SIMILAR PATTERNS OF AMINO ACIDS FOR 5VCG_A_08YA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aw1 TRIOSEPHOSPHATE
ISOMERASE

(Moritella
marina) 		PF00121
(TIM) 		5 ILE A  61
THR A 124
PHE A 244
ALA A 245
ALA A 251
 None
 1.27A 5vcgA-1aw1A:
undetectable		 5vcgA-1aw1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 SER A 220
ILE A 195
PHE A 256
ALA A 216
GLU A 167
 None
 1.21A 5vcgA-1cvrA:
0.0		 5vcgA-1cvrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwv INVASIN

(Yersinia
pseudotuberculosis) 		PF02369
(Big_1)
PF07979
(Intimin_C)
PF09134
(Invasin_D3) 		5 PHE A 641
ILE A 651
THR A 672
ALA A 637
ALA A 680
 None
 1.25A 5vcgA-1cwvA:
0.0		 5vcgA-1cwvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 PHE A 131
PHE A 118
THR A 123
ALA A 183
THR A 155
 None
 1.29A 5vcgA-1e5fA:
undetectable		 5vcgA-1e5fA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 ASP B 921
PHE B 915
PHE B 727
ALA B 487
ALA B 823
 None
 1.20A 5vcgA-1ej6B:
0.0		 5vcgA-1ej6B:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PHE A 402
PHE A 338
ALA A 423
THR A 104
ALA A 364
 None
 1.08A 5vcgA-1g7cA:
0.0		 5vcgA-1g7cA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 SER A 595
ALA A 507
THR A 368
ALA A 515
GLU A 548
 None
 1.16A 5vcgA-1itzA:
0.0		 5vcgA-1itzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		5 PHE A  82
ASP A  75
ILE A 103
THR A 163
ALA A  88
 None
GOL  A1002 (-3.7A)
None
None
None
 1.25A 5vcgA-1iuqA:
undetectable		 5vcgA-1iuqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jal YCHF PROTEIN

(Haemophilus
influenzae) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 PHE A  70
ILE A   7
THR A  67
ALA A 238
ALA A 245
 None
 1.16A 5vcgA-1jalA:
0.0		 5vcgA-1jalA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 PHE A 578
ASP A 352
ILE A 450
ALA A 488
ALA A 568
 3AG  A 900 (-3.6A)
None
None
None
None
 1.17A 5vcgA-1n21A:
undetectable		 5vcgA-1n21A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrm HYPOTHETICAL PROTEIN
TM1553

(Thermotoga
maritima) 		PF02424
(ApbE) 		5 ASP A 316
PHE A 310
ILE A 277
ALA A 258
ALA A 329
 None
None
UNL  A   4 ( 4.0A)
UNL  A   4 ( 3.8A)
None
 1.26A 5vcgA-1vrmA:
undetectable		 5vcgA-1vrmA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		5 PHE A 185
ASP A   9
ILE A  37
THR A  13
PHE A 228
 None
 1.16A 5vcgA-1wr8A:
undetectable		 5vcgA-1wr8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xru 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE

(Escherichia
coli) 		PF04962
(KduI) 		5 PHE A  72
ILE A 256
PHE A 167
THR A 174
ALA A 131
 None
 1.14A 5vcgA-1xruA:
undetectable		 5vcgA-1xruA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 120
ASP A  40
ILE A 345
ALA A  33
GLU A  60
 None
None
None
None
ZN  A1000 ( 4.6A)
 1.22A 5vcgA-1y9aA:
undetectable		 5vcgA-1y9aA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		5 ASP A 231
PHE A 176
ILE A 137
PHE A 111
ALA A 168
 None
 1.30A 5vcgA-1ypxA:
undetectable		 5vcgA-1ypxA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7z 3-KETOACYL-COA
THIOLASE 2

(Arabidopsis
thaliana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 SER A 221
PHE A 234
ALA A 388
THR A 398
GLU A 409
 None
 1.12A 5vcgA-2c7zA:
undetectable		 5vcgA-2c7zA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 SER A 207
PHE A 220
ALA A 373
THR A 383
GLU A 394
 None
 1.17A 5vcgA-2iikA:
undetectable		 5vcgA-2iikA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE

(Streptomyces
virginiae) 		PF00550
(PP-binding) 		5 PHE A6802
ILE A6806
PHE A6763
ALA A6779
ALA A6747
 None
 1.22A 5vcgA-2mf4A:
undetectable		 5vcgA-2mf4A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		5 PHE A 170
SER A 229
ILE A 230
ALA A 224
ALA A  22
 None
 0.95A 5vcgA-2p2vA:
undetectable		 5vcgA-2p2vA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum) 		PF05368
(NmrA) 		5 PHE A 158
PHE A 314
ALA A 313
ALA A 310
GLU A 187
 NAP  A 401 (-4.4A)
PEG  A 901 (-4.8A)
NAP  A 401 ( 4.1A)
None
None
 1.20A 5vcgA-2qw8A:
undetectable		 5vcgA-2qw8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		5 ASP A 317
ILE A 327
THR A 316
PHE A 160
ALA A  95
 CMC  A 701 (-2.7A)
None
OAA  A 501 ( 4.9A)
None
None
 1.29A 5vcgA-2r26A:
0.0		 5vcgA-2r26A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wua ACETOACETYL COA
THIOLASE

(Helianthus
annuus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 SER A 219
PHE A 232
ALA A 386
THR A 396
GLU A 407
 None
 1.21A 5vcgA-2wuaA:
undetectable		 5vcgA-2wuaA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ASP A 444
ILE A  56
THR A 383
ALA A 213
GLU A  60
 None
 1.21A 5vcgA-2wyaA:
undetectable		 5vcgA-2wyaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		5 PHE A 624
PHE A 165
THR A 213
PHE A 589
ALA A 590
 5PL  A 900 (-3.7A)
5PL  A 900 (-4.1A)
None
None
5PL  A 900 ( 3.9A)
 1.21A 5vcgA-2yevA:
undetectable		 5vcgA-2yevA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF06722
(DUF1205) 		5 PHE A 155
ILE A 228
THR A 166
ALA A 157
GLU A 151
 None
 1.22A 5vcgA-2yjnA:
undetectable		 5vcgA-2yjnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy7 L-THREONINE
DEHYDROGENASE

(Flavobacterium
frigidimaris) 		PF01370
(Epimerase) 		5 ASP A 186
ILE A 220
THR A 185
PHE A 114
ALA A  76
 None
None
GOL  A1001 (-3.2A)
None
NAD  A3001 (-3.5A)
 1.29A 5vcgA-2yy7A:
undetectable		 5vcgA-2yy7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoo PROBABLE NITRITE
REDUCTASE

(Pseudoalteromonas
haloplanktis) 		PF00034
(Cytochrom_C)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 ASP A 237
SER A 227
ILE A 256
PHE A 193
ALA A 289
 None
 1.04A 5vcgA-2zooA:
undetectable		 5vcgA-2zooA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		5 ASP A 217
ILE A 315
ALA A 329
THR A 332
ALA A 293
 None
 1.23A 5vcgA-3bfjA:
undetectable		 5vcgA-3bfjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
fabrum) 		PF07229
(VirE2) 		5 ASP A 115
ILE A 263
THR A 132
ALA A 294
GLU A 304
 None
 1.13A 5vcgA-3btpA:
undetectable		 5vcgA-3btpA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djb HYDROLASE, HD FAMILY

(Bacillus
thuringiensis) 		PF01966
(HD) 		5 PHE A  49
PHE A  13
ILE A  17
ALA A  61
ALA A  54
 None
 1.26A 5vcgA-3djbA:
undetectable		 5vcgA-3djbA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnh UNCHARACTERIZED
PROTEIN ATU2129

(Agrobacterium
fabrum) 		PF13883
(Pyrid_oxidase_2) 		5 ASP A 223
ILE A 114
THR A 215
ALA A  71
ALA A  40
 None
 1.23A 5vcgA-3dnhA:
undetectable		 5vcgA-3dnhA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es5 PUTATIVE CAPSID
PROTEIN

