SIMILAR PATTERNS OF AMINO ACIDS FOR 5VCV_A_1N1A404_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9l PROTEIN (EPIMERASE)

(Escherichia
coli) 		PF02152
(FolB) 		4 VAL A  98
HIS A  67
LEU A  76
ASP A  85
 None
 1.21A 5vcvA-1b9lA:
undetectable		 5vcvA-1b9lA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 175
LEU A 215
CYH A 212
ASP A 204
 None
 1.05A 5vcvA-1bkhA:
undetectable		 5vcvA-1bkhA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR

(Bos taurus) 		PF00996
(GDI) 		4 VAL A 265
LEU A  10
CYH A 282
ASP A 391
 None
 1.37A 5vcvA-1d5tA:
undetectable		 5vcvA-1d5tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm1 PROTEIN TYROSINE
PHOSPHATASE

(Mus musculus) 		PF00595
(PDZ) 		4 VAL A  16
HIS A  60
LEU A  25
ASP A  63
 None
 1.29A 5vcvA-1gm1A:
undetectable		 5vcvA-1gm1A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itv MMP9

(Homo sapiens) 		PF00045
(Hemopexin) 		4 VAL A   6
HIS A 150
LEU A 190
ASP A  10
 SO4  A 196 ( 3.9A)
None
None
None
 1.37A 5vcvA-1itvA:
undetectable		 5vcvA-1itvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l4z STREPTOKINASE

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		4 VAL B  13
HIS B  72
LEU B   7
ASP B  41
 None
 1.40A 5vcvA-1l4zB:
undetectable		 5vcvA-1l4zB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 VAL E  97
HIS E  79
LEU E 101
CYH E 135
 None
 1.15A 5vcvA-1nfiE:
undetectable		 5vcvA-1nfiE:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		4 VAL A  20
HIS A 121
LEU A 268
ASP A 218
 None
 1.44A 5vcvA-2ef4A:
undetectable		 5vcvA-2ef4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 VAL A 585
LEU A 397
CYH A 396
ASP A 471
 None
 1.25A 5vcvA-2gv9A:
0.0		 5vcvA-2gv9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11

(Brucella suis) 		PF00437
(T2SSE) 		4 VAL A 239
LEU A 225
CYH A 110
ASP A  87
 None
 1.37A 5vcvA-2gzaA:
undetectable		 5vcvA-2gzaA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 HIS A 230
LEU A 164
CYH A 162
ASP A 194
 None
 1.26A 5vcvA-2ldxA:
undetectable		 5vcvA-2ldxA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn6 EXOSOME COMPLEX
EXONUCLEASE RRP43

(Homo sapiens) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 HIS C 259
LEU C 235
CYH C 234
ASP C 150
 None
 1.38A 5vcvA-2nn6C:
undetectable		 5vcvA-2nn6C:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 VAL A  21
HIS B 144
LEU A 129
ASP B 157
 None
 1.29A 5vcvA-2v4jA:
undetectable		 5vcvA-2v4jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 VAL A 508
HIS A 261
LEU A 487
ASP A 538
 None
 1.00A 5vcvA-2xn1A:
undetectable		 5vcvA-2xn1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		4 VAL A 585
HIS A 707
LEU A 641
ASP A 236
 None
 1.49A 5vcvA-2yfsA:
undetectable		 5vcvA-2yfsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 VAL A 190
HIS A 161
LEU A 133
ASP A  84
 None
 1.49A 5vcvA-2zxoA:
undetectable		 5vcvA-2zxoA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 VAL A 207
HIS A 354
LEU A 650
ASP A 334
 None
SO4  A 656 (-3.7A)
None
None
 1.37A 5vcvA-3af5A:
undetectable		 5vcvA-3af5A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		4 VAL A 109
HIS A 138
LEU A  30
CYH A  29
 None
None
None
SF4  A 500 (-2.2A)
 1.28A 5vcvA-3c8fA:
undetectable		 5vcvA-3c8fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 VAL A 253
HIS A 177
LEU A 226
ASP A 172
 None
None
None
BFD  A 170 (-4.2A)
 1.41A 5vcvA-3ef1A:
undetectable		 5vcvA-3ef1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3C

