SIMILAR PATTERNS OF AMINO ACIDS FOR 5VCV_A_1N1A404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
GLU A 236
VAL A 249
THR A 266
GLY A 272
 None
 1.13A 5vcvA-1k9aA:
24.8		 5vcvA-1k9aA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 267
ALA A 288
LYS A 290
GLU A 305
VAL A 318
GLY A 340
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.4A)
 1.07A 5vcvA-1opkA:
22.9		 5vcvA-1opkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 267
ALA A 288
LYS A 290
GLU A 305
VAL A 318
THR A 334
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
 0.51A 5vcvA-1opkA:
22.9		 5vcvA-1opkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
GLU A 661
VAL A 675
LEU A 689
GLY A 697
 None
 1.09A 5vcvA-1rjbA:
21.9		 5vcvA-1rjbA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
 None
 1.39A 5vcvA-1rjbA:
21.9		 5vcvA-1rjbA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
GLY A 676
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
 0.97A 5vcvA-1t46A:
22.6		 5vcvA-1t46A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
ALA A 367
GLU A 386
VAL A 399
LEU A 412
GLY A 418
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 ( 4.7A)
 0.87A 5vcvA-1u59A:
24.7		 5vcvA-1u59A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
ALA A 367
LYS A 369
GLU A 386
VAL A 399
LEU A 412
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
None
STU  A 100 (-3.5A)
 0.98A 5vcvA-1u59A:
24.7		 5vcvA-1u59A:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
LYS A  57
GLU A  76
LEU A 103
GLY A 110
GLY A 168
 None
 0.93A 5vcvA-1u5qA:
27.2		 5vcvA-1u5qA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
ALA A  36
GLU A  55
VAL A  68
LEU A  82
GLY A  90
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.8A)
None
None
 1.13A 5vcvA-1zltA:
25.5		 5vcvA-1zltA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 605
ALA A 626
LYS A 628
VAL A 656
PHE A 842
GLY A 852
 None
GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.9A)
GOL  A 998 ( 4.2A)
None
 1.06A 5vcvA-1zy4A:
23.7		 5vcvA-1zy4A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		6 LEU A  19
ALA A  40
LYS A  42
GLU A  60
VAL A  73
LEU A  87
 None
 0.72A 5vcvA-2bdwA:
24.3		 5vcvA-2bdwA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		6 LEU A   9
ALA A  83
GLU A 186
VAL A  91
LEU A  78
GLY A  88
 None
 1.40A 5vcvA-2bszA:
undetectable		 5vcvA-2bszA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  26
ALA A  47
LYS A  49
GLU A  65
LEU A  96
GLY A 104
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
STU  A1301 ( 4.0A)
 0.81A 5vcvA-2bujA:
25.3		 5vcvA-2bujA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		6 ALA A  39
LYS A  41
GLU A  55
LEU A  83
GLY A  89
PRO A  90
 CKI  A 300 (-3.6A)
None
None
None
None
None
 0.84A 5vcvA-2csnA:
21.8		 5vcvA-2csnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
ALA X  37
LYS X  39
GLU X  54
VAL X  67
GLY X  88
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-3.5A)
 1.10A 5vcvA-2dq7X:
25.8		 5vcvA-2dq7X:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
ALA X  37
LYS X  39
GLU X  54
VAL X  67
THR X  82
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
 0.43A 5vcvA-2dq7X:
25.8		 5vcvA-2dq7X:
25.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
LYS A  57
GLU A  76
LEU A 103
GLY A 110
GLY A 168
 STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
None
STU  A 400 (-3.4A)
None
 0.95A 5vcvA-2gcdA:
28.2		 5vcvA-2gcdA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
ALA A 271
LYS A 273
GLU A 288
VAL A 301
THR A 316
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.2A)
 0.62A 5vcvA-2hk5A:
25.7		 5vcvA-2hk5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
ALA A 269
GLU A 286
VAL A 299
THR A 315
GLY A 321
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
None
 0.86A 5vcvA-2hz0A:
24.7		 5vcvA-2hz0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
ALA A 269
LYS A 271
GLU A 286
THR A 315
GLY A 321
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
None
 0.96A 5vcvA-2hz0A:
24.7		 5vcvA-2hz0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  47
LYS A  49
GLU A  65
VAL A  78
PHE A 159
GLY A 170
 None
 0.48A 5vcvA-2i6lA:
25.7		 5vcvA-2i6lA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
ALA A 271
LYS A 273
GLU A 288
THR A 316
GLY A 322
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
 1.00A 5vcvA-2og8A:
22.6		 5vcvA-2og8A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
ALA A 614
GLU A 633
VAL A 647
THR A 663
GLY A 669
GLY A 795
 None
 1.03A 5vcvA-2ogvA:
22.0		 5vcvA-2ogvA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
ALA A  46
LYS A  48
GLU A  73
LEU A 101
GLY A 109
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
 1.08A 5vcvA-2phkA:
27.2		 5vcvA-2phkA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ALA A  34
LYS A  36
GLU A  53
VAL A  66
LEU A  80
GLY A 150
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
None
 0.93A 5vcvA-2pmiA:
24.2		 5vcvA-2pmiA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		6 ALA A 509
LYS A 511
GLU A 535
LEU A 603
GLY A 609
GLN A 614
 5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
None
None
5ID  A1800 (-4.7A)
5ID  A1800 ( 4.9A)
 0.83A 5vcvA-2vuwA:
18.9		 5vcvA-2vuwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
 0.44A 5vcvA-2yabA:
25.4		 5vcvA-2yabA:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 326
LYS A 328
GLU A 346
VAL A 360
GLY A 382
PHE A 433
GLY A 462
 770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
None
 0.94A 5vcvA-2z2wA:
32.2		 5vcvA-2z2wA:
30.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		6 LEU A 261
ALA A  55
GLU A 270
GLY A 194
PRO A 195
GLY A 178
 None
 1.46A 5vcvA-2z9vA:
undetectable		 5vcvA-2z9vA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 253
ALA A 273
LYS A 275
GLU A 290
VAL A 303
THR A 319
 None
 0.93A 5vcvA-2zv7A:
25.7		 5vcvA-2zv7A:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  97
ALA A 121
LYS A 123
GLU A 143
VAL A 156
LEU A 170
 STU  A 400 (-3.8A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
None
 0.76A 5vcvA-3a62A:
22.7		 5vcvA-3a62A:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
GLU A 236
VAL A 249
THR A 266
GLY A 272
 None
 1.13A 5vcvA-3d7uA:
25.2		 5vcvA-3d7uA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 432
ALA A 453
LYS A 455
GLU A 468
VAL A 482
LEU A 496
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
None
None
 0.60A 5vcvA-3kn5A:
21.0		 5vcvA-3kn5A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ALA A 579
LYS A 581
GLU A 596
LEU A 628
GLY A 634
PRO A 635
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.60A 5vcvA-3lltA:
25.9		 5vcvA-3lltA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1005
ALA A1031
LYS A1033
VAL A1063
GLY A1085
GLY A1152
 None
None
CCX  A   1 ( 3.7A)
CCX  A   1 (-4.1A)
None
CCX  A   1 (-3.6A)
 1.09A 5vcvA-3lw0A:
22.5		 5vcvA-3lw0A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
LYS A 231
GLU A 244
LEU A 277
THR A 279
GLY A 285
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
 1.04A 5vcvA-3mdyA:
22.6		 5vcvA-3mdyA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 171
ALA A 192
LYS A 194
GLU A 211
VAL A 224
LEU A 238
 FEF  A 668 ( 3.8A)
FEF  A 668 (-3.3A)
None
None
FEF  A 668 (-4.7A)
None
 1.00A 5vcvA-3mtlA:
22.5		 5vcvA-3mtlA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  49
ALA A  70
LYS A  72
GLU A  91
VAL A 104
 XFE  A 351 (-4.2A)
XFE  A 351 (-3.2A)
None
None
None
 0.46A 5vcvA-3mvjA:
24.2		 5vcvA-3mvjA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 269
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
 1.18A 5vcvA-3nyoA:
24.6		 5vcvA-3nyoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
LEU A 261
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
 0.82A 5vcvA-3nyoA:
24.6		 5vcvA-3nyoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		6 ALA A  52
LYS A  54
GLU A  72
LEU A 105
THR A 107
GLY A 111
 1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.2A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
 0.50A 5vcvA-3ohtA:
18.2		 5vcvA-3ohtA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 373
LYS A 375
GLU A 393
THR A 421
PHE A 475
GLY A 485
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-3.0A)
None
 0.83A 5vcvA-3omvA:
23.1		 5vcvA-3omvA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 726
ALA A 751
LYS A 753
LEU A 796
THR A 798
GLY A 804
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
 1.03A 5vcvA-3pp0A:
23.1		 5vcvA-3pp0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
LYS A 578
GLU A 596
VAL A 609
THR A 625
GLY A 631
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
 1.06A 5vcvA-3ppzA:
26.6		 5vcvA-3ppzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  63
ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
 0.76A 5vcvA-3q5iA:
24.1		 5vcvA-3q5iA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		6 LEU A 240
ALA A 261
LYS A 263
LEU A 335
PHE A 396
GLY A 406
 None
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
MLI  A 601 (-4.7A)
ATP  A 600 (-4.4A)
None
 0.92A 5vcvA-3q60A:
19.0		 5vcvA-3q60A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 LEU A 295
ALA A 315
GLU A 334
LEU A 361
GLY A 369
GLY A 433
 None
 0.97A 5vcvA-3ulzA:
22.4		 5vcvA-3ulzA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
ALA A 570
LYS A 572
VAL A 601
GLY A 623
GLY A 696
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-3.3A)
 1.35A 5vcvA-3v5qA:
21.5		 5vcvA-3v5qA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-3.7A)
 1.02A 5vcvA-3vidA:
21.8		 5vcvA-3vidA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
 1.10A 5vcvA-3wzdA:
22.6		 5vcvA-3wzdA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
ALA A  80
GLU A 101
VAL A 114
PHE A 183
GLY A 193
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
None
None
939  A1331 (-4.0A)
None
 0.45A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