(Penicillium
stoloniferum
virus F) 		no annotation 5 ASP A 145
ILE A 315
ALA A 312
THR A 198
GLU A 323
 None
 1.21A 5vcgA-3es5A:
undetectable		 5vcgA-3es5A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		5 ILE A 316
PHE A 287
ALA A 323
THR A   8
ALA A 326
 P33  A 368 ( 4.6A)
None
None
None
None
 0.92A 5vcgA-3ffrA:
undetectable		 5vcgA-3ffrA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 120
ASP A  40
ILE A 345
ALA A  33
GLU A  60
 None
None
None
None
ZN  A 353 ( 4.4A)
 1.24A 5vcgA-3fpcA:
undetectable		 5vcgA-3fpcA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 120
ASP A  40
ILE A 345
ALA A  33
GLU A  60
 None
None
None
None
ZN  A 352 ( 4.4A)
 1.26A 5vcgA-3fplA:
undetectable		 5vcgA-3fplA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5o UNCHARACTERIZED
PROTEIN RV2865
UNCHARACTERIZED
PROTEIN RV2866

(Mycobacterium
tuberculosis) 		PF02604
(PhdYeFM_antitox)
PF05016
(ParE_toxin) 		5 PHE B  22
PHE B  46
THR B  19
ALA A  91
GLU A  88
 None
 1.28A 5vcgA-3g5oB:
undetectable		 5vcgA-3g5oB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		5 PHE A 199
ILE A 140
ALA A 131
ALA A 128
GLU A 171
 None
 1.27A 5vcgA-3g87A:
undetectable		 5vcgA-3g87A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd8 AQUAPORIN-4

(Homo sapiens) 		PF00230
(MIP) 		5 ILE A 110
ALA A  99
THR A 167
ALA A 244
GLU A 249
 None
 1.28A 5vcgA-3gd8A:
undetectable		 5vcgA-3gd8A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ASP A 308
PHE A 279
SER A 283
ILE A 278
ALA A 291
 None
 1.26A 5vcgA-3iv0A:
undetectable		 5vcgA-3iv0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		5 PHE B  13
PHE A 178
ILE A  33
ALA B  24
ALA A 117
 None
 1.20A 5vcgA-3j2jB:
undetectable		 5vcgA-3j2jB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		5 ILE A 202
PHE A 219
ALA A 220
ALA A 223
GLU A 207
 None
 1.28A 5vcgA-3kd6A:
1.2		 5vcgA-3kd6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		5 PHE A 331
THR A 549
PHE A 230
ALA A 321
GLU A 333
 None
 1.15A 5vcgA-3ksyA:
undetectable		 5vcgA-3ksyA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		5 PHE A 313
ILE A  34
PHE A 285
ALA A 301
ALA A 307
 None
 1.20A 5vcgA-3m8yA:
1.7		 5vcgA-3m8yA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		5 PHE A 217
ILE A 176
PHE A 205
PHE A 313
ALA A 197
 None
 1.16A 5vcgA-3p1vA:
undetectable		 5vcgA-3p1vA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnd THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE

(Salmonella
enterica) 		PF02424
(ApbE) 		5 PHE A 324
SER A 286
ILE A 326
PHE A 341
ALA A 297
 None
 1.15A 5vcgA-3pndA:
undetectable		 5vcgA-3pndA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 5 PHE A 446
THR A 224
PHE A 465
ALA A 490
GLU A 448
 None
 1.18A 5vcgA-3q3hA:
undetectable		 5vcgA-3q3hA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		5 ASP A 161
SER A 150
ILE A 151
THR A 134
ALA A 194
 None
 1.24A 5vcgA-3qfwA:
undetectable		 5vcgA-3qfwA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 PHE A 781
ILE A 810
PHE A 846
ALA A 843
THR A 855
 None
 1.21A 5vcgA-3s1sA:
undetectable		 5vcgA-3s1sA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		5 ILE A 307
PHE A 279
THR A 501
ALA A 245
ALA A 237
 None
 1.26A 5vcgA-3slkA:
undetectable		 5vcgA-3slkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		5 PHE A  13
ASP A 402
ALA A 249
THR A 252
ALA A 417
 None
 1.27A 5vcgA-3swgA:
undetectable		 5vcgA-3swgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		5 PHE A 390
ILE A 394
THR A 323
THR A 290
ALA A 305
 None
 1.26A 5vcgA-3us8A:
undetectable		 5vcgA-3us8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5n OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 PHE A 141
ILE A  28
THR A 121
PHE A 339
ALA A  35
 None
 1.16A 5vcgA-3v5nA:
undetectable		 5vcgA-3v5nA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		5 PHE A 273
ILE A 269
PHE A 282
THR A 250
ALA A 220
 None
None
GST  A 303 (-4.9A)
None
None
 1.10A 5vcgA-3vc1A:
undetectable		 5vcgA-3vc1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vib MTRR

