN A 522
ASP A 536
 None
0WB  A 701 (-4.3A)
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
 0.90A 5vcyA-4g3fA:
25.1		 5vcyA-4g3fA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 453
LEU A 471
ASN A 520
ASP A 534
 None
T28  A 701 ( 4.8A)
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
 0.90A 5vcyA-4idtA:
24.9		 5vcyA-4idtA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		4 VAL A 399
LEU A 428
ASN A 373
ASP A 376
 None
 0.83A 5vcyA-4nscA:
undetectable		 5vcyA-4nscA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 VAL A 416
LEU A 434
ASN A 487
ASP A 500
 None
 0.96A 5vcyA-4o1oA:
16.9		 5vcyA-4o1oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 VAL B 418
LEU B 436
ASN B 490
ASP B 503
 None
ACP  B 801 ( 4.9A)
MG  B 802 ( 2.5A)
MG  B 803 (-1.8A)
 0.88A 5vcyA-4oavB:
18.4		 5vcyA-4oavB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oit LYSM DOMAIN PROTEIN

(Mycolicibacterium
smegmatis) 		PF01453
(B_lectin) 		4 VAL A  53
LEU A  11
ASN A  49
ASP A  31
 None
None
MAN  A 201 (-4.1A)
MAN  A 201 (-3.2A)
 1.32A 5vcyA-4oitA:
undetectable		 5vcyA-4oitA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0j INTERLEUKIN-36
RECEPTOR
ANTAGONIST/INTERLEUK
IN-36 GAMMA CHIMERA
PROTEIN

(Homo sapiens) 		PF00340
(IL1) 		4 VAL A 131
LEU A  59
ASN A 142
ASP A  13
 None
 1.21A 5vcyA-4p0jA:
undetectable		 5vcyA-4p0jA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H 120
LEU H 123
ASN H 195
ASP H 206
 None
 1.34A 5vcyA-4qexH:
undetectable		 5vcyA-4qexH:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		4 VAL A 344
LEU A 374
ASN A 433
ASP A 432
 None
 1.31A 5vcyA-4uf7A:
undetectable		 5vcyA-4uf7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v36 LYSYL-TRNA-DEPENDENT
L-YSYL-PHOSPHATIDYLG
YCEROL SYNTHASE

(Bacillus
licheniformis) 		PF09924
(DUF2156) 		4 VAL A 592
LEU A 619
ASN A 564
ASP A 562
 None
 1.28A 5vcyA-4v36A:
undetectable		 5vcyA-4v36A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmo XEEL PROTEIN

(Xenopus laevis) 		no annotation 4 VAL F 221
LEU F 277
ASN F 145
ASP F 143
 None
 1.33A 5vcyA-4wmoF:
undetectable		 5vcyA-4wmoF:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		4 VAL A 275
LEU A 271
ASN A 250
ASP A 248
 None
 1.26A 5vcyA-4y9wA:
undetectable		 5vcyA-4y9wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 VAL A 269
LEU A 282
ASN A 274
ASP A 250
 None
 1.02A 5vcyA-4ztxA:
undetectable		 5vcyA-4ztxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		4 VAL A  52
LEU A 340
ASN A  65
ASP A  64
 None
 1.31A 5vcyA-4zwoA:
undetectable		 5vcyA-4zwoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyj PUTATIVE PEPTIDASE
C60B, SORTASE B

(Clostridioides
difficile) 		PF04203
(Sortase) 		4 VAL A  73
LEU A 146
ASN A  55
ASP A  57
 None
 1.36A 5vcyA-5gyjA:
undetectable		 5vcyA-5gyjA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 VAL A  74
LEU A  92
ASN A 141
ASP A 157
 None
ADP  A 301 ( 4.8A)
MG  A 302 ( 2.8A)
MG  A 302 ( 3.3A)
 0.93A 5vcyA-5hu3A:
28.2		 5vcyA-5hu3A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
coronavirus
HKU1;
Human
immunodeficiency
virus 1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 VAL A 216
LEU A  46
ASN A 108
ASP A 196
 None
 1.38A 5vcyA-5i08A:
undetectable		 5vcyA-5i08A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 449
LEU A 467
ASN A 516
ASP A 533
 None
GUI  A 701 ( 4.7A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.84A 5vcyA-5jznA:
27.5		 5vcyA-5jznA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL B 723
LEU B 741
ASN B 791
ASP B 803
 None
6U7  B1001 (-4.6A)
None
6U7  B1001 (-4.6A)
 0.84A 5vcyA-5kkrB:
20.1		 5vcyA-5kkrB:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL A 126
LEU A 129
ASN A 202
ASP A 213
 None
 1.30A 5vcyA-5kn5A:
undetectable		 5vcyA-5kn5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		4 VAL A 135
LEU A 146
ASN A 152
ASP A 155
 None
 1.14A 5vcyA-5kztA:
undetectable		 5vcyA-5kztA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9p PERIPLASMIC BINDING
PROTEIN

