SIMILAR PATTERNS OF AMINO ACIDS FOR 5VCV_A_1N1A404_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | ALA A 220LYS A 222GLU A 236VAL A 249THR A 266GLY A 272 | None | 1.13A | 5vcvA-1k9aA:24.8 | 5vcvA-1k9aA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | LEU A 267ALA A 288LYS A 290GLU A 305VAL A 318GLY A 340 | P16 A 2 ( 4.2A)P16 A 2 (-3.4A)P16 A 2 (-4.5A)P16 A 2 (-4.2A)P16 A 2 ( 4.7A)P16 A 2 (-3.4A) | 1.07A | 5vcvA-1opkA:22.9 | 5vcvA-1opkA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | LEU A 267ALA A 288LYS A 290GLU A 305VAL A 318THR A 334 | P16 A 2 ( 4.2A)P16 A 2 (-3.4A)P16 A 2 (-4.5A)P16 A 2 (-4.2A)P16 A 2 ( 4.7A)P16 A 2 (-3.7A) | 0.51A | 5vcvA-1opkA:22.9 | 5vcvA-1opkA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 616ALA A 642GLU A 661VAL A 675LEU A 689GLY A 697 | None | 1.09A | 5vcvA-1rjbA:21.9 | 5vcvA-1rjbA:25.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 616ALA A 642LYS A 644GLU A 661LEU A 689GLY A 697 | None | 1.39A | 5vcvA-1rjbA:21.9 | 5vcvA-1rjbA:25.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 595ALA A 621LYS A 623GLU A 640THR A 670GLY A 676 | STI A 3 ( 3.8A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.6A)STI A 3 (-3.2A)STI A 3 ( 3.8A) | 0.97A | 5vcvA-1t46A:22.6 | 5vcvA-1t46A:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u59 | TYROSINE-PROTEINKINASE ZAP-70 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 344ALA A 367GLU A 386VAL A 399LEU A 412GLY A 418 | STU A 100 (-3.8A)STU A 100 (-3.2A)NoneNoneNoneSTU A 100 ( 4.7A) | 0.87A | 5vcvA-1u59A:24.7 | 5vcvA-1u59A:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u59 | TYROSINE-PROTEINKINASE ZAP-70 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 344ALA A 367LYS A 369GLU A 386VAL A 399LEU A 412GLY A 420 | STU A 100 (-3.8A)STU A 100 (-3.2A)STU A 100 ( 4.7A)NoneNoneNoneSTU A 100 (-3.5A) | 0.98A | 5vcvA-1u59A:24.7 | 5vcvA-1u59A:23.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u5q | SERINE/THREONINEPROTEIN KINASE TAO2 (Rattusnorvegicus) |
PF00069(Pkinase) | 6 | ALA A 55LYS A 57GLU A 76LEU A 103GLY A 110GLY A 168 | None | 0.93A | 5vcvA-1u5qA:27.2 | 5vcvA-1u5qA:30.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 15ALA A 36GLU A 55VAL A 68LEU A 82GLY A 90 | HYM A 400 (-4.2A)HYM A 400 (-3.5A)NoneHYM A 400 (-4.8A)NoneNone | 1.13A | 5vcvA-1zltA:25.5 | 5vcvA-1zltA:25.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zy4 | SERINE/THREONINE-PROTEIN KINASE GCN2 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 6 | LEU A 605ALA A 626LYS A 628VAL A 656PHE A 842GLY A 852 | NoneGOL A 998 ( 3.7A)NoneGOL A 998 (-4.9A)GOL A 998 ( 4.2A)None | 1.06A | 5vcvA-1zy4A:23.7 | 5vcvA-1zy4A:28.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bdw | HYPOTHETICAL PROTEINK11E8.1D (Caenorhabditiselegans) |
PF00069(Pkinase) | 6 | LEU A 19ALA A 40LYS A 42GLU A 60VAL A 73LEU A 87 | None | 0.72A | 5vcvA-2bdwA:24.3 | 5vcvA-2bdwA:25.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bsz | ARYLAMINEN-ACETYLTRANSFERASE1 (Mesorhizobiumloti) |
PF00797(Acetyltransf_2) | 6 | LEU A 9ALA A 83GLU A 186VAL A 91LEU A 78GLY A 88 | None | 1.40A | 5vcvA-2bszA:undetectable | 5vcvA-2bszA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2buj | SERINE/THREONINE-PROTEIN KINASE 16 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 26ALA A 47LYS A 49GLU A 65LEU A 96GLY A 104 | STU A1301 (-4.2A)STU A1301 (-3.6A)STU A1301 ( 4.0A)NoneNoneSTU A1301 ( 4.0A) | 0.81A | 5vcvA-2bujA:25.3 | 5vcvA-2bujA:29.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2csn | CASEIN KINASE-1 (Schizosaccharomycespombe) |