(Neisseria
gonorrhoeae) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		5 ASP A  68
PHE A  62
PHE A 108
THR A  31
ALA A  19
 None
 1.21A 5vcgA-3vibA:
undetectable		 5vcgA-3vibA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 ASP A 247
SER A 237
ILE A 266
PHE A 203
ALA A 299
 None
 1.18A 5vcgA-3zbmA:
undetectable		 5vcgA-3zbmA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acz ENDO-ALPHA-MANNOSIDA
SE

(Bacteroides
thetaiotaomicron) 		PF16317
(Glyco_hydro_99) 		5 PHE B 191
ILE B 225
PHE B  45
THR B 255
GLU B 154
 None
 1.17A 5vcgA-4aczB:
undetectable		 5vcgA-4aczB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 SER C 174
PHE C 187
ALA C 354
THR C 364
GLU C 375
 None
 1.20A 5vcgA-4b3iC:
undetectable		 5vcgA-4b3iC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blf SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
tumefaciens) 		PF07229
(VirE2) 		5 ASP A 115
ILE A 263
THR A 132
ALA A 294
GLU A 304
 None
 1.15A 5vcgA-4blfA:
undetectable		 5vcgA-4blfA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		5 SER A 137
THR A 185
ALA A 146
ALA A 169
GLU A 165
 None
 1.29A 5vcgA-4c1nA:
undetectable		 5vcgA-4c1nA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		5 PHE A 217
ILE A 176
PHE A 205
PHE A 313
ALA A 197
 None
 1.15A 5vcgA-4df9A:
undetectable		 5vcgA-4df9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejy 3-METHYLADENINE DNA
GLYCOSYLASE

(Caldanaerobacter
subterraneus) 		PF00730
(HhH-GPD)
PF07934
(OGG_N) 		5 ASP A  48
PHE A 157
ALA A 180
ALA A 187
GLU A 162
 None
 1.02A 5vcgA-4ejyA:
undetectable		 5vcgA-4ejyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		5 PHE A  90
ILE A  86
ALA A 270
ALA A 223
GLU A 226
 None
None
None
PLP  A 501 ( 4.1A)
None
 1.22A 5vcgA-4emyA:
0.4		 5vcgA-4emyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE

(Bacteroides
uniformis) 		PF10091
(Glycoamylase) 		5 PHE A  55
PHE A 154
ILE A 223
PHE A  84
THR A  78
 None
 1.30A 5vcgA-4gl3A:
undetectable		 5vcgA-4gl3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 PHE A 202
ASP A 164
PHE A 157
ILE A 152
ALA A 195
 None
 1.24A 5vcgA-4gtuA:
undetectable		 5vcgA-4gtuA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h61 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 6

(Schizosaccharomyces
pombe) 		PF04934
(Med6) 		5 PHE A  78
ILE A  76
PHE A  37
THR A  12
ALA A 118
 None
 1.23A 5vcgA-4h61A:
undetectable		 5vcgA-4h61A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8i HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16227
(DUF4886) 		5 PHE A  41
ASP A 223
ILE A 216
ALA A 271
ALA A  45
 ACT  A 300 (-3.7A)
None
None
None
None
 1.25A 5vcgA-4i8iA:
undetectable		 5vcgA-4i8iA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 ASP A 916
SER A  80
ILE A  79
THR A 914
GLU A  95
 None
 1.14A 5vcgA-4iglA:
undetectable		 5vcgA-4iglA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		5 ILE A 155
THR A 216
ALA A 110
THR A  24
GLU A  19
 None
None
None
None
CA  A 401 (-3.3A)
 1.22A 5vcgA-4infA:
undetectable		 5vcgA-4infA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4w NUCLEOCAPSID

