SIMILAR PATTERNS OF AMINO ACIDS FOR 5VCV_A_1N1A404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
GLU A 236
VAL A 249
THR A 266
GLY A 272
 None
 1.13A 5vcvA-1k9aA:
24.8		 5vcvA-1k9aA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 267
ALA A 288
LYS A 290
GLU A 305
VAL A 318
GLY A 340
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.4A)
 1.07A 5vcvA-1opkA:
22.9		 5vcvA-1opkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 267
ALA A 288
LYS A 290
GLU A 305
VAL A 318
THR A 334
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
 0.51A 5vcvA-1opkA:
22.9		 5vcvA-1opkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
GLU A 661
VAL A 675
LEU A 689
GLY A 697
 None
 1.09A 5vcvA-1rjbA:
21.9		 5vcvA-1rjbA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
 None
 1.39A 5vcvA-1rjbA:
21.9		 5vcvA-1rjbA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
GLY A 676
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
 0.97A 5vcvA-1t46A:
22.6		 5vcvA-1t46A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
ALA A 367
GLU A 386
VAL A 399
LEU A 412
GLY A 418
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 ( 4.7A)
 0.87A 5vcvA-1u59A:
24.7		 5vcvA-1u59A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
ALA A 367
LYS A 369
GLU A 386
VAL A 399
LEU A 412
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
None
STU  A 100 (-3.5A)
 0.98A 5vcvA-1u59A:
24.7		 5vcvA-1u59A:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
LYS A  57
GLU A  76
LEU A 103
GLY A 110
GLY A 168
 None
 0.93A 5vcvA-1u5qA:
27.2		 5vcvA-1u5qA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
ALA A  36
GLU A  55
VAL A  68
LEU A  82
GLY A  90
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
None
None
 1.13A 5vcvA-1zltA:
25.5		 5vcvA-1zltA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 605
ALA A 626
LYS A 628
VAL A 656
PHE A 842
GLY A 852
 None
GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.9A)
GOL  A 998 ( 4.2A)
None
 1.06A 5vcvA-1zy4A:
23.7		 5vcvA-1zy4A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		6 LEU A  19
ALA A  40
LYS A  42
GLU A  60
VAL A  73
LEU A  87
 None
 0.72A 5vcvA-2bdwA:
24.3		 5vcvA-2bdwA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		6 LEU A   9
ALA A  83
GLU A 186
VAL A  91
LEU A  78
GLY A  88
 None
 1.40A 5vcvA-2bszA:
undetectable		 5vcvA-2bszA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  26
ALA A  47
LYS A  49
GLU A  65
LEU A  96
GLY A 104
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
STU  A1301 ( 4.0A)
 0.81A 5vcvA-2bujA:
25.3		 5vcvA-2bujA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		6 ALA A  39
LYS A  41
GLU A  55
LEU A  83
GLY A  89
PRO A  90
 CKI  A 300 (-3.6A)
None
None
None
None
None
 0.84A 5vcvA-2csnA:
21.8		 5vcvA-2csnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
ALA X  37
LYS X  39
GLU X  54
VAL X  67
GLY X  88
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-3.5A)
 1.10A 5vcvA-2dq7X:
25.8		 5vcvA-2dq7X:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
ALA X  37
LYS X  39
GLU X  54
VAL X  67
THR X  82
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
 0.43A 5vcvA-2dq7X:
25.8		 5vcvA-2dq7X:
25.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
LYS A  57
GLU A  76
LEU A 103
GLY A 110
GLY A 168
 STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
None
STU  A 400 (-3.4A)
None
 0.95A 5vcvA-2gcdA:
28.2		 5vcvA-2gcdA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
ALA A 271
LYS A 273
GLU A 288
VAL A 301
THR A 316
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.2A)
 0.62A 5vcvA-2hk5A:
25.7		 5vcvA-2hk5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
ALA A 269
GLU A 286
VAL A 299
THR A 315
GLY A 321
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
None
 0.86A 5vcvA-2hz0A:
24.7		 5vcvA-2hz0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
ALA A 269
LYS A 271
GLU A 286
THR A 315
GLY A 321