(Saccharomyces
cerevisiae) 		PF00203
(Ribosomal_S19) 		4 VAL p 675
LEU p 627
CYH p 624
ASP p 618
 None
 1.33A 5vcvA-3japp:
2.1		 5vcvA-3japp:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 VAL A  18
HIS B 133
LEU A 126
ASP B 146
 None
 1.37A 5vcvA-3mm5A:
undetectable		 5vcvA-3mm5A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwn PHYCOERYTHRIN

(Phormidium
tenue) 		PF00502
(Phycobilisome) 		4 VAL A1051
LEU A1156
CYH A1153
ASP A1143
 CYC  A3002 ( 4.5A)
None
None
CYC  A3002 ( 3.8A)
 1.29A 5vcvA-3mwnA:
undetectable		 5vcvA-3mwnA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3t PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Thiobacillus
denitrificans) 		PF00563
(EAL) 		4 VAL A 641
LEU A 633
CYH A 632
ASP A 600
 None
 1.39A 5vcvA-3n3tA:
undetectable		 5vcvA-3n3tA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		4 VAL A 204
LEU A 247
CYH A 244
ASP A 281
 None
 1.23A 5vcvA-3o8lA:
undetectable		 5vcvA-3o8lA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		4 VAL B 603
LEU B 888
CYH B 889
ASP B 953
 None
 0.72A 5vcvA-3qd2B:
19.9		 5vcvA-3qd2B:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 VAL A 518
LEU A 103
CYH A 104
ASP A 146
 None
None
ZN  A 539 (-2.3A)
9MR  A 601 ( 2.9A)
 1.23A 5vcvA-3rx8A:
undetectable		 5vcvA-3rx8A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry6 LOW AFFINITY
IMMUNOGLOBULIN GAMMA
FC REGION RECEPTOR
II-A

(Homo sapiens) 		PF13895
(Ig_2) 		4 VAL C  86
HIS C  44
LEU C  12
ASP C  65
 None
 1.32A 5vcvA-3ry6C:
undetectable		 5vcvA-3ry6C:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT

(Cryptococcus
neoformans) 		PF01239
(PPTA) 		4 VAL A 198
HIS A 152
LEU A 173
CYH A 176
 None
 1.44A 5vcvA-3sfyA:
undetectable		 5vcvA-3sfyA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soz CYTOPLASMIC PROTEIN
STM1381

(Salmonella
enterica) 		PF07090
(GATase1_like) 		4 VAL A 133
HIS A 206
LEU A 138
ASP A 103
 None
 1.43A 5vcvA-3sozA:
undetectable		 5vcvA-3sozA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 VAL A 150
HIS A 271
LEU A 247
ASP A 143
 None
 1.42A 5vcvA-3v9aA:
undetectable		 5vcvA-3v9aA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ved DYPB

(Rhodococcus
jostii) 		PF04261
(Dyp_perox) 		4 VAL A  64
LEU A 119
CYH A 116
ASP A 245
 None
 1.39A 5vcvA-3vedA:
undetectable		 5vcvA-3vedA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 105
LEU A 132
CYH A 133
ASP A 194
 None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
939  A1331 (-3.1A)
 0.72A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 114
LEU A 141
CYH A 142
ASP A 203
 None
9ZP  A1333 (-4.7A)
9ZP  A1333 (-4.1A)
None
 0.72A 5vcvA-4b6lA:
27.0		 5vcvA-4b6lA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		4 VAL A 457
HIS A 397
LEU A 445
ASP A 417
 None
 1.47A 5vcvA-4berA:
undetectable		 5vcvA-4berA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 VAL A 103
LEU A 181
CYH A 180
ASP A 151
 None
 1.15A 5vcvA-4bkmA:
undetectable		 5vcvA-4bkmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1t METALLO-B-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 VAL A 203
HIS A 116
LEU A 175
ASP A  84
 None
ZN  A1292 (-3.2A)
None
None
 1.48A 5vcvA-4d1tA:
undetectable		 5vcvA-4d1tA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 VAL A  55
LEU A 125
CYH A 123
ASP A  88
 None
 1.45A 5vcvA-4efcA:
undetectable		 5vcvA-4efcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		4 VAL A 242
HIS A  44
LEU A 229
ASP A 273
 None
 1.22A 5vcvA-4eipA:
undetectable		 5vcvA-4eipA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 VAL B 766
LEU B 673
CYH B 674
ASP B  12
 None
 1.33A 5vcvA-4fhnB:
undetectable		 5vcvA-4fhnB:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 VAL A 575
LEU A 450
CYH A 449
ASP A 404
 None
 1.11A 5vcvA-4fixA:
2.2		 5vcvA-4fixA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 VAL A 368
LEU A  97
CYH A  96
ASP A 105
 None
 1.49A 5vcvA-4inaA:
undetectable		 5vcvA-4inaA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ium PAPAIN-LIKE PROTEASE
2