(Punta Toro
phlebovirus) 		PF05733
(Tenui_N) 		5 PHE A 139
ILE A 203
ALA A 111
THR A 114
ALA A 142
 None
 1.29A 5vcgA-4j4wA:
undetectable		 5vcgA-4j4wA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2a HALOALKANE
DEHALOGENASE

(Bradyrhizobium
elkanii) 		PF00561
(Abhydrolase_1) 		5 ASP A 142
PHE A 148
PHE A 138
THR A 218
ALA A 211
 None
 1.17A 5vcgA-4k2aA:
undetectable		 5vcgA-4k2aA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 ASP A 187
PHE A 182
SER A  17
ILE A  14
THR A 133
 None
 1.25A 5vcgA-4nfuA:
undetectable		 5vcgA-4nfuA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		11 PHE A  57
ASP A  76
PHE A 108
SER A 119
ILE A 120
PHE A 215
THR A 224
ALA A 305
THR A 309
ALA A 370
GLU A 374
 None
None
2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
2QH  A 602 (-3.9A)
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 3.1A)
2QH  A 602 ( 4.8A)
 0.62A 5vcgA-4ny4A:
58.5		 5vcgA-4ny4A:
98.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ASP A 359
PHE A 410
ILE A 259
ALA A 189
ALA A  85
 None
 1.15A 5vcgA-4qavA:
undetectable		 5vcgA-4qavA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2v CYSTEINE SYNTHETASE

(Helicobacter
pylori) 		PF00291
(PALP) 		5 PHE A 185
ILE A 179
PHE A 175
ALA A 274
ALA A  34
 None
 1.23A 5vcgA-4r2vA:
undetectable		 5vcgA-4r2vA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME

(Bacillus
licheniformis) 		PF01547
(SBP_bac_1) 		5 ILE A  67
PHE A 137
THR A 342
ALA A 322
ALA A 134
 None
 1.18A 5vcgA-4rk9A:
undetectable		 5vcgA-4rk9A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME

(Bacillus
licheniformis) 		PF01547
(SBP_bac_1) 		5 ILE A  67
PHE A 137
THR A 342
PHE A 325
ALA A 134
 None
 1.21A 5vcgA-4rk9A:
undetectable		 5vcgA-4rk9A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trk C. ELEGANS HIM-3

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		5 PHE A 190
ILE A 285
PHE A 104
PHE A  75
THR A  73
 None
 1.27A 5vcgA-4trkA:
undetectable		 5vcgA-4trkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzn PROTEIN HTP-2

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		5 ASP A 116
PHE A 197
ILE A 108
THR A 194
ALA A  95
 None
 1.28A 5vcgA-4tznA:
undetectable		 5vcgA-4tznA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Cellvibrio sp.
BR) 		PF13738
(Pyr_redox_3) 		5 PHE A 218
ILE A 341
ALA A 347
THR A 350
GLU A 331
 None
 1.09A 5vcgA-4usqA:
undetectable		 5vcgA-4usqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utf GLYCOSYL HYDROLASE
FAMILY 71

(Bacteroides
xylanisolvens) 		PF16317
(Glyco_hydro_99) 		5 PHE A 193
ILE A 227
PHE A  44
THR A 259
GLU A 156
 None
None
None
None
IFM  A 501 (-2.8A)
 1.20A 5vcgA-4utfA:
undetectable		 5vcgA-4utfA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ASP C 263
ILE C 539
THR C 264
ALA C 547
THR C 545
 None
 1.07A 5vcgA-4z42C:
undetectable		 5vcgA-4z42C:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 PHE D 419
ILE D 422
PHE D 408
ALA D 336
GLU D 417
 None
 1.21A 5vcgA-5a6bD:
undetectable		 5vcgA-5a6bD:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0s LIN0857 PROTEIN

