SIMILAR PATTERNS OF AMINO ACIDS FOR 5VCG_A_08YA602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cii COLICIN IA

(Escherichia
coli) 		PF01024
(Colicin)
PF11504
(Colicin_Ia) 		3 ARG A 109
ARG A 142
ARG A 135
 None
 0.92A 5vcgA-1ciiA:
0.0		 5vcgA-1ciiA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		3 ARG A  95
ARG A  58
ARG A 136
 None
None
SO4  A 802 (-2.8A)
 1.00A 5vcgA-1dk5A:
0.0		 5vcgA-1dk5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens) 		PF01852
(START) 		3 ARG A 352
ARG A 355
ARG A 351
 None
 1.00A 5vcgA-1em2A:
undetectable		 5vcgA-1em2A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hz4 MALT REGULATORY
PROTEIN

(Escherichia
coli) 		no annotation 3 ARG A 285
ARG A 323
ARG A 282
 None
 0.95A 5vcgA-1hz4A:
0.0		 5vcgA-1hz4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 ARG A 504
ARG A 469
ARG A 332
 None
PYR  A1601 ( 3.9A)
None
 0.72A 5vcgA-1i7qA:
0.0		 5vcgA-1i7qA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 ARG A  80
ARG A  39
ARG A  81
 None
 1.02A 5vcgA-1ileA:
0.0		 5vcgA-1ileA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3z TRANSCRIPTION FACTOR
P65

(Mus musculus) 		PF16179
(RHD_dimer) 		3 ARG A 304
ARG A 297
ARG A 302
 None
 0.99A 5vcgA-1k3zA:
undetectable		 5vcgA-1k3zA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpv DOUBLESEX PROTEIN

(Drosophila
melanogaster) 		PF00751
(DM) 		3 ARG A  40
ARG A  12
ARG A  47
 None
 1.02A 5vcgA-1lpvA:
undetectable		 5vcgA-1lpvA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		3 ARG A  99
ARG A 130
ARG A  97
 None
 0.96A 5vcgA-1o9jA:
0.0		 5vcgA-1o9jA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 591
ARG A 126
ARG A 108
 None
 0.82A 5vcgA-1po0A:
0.0		 5vcgA-1po0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 ARG A  41
ARG A  26
ARG A  49
 None
 1.02A 5vcgA-1q51A:
undetectable		 5vcgA-1q51A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 ARG A 602
ARG A 359
ARG A 260
 None
 0.99A 5vcgA-1qhgA:
undetectable		 5vcgA-1qhgA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi) 		PF03291
(Pox_MCEL) 		3 ARG A 106
ARG A 112
ARG A 104
 None
 0.89A 5vcgA-1ri3A:
1.1		 5vcgA-1ri3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		3 ARG A 194
ARG A 537
ARG A 164
 None
 0.76A 5vcgA-1uc4A:
undetectable		 5vcgA-1uc4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		3 ARG A 218
ARG A 212
ARG A 221
 None
 0.66A 5vcgA-1ve5A:
undetectable		 5vcgA-1ve5A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 ARG A 377
ARG A 395
ARG A 203
 None
 0.95A 5vcgA-1vkzA:
undetectable		 5vcgA-1vkzA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		3 ARG A 208
ARG A 232
ARG A  96
 APR  A 400 ( 2.6A)
CXY  A 401 (-3.5A)
None
 0.96A 5vcgA-1wvgA:
undetectable		 5vcgA-1wvgA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		3 ARG A 815
ARG A 771
ARG A 795
 None
 1.00A 5vcgA-2a3lA:
undetectable		 5vcgA-2a3lA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		3 ARG A 368
ARG A 371
ARG A 366
 None
 0.86A 5vcgA-2c4mA:
undetectable		 5vcgA-2c4mA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 ARG A 318
ARG A 347
ARG A 279
 None
 0.70A 5vcgA-2cg9A:
undetectable		 5vcgA-2cg9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxx PROBABLE GTP-BINDING
PROTEIN ENGB

(Pyrococcus
horikoshii) 		PF01926
(MMR_HSR1) 		3 ARG A 183
ARG A 177
ARG A 185
 None
 0.71A 5vcgA-2cxxA:
undetectable		 5vcgA-2cxxA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gai DNA TOPOISOMERASE I