PF00069(Pkinase) | 6 | ALA A 39LYS A 41GLU A 55LEU A 83GLY A 89PRO A 90 | CKI A 300 (-3.6A)NoneNoneNoneNoneNone | 0.84A | 5vcvA-2csnA:21.8 | 5vcvA-2csnA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU X 17ALA X 37LYS X 39GLU X 54VAL X 67GLY X 88 | STU X 902 (-3.8A)STU X 902 (-3.1A)STU X 902 (-3.1A)STU X 902 ( 4.4A)NoneSTU X 902 (-3.5A) | 1.10A | 5vcvA-2dq7X:25.8 | 5vcvA-2dq7X:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU X 17ALA X 37LYS X 39GLU X 54VAL X 67THR X 82 | STU X 902 (-3.8A)STU X 902 (-3.1A)STU X 902 (-3.1A)STU X 902 ( 4.4A)NoneSTU X 902 (-4.1A) | 0.43A | 5vcvA-2dq7X:25.8 | 5vcvA-2dq7X:25.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gcd | SERINE/THREONINE-PROTEIN KINASE TAO2 (Rattusnorvegicus) |
PF00069(Pkinase) | 6 | ALA A 55LYS A 57GLU A 76LEU A 103GLY A 110GLY A 168 | STU A 400 (-3.2A)STU A 400 ( 4.5A)NoneNoneSTU A 400 (-3.4A)None | 0.95A | 5vcvA-2gcdA:28.2 | 5vcvA-2gcdA:30.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 251ALA A 271LYS A 273GLU A 288VAL A 301THR A 316 | 1BM A 499 ( 3.7A)1BM A 499 (-3.6A)1BM A 499 (-3.8A)1BM A 499 (-3.2A)None1BM A 499 (-3.2A) | 0.62A | 5vcvA-2hk5A:25.7 | 5vcvA-2hk5A:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 248ALA A 269GLU A 286VAL A 299THR A 315GLY A 321 | GIN A 600 ( 4.6A)GIN A 600 (-3.1A)GIN A 600 (-3.6A)GIN A 600 (-4.6A)GIN A 600 (-3.4A)None | 0.86A | 5vcvA-2hz0A:24.7 | 5vcvA-2hz0A:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 248ALA A 269LYS A 271GLU A 286THR A 315GLY A 321 | GIN A 600 ( 4.6A)GIN A 600 (-3.1A)GIN A 600 (-3.6A)GIN A 600 (-3.6A)GIN A 600 (-3.4A)None | 0.96A | 5vcvA-2hz0A:24.7 | 5vcvA-2hz0A:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i6l | MITOGEN-ACTIVATEDPROTEIN KINASE 6 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 47LYS A 49GLU A 65VAL A 78PHE A 159GLY A 170 | None | 0.48A | 5vcvA-2i6lA:25.7 | 5vcvA-2i6lA:24.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 251ALA A 271LYS A 273GLU A 288THR A 316GLY A 322 | None1N8 A 501 ( 3.4A)1N8 A 501 ( 3.4A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.3A)1N8 A 501 ( 3.5A) | 1.00A | 5vcvA-2og8A:22.6 | 5vcvA-2og8A:26.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 588ALA A 614GLU A 633VAL A 647THR A 663GLY A 669GLY A 795 | None | 1.03A | 5vcvA-2ogvA:22.0 | 5vcvA-2ogvA:26.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2phk | PHOSPHORYLASE KINASE (Oryctolaguscuniculus) |
PF00069(Pkinase) | 6 | LEU A 25ALA A 46LYS A 48GLU A 73LEU A 101GLY A 109 | ATP A 381 ( 4.3A)ATP A 381 (-3.5A)ATP A 381 (-3.2A)NoneNoneNone | 1.08A | 5vcvA-2phkA:27.2 | 5vcvA-2phkA:27.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pmi | CYCLIN-DEPENDENTPROTEIN KINASE PHO85 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 6 | ALA A 34LYS A 36GLU A 53VAL A 66LEU A 80GLY A 150 | AGS A3001 (-3.5A)AGS A3001 (-3.4A)AGS A3001 ( 4.8A)NoneNoneNone | 0.93A | 5vcvA-2pmiA:24.2 | 5vcvA-2pmiA:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vuw | SERINE/THREONINE-PROTEIN KINASE HASPIN (Homo sapiens) |
PF12330(Haspin_kinase) | 6 | ALA A 509LYS A 511GLU A 535LEU A 603GLY A 609GLN A 614 | 5ID A1800 (-3.4A)IOD A1799 (-3.2A)NoneNone5ID A1800 (-4.7A)5ID A1800 ( 4.9A) | 0.83A | 5vcvA-2vuwA:18.9 | 5vcvA-2vuwA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yab | DEATH-ASSOCIATEDPROTEIN KINASE 2 (Mus musculus) |