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
None
 0.96A 5vcvA-2hz0A:
24.7		 5vcvA-2hz0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  47
LYS A  49
GLU A  65
VAL A  78
PHE A 159
GLY A 170
 None
 0.48A 5vcvA-2i6lA:
25.7		 5vcvA-2i6lA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
ALA A 271
LYS A 273
GLU A 288
THR A 316
GLY A 322
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
 1.00A 5vcvA-2og8A:
22.6		 5vcvA-2og8A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
ALA A 614
GLU A 633
VAL A 647
THR A 663
GLY A 669
GLY A 795
 None
 1.03A 5vcvA-2ogvA:
22.0		 5vcvA-2ogvA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
ALA A  46
LYS A  48
GLU A  73
LEU A 101
GLY A 109
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
 1.08A 5vcvA-2phkA:
27.2		 5vcvA-2phkA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ALA A  34
LYS A  36
GLU A  53
VAL A  66
LEU A  80
GLY A 150
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
None
 0.93A 5vcvA-2pmiA:
24.2		 5vcvA-2pmiA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		6 ALA A 509
LYS A 511
GLU A 535
LEU A 603
GLY A 609
GLN A 614
 5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
None
None
5ID  A1800 (-4.7A)
5ID  A1800 ( 4.9A)
 0.83A 5vcvA-2vuwA:
18.9		 5vcvA-2vuwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
 0.44A 5vcvA-2yabA:
25.4		 5vcvA-2yabA:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 326
LYS A 328
GLU A 346
VAL A 360
GLY A 382
PHE A 433
GLY A 462
 770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
None
 0.94A 5vcvA-2z2wA:
32.2		 5vcvA-2z2wA:
30.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		6 LEU A 261
ALA A  55
GLU A 270
GLY A 194
PRO A 195
GLY A 178
 None
 1.46A 5vcvA-2z9vA:
undetectable		 5vcvA-2z9vA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 253
ALA A 273
LYS A 275
GLU A 290
VAL A 303
THR A 319
 None
 0.93A 5vcvA-2zv7A:
25.7		 5vcvA-2zv7A:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  97
ALA A 121
LYS A 123
GLU A 143
VAL A 156
LEU A 170
 STU  A 400 (-3.8A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
None
 0.76A 5vcvA-3a62A:
22.7		 5vcvA-3a62A:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
GLU A 236
VAL A 249
THR A 266
GLY A 272
 None
 1.13A 5vcvA-3d7uA:
25.2		 5vcvA-3d7uA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 432
ALA A 453
LYS A 455
GLU A 468
VAL A 482
LEU A 496
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
None
None
 0.60A 5vcvA-3kn5A:
21.0		 5vcvA-3kn5A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ALA A 579
LYS A 581
GLU A 596
LEU A 628
GLY A 634
PRO A 635
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.60A 5vcvA-3lltA:
25.9		 5vcvA-3lltA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1005
ALA A1031
LYS A1033
VAL A1063
GLY A1085
GLY A1152
 None
None
CCX  A   1 ( 3.7A)
CCX  A   1 (-4.1A)
None
CCX  A   1 (-3.6A)
 1.09A 5vcvA-3lw0A:
22.5		 5vcvA-3lw0A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
LYS A 231
GLU A 244
LEU A 277
THR A 279
GLY A 285
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
 1.04A 5vcvA-3mdyA:
22.6		 5vcvA-3mdyA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 171
ALA A 192
LYS A 194
GLU A 211
VAL A 224
LEU A 238
 FEF  A 668 ( 3.8A)
FEF  A 668 (-3.3A)
None
None
FEF  A 668 (-4.7A)
None
 1.00A 5vcvA-3mtlA:
22.5		 5vcvA-3mtlA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  49
ALA A  70
LYS A  72
GLU A  91
VAL A 104
 XFE  A 351 (-4.2A)
XFE  A 351 (-3.2A)
None
None
None
 0.46A 5vcvA-3mvjA:
24.2		 5vcvA-3mvjA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 269
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
 1.18A 5vcvA-3nyoA:
24.6		 5vcvA-3nyoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
LEU A 261
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
 0.82A 5vcvA-3nyoA:
24.6		 5vcvA-3nyoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		6 ALA A  52
LYS A  54
GLU A  72