(Equine
arteritis virus) 		PF05412
(Peptidase_C33)
PF14755
(ER-remodelling) 		4 VAL A 384
LEU A 275
CYH A 274
ASP A 267
 None
 1.47A 5vcvA-4iumA:
undetectable		 5vcvA-4iumA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		4 VAL A  77
HIS A 128
LEU A 153
ASP A 181
 None
 1.50A 5vcvA-4mhpA:
undetectable		 5vcvA-4mhpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 VAL A  63
LEU A  44
CYH A  48
ASP A  52
 None
 1.45A 5vcvA-4otkA:
undetectable		 5vcvA-4otkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 VAL A 971
LEU A 872
CYH A 881
ASP A 947
 None
 1.11A 5vcvA-4ptfA:
undetectable		 5vcvA-4ptfA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 VAL A 387
LEU A  97
CYH A  96
ASP A 105
 None
 1.44A 5vcvA-4rl6A:
undetectable		 5vcvA-4rl6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlg SEC14-LIKE PROTEIN 4

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 VAL A  79
LEU A 270
CYH A 271
ASP A 107
 None
None
None
EDO  A 509 (-3.7A)
 1.44A 5vcvA-4tlgA:
undetectable		 5vcvA-4tlgA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		4 VAL C 675
LEU C 627
CYH C 624
ASP C 618
 None
 1.37A 5vcvA-4u1cC:
2.7		 5vcvA-4u1cC:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3C

(Lachancea
kluyveri) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 VAL c 675
LEU c 627
CYH c 624
ASP c 618
 None
 1.37A 5vcvA-4uerc:
2.9		 5vcvA-4uerc:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		4 VAL A 168
HIS A 482
LEU A 193
ASP A 121
 None
 1.37A 5vcvA-4ug4A:
undetectable		 5vcvA-4ug4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 VAL A 443
HIS A 336
LEU A 461
ASP A 346
 None
 1.05A 5vcvA-4uphA:
undetectable		 5vcvA-4uphA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 VAL A 253
HIS A 177
LEU A 226
ASP A 172
 None
None
None
AF3  A 601 ( 4.0A)
 1.42A 5vcvA-4xpzA:
undetectable		 5vcvA-4xpzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 VAL A 586
LEU A 644
CYH A 645
ASP A 711
 None
 0.82A 5vcvA-4z7gA:
20.0		 5vcvA-4z7gA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a87 METALLO-BETA-LACTAMA
SE VIM-5

(Klebsiella
pneumoniae) 		PF00753
(Lactamase_B) 		4 VAL A 186
HIS A 114
LEU A 158
ASP A  84
 None
ZN  A1263 (-3.2A)
None
None
 1.45A 5vcvA-5a87A:
undetectable		 5vcvA-5a87A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE

(Serratia
marcescens) 		PF00753
(Lactamase_B) 		4 VAL A 192
HIS A  72
LEU A 253
ASP A 111
 None
ZN  A 301 (-3.2A)
None
NA  A 311 (-4.1A)
 1.47A 5vcvA-5b1uA:
undetectable		 5vcvA-5b1uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		4 VAL A 287
LEU A 226
CYH A 227
ASP A 230
 None
None
None
MG  A 401 (-2.6A)
 1.32A 5vcvA-5dxiA:
undetectable		 5vcvA-5dxiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Aspergillus
fumigatus) 		PF02358
(Trehalose_PPase) 		4 VAL A 260
LEU A 211
CYH A 212
ASP A 215
 None
 1.35A 5vcvA-5dxlA:
undetectable		 5vcvA-5dxlA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2

(Mus musculus) 		PF00856
(SET)
PF07531
(TAFH) 		4 VAL A  85
LEU A  60
CYH A  77
ASP A 161
 None
 1.27A 5vcvA-5ecjA:
undetectable		 5vcvA-5ecjA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		4 VAL A 250
HIS A 111
LEU A 157
ASP A  42
 None
GOL  A 518 (-2.7A)
None
ZN  A 501 (-3.1A)
 1.47A 5vcvA-5fcaA:
undetectable		 5vcvA-5fcaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		4 HIS A 611
LEU A 663
CYH A 661
ASP A 655
 None
 1.49A 5vcvA-5h11A:
undetectable		 5vcvA-5h11A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk7 PROTEIN VPRBP

(Homo sapiens) 		no annotation 4 VAL C1122
LEU C1110
CYH C1099
ASP C1360
 None
 1.29A 5vcvA-5jk7C:
undetectable		 5vcvA-5jk7C:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL B 680
LEU B 741
CYH B 742
ASP B 803
 6U7  B1001 ( 4.3A)
6U7  B1001 (-4.6A)
6U7  B1001 (-3.5A)
6U7  B1001 (-4.6A)
 0.84A 5vcvA-5kkrB:
20.1		 5vcvA-5kkrB:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov3 RETINOBLASTOMA-BINDI
NG PROTEIN 5

(Mus musculus) 		no annotation 4 VAL A  95
LEU A  72
CYH A  73
ASP A  77
 None
 1.18A 5vcvA-5ov3A:
undetectable		 5vcvA-5ov3A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 221
HIS A 451
LEU A 152
ASP A 138
 None
 1.50A 5vcvA-5u25A:
undetectable		 5vcvA-5u25A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzb TOLL/INTERLEUKIN-1
RECEPTOR
DOMAIN-CONTAINING
ADAPTER PROTEIN

(Homo sapiens) 		PF13676
(TIR_2) 		4 VAL A 104
LEU A 146
CYH A  91
ASP A 122
 None
 1.48A 5vcvA-5uzbA:
undetectable		 5vcvA-5uzbA:
27.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 124
HIS A 161
LEU A 189
CYH A 190
ASP A 251
 H8H  A 401 (-4.7A)
None
None
H8H  A 401 (-4.3A)
EDO  A 402 ( 2.9A)
 0.50A 5vcvA-5vcxA:
44.0		 5vcvA-5vcxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 4 VAL A  80
LEU A 114
CYH A 111
ASP A 180
 None
None
None
C6P  A 502 (-2.9A)
 1.41A 5vcvA-5wt4A:
undetectable		 5vcvA-5wt4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 VAL A 303
HIS A 431
LEU A 313
ASP A 342
 None
01B  A 604 (-4.0A)
DMS  A 605 (-4.2A)
MN  A 602 (-2.6A)
 1.29A 5vcvA-5x49A:
undetectable		 5vcvA-5x49A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1z PROTEIN KINASE
C-BINDING PROTEIN 1

(Homo sapiens) 		no annotation 4 VAL C 100
HIS C  95
LEU C 115
ASP C  88
 None
 1.44A 5vcvA-5y1zC:
undetectable		 5vcvA-5y1zC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k DRAXIN
NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 4 VAL A 391
HIS B 284
LEU A 415
ASP B 280
 None
 1.23A 5vcvA-5z5kA:
undetectable		 5vcvA-5z5kA:
15.81