PF00069(Pkinase) | 5 | LEU A 19ALA A 40LYS A 42GLU A 64LEU A 91 | AMP A1302 (-3.7A)AMP A1302 (-3.6A)AMP A1302 (-2.8A)NoneNone | 0.44A | 5vcvA-2yabA:25.4 | 5vcvA-2yabA:23.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2z2w | WEE1-LIKE PROTEINKINASE (Homo sapiens) |
PF00069(Pkinase) | 7 | ALA A 326LYS A 328GLU A 346VAL A 360GLY A 382PHE A 433GLY A 462 | 770 A 901 (-3.5A)770 A 901 (-4.6A)770 A 901 (-3.9A)770 A 901 ( 4.7A)770 A 901 (-3.4A)770 A 901 (-4.0A)None | 0.94A | 5vcvA-2z2wA:32.2 | 5vcvA-2z2wA:30.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z9v | ASPARTATEAMINOTRANSFERASE (Mesorhizobiumloti) |
PF00266(Aminotran_5) | 6 | LEU A 261ALA A 55GLU A 270GLY A 194PRO A 195GLY A 178 | None | 1.46A | 5vcvA-2z9vA:undetectable | 5vcvA-2z9vA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 6 | LEU A 253ALA A 273LYS A 275GLU A 290VAL A 303THR A 319 | None | 0.93A | 5vcvA-2zv7A:25.7 | 5vcvA-2zv7A:22.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3a62 | RIBOSOMAL PROTEIN S6KINASE BETA-1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 97ALA A 121LYS A 123GLU A 143VAL A 156LEU A 170 | STU A 400 (-3.8A)STU A 400 (-3.1A)STU A 400 ( 4.3A)STU A 400 ( 4.3A)NoneNone | 0.76A | 5vcvA-3a62A:22.7 | 5vcvA-3a62A:30.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 220LYS A 222GLU A 236VAL A 249THR A 266GLY A 272 | None | 1.13A | 5vcvA-3d7uA:25.2 | 5vcvA-3d7uA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kn5 | RIBOSOMAL PROTEIN S6KINASE ALPHA-5 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 432ALA A 453LYS A 455GLU A 468VAL A 482LEU A 496 | ANP A 400 (-4.1A)ANP A 400 ( 3.8A)NoneNoneNoneNone | 0.60A | 5vcvA-3kn5A:21.0 | 5vcvA-3kn5A:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3llt | SERINE/THREONINEKINASE-1, PFLAMMER (Plasmodiumfalciparum) |
PF00069(Pkinase) | 6 | ALA A 579LYS A 581GLU A 596LEU A 628GLY A 634PRO A 635 | ANP A 877 ( 3.7A)ANP A 877 (-2.7A)ANP A 877 ( 4.4A)NoneNoneNone | 0.60A | 5vcvA-3lltA:25.9 | 5vcvA-3lltA:24.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lw0 | INSULIN-LIKE GROWTHFACTOR 1 RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A1005ALA A1031LYS A1033VAL A1063GLY A1085GLY A1152 | NoneNoneCCX A 1 ( 3.7A)CCX A 1 (-4.1A)NoneCCX A 1 (-3.6A) | 1.09A | 5vcvA-3lw0A:22.5 | 5vcvA-3lw0A:25.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdy | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-1B (Homo sapiens) |
PF07714(Pkinase_Tyr)PF08515(TGF_beta_GS) | 6 | ALA A 229LYS A 231GLU A 244LEU A 277THR A 279GLY A 285 | LDN A 1 (-3.6A)NoneNoneNoneLDN A 1 (-3.8A)LDN A 1 (-3.3A) | 1.04A | 5vcvA-3mdyA:22.6 | 5vcvA-3mdyA:26.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mtl | CELL DIVISIONPROTEIN KINASE 16 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 171ALA A 192LYS A 194GLU A 211VAL A 224LEU A 238 | FEF A 668 ( 3.8A)FEF A 668 (-3.3A)NoneNoneFEF A 668 (-4.7A)None | 1.00A | 5vcvA-3mtlA:22.5 | 5vcvA-3mtlA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvj | CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 49ALA A 70LYS A 72GLU A 91VAL A 104 | XFE A 351 (-4.2A)XFE A 351 (-3.2A)NoneNoneNone | 0.46A | 5vcvA-3mvjA:24.2 | 5vcvA-3mvjA:28.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyo | G PROTEIN-COUPLEDRECEPTOR KINASE 6 (Homo sapiens) |
PF00069(Pkinase)PF00615(RGS) | 6 | LEU A 192ALA A 213LYS A 215GLU A 234LEU A 261GLY A 269 | AMP A 577 ( 4.3A)AMP A 577 (-3.4A)AMP A 577 (-2.8A)NoneNoneNone | 1.18A | 5vcvA-3nyoA:24.6 | 5vcvA-3nyoA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyo | G PROTEIN-COUPLEDRECEPTOR KINASE 6 (Homo sapiens) |