ALA A  80
LYS A  82
GLU A 101
VAL A 114
PHE A 183
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
None
939  A1331 (-4.0A)
 0.60A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 560
ALA A 586
LYS A 588
VAL A 617
GLY A 639
GLY A 709
 LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-3.4A)
LTI  A1839 (-3.4A)
 1.18A 5vcvA-4at3A:
22.0		 5vcvA-4at3A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
ALA A  89
LYS A  91
GLU A 110
VAL A 123
PHE A 192
GLY A 202
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-4.4A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.65A 5vcvA-4b6lA:
27.0		 5vcvA-4b6lA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
ALA A 653
LYS A 655
GLU A 672
THR A 701
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
 0.42A 5vcvA-4ckrA:
21.8		 5vcvA-4ckrA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
ALA A  36
LYS A  38
GLU A  55
VAL A  68
LEU A  84
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
None
BX7  A 401 (-3.5A)
 0.94A 5vcvA-4eutA:
20.9		 5vcvA-4eutA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
ALA A  36
LYS A  38
GLU A  55
VAL A  68
LEU A  84
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
None
BX7  A 401 (-3.3A)
 0.92A 5vcvA-4euuA:
23.3		 5vcvA-4euuA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 515
ALA A 541
LYS A 543
VAL A 572
GLY A 594
GLY A 666
 None
 1.03A 5vcvA-4f0iA:
15.6		 5vcvA-4f0iA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 377
ALA A 400
LYS A 402
GLU A 420
VAL A 433
LEU A 446
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
 0.94A 5vcvA-4f4pA:
24.8		 5vcvA-4f4pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
ALA A1148
GLU A1167
VAL A1180
GLY A1202
GLY A1269
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.5A)
 1.36A 5vcvA-4fodA:
22.8		 5vcvA-4fodA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 6 ALA A 219
VAL A 185
LEU A 225
GLY A 131
GLN A 154
GLY A 184
 None
 1.48A 5vcvA-4g4iA:
undetectable		 5vcvA-4g4iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
ALA A 880
LYS A 882
GLU A 898
VAL A 911
GLY A 993
 IZA  A2001 (-3.7A)
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
None
 0.70A 5vcvA-4gl9A:
23.6		 5vcvA-4gl9A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
ALA A 853
LYS A 855
GLU A 871
LEU A 900
GLY A 908
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
 1.05A 5vcvA-4hviA:
24.3		 5vcvA-4hviA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
ALA A 853
LYS A 855
GLU A 871
VAL A 884
GLY A 908
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
 1.03A 5vcvA-4hviA:
24.3		 5vcvA-4hviA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
ALA A 109
GLU A 130
VAL A 143
PHE A 212
GLY A 222
 1C7  A 401 ( 4.4A)
1C7  A 401 (-3.2A)
None
1C7  A 401 (-4.5A)
1C7  A 401 (-4.0A)
None
 0.69A 5vcvA-4i6fA:
24.8		 5vcvA-4i6fA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
ALA A 109
LYS A 111
GLU A 130
VAL A 143
GLY A 222
 1C7  A 401 ( 4.4A)
1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.5A)
None
 0.85A 5vcvA-4i6fA:
24.8		 5vcvA-4i6fA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 406
ALA A 427
LYS A 429
GLU A 440
VAL A 453
GLN A 479
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
None
T28  A 701 (-3.0A)
 0.79A 5vcvA-4idtA:
25.0		 5vcvA-4idtA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		7 LEU A  45
ALA A  66
LYS A  68
GLU A  87
VAL A 100
PHE A 169
GLY A 179
 None
 0.66A 5vcvA-4j7bA:
26.0		 5vcvA-4j7bA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  15
ALA A  36
LYS A  38
VAL A  68
LEU A  84
GLY A  92
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.4A)
None
None
None
SU6  A 701 (-3.8A)
 0.90A 5vcvA-4jlcA:
18.3		 5vcvA-4jlcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
ALA A  54
LYS A  56
GLU A  70
VAL A  83
GLY A 103
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
GOL  A 403 (-4.1A)
None
 1.00A 5vcvA-4lg4A:
24.3		 5vcvA-4lg4A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  78
ALA A  99
LYS A 101
GLU A 117
LEU A 144
GLY A 151
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-3.4A)
 1.10A 5vcvA-4mvfA:
22.5		 5vcvA-4mvfA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  78
ALA A  99
LYS A 101
GLU A 117
VAL A 130
LEU A 144
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
None
 0.80A 5vcvA-4mvfA:
22.5		 5vcvA-4mvfA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
ALA A  67
LYS A  69
GLU A  85
VAL A  99
LEU A 121
THR A 123
GLY A 128
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
 1.08A 5vcvA-4o38A:
21.8		 5vcvA-4o38A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
ALA A 928
GLU A 947
LEU A 976
GLY A 984
GLY A1040
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-3.4A)
 1.12A 5vcvA-4oliA:
23.4		 5vcvA-4oliA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
ALA A 928
LYS A 930
GLU A 947
GLY A 984
GLY A1040