(Agrobacterium
tumefaciens) 		PF13416
(SBP_bac_8) 		4 VAL A 120
LEU A 105
ASN A 301
ASP A 114
 None
None
SO4  A 403 (-3.6A)
None
 1.33A 5vcyA-5l9pA:
undetectable		 5vcyA-5l9pA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE TLDD

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 VAL A 250
LEU A 260
ASN A 474
ASP A 473
 None
 1.28A 5vcyA-5njfA:
undetectable		 5vcyA-5njfA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szi RAS-RELATED PROTEIN
RAB-8A

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 131
LEU A 139
ASN A  92
ASP A  89
 None
 1.18A 5vcyA-5sziA:
undetectable		 5vcyA-5sziA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 VAL A 500
LEU A 414
ASN A 504
ASP A 463
 None
 1.26A 5vcyA-5tw7A:
undetectable		 5vcyA-5tw7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 VAL A 137
LEU A 128
ASN A  35
ASP A 135
 None
 1.38A 5vcyA-5u3cA:
undetectable		 5vcyA-5u3cA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 255
LEU A 273
ASN A 322
ASP A 335
 None
None
None
QRW  A 601 (-3.7A)
 1.10A 5vcyA-5uuuA:
25.2		 5vcyA-5uuuA:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 171
LEU A 189
ASN A 238
ASP A 251
 None
None
EDO  A 402 (-3.9A)
EDO  A 402 ( 2.9A)
 0.75A 5vcyA-5vcxA:
42.4		 5vcyA-5vcxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wix P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 4 VAL A   9
LEU A 202
ASN A   2
ASP A 207
 None
 1.18A 5vcyA-5wixA:
undetectable		 5vcyA-5wixA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2p -

(-) 		no annotation 4 VAL A 228
LEU A 261
ASN A 226
ASP A 218
 None
 1.38A 5vcyA-5y2pA:
undetectable		 5vcyA-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 4 VAL A  34
LEU A  23
ASN A  45
ASP A  48
 None
 1.36A 5vcyA-6b92A:
undetectable		 5vcyA-6b92A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 4 VAL A 212
LEU A 232
ASN A 280
ASP A 293
 H1N  A 501 (-4.9A)
H1N  A 501 (-4.3A)
H1N  A 501 (-4.5A)
H1N  A 501 (-3.5A)
 0.92A 5vcyA-6ccfA:
24.4		 5vcyA-6ccfA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 4 VAL A 249
LEU A 269
ASN A 317
ASP A 330
 None
F6J  A 501 ( 4.4A)
F6J  A 501 ( 4.7A)
F6J  A 501 (-3.8A)
 0.85A 5vcyA-6cmjA:
24.2		 5vcyA-6cmjA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 HEAVY CHAIN

(Mus musculus) 		no annotation 4 VAL G 128
LEU G 131
ASN G 203
ASP G 214
 None
 1.35A 5vcyA-6cnkG:
undetectable		 5vcyA-6cnkG:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 4 VAL A  94
LEU A 109
ASN A 119
ASP A 121
 None
 1.35A 5vcyA-6czmA:
undetectable		 5vcyA-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 VAL A1083
LEU A1099
ASN A1052
ASP A1048
 None
 1.16A 5vcyA-6en4A:
undetectable		 5vcyA-6en4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 VAL A 225
LEU A 243
ASN A 293
ASP A 325
 None
EAQ  A 501 ( 4.9A)
None
EAQ  A 501 (-4.6A)
 0.95A 5vcyA-6fyoA:
26.7		 5vcyA-6fyoA:
undetectable