PF00069(Pkinase)PF00615(RGS) | 6 | LEU A 192ALA A 213LYS A 215GLU A 234VAL A 247LEU A 261 | AMP A 577 ( 4.3A)AMP A 577 (-3.4A)AMP A 577 (-2.8A)NoneNoneNone | 0.82A | 5vcvA-3nyoA:24.6 | 5vcvA-3nyoA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oht | P38A (Salmo salar) |
PF00069(Pkinase) | 6 | ALA A 52LYS A 54GLU A 72LEU A 105THR A 107GLY A 111 | 1N1 A1000 (-3.7A)1N1 A1000 (-4.5A)1N1 A1000 (-4.2A)1N1 A1000 (-4.2A)1N1 A1000 (-3.3A)1N1 A1000 (-4.7A) | 0.50A | 5vcvA-3ohtA:18.2 | 5vcvA-3ohtA:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ALA A 373LYS A 375GLU A 393THR A 421PHE A 475GLY A 485 | SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 (-4.3A)SM5 A 1 (-4.4A)SM5 A 1 (-3.0A)None | 0.83A | 5vcvA-3omvA:23.1 | 5vcvA-3omvA:27.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pp0 | RECEPTORTYROSINE-PROTEINKINASE ERBB-2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 726ALA A 751LYS A 753LEU A 796THR A 798GLY A 804 | 03Q A 1 (-3.8A)03Q A 1 (-3.1A)03Q A 1 (-4.7A)03Q A 1 (-4.3A)03Q A 1 (-4.1A)03Q A 1 ( 3.9A) | 1.03A | 5vcvA-3pp0A:23.1 | 5vcvA-3pp0A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 6 | ALA A 576LYS A 578GLU A 596VAL A 609THR A 625GLY A 631 | STU A 1 (-3.3A)STU A 1 (-3.5A)NoneNoneSTU A 1 (-4.1A)STU A 1 (-3.2A) | 1.06A | 5vcvA-3ppzA:26.6 | 5vcvA-3ppzA:28.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q5i | PROTEIN KINASE (Plasmodiumberghei) |
PF00069(Pkinase)PF13499(EF-hand_7) | 6 | LEU A 63ALA A 84LYS A 86GLU A 115LEU A 142THR A 144 | ANP A1634 ( 4.3A)ANP A1634 (-3.6A)ANP A1634 (-3.1A)NoneNoneANP A1634 (-4.6A) | 0.76A | 5vcvA-3q5iA:24.1 | 5vcvA-3q5iA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q60 | ROP5B (Toxoplasmagondii) |
PF14531(Kinase-like) | 6 | LEU A 240ALA A 261LYS A 263LEU A 335PHE A 396GLY A 406 | NoneATP A 600 (-3.6A)MLI A 601 ( 2.8A)MLI A 601 (-4.7A)ATP A 600 (-4.4A)None | 0.92A | 5vcvA-3q60A:19.0 | 5vcvA-3q60A:26.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ulz | BRASSINOSTEROIDINSENSITIVE1-ASSOCIATEDRECEPTOR KINASE 1 (Arabidopsisthaliana) |
PF00069(Pkinase) | 6 | LEU A 295ALA A 315GLU A 334LEU A 361GLY A 369GLY A 433 | None | 0.97A | 5vcvA-3ulzA:22.4 | 5vcvA-3ulzA:28.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v5q | NT-3 GROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 544ALA A 570LYS A 572VAL A 601GLY A 623GLY A 696 | 0F4 A 902 ( 4.2A)0F4 A 902 (-3.2A)0F4 A 902 (-4.0A)None0F4 A 902 (-3.4A)0F4 A 902 (-3.3A) | 1.35A | 5vcvA-3v5qA:21.5 | 5vcvA-3v5qA:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vid | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 840ALA A 866LYS A 868GLU A 885VAL A 899GLY A 922 | 4TT A2001 ( 4.0A)4TT A2001 (-3.5A)NoneNoneNone4TT A2001 (-3.7A) | 1.02A | 5vcvA-3vidA:21.8 | 5vcvA-3vidA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wzd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 840ALA A 866LYS A 868GLU A 885VAL A 899GLY A 922 | LEV A1201 ( 3.8A)LEV A1201 (-3.5A)NoneLEV A1201 (-3.7A)NoneLEV A1201 (-3.6A) | 1.10A | 5vcvA-3wzdA:22.6 | 5vcvA-3wzdA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a4l | SERINE/THREONINE-PROTEIN KINASE PLK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 59ALA A 80GLU A 101VAL A 114PHE A 183GLY A 193 | 939 A1331 (-3.7A)939 A1331 (-3.5A)NoneNone939 A1331 (-4.0A)None | 0.45A | 5vcvA-4a4lA:26.1 | 5vcvA-4a4lA:25.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a4l | SERINE/THREONINE-PROTEIN KINASE PLK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 59ALA A 80LYS A 82GLU A 101VAL A 114PHE A 183 | 939 A1331 (-3.7A)939 A1331 (-3.5A)939 A1331 (-2.6A)NoneNone939 A1331 (-4.0A) | 0.60A | 5vcvA-4a4lA:26.1 | 5vcvA-4a4lA:25.