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-3.4A)
 1.06A 5vcvA-4oliA:
23.4		 5vcvA-4oliA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 248
VAL A 281
LEU A 299
THR A 301
PHE A 356
GLY A 367
 None
 0.59A 5vcvA-4pwnA:
23.1		 5vcvA-4pwnA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
GLU A 661
VAL A 675
LEU A 689
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 (-3.4A)
 1.01A 5vcvA-4rt7A:
22.5		 5vcvA-4rt7A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
 1.12A 5vcvA-4rt7A:
22.5		 5vcvA-4rt7A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 268
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 0.99A 5vcvA-4tnbA:
23.0		 5vcvA-4tnbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
ALA A  72
LYS A  74
GLU A  90
VAL A 104
GLY A 132
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-3.5A)
 0.94A 5vcvA-4wsqA:
25.8		 5vcvA-4wsqA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
 1.03A 5vcvA-4xufA:
22.6		 5vcvA-4xufA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
LEU A 689
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
None
 0.78A 5vcvA-4xufA:
22.6		 5vcvA-4xufA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  34
ALA A  55
LYS A  57
GLU A  76
LEU A 103
GLY A 111
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
 1.33A 5vcvA-4ysjA:
27.9		 5vcvA-4ysjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  34
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 0.64A 5vcvA-4ysjA:
27.9		 5vcvA-4ysjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
ALA A 625
LYS A 627
GLU A 644
THR A 674
GLY A 680
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
 0.98A 5vcvA-5grnA:
22.2		 5vcvA-5grnA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  88
GLY A  96
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
 1.22A 5vcvA-5hu3A:
28.2		 5vcvA-5hu3A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  57
ALA A  77
LYS A  79
GLU A  95
VAL A 109
GLY A 136
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.4A)
 0.99A 5vcvA-5i3oA:
25.0		 5vcvA-5i3oA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 417
GLU A 436
VAL A 449
LEU A 463
GLY A 471
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
GUI  A 701 (-3.6A)
GUI  A 701 ( 4.7A)
 1.07A 5vcvA-5jznA:
23.5		 5vcvA-5jznA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		6 LEU A 127
ALA A 138
LEU A 175
GLY A 135
PRO A 134
GLN A 131
 None
 1.22A 5vcvA-5kp7A:
undetectable		 5vcvA-5kp7A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		6 ALA A 174
VAL A 207
LEU A 225
THR A 227
PHE A 282
GLY A 293
 GOL  A 604 ( 3.8A)
GOL  A 604 ( 4.9A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.64A 5vcvA-5o2cA:
23.1		 5vcvA-5o2cA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		6 LEU A 153
ALA A 174
VAL A 207
LEU A 225
THR A 227
GLY A 293
 None
GOL  A 604 ( 3.8A)
GOL  A 604 ( 4.9A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.6A)
 0.66A 5vcvA-5o2cA:
23.1		 5vcvA-5o2cA:
23.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		12 LEU A 116
ALA A 137
LYS A 139
GLU A 157
VAL A 171
LEU A 185
THR A 187
GLY A 191
PRO A 192
GLN A 196
PHE A 240
GLY A 250
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
H8H  A 401 ( 4.1A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
 0.59A 5vcvA-5vcxA:
43.9		 5vcvA-5vcxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 239
LYS A 241
GLU A 259
VAL A 273
GLY A 295
PHE A 346
GLY A 379
 8X7  A 501 ( 3.7A)
PO4  A 502 (-3.6A)
PO4  A 502 (-3.8A)
8X7  A 501 ( 4.6A)
8X7  A 501 (-3.6A)
8X7  A 501 (-3.7A)
None
 1.02A 5vcvA-5vdkA:
30.8		 5vcvA-5vdkA:
31.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
ALA A 906
LYS A 908
GLU A 925
LEU A 954
GLY A 962
GLY A1020
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
None
 1.22A 5vcvA-6c7yA:
24.0		 5vcvA-6c7yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
GLY A1020
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
None
 1.18A 5vcvA-6c7yA:
24.0		 5vcvA-6c7yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 6 LEU A 275
ALA A 296
LYS A 298
VAL A 327
LEU A 341
GLY A 410
 FE7  A 601 (-3.8A)
FE7  A 601 (-3.3A)
FE7  A 601 (-3.6A)
None
None
FE7  A 601 ( 4.1A)
 0.81A 5vcvA-6cthA:
7.5		 5vcvA-6cthA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 6 LEU A 275
ALA A 296
VAL A 327
LEU A 341
GLY A 349
GLY A 410
 FE7  A 601 (-3.8A)
FE7  A 601 (-3.3A)
None
None
FE7  A 601 ( 3.7A)
FE7  A 601 ( 4.1A)
 1.05A 5vcvA-6cthA:
7.5		 5vcvA-6cthA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 LEU U  20
ALA U  42
LYS U  44
VAL U  75
LEU U  89
GLY U  97
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
None
DB8  U 301 ( 4.1A)
 1.37A 5vcvA-6fdyU:
24.8		 5vcvA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 LEU A 167
ALA A 189
LYS A 191
GLU A 206
GLY A 245
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
 0.47A 5vcvA-6fyvA:
27.2		 5vcvA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9l PROTEIN (EPIMERASE)