LEU A 105
THR A 107
GLY A 111
 1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.2A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
 0.50A 5vcvA-3ohtA:
18.2		 5vcvA-3ohtA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 373
LYS A 375
GLU A 393
THR A 421
PHE A 475
GLY A 485
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
 0.83A 5vcvA-3omvA:
23.1		 5vcvA-3omvA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 726
ALA A 751
LYS A 753
LEU A 796
THR A 798
GLY A 804
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
 1.03A 5vcvA-3pp0A:
23.1		 5vcvA-3pp0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
LYS A 578
GLU A 596
VAL A 609
THR A 625
GLY A 631
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
 1.06A 5vcvA-3ppzA:
26.6		 5vcvA-3ppzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  63
ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
 0.76A 5vcvA-3q5iA:
24.1		 5vcvA-3q5iA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		6 LEU A 240
ALA A 261
LYS A 263
LEU A 335
PHE A 396
GLY A 406
 None
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
MLI  A 601 (-4.7A)
ATP  A 600 (-4.4A)
None
 0.92A 5vcvA-3q60A:
19.0		 5vcvA-3q60A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 LEU A 295
ALA A 315
GLU A 334
LEU A 361
GLY A 369
GLY A 433
 None
 0.97A 5vcvA-3ulzA:
22.4		 5vcvA-3ulzA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
ALA A 570
LYS A 572
VAL A 601
GLY A 623
GLY A 696
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-3.3A)
 1.35A 5vcvA-3v5qA:
21.5		 5vcvA-3v5qA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-3.7A)
 1.02A 5vcvA-3vidA:
21.8		 5vcvA-3vidA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
 1.10A 5vcvA-3wzdA:
22.6		 5vcvA-3wzdA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
ALA A  80
GLU A 101
VAL A 114
PHE A 183
GLY A 193
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
None
None
939  A1331 (-4.0A)
None
 0.45A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
ALA A  80
LYS A  82
GLU A 101
VAL A 114
PHE A 183
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
None
939  A1331 (-4.0A)
 0.60A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 560
ALA A 586
LYS A 588
VAL A 617
GLY A 639
GLY A 709
 LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-3.4A)
LTI  A1839 (-3.4A)
 1.18A 5vcvA-4at3A:
22.0		 5vcvA-4at3A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
ALA A  89
LYS A  91
GLU A 110
VAL A 123
PHE A 192
GLY A 202
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-4.4A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.65A 5vcvA-4b6lA:
27.0		 5vcvA-4b6lA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
ALA A 653
LYS A 655
GLU A 672
THR A 701
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
 0.42A 5vcvA-4ckrA:
21.8		 5vcvA-4ckrA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
ALA A  36
LYS A  38
GLU A  55
VAL A  68
LEU A  84
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
None
BX7  A 401 (-3.5A)
 0.94A 5vcvA-4eutA:
20.9		 5vcvA-4eutA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
ALA A  36
LYS A  38
GLU A  55
VAL A  68
LEU A  84
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
None
BX7  A 401 (-3.3A)
 0.92A 5vcvA-4euuA:
23.3		 5vcvA-4euuA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 515
ALA A 541
LYS A 543
VAL A 572
GLY A 594
GLY A 666
 None
 1.03A 5vcvA-4f0iA:
15.6		 5vcvA-4f0iA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 377
ALA A 400
LYS A 402
GLU A 420
VAL A 433
LEU A 446
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
 0.94A 5vcvA-4f4pA:
24.8		 5vcvA-4f4pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
ALA A1148
GLU A1167
VAL A1180
GLY A1202
GLY A1269
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.5A)
 1.36A 5vcvA-4fodA:
22.8		 5vcvA-4fodA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 6 ALA A 219
VAL A 185
LEU A 225
GLY A 131