(Thermotoga
maritima) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ARG A  87
ARG A 290
ARG A 141
 None
 0.91A 5vcgA-2gaiA:
undetectable		 5vcgA-2gaiA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 967
ARG A1142
ARG A1044
 None
 1.01A 5vcgA-2gjtA:
undetectable		 5vcgA-2gjtA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k6g REPLICATION FACTOR C
SUBUNIT 1

(Homo sapiens) 		PF00533
(BRCT) 		3 ARG A 452
ARG A 423
ARG A 388
 None
 0.90A 5vcgA-2k6gA:
undetectable		 5vcgA-2k6gA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
RIBONUCLEASE P
PROTEIN COMPONENT 4

(Pyrococcus
furiosus) 		PF01868
(UPF0086)
PF04032
(Rpr2) 		3 ARG A  37
ARG A  35
ARG B  17
 None
 0.91A 5vcgA-2ki7A:
undetectable		 5vcgA-2ki7A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkv INTEGRASE

(Salmonella
enterica) 		no annotation 3 ARG A  78
ARG A  28
ARG A  74
 None
 0.85A 5vcgA-2kkvA:
undetectable		 5vcgA-2kkvA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 ARG A 181
ARG A 127
ARG A  98
 None
 0.84A 5vcgA-2ng1A:
0.7		 5vcgA-2ng1A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 879
ARG A1066
ARG A 958
 None
 1.02A 5vcgA-2nlkA:
undetectable		 5vcgA-2nlkA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR

(Nostoc sp. PCC
7120) 		PF01223
(Endonuclease_NS)
PF07924
(NuiA) 		3 ARG B  69
ARG A  93
ARG A 122
 MES  A 900 (-4.4A)
None
None
 0.70A 5vcgA-2o3bB:
undetectable		 5vcgA-2o3bB:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogg TREHALOSE OPERON
TRANSCRIPTIONAL
REPRESSOR

(Bacillus
subtilis) 		PF07702
(UTRA) 		3 ARG A 222
ARG A 190
ARG A 224
 None
 1.00A 5vcgA-2oggA:
undetectable		 5vcgA-2oggA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8s CLATHRIN INTERACTOR
1

(Homo sapiens) 		PF01417
(ENTH) 		3 ARG E 102
ARG E 149
ARG E  96
 None
 1.02A 5vcgA-2v8sE:
undetectable		 5vcgA-2v8sE:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF06722
(DUF1205) 		3 ARG A 182
ARG A 170
ARG A 180
 None
 0.98A 5vcgA-2yjnA:
undetectable		 5vcgA-2yjnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		3 ARG A 112
ARG A 110
ARG A 141
 None
 0.69A 5vcgA-2zgiA:
undetectable		 5vcgA-2zgiA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Mus musculus) 		PF02182
(SAD_SRA) 		3 ARG A 558
ARG A 586
ARG A 601
 None
 0.96A 5vcgA-2zkgA:
undetectable		 5vcgA-2zkgA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8r PUTATIVE
UNCHARACTERIZED
PROTEIN

(Oryza sativa) 		PF08414
(NADPH_Ox)
PF13499
(EF-hand_7) 		3 ARG A 204
ARG A 235
ARG A 248
 None
 0.94A 5vcgA-3a8rA:
undetectable		 5vcgA-3a8rA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN ALPHA
CHAIN

(Homo sapiens) 		PF08702
(Fib_alpha) 		3 ARG A 162
ARG A 167
ARG A 171
 None
 0.88A 5vcgA-3bvhA:
undetectable		 5vcgA-3bvhA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		3 ARG A 509
ARG A 503
ARG A 530
 None
 1.01A 5vcgA-3cv2A:
undetectable		 5vcgA-3cv2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		3 ARG A 214
ARG A 315
ARG A 320
 None
 1.01A 5vcgA-3g7uA:
undetectable		 5vcgA-3g7uA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghg FIBRINOGEN ALPHA
CHAIN

(Homo sapiens) 		PF08702
(Fib_alpha) 		3 ARG A 162
ARG A 167
ARG A 171
 ARG  A 162 ( 0.6A)
ARG  A 167 ( 0.6A)
ARG  A 171 ( 0.6A)
 0.93A 5vcgA-3ghgA:
undetectable		 5vcgA-3ghgA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4