(Escherichia
coli) 		PF02152
(FolB) 		4 VAL A  98
HIS A  67
LEU A  76
ASP A  85
 None
 1.21A 5vcvA-1b9lA:
undetectable		 5vcvA-1b9lA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 175
LEU A 215
CYH A 212
ASP A 204
 None
 1.05A 5vcvA-1bkhA:
undetectable		 5vcvA-1bkhA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR

(Bos taurus) 		PF00996
(GDI) 		4 VAL A 265
LEU A  10
CYH A 282
ASP A 391
 None
 1.37A 5vcvA-1d5tA:
undetectable		 5vcvA-1d5tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm1 PROTEIN TYROSINE
PHOSPHATASE

(Mus musculus) 		PF00595
(PDZ) 		4 VAL A  16
HIS A  60
LEU A  25
ASP A  63
 None
 1.29A 5vcvA-1gm1A:
undetectable		 5vcvA-1gm1A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itv MMP9

(Homo sapiens) 		PF00045
(Hemopexin) 		4 VAL A   6
HIS A 150
LEU A 190
ASP A  10
 SO4  A 196 ( 3.9A)
None
None
None
 1.37A 5vcvA-1itvA:
undetectable		 5vcvA-1itvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l4z STREPTOKINASE

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		4 VAL B  13
HIS B  72
LEU B   7
ASP B  41
 None
 1.40A 5vcvA-1l4zB:
undetectable		 5vcvA-1l4zB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 VAL E  97
HIS E  79
LEU E 101
CYH E 135
 None
 1.15A 5vcvA-1nfiE:
undetectable		 5vcvA-1nfiE:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		4 VAL A  20
HIS A 121
LEU A 268
ASP A 218
 None
 1.44A 5vcvA-2ef4A:
undetectable		 5vcvA-2ef4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 VAL A 585
LEU A 397
CYH A 396
ASP A 471
 None
 1.25A 5vcvA-2gv9A:
0.0		 5vcvA-2gv9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11

(Brucella suis) 		PF00437
(T2SSE) 		4 VAL A 239
LEU A 225
CYH A 110
ASP A  87
 None
 1.37A 5vcvA-2gzaA:
undetectable		 5vcvA-2gzaA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 HIS A 230
LEU A 164
CYH A 162
ASP A 194
 None
 1.26A 5vcvA-2ldxA:
undetectable		 5vcvA-2ldxA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn6 EXOSOME COMPLEX
EXONUCLEASE RRP43