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4at3 | BDNF/NT-3 GROWTHFACTORS RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 560ALA A 586LYS A 588VAL A 617GLY A 639GLY A 709 | LTI A1839 ( 4.2A)LTI A1839 (-3.3A)NoneNoneLTI A1839 (-3.4A)LTI A1839 (-3.4A) | 1.18A | 5vcvA-4at3A:22.0 | 5vcvA-4at3A:24.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b6l | SERINE/THREONINE-PROTEIN KINASE PLK3 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 68ALA A 89LYS A 91GLU A 110VAL A 123PHE A 192GLY A 202 | 9ZP A1333 (-3.9A)9ZP A1333 (-3.5A)NoneNone9ZP A1333 (-4.4A)9ZP A1333 (-3.6A)9ZP A1333 ( 4.4A) | 0.65A | 5vcvA-4b6lA:27.0 | 5vcvA-4b6lA:29.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckr | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 616ALA A 653LYS A 655GLU A 672THR A 701 | NoneDI1 A1000 (-3.6A)DI1 A1000 (-3.9A)DI1 A1000 (-3.8A)DI1 A1000 (-3.6A) | 0.42A | 5vcvA-4ckrA:21.8 | 5vcvA-4ckrA:28.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eut | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 15ALA A 36LYS A 38GLU A 55VAL A 68LEU A 84GLY A 92 | BX7 A 401 (-3.7A)BX7 A 401 (-3.4A)BX7 A 401 ( 4.0A)NoneNoneNoneBX7 A 401 (-3.5A) | 0.94A | 5vcvA-4eutA:20.9 | 5vcvA-4eutA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euu | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 15ALA A 36LYS A 38GLU A 55VAL A 68LEU A 84GLY A 92 | BX7 A 401 (-3.9A)BX7 A 401 (-3.4A)BX7 A 401 (-3.5A)NoneNoneNoneBX7 A 401 (-3.3A) | 0.92A | 5vcvA-4euuA:23.3 | 5vcvA-4euuA:25.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0i | HIGH AFFINITY NERVEGROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 515ALA A 541LYS A 543VAL A 572GLY A 594GLY A 666 | None | 1.03A | 5vcvA-4f0iA:15.6 | 5vcvA-4f0iA:26.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4p | TYROSINE-PROTEINKINASE SYK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 377ALA A 400LYS A 402GLU A 420VAL A 433LEU A 446 | 0SB A 701 ( 3.9A)0SB A 701 (-3.3A)0SB A 701 ( 4.8A)NoneNoneNone | 0.94A | 5vcvA-4f4pA:24.8 | 5vcvA-4f4pA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fod | ALK TYROSINE KINASERECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A1122ALA A1148GLU A1167VAL A1180GLY A1202GLY A1269 | 0UV A1501 (-3.8A)0UV A1501 (-3.4A)None0UV A1501 ( 4.9A)0UV A1501 (-3.6A)0UV A1501 (-4.5A) | 1.36A | 5vcvA-4fodA:22.8 | 5vcvA-4fodA:24.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4i | 4-O-METHYL-GLUCURONOYL METHYLESTERASE (Thermothelomycesthermophila) |
no annotation | 6 | ALA A 219VAL A 185LEU A 225GLY A 131GLN A 154GLY A 184 | None | 1.48A | 5vcvA-4g4iA:undetectable | 5vcvA-4g4iA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gl9 | TYROSINE-PROTEINKINASE (Mus musculus) |
PF07714(Pkinase_Tyr) | 6 | LEU A 855ALA A 880LYS A 882GLU A 898VAL A 911GLY A 993 | IZA A2001 (-3.7A)IZA A2001 (-3.4A)IZA A2001 ( 4.7A)NoneNoneNone | 0.70A | 5vcvA-4gl9A:23.6 | 5vcvA-4gl9A:25.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 828ALA A 853LYS A 855GLU A 871LEU A 900GLY A 908 | 19S A1201 (-3.9A)19S A1201 (-3.3A)19S A1201 (-3.5A)NoneNone19S A1201 ( 3.8A) | 1.05A | 5vcvA-4hviA:24.3 | 5vcvA-4hviA:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 828ALA A 853LYS A 855GLU A 871VAL A 884GLY A 908 | 19S A1201 (-3.9A)19S A1201 (-3.3A)19S A1201 (-3.5A)NoneNone19S A1201 ( 3.8A) | 1.03A | 5vcvA-4hviA:24.3 | 5vcvA-4hviA:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6f | SERINE/THREONINE-PROTEIN KINASE PLK2 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 88ALA A 109GLU A 130VAL A 143PHE A 212GLY A 222 | 1C7 A 401 ( 4.4A)1C7 A 401 (-3.2A)None1C7 A 401 (-4.5A)1C7 A 401 (-4.0A)None | 0.69A | 5vcvA-4i6fA:24.8 | 5vcvA-4i6fA:25.