(Listeria
innocua) 		PF04041
(Glyco_hydro_130) 		5 PHE A 228
PHE A 155
ILE A 139
THR A 145
ALA A 184
 None
 1.11A 5vcgA-5b0sA:
undetectable		 5vcgA-5b0sA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 PHE A 301
ILE A 297
PHE A 258
ALA A 261
ALA A 210
 None
 1.26A 5vcgA-5b25A:
undetectable		 5vcgA-5b25A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsz N-METHYLTRANSFERASE

(Streptoalloteichus
sp. ATCC 53650) 		PF13649
(Methyltransf_25) 		5 PHE A 239
THR A 152
ALA A 123
ALA A 216
GLU A 212
 None
 1.09A 5vcgA-5bszA:
undetectable		 5vcgA-5bszA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE

(Medicago
truncatula) 		PF00795
(CN_hydrolase) 		5 ASP A 110
ILE A 157
PHE A 146
ALA A 166
ALA A 175
 None
 1.15A 5vcgA-5h8kA:
undetectable		 5vcgA-5h8kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ASP A 385
SER A 364
ILE A 157
THR A 416
ALA A 370
 None
 1.00A 5vcgA-5ik2A:
undetectable		 5vcgA-5ik2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8

(Homo sapiens) 		no annotation 5 ASP A 347
PHE A 466
ILE A 429
ALA A 436
THR A 440
 None
 1.27A 5vcgA-5kdiA:
0.5		 5vcgA-5kdiA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 5 PHE A 371
SER A 315
ILE A 314
THR A 361
ALA A 379
 None
 1.15A 5vcgA-5oj3A:
undetectable		 5vcgA-5oj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanothermobacter
marburgensis) 		no annotation 5 PHE A 117
ILE A  73
PHE A  22
THR A  45
ALA A  84
 None
 1.20A 5vcgA-5ok4A:
undetectable		 5vcgA-5ok4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01030
(Recep_L_domain) 		5 SER M 326
ILE M 327
PHE M 396
ALA M 385
ALA M 415
 None
 1.12A 5vcgA-5sx4M:
undetectable		 5vcgA-5sx4M:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 PHE A   4
ASP A 397
ALA A 243
THR A 246
ALA A 412
 None
 1.30A 5vcgA-5u4hA:
undetectable		 5vcgA-5u4hA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		5 PHE A 781
ILE A 804
PHE A 758
THR A 760
PHE A 852
 None
 1.18A 5vcgA-5va3A:
0.4		 5vcgA-5va3A:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 5 PHE A 304
ALA A 305
THR A 309
ALA A 370
GLU A 374
 RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
RIT  A 602 ( 4.8A)
 1.05A 5vcgA-5veuA:
52.9		 5vcgA-5veuA:
82.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlq LOC100158544 PROTEIN

(Xenopus
tropicalis) 		PF03133
(TTL) 		5 PHE A 392
ILE A 483
THR A 545
PHE A 143
ALA A 490
 None
 1.22A 5vcgA-5vlqA:
undetectable		 5vcgA-5vlqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA

(Neurospora
crassa) 		no annotation 5 SER B 220
ALA B 229
THR B 232
ALA B 186
GLU B 179
 None
 1.20A 5vcgA-5vqiB:
undetectable		 5vcgA-5vqiB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 5 ASP A 298
PHE A 399
ALA A 441
ALA A 370
GLU A 304
 None
 1.29A 5vcgA-5yfbA:
undetectable		 5vcgA-5yfbA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3b UNCHARACTERIZED
PROTEIN

(Streptomyces
cattleya) 		no annotation 5 PHE A 141
ILE A 230
THR A 113
ALA A 202
THR A 205
 EDO  A 403 ( 4.2A)
None
None
None
None
 1.21A 5vcgA-6c3bA:
undetectable		 5vcgA-6c3bA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN DEPDC5

(Homo sapiens) 		no annotation 5 ILE D 803
PHE D1286
THR D1355
ALA D 795
GLU D 979
 None
 1.20A 5vcgA-6cetD:
undetectable		 5vcgA-6cetD:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN DEPDC5

(Homo sapiens) 		no annotation 5 PHE D 802
PHE D1286
THR D1355
ALA D 795
GLU D 979
 None
 1.27A 5vcgA-6cetD:
undetectable		 5vcgA-6cetD:
13.05