(Homo sapiens) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 HIS C 259
LEU C 235
CYH C 234
ASP C 150
 None
 1.38A 5vcvA-2nn6C:
undetectable		 5vcvA-2nn6C:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 VAL A  21
HIS B 144
LEU A 129
ASP B 157
 None
 1.29A 5vcvA-2v4jA:
undetectable		 5vcvA-2v4jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 VAL A 508
HIS A 261
LEU A 487
ASP A 538
 None
 1.00A 5vcvA-2xn1A:
undetectable		 5vcvA-2xn1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		4 VAL A 585
HIS A 707
LEU A 641
ASP A 236
 None
 1.49A 5vcvA-2yfsA:
undetectable		 5vcvA-2yfsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 VAL A 190
HIS A 161
LEU A 133
ASP A  84
 None
 1.49A 5vcvA-2zxoA:
undetectable		 5vcvA-2zxoA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 VAL A 207
HIS A 354
LEU A 650
ASP A 334
 None
SO4  A 656 (-3.7A)
None
None
 1.37A 5vcvA-3af5A:
undetectable		 5vcvA-3af5A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		4 VAL A 109
HIS A 138
LEU A  30
CYH A  29
 None
None
None
SF4  A 500 (-2.2A)
 1.28A 5vcvA-3c8fA:
undetectable		 5vcvA-3c8fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 VAL A 253
HIS A 177
LEU A 226
ASP A 172
 None
None
None
BFD  A 170 (-4.2A)
 1.41A 5vcvA-3ef1A:
undetectable		 5vcvA-3ef1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3C

(Saccharomyces
cerevisiae) 		PF00203
(Ribosomal_S19) 		4 VAL p 675
LEU p 627
CYH p 624
ASP p 618
 None
 1.33A 5vcvA-3japp:
2.1		 5vcvA-3japp:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 VAL A  18
HIS B 133
LEU A 126
ASP B 146
 None
 1.37A 5vcvA-3mm5A:
undetectable		 5vcvA-3mm5A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwn PHYCOERYTHRIN

(Phormidium
tenue) 		PF00502
(Phycobilisome) 		4 VAL A1051
LEU A1156
CYH A1153
ASP A1143
 CYC  A3002 ( 4.5A)
None
None
CYC  A3002 ( 3.8A)
 1.29A 5vcvA-3mwnA:
undetectable		 5vcvA-3mwnA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3t PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Thiobacillus
denitrificans) 		PF00563
(EAL) 		4 VAL A 641
LEU A 633
CYH A 632
ASP A 600
 None
 1.39A 5vcvA-3n3tA:
undetectable		 5vcvA-3n3tA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		4 VAL A 204
LEU A 247
CYH A 244
ASP A 281
 None
 1.23A 5vcvA-3o8lA:
undetectable		 5vcvA-3o8lA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		4 VAL B 603
LEU B 888
CYH B 889
ASP B 953
 None
 0.72A 5vcvA-3qd2B:
19.9		 5vcvA-3qd2B:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 VAL A 518
LEU A 103
CYH A 104
ASP A 146
 None
None
ZN  A 539 (-2.3A)
9MR  A 601 ( 2.9A)
 1.23A 5vcvA-3rx8A:
undetectable		 5vcvA-3rx8A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry6 LOW AFFINITY
IMMUNOGLOBULIN GAMMA
FC REGION RECEPTOR
II-A

(Homo sapiens) 		PF13895
(Ig_2) 		4 VAL C  86
HIS C  44
LEU C  12
ASP C  65
 None
 1.32A 5vcvA-3ry6C:
undetectable		 5vcvA-3ry6C:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT

(Cryptococcus
neoformans) 		PF01239
(PPTA) 		4 VAL A 198
HIS A 152
LEU A 173
CYH A 176
 None
 1.44A 5vcvA-3sfyA:
undetectable		 5vcvA-3sfyA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soz CYTOPLASMIC PROTEIN
STM1381

(Salmonella
enterica) 		PF07090
(GATase1_like) 		4 VAL A 133
HIS A 206
LEU A 138
ASP A 103
 None
 1.43A 5vcvA-3sozA:
undetectable		 5vcvA-3sozA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 VAL A 150
HIS A 271
LEU A 247
ASP A 143
 None
 1.42A 5vcvA-3v9aA:
undetectable		 5vcvA-3v9aA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ved DYPB