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6f | SERINE/THREONINE-PROTEIN KINASE PLK2 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 88ALA A 109LYS A 111GLU A 130VAL A 143GLY A 222 | 1C7 A 401 ( 4.4A)1C7 A 401 (-3.2A)1C7 A 401 ( 4.7A)None1C7 A 401 (-4.5A)None | 0.85A | 5vcvA-4i6fA:24.8 | 5vcvA-4i6fA:25.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4idt | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 14 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 406ALA A 427LYS A 429GLU A 440VAL A 453GLN A 479 | T28 A 701 (-3.8A)T28 A 701 (-3.0A)T28 A 701 ( 3.8A)NoneNoneT28 A 701 (-3.0A) | 0.79A | 5vcvA-4idtA:25.0 | 5vcvA-4idtA:29.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j7b | POLO-LIKE KINASE (Danio rerio) |
PF00069(Pkinase) | 7 | LEU A 45ALA A 66LYS A 68GLU A 87VAL A 100PHE A 169GLY A 179 | None | 0.66A | 5vcvA-4j7bA:26.0 | 5vcvA-4j7bA:24.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlc | SERINE/THREONINE-PROTEIN KINASE TBK1 (Mus musculus) |
PF00069(Pkinase) | 6 | LEU A 15ALA A 36LYS A 38VAL A 68LEU A 84GLY A 92 | SU6 A 701 (-3.6A)SU6 A 701 (-3.4A)NoneNoneNoneSU6 A 701 (-3.8A) | 0.90A | 5vcvA-4jlcA:18.3 | 5vcvA-4jlcA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg4 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 33ALA A 54LYS A 56GLU A 70VAL A 83GLY A 103 | GOL A 404 ( 3.6A)GOL A 404 ( 3.1A)GOL A 403 ( 4.6A)NoneGOL A 403 (-4.1A)None | 1.00A | 5vcvA-4lg4A:24.3 | 5vcvA-4lg4A:29.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mvf | CALCIUM-DEPENDENTPROTEIN KINASE 2 (Plasmodiumfalciparum) |
PF00069(Pkinase)PF13499(EF-hand_7) | 6 | LEU A 78ALA A 99LYS A 101GLU A 117LEU A 144GLY A 151 | STU A 601 ( 4.0A)STU A 601 (-3.3A)STU A 601 (-3.9A)NoneNoneSTU A 601 (-3.4A) | 1.10A | 5vcvA-4mvfA:22.5 | 5vcvA-4mvfA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mvf | CALCIUM-DEPENDENTPROTEIN KINASE 2 (Plasmodiumfalciparum) |
PF00069(Pkinase)PF13499(EF-hand_7) | 6 | LEU A 78ALA A 99LYS A 101GLU A 117VAL A 130LEU A 144 | STU A 601 ( 4.0A)STU A 601 (-3.3A)STU A 601 (-3.9A)NoneNoneNone | 0.80A | 5vcvA-4mvfA:22.5 | 5vcvA-4mvfA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o38 | CYCLIN-G-ASSOCIATEDKINASE (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 46ALA A 67LYS A 69GLU A 85VAL A 99LEU A 121THR A 123GLY A 128 | SIN A 401 ( 3.9A)SIN A 401 ( 3.7A)NoneNoneNoneNoneNoneSIN A 401 (-3.5A) | 1.08A | 5vcvA-4o38A:21.8 | 5vcvA-4o38A:26.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oli | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 903ALA A 928GLU A 947LEU A 976GLY A 984GLY A1040 | 2TT A1202 (-3.5A)2TT A1202 ( 3.9A)NoneNone2TT A1202 (-3.4A)2TT A1202 (-3.4A) | 1.12A | 5vcvA-4oliA:23.4 | 5vcvA-4oliA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oli | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 903ALA A 928LYS A 930GLU A 947GLY A 984GLY A1040 | 2TT A1202 (-3.5A)2TT A1202 ( 3.9A)NoneNone2TT A1202 (-3.4A)2TT A1202 (-3.4A) | 1.06A | 5vcvA-4oliA:23.4 | 5vcvA-4oliA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pwn | SERINE/THREONINE-PROTEIN KINASE WNK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 248VAL A 281LEU A 299THR A 301PHE A 356GLY A 