SIMILAR PATTERNS OF AMINO ACIDS FOR 5VCE_A_RITA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b48 PROTEIN (GLUTATHIONE
S-TRANSFERASE)


(Mus musculus)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 PHE A 147
ILE A 188
ILE A 194
ALA A  24
ALA A  76
None
0.96A 5vceA-1b48A:
undetectable
5vceA-1b48A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF00465
(Fe-ADH)
5 ILE A 325
ALA A 329
THR A 333
ILE A 339
ALA A 254
None
1.00A 5vceA-1jpuA:
undetectable
5vceA-1jpuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E


(Medicago sativa)
PF00891
(Methyltransf_2)
PF08100
(Dimerisation)
5 PHE A 344
ILE A 256
PHE A 279
ALA A 296
GLU A 360
None
0.96A 5vceA-1kywA:
undetectable
5vceA-1kywA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi)
PF00921
(Lipoprotein_2)
5 PHE A  74
ILE A 324
ALA A 282
ILE A 256
GLU A 173
None
1.12A 5vceA-1l8wA:
0.0
5vceA-1l8wA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT


(Wolinella
succinogenes)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 ILE A 375
ALA A 246
THR A 243
ALA A 183
GLU A 180
None
1.06A 5vceA-1qlbA:
undetectable
5vceA-1qlbA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans)
PF00232
(Glyco_hydro_1)
5 PHE A 290
ILE A 242
PHE A 185
ALA A 186
ILE A 252
None
1.03A 5vceA-1qvbA:
0.0
5vceA-1qvbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis)
PF00067
(p450)
5 PHE A 175
ILE A 179
PHE A 199
ALA A 241
GLU A 163
None
None
None
PG4  A4502 (-4.3A)
None
1.12A 5vceA-1uedA:
9.7
5vceA-1uedA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5k MICROTUBULE-ASSOCIAT
ED PROTEIN, RP/EB
FAMILY, MEMBER 1


(Mus musculus)
PF00307
(CH)
5 PHE A  75
ILE A  84
PHE A 104
ALA A  35
ALA A  50
None
1.07A 5vceA-1v5kA:
undetectable
5vceA-1v5kA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER


(Saccharomyces
cerevisiae)
PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1)
5 ILE C 472
PHE C 357
ALA C 516
THR C 519
ILE C 482
None
1.04A 5vceA-1wa5C:
0.0
5vceA-1wa5C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY


(Streptococcus
pneumoniae)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
5 ALA A 172
THR A 173
ILE A 137
ALA A 136
GLU A 112
None
1.10A 5vceA-1ydfA:
0.0
5vceA-1ydfA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus)
PF02171
(Piwi)
PF12212
(PAZ_siRNAbind)
5 PHE A 611
ILE A 555
PHE A 747
ALA A 748
ILE A 569
None
1.05A 5vceA-1z26A:
undetectable
5vceA-1z26A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST


(Spinacia
oleracea)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 ILE A 194
ILE A 230
ALA A 245
ALA A 338
GLU A 341
None
1.01A 5vceA-2akjA:
undetectable
5vceA-2akjA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST


(Spinacia
oleracea)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 PHE A 255
ILE A 230
ALA A 245
ALA A 338
GLU A 341
None
1.07A 5vceA-2akjA:
undetectable
5vceA-2akjA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b30 PVIVAX HYPOTHETICAL
PROTEIN


(Plasmodium
vivax)
PF08282
(Hydrolase_3)
5 PHE A  34
ILE A  66
PHE A  79
ALA A  53
ALA A 288
None
1.11A 5vceA-2b30A:
undetectable
5vceA-2b30A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV


(Sus scrofa)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 ILE A 703
ALA A 652
THR A 636
ILE A 626
ALA A 625
None
0.92A 5vceA-2bucA:
undetectable
5vceA-2bucA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 ILE A 297
THR A 308
ILE A 307
ALA A 247
GLU A 245
None
0.91A 5vceA-2dzdA:
undetectable
5vceA-2dzdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
5 PHE A 366
PHE A 336
ALA A 337
ILE A 382
ALA A   9
None
0.96A 5vceA-2fa0A:
undetectable
5vceA-2fa0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4


(Homo sapiens)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 ILE A 703
ALA A 652
THR A 636
ILE A 626
ALA A 625
None
0.89A 5vceA-2g5tA:
undetectable
5vceA-2g5tA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE


(Staphylococcus
aureus)
PF01467
(CTP_transf_like)
5 PHE A  11
ILE A  60
ILE A  64
ILE A   4
GLU A  76
None
None
None
None
DND  A 998 ( 4.6A)
1.13A 5vceA-2h29A:
undetectable
5vceA-2h29A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j28 50S RIBOSOMAL
PROTEIN L2


(Escherichia
coli)
PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C)
5 ILE C  90
ALA C 105
ILE C 115
ALA C  75
GLU C  99
None
None
None
None
G  B1491 ( 3.5A)
0.99A 5vceA-2j28C:
undetectable
5vceA-2j28C:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1


(Homo sapiens)
PF00171
(Aldedh)
5 PHE A 402
ALA A 193
THR A 196
ILE A 199
GLU A 122
NAI  A1501 (-3.9A)
NAI  A1501 (-4.3A)
None
None
None
1.12A 5vceA-2j6lA:
undetectable
5vceA-2j6lA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE


(Desulfovibrio
desulfuricans)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
6 PHE A 228
ILE A 289
PHE A 296
ALA A 297
THR A 330
ILE A 329
None
1.46A 5vceA-2jirA:
undetectable
5vceA-2jirA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4


(Rattus
norvegicus)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 ILE A 704
ALA A 653
THR A 637
ILE A 627
ALA A 626
None
0.90A 5vceA-2oaeA:
undetectable
5vceA-2oaeA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 SER A  76
ILE A 117
ALA A   9
THR A  39
ALA A  66
None
1.13A 5vceA-2pwzA:
undetectable
5vceA-2pwzA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqx METALLOPROTEINASE

(Serratia
proteamaculans)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
PF16485
(PLN_propep)
5 PHE A 311
ALA A 312
THR A 315
ILE A 292
ALA A 289
None
0.85A 5vceA-2vqxA:
undetectable
5vceA-2vqxA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
pneumoniae)
PF13519
(VWA_2)
5 ILE A 541
ILE A 539
ALA A 251
THR A 255
ILE A 229
None
1.10A 5vceA-2ww8A:
undetectable
5vceA-2ww8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila)
PF16849
(Glyco_transf_88)
5 ILE A  44
ALA A  77
ILE A  56
ALA A  55
GLU A  49
None
1.05A 5vceA-2wzfA:
undetectable
5vceA-2wzfA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila)
PF16849
(Glyco_transf_88)
5 ILE A  44
ALA A  77
ILE A  56
ALA A  55
GLU A  49
None
0.92A 5vceA-2wzgA:
undetectable
5vceA-2wzgA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM


(Thermus
thermophilus)
PF11104
(PilM_2)
5 ILE A  65
ILE A  20
ALA A  82
ALA A 369
GLU A  29
None
1.13A 5vceA-2ychA:
undetectable
5vceA-2ychA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli)
PF00595
(PDZ)
PF13365
(Trypsin_2)
5 ILE A 104
ILE A 102
ALA A 100
ILE A 179
ALA A 168
None
1.13A 5vceA-2zleA:
undetectable
5vceA-2zleA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayn RHODOPSIN

(Todarodes
pacificus)
PF00001
(7tm_1)
5 SER A 263
ILE A 266
ILE A 129
ALA A  69
THR A  67
None
1.04A 5vceA-3aynA:
undetectable
5vceA-3aynA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens)
PF01522
(Polysacc_deac_1)
5 ILE A 276
PHE A 275
ALA A 279
ILE A  27
ALA A  28
None
1.01A 5vceA-3cl6A:
undetectable
5vceA-3cl6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzb PREPHENATE
DEHYDROGENASE


(Streptococcus
thermophilus)
PF02153
(PDH)
5 ILE A  22
ILE A  68
ALA A  97
ALA A 126
GLU A 142
None
1.02A 5vceA-3dzbA:
undetectable
5vceA-3dzbA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5d PUTATIVE GLYOXALASE
I


(Listeria
monocytogenes)
PF00903
(Glyoxalase)
5 ILE A  74
ILE A  76
THR A  88
ILE A  98
ALA A  99
None
1.09A 5vceA-3e5dA:
undetectable
5vceA-3e5dA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6g ALPHA-ISOPROPYLMALAT
E SYNTHASE