(Rhodococcus
jostii) 		PF04261
(Dyp_perox) 		4 VAL A  64
LEU A 119
CYH A 116
ASP A 245
 None
 1.39A 5vcvA-3vedA:
undetectable		 5vcvA-3vedA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 105
LEU A 132
CYH A 133
ASP A 194
 None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
939  A1331 (-3.1A)
 0.72A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 114
LEU A 141
CYH A 142
ASP A 203
 None
9ZP  A1333 (-4.7A)
9ZP  A1333 (-4.1A)
None
 0.72A 5vcvA-4b6lA:
27.0		 5vcvA-4b6lA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		4 VAL A 457
HIS A 397
LEU A 445
ASP A 417
 None
 1.47A 5vcvA-4berA:
undetectable		 5vcvA-4berA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 VAL A 103
LEU A 181
CYH A 180
ASP A 151
 None
 1.15A 5vcvA-4bkmA:
undetectable		 5vcvA-4bkmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1t METALLO-B-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 VAL A 203
HIS A 116
LEU A 175
ASP A  84
 None
ZN  A1292 (-3.2A)
None
None
 1.48A 5vcvA-4d1tA:
undetectable		 5vcvA-4d1tA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 VAL A  55
LEU A 125
CYH A 123
ASP A  88
 None
 1.45A 5vcvA-4efcA:
undetectable		 5vcvA-4efcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		4 VAL A 242
HIS A  44
LEU A 229
ASP A 273
 None
 1.22A 5vcvA-4eipA:
undetectable		 5vcvA-4eipA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 VAL B 766
LEU B 673
CYH B 674
ASP B  12
 None
 1.33A 5vcvA-4fhnB:
undetectable		 5vcvA-4fhnB:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 VAL A 575
LEU A 450
CYH A 449
ASP A 404
 None
 1.11A 5vcvA-4fixA:
2.2		 5vcvA-4fixA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 VAL A 368
LEU A  97
CYH A  96
ASP A 105
 None
 1.49A 5vcvA-4inaA:
undetectable		 5vcvA-4inaA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ium PAPAIN-LIKE PROTEASE
2

(Equine
arteritis virus) 		PF05412
(Peptidase_C33)
PF14755
(ER-remodelling) 		4 VAL A 384
LEU A 275
CYH A 274
ASP A 267
 None
 1.47A 5vcvA-4iumA:
undetectable		 5vcvA-4iumA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		4 VAL A  77
HIS A 128
LEU A 153
ASP A 181
 None
 1.50A 5vcvA-4mhpA:
undetectable		 5vcvA-4mhpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 VAL A  63
LEU A  44
CYH A  48
ASP A  52
 None
 1.45A 5vcvA-4otkA:
undetectable		 5vcvA-4otkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 VAL A 971
LEU A 872
CYH A 881
ASP A 947
 None
 1.11A 5vcvA-4ptfA:
undetectable		 5vcvA-4ptfA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 VAL A 387
LEU A  97
CYH A  96
ASP A 105
 None
 1.44A 5vcvA-4rl6A:
undetectable		 5vcvA-4rl6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlg SEC14-LIKE PROTEIN 4

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 VAL A  79
LEU A 270
CYH A 271
ASP A 107
 None
None
None
EDO  A 509 (-3.7A)
 1.44A 5vcvA-4tlgA:
undetectable		 5vcvA-4tlgA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		4 VAL C 675
LEU C 627
CYH C 624
ASP C 618
 None
 1.37A 5vcvA-4u1cC:
2.7		 5vcvA-4u1cC:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3C

(Lachancea
kluyveri) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 VAL c 675
LEU c 627
CYH c 624
ASP c 618
 None
 1.37A 5vcvA-4uerc:
2.9		 5vcvA-4uerc:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		4 VAL A 168
HIS A 482
LEU A 193
ASP A 121
 None
 1.37A 5vcvA-4ug4A:
undetectable		 5vcvA-4ug4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 VAL A 443
HIS A 336
LEU A 461
ASP A 346
 None
 1.05A 5vcvA-4uphA:
undetectable		 5vcvA-4uphA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 VAL A 253
HIS A 177
LEU A 226
ASP A 172
 None
None
None
AF3  A 601 ( 4.0A)
 1.42A 5vcvA-4xpzA:
undetectable		 5vcvA-4xpzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 VAL A 586
LEU A 644
CYH A 645
ASP A 711
 None
 0.82A 5vcvA-4z7gA:
20.0		 5vcvA-4z7gA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a87 METALLO-BETA-LACTAMA
SE VIM-5