GLN A 154
GLY A 184
 None
 1.48A 5vcvA-4g4iA:
undetectable		 5vcvA-4g4iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
ALA A 880
LYS A 882
GLU A 898
VAL A 911
GLY A 993
 IZA  A2001 (-3.7A)
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
None
 0.70A 5vcvA-4gl9A:
23.6		 5vcvA-4gl9A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
ALA A 853
LYS A 855
GLU A 871
LEU A 900
GLY A 908
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
 1.05A 5vcvA-4hviA:
24.3		 5vcvA-4hviA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
ALA A 853
LYS A 855
GLU A 871
VAL A 884
GLY A 908
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
 1.03A 5vcvA-4hviA:
24.3		 5vcvA-4hviA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
ALA A 109
GLU A 130
VAL A 143
PHE A 212
GLY A 222
 1C7  A 401 ( 4.4A)
1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.5A)
1C7  A 401 (-4.0A)
None
 0.69A 5vcvA-4i6fA:
24.8		 5vcvA-4i6fA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
ALA A 109
LYS A 111
GLU A 130
VAL A 143
GLY A 222
 1C7  A 401 ( 4.4A)
1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.5A)
None
 0.85A 5vcvA-4i6fA:
24.8		 5vcvA-4i6fA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 406
ALA A 427
LYS A 429
GLU A 440
VAL A 453
GLN A 479
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 (-3.0A)
 0.79A 5vcvA-4idtA:
25.0		 5vcvA-4idtA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		7 LEU A  45
ALA A  66
LYS A  68
GLU A  87
VAL A 100
PHE A 169
GLY A 179
 None
 0.66A 5vcvA-4j7bA:
26.0		 5vcvA-4j7bA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  15
ALA A  36
LYS A  38
VAL A  68
LEU A  84
GLY A  92
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.4A)
None
None
None
SU6  A 701 (-3.8A)
 0.90A 5vcvA-4jlcA:
18.3		 5vcvA-4jlcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
ALA A  54
LYS A  56
GLU A  70
VAL A  83
GLY A 103
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
GOL  A 403 (-4.1A)
None
 1.00A 5vcvA-4lg4A:
24.3		 5vcvA-4lg4A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  78
ALA A  99
LYS A 101
GLU A 117
LEU A 144
GLY A 151
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-3.4A)
 1.10A 5vcvA-4mvfA:
22.5		 5vcvA-4mvfA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  78
ALA A  99
LYS A 101
GLU A 117
VAL A 130
LEU A 144
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
None
 0.80A 5vcvA-4mvfA:
22.5		 5vcvA-4mvfA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
ALA A  67
LYS A  69
GLU A  85
VAL A  99
LEU A 121
THR A 123
GLY A 128
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
 1.08A 5vcvA-4o38A:
21.8		 5vcvA-4o38A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
ALA A 928
GLU A 947
LEU A 976
GLY A 984
GLY A1040
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-3.4A)
 1.12A 5vcvA-4oliA:
23.4		 5vcvA-4oliA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
ALA A 928
LYS A 930
GLU A 947
GLY A 984
GLY A1040
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-3.4A)
 1.06A 5vcvA-4oliA:
23.4		 5vcvA-4oliA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 248
VAL A 281
LEU A 299
THR A 301
PHE A 356
GLY A 367
 None
 0.59A 5vcvA-4pwnA:
23.1		 5vcvA-4pwnA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
GLU A 661
VAL A 675
LEU A 689
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 (-3.4A)
 1.01A 5vcvA-4rt7A:
22.5		 5vcvA-4rt7A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
 1.12A 5vcvA-4rt7A:
22.5		 5vcvA-4rt7A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 268
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 0.99A 5vcvA-4tnbA:
23.0		 5vcvA-4tnbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
ALA A  72
LYS A  74
GLU A  90
VAL A 104
GLY A 132
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-3.5A)
 0.94A 5vcvA-4wsqA:
25.8		 5vcvA-4wsqA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
 1.03A 5vcvA-4xufA:
22.6		 5vcvA-4xufA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
LEU A 689
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
None
 0.78A 5vcvA-4xufA:
22.6		 5vcvA-4xufA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  34
ALA A  55
LYS A  57
GLU A  76
LEU A 103
GLY A 111
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
 1.33A 5vcvA-4ysjA:
27.9		 5vcvA-4ysjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  34
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 0.64A 5vcvA-4ysjA:
27.9		 5vcvA-4ysjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
ALA A 625
LYS A 627
GLU A 644
THR A 674
GLY A 680
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
 0.98A 5vcvA-5grnA:
22.2		 5vcvA-5grnA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  88
GLY A  96
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
 1.22A 5vcvA-5hu3A:
28.2		 5vcvA-5hu3A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  57
ALA A  77
LYS A  79
GLU A  95
VAL A 109
GLY A 136
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.4A)
 0.99A 5vcvA-5i3oA:
25.0		 5vcvA-5i3oA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 417
GLU A 436
VAL A 449
LEU A 463
GLY A 471
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
GUI  A 701 (-3.6A)
GUI  A 701 ( 4.7A)
 1.07A 5vcvA-5jznA:
23.5		 5vcvA-5jznA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		6 LEU A 127
ALA A 138
LEU A 175
GLY A 135
PRO A 134
GLN A 131
 None
 1.22A 5vcvA-5kp7A:
undetectable		 5vcvA-5kp7A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		6 ALA A 174
VAL A 207
LEU A 225
THR A 227
PHE A 282
GLY A 293
 GOL  A 604 ( 3.8A)
GOL  A 604 ( 4.9A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.64A 5vcvA-5o2cA:
23.1		 5vcvA-5o2cA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		6 LEU A 153
ALA A 174
VAL A 207
LEU A 225
THR A 227
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 ( 4.9A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.6A)
 0.66A 5vcvA-5o2cA:
23.1		 5vcvA-5o2cA:
23.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		12 LEU A 116
ALA A 137
LYS A 139
GLU A 157
VAL A 171
LEU A 185
THR A 187
GLY A 191
PRO A 192
GLN A 196
PHE A 240
GLY A 250
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
H8H  A 401 ( 4.1A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
 0.59A 5vcvA-5vcxA:
43.9		 5vcvA-5vcxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 239
LYS A 241
GLU A 259
VAL A 273
GLY A 295
PHE A 346
GLY A 379
 8X7  A 501 ( 3.7A)
PO4  A 502 (-3.6A)
PO4  A 502 (-3.8A)
8X7  A 501 ( 4.6A)
8X7  A 501 (-3.6A)
8X7  A 501 (-3.7A)
None
 1.02A 5vcvA-5vdkA:
30.8		 5vcvA-5vdkA:
31.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
ALA A 906
LYS A 908
GLU A 925
LEU A 954
GLY A 962
GLY A1020
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
None
 1.22A 5vcvA-6c7yA:
24.0		 5vcvA-6c7yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
GLY A1020
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
None
 1.18A 5vcvA-6c7yA:
24.0		 5vcvA-6c7yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 6 LEU A 275
ALA A 296
LYS A 298
VAL A 327
LEU A 341
GLY A 410
 FE7  A 601 (-3.8A)
FE7  A 601 (-3.3A)
FE7  A 601 (-3.6A)
None
None
FE7  A 601 ( 4.1A)
 0.81A 5vcvA-6cthA:
7.5		 5vcvA-6cthA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 6 LEU A 275
ALA A 296
VAL A 327
LEU A 341
GLY A 349
GLY A 410
 FE7  A 601 (-3.8A)
FE7  A 601 (-3.3A)
None
None
FE7  A 601 ( 3.7A)
FE7  A 601 ( 4.1A)
 1.05A 5vcvA-6cthA:
7.5		 5vcvA-6cthA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 LEU U  20
ALA U  42
LYS U  44
VAL U  75
LEU U  89
GLY U  97
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
None
DB8  U 301 ( 4.1A)
 1.37A 5vcvA-6fdyU:
24.8		 5vcvA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 LEU A 167
ALA A 189
LYS A 191
GLU A 206
GLY A 245
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
 0.47A 5vcvA-6fyvA:
27.2		 5vcvA-6fyvA:
undetectable