(Leptospira
interrogans)
no annotation 6 ILE B 448
ALA B 499
THR B 496
ILE B 399
ALA B 409
GLU B 422
None
1.47A 5vceA-3f6gB:
undetectable
5vceA-3f6gB:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1


(Schizosaccharomyces
pombe)
PF04857
(CAF1)
5 PHE A 109
ILE A  84
ALA A 241
THR A 104
ILE A  22
None
1.11A 5vceA-3g10A:
undetectable
5vceA-3g10A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g40 NA-K-CL
COTRANSPORTER


(Methanosarcina
acetivorans)
no annotation 5 ILE A 631
ILE A 722
ALA A 748
ILE A 585
ALA A 494
None
1.13A 5vceA-3g40A:
undetectable
5vceA-3g40A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)


(Clostridium
acetobutylicum)
PF13377
(Peripla_BP_3)
5 ILE A 307
ILE A 127
PHE A 151
ALA A 129
ILE A  80
None
1.09A 5vceA-3g85A:
undetectable
5vceA-3g85A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 ILE A 293
THR A 304
ILE A 303
ALA A 243
GLU A 241
None
0.95A 5vceA-3g8dA:
undetectable
5vceA-3g8dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvn HEMOLYSIN

(Streptococcus
suis)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
5 PHE A  37
ILE A 256
PHE A 242
ILE A 117
ALA A 370
None
0.84A 5vceA-3hvnA:
undetectable
5vceA-3hvnA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3li9 HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE


(Methanosarcina
mazei)
PF02743
(dCache_1)
5 SER A 291
ILE A 259
ALA A  51
ILE A 212
ALA A 209
None
1.02A 5vceA-3li9A:
undetectable
5vceA-3li9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
5 PHE A 604
ILE A 472
ILE A 457
ALA A 459
GLU A 432
None
1.03A 5vceA-3lk6A:
undetectable
5vceA-3lk6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne2 PROBABLE AQUAPORIN
AQPM


(Archaeoglobus
fulgidus)
PF00230
(MIP)
5 PHE A 109
ILE A 105
ILE A  88
ALA A 233
THR A 155
None
1.08A 5vceA-3ne2A:
undetectable
5vceA-3ne2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2


(Helicobacter
mustelae)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
5 ILE C 401
PHE C 441
ILE C 405
ALA C 129
ILE C  85
None
1.11A 5vceA-3qgkC:
undetectable
5vceA-3qgkC:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT


(Legionella
pneumophila)
PF01596
(Methyltransf_3)
5 PHE A 137
ILE A  89
ALA A 144
ILE A 168
ALA A 167
None
1.07A 5vceA-3r3hA:
undetectable
5vceA-3r3hA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K


(Escherichia
coli)
no annotation 5 SER J  40
ILE J  56
ALA J  12
THR J  16
ILE K  37
None
1.01A 5vceA-3rkoJ:
undetectable
5vceA-3rkoJ:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II


(Bacillus
anthracis)
PF00155
(Aminotran_1_2)
5 ILE A  85
ALA A  94
THR A  97
ALA A 252
GLU A 247
None
1.10A 5vceA-3t32A:
undetectable
5vceA-3t32A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7c CARVEOL
DEHYDROGENASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
5 ILE A 143
ILE A 152
ALA A 102
THR A  13
ILE A  37
None
0.93A 5vceA-3t7cA:
undetectable
5vceA-3t7cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]


(Francisella
tularensis)
PF01380
(SIS)
5 ILE A 481
PHE A 407
ALA A 415
THR A 418
ILE A 316
None
1.09A 5vceA-3tbfA:
undetectable
5vceA-3tbfA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ILE A 363
ALA A 422
ILE A 282
ALA A 242
GLU A 166
None
None
None
None
MG  A 430 ( 4.7A)
1.11A 5vceA-3tqpA:
2.1
5vceA-3tqpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00266
(Aminotran_5)
5 PHE A  22
ALA A 292
THR A 298
ALA A 323
GLU A 339
None
1.12A 5vceA-3vomA:
undetectable
5vceA-3vomA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE


(Streptomyces
lavendulae)
PF00561
(Abhydrolase_1)
5 PHE A 118
ILE A 126
ALA A 130
THR A 133
GLU A   3
None
1.04A 5vceA-3vvlA:
undetectable
5vceA-3vvlA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N)
5 PHE A 619
ILE A 750
PHE A 727
ALA A 644
ILE A 349
None
0.94A 5vceA-3welA:
undetectable
5vceA-3welA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13