(Klebsiella
pneumoniae) 		PF00753
(Lactamase_B) 		4 VAL A 186
HIS A 114
LEU A 158
ASP A  84
 None
ZN  A1263 (-3.2A)
None
None
 1.45A 5vcvA-5a87A:
undetectable		 5vcvA-5a87A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE

(Serratia
marcescens) 		PF00753
(Lactamase_B) 		4 VAL A 192
HIS A  72
LEU A 253
ASP A 111
 None
ZN  A 301 (-3.2A)
None
NA  A 311 (-4.1A)
 1.47A 5vcvA-5b1uA:
undetectable		 5vcvA-5b1uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		4 VAL A 287
LEU A 226
CYH A 227
ASP A 230
 None
None
None
MG  A 401 (-2.6A)
 1.32A 5vcvA-5dxiA:
undetectable		 5vcvA-5dxiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Aspergillus
fumigatus) 		PF02358
(Trehalose_PPase) 		4 VAL A 260
LEU A 211
CYH A 212
ASP A 215
 None
 1.35A 5vcvA-5dxlA:
undetectable		 5vcvA-5dxlA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2

(Mus musculus) 		PF00856
(SET)
PF07531
(TAFH) 		4 VAL A  85
LEU A  60
CYH A  77
ASP A 161
 None
 1.27A 5vcvA-5ecjA:
undetectable		 5vcvA-5ecjA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		4 VAL A 250
HIS A 111
LEU A 157
ASP A  42
 None
GOL  A 518 (-2.7A)
None
ZN  A 501 (-3.1A)
 1.47A 5vcvA-5fcaA:
undetectable		 5vcvA-5fcaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		4 HIS A 611
LEU A 663
CYH A 661
ASP A 655
 None
 1.49A 5vcvA-5h11A:
undetectable		 5vcvA-5h11A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk7 PROTEIN VPRBP

(Homo sapiens) 		no annotation 4 VAL C1122
LEU C1110
CYH C1099
ASP C1360
 None
 1.29A 5vcvA-5jk7C:
undetectable		 5vcvA-5jk7C:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL B 680
LEU B 741
CYH B 742
ASP B 803
 6U7  B1001 ( 4.3A)
6U7  B1001 (-4.6A)
6U7  B1001 (-3.5A)
6U7  B1001 (-4.6A)
 0.84A 5vcvA-5kkrB:
20.1		 5vcvA-5kkrB:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov3 RETINOBLASTOMA-BINDI
NG PROTEIN 5

(Mus musculus) 		no annotation 4 VAL A  95
LEU A  72
CYH A  73
ASP A  77
 None
 1.18A 5vcvA-5ov3A:
undetectable		 5vcvA-5ov3A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 221
HIS A 451
LEU A 152
ASP A 138
 None
 1.50A 5vcvA-5u25A:
undetectable		 5vcvA-5u25A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzb TOLL/INTERLEUKIN-1
RECEPTOR
DOMAIN-CONTAINING
ADAPTER PROTEIN

(Homo sapiens) 		PF13676
(TIR_2) 		4 VAL A 104
LEU A 146
CYH A  91
ASP A 122
 None
 1.48A 5vcvA-5uzbA:
undetectable		 5vcvA-5uzbA:
27.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 124
HIS A 161
LEU A 189
CYH A 190
ASP A 251
 H8H  A 401 (-4.7A)
None
None
H8H  A 401 (-4.3A)
EDO  A 402 ( 2.9A)
 0.50A 5vcvA-5vcxA:
44.0		 5vcvA-5vcxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 4 VAL A  80
LEU A 114
CYH A 111
ASP A 180
 None
None
None
C6P  A 502 (-2.9A)
 1.41A 5vcvA-5wt4A:
undetectable		 5vcvA-5wt4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 VAL A 303
HIS A 431
LEU A 313
ASP A 342
 None
01B  A 604 (-4.0A)
DMS  A 605 (-4.2A)
MN  A 602 (-2.6A)
 1.29A 5vcvA-5x49A:
undetectable		 5vcvA-5x49A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1z PROTEIN KINASE
C-BINDING PROTEIN 1

(Homo sapiens) 		no annotation 4 VAL C 100
HIS C  95
LEU C 115
ASP C  88
 None
 1.44A 5vcvA-5y1zC:
undetectable		 5vcvA-5y1zC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k DRAXIN
NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 4 VAL A 391
HIS B 284
LEU A 415
ASP B 280
 None
 1.23A 5vcvA-5z5kA:
undetectable		 5vcvA-5z5kA:
15.81