(Thermus
thermophilus) 		PF00346
(Complex1_49kDa) 		3 ARG 4 409
ARG 4 371
ARG 4 350
 None
 0.96A 5vcgA-3i9v4:
undetectable		 5vcgA-3i9v4:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		3 ARG A 428
ARG A 434
ARG A 474
 None
 0.93A 5vcgA-3j1cA:
undetectable		 5vcgA-3j1cA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1c KINESIN-14 NCD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		3 ARG A 306
ARG A 312
ARG A 304
 None
 1.00A 5vcgA-3l1cA:
undetectable		 5vcgA-3l1cA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		3 ARG A 213
ARG A 169
ARG A 161
 None
 0.98A 5vcgA-3lmmA:
undetectable		 5vcgA-3lmmA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7n PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
PUTATIVE
UNCHARACTERIZED
PROTEIN AF_0206

(Archaeoglobus
fulgidus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF10447
(EXOSC1)
PF14382
(ECR1_N) 		3 ARG A  85
ARG D  60
ARG D  38
 None
 0.99A 5vcgA-3m7nA:
undetectable		 5vcgA-3m7nA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq0 TRANSCRIPTIONAL
REPRESSOR OF THE
BLCABC OPERON

(Agrobacterium
tumefaciens) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		3 ARG A 258
ARG A 226
ARG A 203
 None
 0.96A 5vcgA-3mq0A:
undetectable		 5vcgA-3mq0A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		3 ARG A 219
ARG A 221
ARG A 213
 None
 0.68A 5vcgA-3r9bA:
28.2		 5vcgA-3r9bA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh0 ARSENATE REDUCTASE

(Corynebacterium
glutamicum) 		PF01451
(LMWPc) 		3 ARG A  76
ARG A 122
ARG A  98
 None
 0.92A 5vcgA-3rh0A:
undetectable		 5vcgA-3rh0A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpq MAL

(Mus musculus) 		PF02755
(RPEL) 		3 ARG M 113
ARG M 106
ARG M 111
 None
 0.97A 5vcgA-3tpqM:
undetectable		 5vcgA-3tpqM:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		3 ARG A 226
ARG A 217
ARG A 106
 None
 0.88A 5vcgA-3ue9A:
undetectable		 5vcgA-3ue9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		3 ARG A 860
ARG A 895
ARG A 884
 None
 0.75A 5vcgA-3un9A:
undetectable		 5vcgA-3un9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		3 ARG A 118
ARG A 119
ARG A 114
 None
 0.90A 5vcgA-3upnA:
undetectable		 5vcgA-3upnA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		3 ARG A 971
ARG A 967
ARG A 418
 None
 0.80A 5vcgA-3w9iA:
undetectable		 5vcgA-3w9iA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		3 ARG A 373
ARG A 425
ARG A 371
 None
 0.85A 5vcgA-3zjkA:
undetectable		 5vcgA-3zjkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 ARG A 767
ARG A 504
ARG A 766
 ANP  A2288 (-3.5A)
None
None
 0.84A 5vcgA-4a4zA:
undetectable		 5vcgA-4a4zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1

(Saccharomyces
cerevisiae) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		3 ARG A 322
ARG A 326
ARG A 442
 None
 1.01A 5vcgA-4c0hA:
undetectable		 5vcgA-4c0hA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ARG A  98
ARG A  40
ARG A 101
 None
 0.95A 5vcgA-4c23A:
undetectable		 5vcgA-4c23A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ARG A 583
ARG A  18
ARG A 578
 None
 0.86A 5vcgA-4cw4A:
undetectable		 5vcgA-4cw4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 ARG A 354
ARG A 341
ARG A 200
 CL  A 516 ( 3.8A)
None
None
 0.72A 5vcgA-4eudA:
undetectable		 5vcgA-4eudA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		3 ARG A 361
ARG A 182
ARG A 368
 None
None
SO4  A 502 ( 4.5A)
 0.95A 5vcgA-4fqdA:
undetectable		 5vcgA-4fqdA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		3 ARG A 191
ARG A 247
ARG A 189
 None
 0.70A 5vcgA-4g3jA:
33.7		 5vcgA-4g3jA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc0 PUTATIVE
SESQUITERPENE
CYCLASE