367 | None | 0.59A | 5vcvA-4pwnA:23.1 | 5vcvA-4pwnA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 616ALA A 642GLU A 661VAL A 675LEU A 689GLY A 697 | P30 A1001 (-3.8A)P30 A1001 (-3.4A)P30 A1001 (-3.6A)NoneNoneP30 A1001 (-3.4A) | 1.01A | 5vcvA-4rt7A:22.5 | 5vcvA-4rt7A:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 616ALA A 642LYS A 644GLU A 661VAL A 675GLY A 697 | P30 A1001 (-3.8A)P30 A1001 (-3.4A)P30 A1001 (-3.4A)P30 A1001 (-3.6A)NoneP30 A1001 (-3.4A) | 1.12A | 5vcvA-4rt7A:22.5 | 5vcvA-4rt7A:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tnb | G PROTEIN-COUPLEDRECEPTOR KINASE 5 (Homo sapiens) |
PF00069(Pkinase)PF00615(RGS) | 6 | LEU A 192ALA A 213LYS A 215GLU A 234LEU A 261GLY A 268 | SGV A 601 (-4.1A)SGV A 601 (-3.3A)SGV A 601 ( 4.2A)NoneNoneNone | 0.99A | 5vcvA-4tnbA:23.0 | 5vcvA-4tnbA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wsq | AP2-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 52ALA A 72LYS A 74GLU A 90VAL A 104GLY A 132 | KSA A 405 ( 4.0A)KSA A 405 (-3.2A)NoneNoneNoneKSA A 405 (-3.5A) | 0.94A | 5vcvA-4wsqA:25.8 | 5vcvA-4wsqA:25.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 616ALA A 642LYS A 644GLU A 661LEU A 689GLY A 697 | P30 A1001 (-4.0A)P30 A1001 (-3.5A)P30 A1001 ( 4.0A)P30 A1001 (-3.1A)NoneP30 A1001 (-3.5A) | 1.03A | 5vcvA-4xufA:22.6 | 5vcvA-4xufA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 616ALA A 642LYS A 644GLU A 661VAL A 675LEU A 689 | P30 A1001 (-4.0A)P30 A1001 (-3.5A)P30 A1001 ( 4.0A)P30 A1001 (-3.1A)NoneNone | 0.78A | 5vcvA-4xufA:22.6 | 5vcvA-4xufA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysj | CALMODULIN-LIKEDOMAIN PROTEINKINASE (Eimeria tenella) |
PF00069(Pkinase)PF13499(EF-hand_7) | 6 | LEU A 34ALA A 55LYS A 57GLU A 76LEU A 103GLY A 111 | ADP A 506 ( 3.8A)ADP A 506 (-3.3A)ADP A 506 (-2.4A)NoneNoneNone | 1.33A | 5vcvA-4ysjA:27.9 | 5vcvA-4ysjA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysj | CALMODULIN-LIKEDOMAIN PROTEINKINASE (Eimeria tenella) |
PF00069(Pkinase)PF13499(EF-hand_7) | 6 | LEU A 34ALA A 55LYS A 57GLU A 76LEU A 103THR A 105 | ADP A 506 ( 3.8A)ADP A 506 (-3.3A)ADP A 506 (-2.4A)NoneNoneADP A 506 ( 4.6A) | 0.64A | 5vcvA-4ysjA:27.9 | 5vcvA-4ysjA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 599ALA A 625LYS A 627GLU A 644THR A 674GLY A 680 | 748 A1001 (-3.8A)748 A1001 (-3.7A)748 A1001 (-4.0A)748 A1001 (-3.3A)748 A1001 (-3.2A)748 A1001 ( 4.0A) | 0.98A | 5vcvA-5grnA:22.2 | 5vcvA-5grnA:25.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hu3 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE II ALPHACHAIN (Drosophilamelanogaster) |
PF00069(Pkinase) | 6 | LEU A 20ALA A 41LYS A 43GLU A 61LEU A 88GLY A 96 | ADP A 301 ( 4.0A)ADP A 301 (-3.5A)ADP A 301 (-2.7A)NoneNoneNone | 1.22A | 5vcvA-5hu3A:28.2 | 5vcvA-5hu3A:27.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3o | BMP-2-INDUCIBLEPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 57ALA A 77LYS A 79GLU A 95VAL A 109GLY A 136 | IDV A 401 (-3.8A)IDV A 401 (-3.6A)IDV A 401 ( 4.8A)NoneNoneIDV A 401 (-3.4A) | 0.99A | 5vcvA-5i3oA:25.0 | 5vcvA-5i3oA:26.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jzn | SERINE/THREONINE-PROTEIN KINASE DCLK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | ALA A 417GLU A 436VAL A 449LEU A 463GLY A 471GLY A 532 | GUI A 701 ( 3.9A)NoneNoneNoneGUI A 701 (-3.6A)GUI A 701 ( 4.7A) | 1.07A | 5vcvA-5jznA:23.5 | 5vcvA-5jznA:25.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kp7 | CURD (Mooreaproducens) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 6 | LEU A 127ALA A 138LEU A 175GLY A 135PRO A 134GLN A 131 | None | 1.22A | 5vcvA-5kp7A:undetectable | 5vcvA-5kp7A:25.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o2c | SERINE/THREONINE-PROTEIN KINASE WNK3 (Homo sapiens) |