(Mycobacterium
tuberculosis)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
5 ILE A 357
ILE A 487
ALA A 489
ILE A 570
ALA A 367
None
1.08A 5vceA-3zukA:
undetectable
5vceA-3zukA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dna PROBABLE GLUTATHIONE
REDUCTASE


(Sinorhizobium
meliloti)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A  11
PHE A 324
ALA A 321
ALA A  25
GLU A 109
FAD  A 500 (-4.8A)
None
None
None
None
1.12A 5vceA-4dnaA:
undetectable
5vceA-4dnaA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
ovatus)
PF07523
(Big_3)
PF13306
(LRR_5)
5 PHE A 191
ILE A 189
PHE A 203
ALA A 158
GLU A 171
None
1.06A 5vceA-4fdwA:
undetectable
5vceA-4fdwA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgs PROBABLE
DEHYDROGENASE
PROTEIN


(Rhizobium etli)
PF13561
(adh_short_C2)
5 ILE A 176
ILE A 174
ALA A 128
ILE A   9
ALA A  10
None
1.11A 5vceA-4fgsA:
undetectable
5vceA-4fgsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE


(Trichormus
variabilis)
PF00171
(Aldedh)
5 PHE A 279
ILE A 269
ILE A 266
ILE A 415
ALA A 401
None
1.13A 5vceA-4h7nA:
undetectable
5vceA-4h7nA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkt INOSITOL
2-DEHYDROGENASE


(Sinorhizobium
meliloti)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 PHE A   5
PHE A 290
ILE A  89
THR A  70
ALA A  33
None
1.06A 5vceA-4hktA:
undetectable
5vceA-4hktA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN


(Acidovorax
citrulli)
PF00544
(Pec_lyase_C)
5 SER A 436
ILE A 417
ALA A 419
ALA A 426
GLU A 433
None
1.03A 5vceA-4hwvA:
undetectable
5vceA-4hwvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens)
PF00067
(p450)
5 PHE A 123
SER A 116
ILE A 115
PHE A 224
ALA A 138
None
BHF  A 602 (-3.2A)
BHF  A 602 (-4.7A)
BHF  A 602 (-3.3A)
None
1.13A 5vceA-4i8vA:
31.3
5vceA-4i8vA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij4 CHITINASE A

(Gemmabryum
coronatum)
PF00182
(Glyco_hydro_19)
5 PHE A  12
ILE A  58
ALA A 136
THR A 135
ALA A 126
None
1.10A 5vceA-4ij4A:
0.4
5vceA-4ij4A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II


(Acidothermus
cellulolyticus)
no annotation 5 ILE A 341
ILE A 421
ALA A 406
ILE A  23
ALA A 385
None
None
ACT  A 826 (-4.3A)
None
None
1.06A 5vceA-4lgnA:
undetectable
5vceA-4lgnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A


(Streptococcus
pneumoniae)
PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix)
5 ILE A 171
PHE A 189
ILE A 175
ILE A 284
ALA A 283
None
1.01A 5vceA-4mr0A:
undetectable
5vceA-4mr0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 ILE A 293
THR A 304
ILE A 303
ALA A 243
GLU A 241
None
0.95A 5vceA-4mv3A:
undetectable
5vceA-4mv3A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Anaerococcus
prevotii)
PF03480
(DctP)
5 PHE A 115
ILE A 328
PHE A 109
ILE A 130
GLU A 119
None
1.11A 5vceA-4n91A:
0.0
5vceA-4n91A:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
10 PHE A 108
SER A 119
ILE A 120
PHE A 241
ILE A 301
ALA A 305
THR A 309
ILE A 369
ALA A 370
GLU A 374
2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
2QH  A 602 (-4.5A)
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
HEM  A 601 (-4.7A)
2QH  A 602 ( 3.1A)
2QH  A 602 ( 4.8A)
0.61A 5vceA-4ny4A:
57.8
5vceA-4ny4A:
98.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
7 SER A 119
ILE A 120
ARG A 212
PHE A 241
ILE A 301
THR A 309
ILE A 369
2QH  A 602 (-3.9A)
None
2QH  A 602 (-4.0A)
2QH  A 602 (-4.5A)
None
2QH  A 602 ( 3.7A)
HEM  A 601 (-4.7A)
1.24A 5vceA-4ny4A:
57.8
5vceA-4ny4A:
98.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE


(Leptospira
biflexa)
PF00682
(HMGL-like)
5 ILE A 100
ILE A 124
ALA A 161
ILE A 194
GLU A 231
None
1.13A 5vceA-4ov4A:
undetectable
5vceA-4ov4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po5 ALLOPHYCOCYANIN
SUBUNIT ALPHA-B


(Synechocystis
sp. PCC 6803)
PF00502
(Phycobilisome)
5 ILE A 156
PHE A 153
THR A 149
ILE A  39
ALA A  40
None
1.08A 5vceA-4po5A:
2.3
5vceA-4po5A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II


(Yersinia pestis)
PF00557
(Peptidase_M24)
PF05195
(AMP_N)
5 ILE A 111
PHE A  26
ILE A  61
ALA A  22
ALA A 156
None
None
None
None
EDO  A 505 ( 4.9A)
0.99A 5vceA-4pv4A:
undetectable
5vceA-4pv4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN


(Zea mays)
PF00171
(Aldedh)
5 PHE A 399
ALA A 191
THR A 194
ILE A 197
GLU A 120
NAD  A 601 (-3.9A)
NAD  A 601 (-4.2A)
None
None
None
1.07A 5vceA-4pxnA:
undetectable
5vceA-4pxnA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3k MGS-M1

(unidentified)
PF00326
(Peptidase_S9)
PF07859
(Abhydrolase_3)
5 ILE A 110
ALA A 123
THR A 158
ILE A 189
GLU A 192
None
1.07A 5vceA-4q3kA:
undetectable
5vceA-4q3kA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tjv VACUOLAR-SORTING
RECEPTOR 1


(Arabidopsis
thaliana)
PF02225
(PA)
5 ILE A 159
ILE A 151
ALA A 149
ILE A 146
ALA A 113
None
0.99A 5vceA-4tjvA:
undetectable
5vceA-4tjvA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA


(Bacillus
subtilis)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
5 ILE A 304
PHE A 273
ILE A 302
THR A 264
ALA A 356
None
1.10A 5vceA-4tr6A:
undetectable
5vceA-4tr6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE


(Sulfurisphaera
tokodaii)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ILE A  83
ILE A 227
ALA A 255
ILE A 264
ALA A 267
None
1.08A 5vceA-4yzoA:
0.2
5vceA-4yzoA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5s ALDEHYDE
DECARBONYLASE


(Synechocystis
sp. PCC 6803)
PF11266
(Ald_deCOase)
5 ILE A 109
PHE A 117
ALA A 118
ILE A  27
ALA A  83
None
1.09A 5vceA-4z5sA:
undetectable
5vceA-4z5sA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7s CYSTEINE DESULFURASE

(Thermococcus
onnurineus)
PF00266
(Aminotran_5)
5 PHE A  82
ILE A  80
ILE A  73
ALA A 195
GLU A  88
None
1.03A 5vceA-5b7sA:
undetectable
5vceA-5b7sA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep5 THIOESTERASE

(Staphylococcus
aureus)
PF03061
(4HBT)
5 ILE A  90
ALA A  72
THR A 112
ILE A 103
ALA A  85
None
1.08A 5vceA-5ep5A:
undetectable
5vceA-5ep5A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0k UNCHARACTERIZED
PROTEIN


(Pedobacter
heparinus)
PF16265
(DUF4918)
5 ILE A 103
PHE A 116
ILE A 122
ILE A 200
ALA A 202
None
1.07A 5vceA-5h0kA:
undetectable
5vceA-5h0kA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0k UNCHARACTERIZED
PROTEIN


(Pedobacter
heparinus)
PF16265
(DUF4918)
5 ILE A 103
PHE A 116
ILE A 122
ILE A 200
GLU A 204
None
0.94A 5vceA-5h0kA:
undetectable
5vceA-5h0kA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17


(Sphingomonas
sp. PAMC 26605)
PF00067
(p450)
5 ILE A  79
ALA A  76
THR A  74
ILE A  73
ALA A  93
None
None
D12  A 502 (-3.5A)
None
None
0.97A 5vceA-5h1zA:
28.0
5vceA-5h1zA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803)
no annotation 5 ILE A 542
ILE A 534
ALA A 340
ILE A 328
ALA A 329
None
1.10A 5vceA-5h3kA:
undetectable
5vceA-5h3kA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC


(Zea mays)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
6 SER A 302
PHE A 209
ALA A 210
THR A 213
ILE A 344
GLU A 394
None
1.49A 5vceA-5h8yA:
undetectable
5vceA-5h8yA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE


(Limnothrix sp.
KNUA012)
PF11266
(Ald_deCOase)
5 ILE A 109
PHE A 117
ALA A 118
ILE A  27
ALA A  83
None
OCD  A 500 (-3.9A)
OCD  A 500 (-3.6A)
OCD  A 500 ( 4.6A)
None
1.12A 5vceA-5k52A:
undetectable
5vceA-5k52A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf2 PREDICTED
ACETYLTRANSFERASE


(Clostridium
acetobutylicum)
PF00583
(Acetyltransf_1)
5 PHE A 136
ILE A  78
ALA A 100
ILE A   3
ALA A  47
None
1.13A 5vceA-5kf2A:
undetectable
5vceA-5kf2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
5 ILE A1472
ILE A1398
PHE A1452
ILE A1498
ALA A1499
None
1.03A 5vceA-5m5pA:
undetectable
5vceA-5m5pA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 PHE A  29
ILE A  35
ALA A  11
ILE A  15
ALA A 246
None
None
None
NAD  A 334 (-3.4A)
None
1.11A 5vceA-5mdhA:
undetectable
5vceA-5mdhA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-)
no annotation 5 SER A  50
ILE A 122
THR A 777
ILE A 790
ALA A  44
PO4  A1002 (-4.4A)
None
None
None
None
1.12A 5vceA-5mz9A:
undetectable
5vceA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE


(Citrus sinensis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 SER A 454
ILE A 453
ILE A 319
ILE A 476
GLU A 471
None
1.05A 5vceA-5uv2A:
undetectable
5vceA-5uv2A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis)
no annotation 5 ILE A 557
PHE A 569
ALA A 600
ILE A 617
GLU A 582
None
0.95A 5vceA-5ve8A:
undetectable
5vceA-5ve8A:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 7 SER A 119
PHE A 241
ILE A 301
PHE A 304
ALA A 305
THR A 309
ALA A 370
RIT  A 602 (-3.7A)
RIT  A 602 (-3.9A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
0.74A 5vceA-5veuA:
53.9
5vceA-5veuA:
82.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160


(Human
immunodeficiency
virus 1)
no annotation 5 PHE G 176
PHE G 159
ILE G 307
ALA G 316
ALA G 204
None
1.07A 5vceA-5wduG:
undetectable
5vceA-5wduG:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE


(unidentified)
PF00465
(Fe-ADH)
5 SER A 288
ILE A 293
ALA A 355
ILE A 256
ALA A 252
None
1.05A 5vceA-5xn8A:
undetectable
5vceA-5xn8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1


(Homo sapiens)
no annotation 5 PHE B 272
SER B 229
ILE B 547
ARG B 533
GLU B 269
None
1.12A 5vceA-5y31B:
undetectable
5vceA-5y31B:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y33 ALGINATE LYASE

(Flavobacterium
sp. UMI-01)
no annotation 5 ILE A 104
ILE A 120
ALA A 236
ILE A   6
ALA A   4
None
1.07A 5vceA-5y33A:
undetectable
5vceA-5y33A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT


(Methylobacillus
sp. KY4400)
no annotation 5 PHE B 195
ILE B 191
ILE B 217
ALA B  70
ILE B 213
None
None
None
FAD  B 401 ( 4.0A)
FAD  B 401 (-3.5A)
1.08A 5vceA-5y6qB:
undetectable
5vceA-5y6qB:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ


(Pyrococcus
furiosus)
no annotation 5 ILE L  70
ILE J  40
ALA J  44
THR J  47
ALA L 134
NFU  L 401 ( 4.8A)
None
None
None
None
0.95A 5vceA-6cfwL:
undetectable
5vceA-6cfwL:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F


(Pyrococcus
furiosus)
no annotation 5 PHE F  23
ILE B  62
ILE B  58
ALA B  55
ALA A  19
None
1.07A 5vceA-6cfwF:
undetectable
5vceA-6cfwF:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum)
no annotation 5 PHE A  92
PHE A 323
ILE A 478
ILE A 170
GLU A 289
None
HEM  A 604 ( 3.9A)
None
None
None
1.05A 5vceA-6ercA:
undetectable
5vceA-6ercA:
10.53