(Kitasatospora
setae) 		no annotation 3 ARG A  44
ARG A  80
ARG A  42
 None
 0.63A 5vcgA-4mc0A:
1.0		 5vcgA-4mc0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		no annotation 3 ARG A 488
ARG A 478
ARG A 476
 None
None
ZN  A 702 ( 4.8A)
 0.83A 5vcgA-4qbrA:
undetectable		 5vcgA-4qbrA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 3 ARG A 264
ARG A 222
ARG A 180
 None
 0.99A 5vcgA-4tz5A:
undetectable		 5vcgA-4tz5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y IRON-SULFUR
CLUSTER-BINDING
OXIDOREDUCTASE,
PUTATIVE BENZOYL-COA
REDUCTASE ELECTRON
TRANSFER PROTEIN

(Geobacter
metallireducens) 		no annotation 3 ARG E  50
ARG E  99
ARG E  93
 None
SF4  E1003 (-3.6A)
None
 0.97A 5vcgA-4z3yE:
undetectable		 5vcgA-4z3yE:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE

(Toxoplasma
gondii) 		PF00202
(Aminotran_3) 		3 ARG A 265
ARG A 351
ARG A 268
 None
SO4  A 504 (-3.9A)
None
 0.88A 5vcgA-4zlvA:
undetectable		 5vcgA-4zlvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		3 ARG A 213
ARG A 221
ARG A  76
 None
 1.02A 5vcgA-4zwnA:
undetectable		 5vcgA-4zwnA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aar POTASSIUM CHANNEL
AKT1

(Arabidopsis
thaliana) 		PF12796
(Ank_2) 		3 ARG A 643
ARG A 580
ARG A 645
 None
 1.01A 5vcgA-5aarA:
undetectable		 5vcgA-5aarA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		3 ARG A  99
ARG A 130
ARG A  97
 None
 0.96A 5vcgA-5abmA:
undetectable		 5vcgA-5abmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 ARG B 379
ARG B 529
ARG B 473
 None
 0.77A 5vcgA-5b3hB:
undetectable		 5vcgA-5b3hB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		3 ARG A 519
ARG A 486
ARG A 200
 None
 0.97A 5vcgA-5bxpA:
undetectable		 5vcgA-5bxpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 ARG A 360
ARG A 260
ARG A 358
 None
 0.96A 5vcgA-5cioA:
undetectable		 5vcgA-5cioA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN

(Homo sapiens) 		PF06632
(XRCC4) 		3 ARG A1608
ARG A1613
ARG A1606
 MLY  A1615 ( 4.2A)
None
None
 0.81A 5vcgA-5cj4A:
undetectable		 5vcgA-5cj4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwc DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 3 ARG A 140
ARG A  97
ARG A  90
 None
 0.84A 5vcgA-5cwcA:
undetectable		 5vcgA-5cwcA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1i CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Brucella
abortus) 		PF00027
(cNMP_binding) 		3 ARG A 110
ARG A 107
ARG A 115
 None
 1.00A 5vcgA-5d1iA:
undetectable		 5vcgA-5d1iA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		3 ARG A 579
ARG A 584
ARG A 658
 C2E  A 919 ( 3.1A)
C2E  A 920 ( 3.3A)
C2E  A 919 ( 4.5A)
 0.95A 5vcgA-5ej1A:
undetectable		 5vcgA-5ej1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewn STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF03115
(Astro_capsid_N) 		3 ARG A 365
ARG A 317
ARG A 361
 None
 0.82A 5vcgA-5ewnA:
undetectable		 5vcgA-5ewnA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5v PRP38
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03371
(PRP38)
PF06991
(MFAP1) 		3 ARG B 248
ARG B 240
ARG A 184
 None
 0.84A 5vcgA-5f5vB:
undetectable		 5vcgA-5f5vB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO

(Homo sapiens) 		PF12933
(FTO_NTD)
PF12934
(FTO_CTD) 		3 ARG A 380
ARG A 455
ARG A 112
 None
None
SO4  A 601 (-2.8A)
 0.97A 5vcgA-5f8pA:
undetectable		 5vcgA-5f8pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY PROTEIN
LPTD

(Yersinia pestis) 		PF04453
(OstA_C) 		3 ARG A 326
ARG A 204
ARG A 319
 None
 1.01A 5vcgA-5ixmA:
undetectable		 5vcgA-5ixmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 3 ARG A 393
ARG A 386
ARG A 411
 None
 0.98A 5vcgA-5kk5A:
undetectable		 5vcgA-5kk5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		3 ARG A 409
ARG A 431
ARG A 515
 None
 0.94A 5vcgA-5l8sA:
undetectable		 5vcgA-5l8sA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE

(Pseudomonas
mendocina) 		PF11927
(DUF3445) 		3 ARG A  71
ARG A  81
ARG A  73
 None
 0.93A 5vcgA-5ltiA:
undetectable		 5vcgA-5ltiA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx OXYGEN-EVOLVING
ENHANCER PROTEIN
1-1, CHLOROPLASTIC
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
PROTEIN D1

(Arabidopsis
thaliana) 		PF00124
(Photo_RC)
PF00421
(PSII)
PF01716
(MSP) 		3 ARG O 166
ARG A  64
ARG C 343
 None
 0.91A 5vcgA-5mdxO:
undetectable		 5vcgA-5mdxO:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 ARG A 255
ARG B  23
ARG B  88
 None
 1.01A 5vcgA-5mkkA:
1.1		 5vcgA-5mkkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 ARG B  81
ARG B  23
ARG B  88
 None
 0.98A 5vcgA-5mkkB:
0.5		 5vcgA-5mkkB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mra SORCIN

(Homo sapiens) 		no annotation 3 ARG A 167
ARG A  84
ARG A 174
 None
 0.95A 5vcgA-5mraA:
undetectable		 5vcgA-5mraA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhx OUTER MEMBRANE
PROTEIN A

(Klebsiella
pneumoniae) 		no annotation 3 ARG A  56
ARG A 121
ARG A 110
 None
 1.00A 5vcgA-5nhxA:
undetectable		 5vcgA-5nhxA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		3 ARG A 773
ARG A 675
ARG A 786
 None
 0.98A 5vcgA-5t8vA:
undetectable		 5vcgA-5t8vA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		3 ARG A 114
ARG A  81
ARG A 269
 None
 0.83A 5vcgA-5vn6A:
undetectable		 5vcgA-5vn6A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vt9 MYOSIN-A

(Toxoplasma
gondii) 		no annotation 3 ARG C 814
ARG C 808
ARG C 815
 None
 1.02A 5vcgA-5vt9C:
undetectable		 5vcgA-5vt9C:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa2 SURFACE ANTIGEN

(Toxoplasma
gondii) 		no annotation 3 ARG A 134
ARG A 185
ARG A 132
 None
 0.90A 5vcgA-5wa2A:
undetectable		 5vcgA-5wa2A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkn NUCLEOPROTEIN

(Mammalian
rubulavirus 5) 		no annotation 3 ARG A 119
ARG A 113
ARG A 124
 None
 0.96A 5vcgA-5wknA:
undetectable		 5vcgA-5wknA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		3 ARG A 588
ARG A 491
ARG A 593
 ARG  A 588 ( 0.6A)
ARG  A 491 ( 0.6A)
ARG  A 593 ( 0.6A)
 0.82A 5vcgA-5wo6A:
undetectable		 5vcgA-5wo6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 3 ARG A 126
ARG A  95
ARG A 128
 None
 0.78A 5vcgA-5xevA:
undetectable		 5vcgA-5xevA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10588
(NADH-G_4Fe-4S_3)
PF10589
(NADH_4Fe-4S)
PF13459
(Fer4_15)
PF13510
(Fer2_4) 		3 ARG A 332
ARG B 161
ARG B  55
 None
None
FES  B 303 (-4.8A)
 1.02A 5vcgA-5xfaA:
undetectable		 5vcgA-5xfaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnw ADENYLATE CYCLASE
EXOY

(Pseudomonas
aeruginosa) 		no annotation 3 ARG A 143
ARG A 149
ARG A 141
 None
 0.89A 5vcgA-5xnwA:
undetectable		 5vcgA-5xnwA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvd HYDROGENASE-2 SMALL
CHAIN

(Citrobacter sp.
MGH106) 		no annotation 3 ARG S 197
ARG S 205
ARG S 198
 None
 1.00A 5vcgA-5xvdS:
undetectable		 5vcgA-5xvdS:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 3 ARG A 942
ARG A 948
ARG A 802
 None
 0.96A 5vcgA-6b3rA:
undetectable		 5vcgA-6b3rA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 3 ARG A 117
ARG A 148
ARG A 115
 None
 0.82A 5vcgA-6b5iA:
undetectable		 5vcgA-6b5iA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkx ACETYL XYLAN
ESTERASE

(metagenome) 		no annotation 3 ARG C 200
ARG C 202
ARG C 264
 None
 0.99A 5vcgA-6fkxC:
undetectable		 5vcgA-6fkxC:
9.55