PF00069(Pkinase)PF12202(OSR1_C) | 6 | ALA A 174VAL A 207LEU A 225THR A 227PHE A 282GLY A 293 | GOL A 604 ( 3.8A)GOL A 604 ( 4.9A)NoneGOL A 604 (-3.9A)GOL A 604 ( 4.5A)GOL A 604 ( 4.6A) | 0.64A | 5vcvA-5o2cA:23.1 | 5vcvA-5o2cA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o2c | SERINE/THREONINE-PROTEIN KINASE WNK3 (Homo sapiens) |
PF00069(Pkinase)PF12202(OSR1_C) | 6 | LEU A 153ALA A 174VAL A 207LEU A 225THR A 227GLY A 293 | NoneGOL A 604 ( 3.8A)GOL A 604 ( 4.9A)NoneGOL A 604 (-3.9A)GOL A 604 ( 4.6A) | 0.66A | 5vcvA-5o2cA:23.1 | 5vcvA-5o2cA:23.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vcx | MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE (Homo sapiens) |
PF00069(Pkinase) | 12 | LEU A 116ALA A 137LYS A 139GLU A 157VAL A 171LEU A 185THR A 187GLY A 191PRO A 192GLN A 196PHE A 240GLY A 250 | H8H A 401 (-3.7A)H8H A 401 (-3.3A)H8H A 401 (-4.9A)NoneNoneH8H A 401 (-4.3A)H8H A 401 (-3.5A)H8H A 401 (-4.4A)H8H A 401 ( 4.1A)H8H A 401 ( 4.4A)H8H A 401 (-4.3A)None | 0.59A | 5vcvA-5vcxA:43.9 | 5vcvA-5vcxA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vdk | WEE1-LIKE PROTEINKINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 7 | ALA A 239LYS A 241GLU A 259VAL A 273GLY A 295PHE A 346GLY A 379 | 8X7 A 501 ( 3.7A)PO4 A 502 (-3.6A)PO4 A 502 (-3.8A)8X7 A 501 ( 4.6A)8X7 A 501 (-3.6A)8X7 A 501 (-3.7A)None | 1.02A | 5vcvA-5vdkA:30.8 | 5vcvA-5vdkA:31.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7y | TYROSINE-PROTEINKINASE JAK1 (Homo sapiens) |
no annotation | 7 | LEU A 881ALA A 906LYS A 908GLU A 925LEU A 954GLY A 962GLY A1020 | ADP A1201 ( 4.5A)ADP A1201 (-3.4A)ADP A1201 (-2.8A)NoneNoneADP A1201 ( 4.1A)None | 1.22A | 5vcvA-6c7yA:24.0 | 5vcvA-6c7yA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7y | TYROSINE-PROTEINKINASE JAK1 (Homo sapiens) |
no annotation | 7 | LEU A 881ALA A 906LYS A 908GLU A 925VAL A 938GLY A 962GLY A1020 | ADP A1201 ( 4.5A)ADP A1201 (-3.4A)ADP A1201 (-2.8A)NoneNoneADP A1201 ( 4.1A)None | 1.18A | 5vcvA-6c7yA:24.0 | 5vcvA-6c7yA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cth | CONCANAVALIN A-LIKELECTIN PROTEINKINASE FAMILYPROTEIN (Theobroma cacao) |
no annotation | 6 | LEU A 275ALA A 296LYS A 298VAL A 327LEU A 341GLY A 410 | FE7 A 601 (-3.8A)FE7 A 601 (-3.3A)FE7 A 601 (-3.6A)NoneNoneFE7 A 601 ( 4.1A) | 0.81A | 5vcvA-6cthA:7.5 | 5vcvA-6cthA:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cth | CONCANAVALIN A-LIKELECTIN PROTEINKINASE FAMILYPROTEIN (Theobroma cacao) |
no annotation | 6 | LEU A 275ALA A 296VAL A 327LEU A 341GLY A 349GLY A 410 | FE7 A 601 (-3.8A)FE7 A 601 (-3.3A)NoneNoneFE7 A 601 ( 3.7A)FE7 A 601 ( 4.1A) | 1.05A | 5vcvA-6cthA:7.5 | 5vcvA-6cthA:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fdy | - (-) |
no annotation | 6 | LEU U 20ALA U 42LYS U 44VAL U 75LEU U 89GLY U 97 | DB8 U 301 (-3.7A)DB8 U 301 (-3.6A)DB8 U 301 ( 4.0A)DB8 U 301 (-4.8A)NoneDB8 U 301 ( 4.1A) | 1.37A | 5vcvA-6fdyU:24.8 | 5vcvA-6fdyU:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fyv | DUAL SPECIFICITYPROTEIN KINASE CLK4 (Homo sapiens) |
no annotation | 5 | LEU A 167ALA A 189LYS A 191GLU A 206GLY A 245 | 3NG A 501 (-3.9A)3NG A 501 (-3.5A)3NG A 501 (-2.7A)3NG A 501 ( 4.7A)None | 0.47A | 5vcvA-6fyvA:27.2 | 5vcvA-6fyvA:undetectable |