SIMILAR PATTERNS OF AMINO ACIDS FOR 5VCE_A_RITA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b48 PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 PHE A 147
ILE A 188
ILE A 194
ALA A  24
ALA A  76
 None
 0.96A 5vceA-1b48A:
undetectable		 5vceA-1b48A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		5 ILE A 325
ALA A 329
THR A 333
ILE A 339
ALA A 254
 None
 1.00A 5vceA-1jpuA:
undetectable		 5vceA-1jpuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 PHE A 344
ILE A 256
PHE A 279
ALA A 296
GLU A 360
 None
 0.96A 5vceA-1kywA:
undetectable		 5vceA-1kywA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 PHE A  74
ILE A 324
ALA A 282
ILE A 256
GLU A 173
 None
 1.12A 5vceA-1l8wA:
0.0		 5vceA-1l8wA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 375
ALA A 246
THR A 243
ALA A 183
GLU A 180
 None
 1.06A 5vceA-1qlbA:
undetectable		 5vceA-1qlbA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		5 PHE A 290
ILE A 242
PHE A 185
ALA A 186
ILE A 252
 None
 1.03A 5vceA-1qvbA:
0.0		 5vceA-1qvbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 PHE A 175
ILE A 179
PHE A 199
ALA A 241
GLU A 163
 None
None
None
PG4  A4502 (-4.3A)
None
 1.12A 5vceA-1uedA:
9.7		 5vceA-1uedA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5k MICROTUBULE-ASSOCIAT
ED PROTEIN, RP/EB
FAMILY, MEMBER 1

(Mus musculus) 		PF00307
(CH) 		5 PHE A  75
ILE A  84
PHE A 104
ALA A  35
ALA A  50
 None
 1.07A 5vceA-1v5kA:
undetectable		 5vceA-1v5kA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 ILE C 472
PHE C 357
ALA C 516
THR C 519
ILE C 482
 None
 1.04A 5vceA-1wa5C:
0.0		 5vceA-1wa5C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 ALA A 172
THR A 173
ILE A 137
ALA A 136
GLU A 112
 None
 1.10A 5vceA-1ydfA:
0.0		 5vceA-1ydfA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		5 PHE A 611
ILE A 555
PHE A 747
ALA A 748
ILE A 569
 None
 1.05A 5vceA-1z26A:
undetectable		 5vceA-1z26A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ILE A 194
ILE A 230
ALA A 245
ALA A 338
GLU A 341
 None
 1.01A 5vceA-2akjA:
undetectable		 5vceA-2akjA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 PHE A 255
ILE A 230
ALA A 245
ALA A 338
GLU A 341
 None
 1.07A 5vceA-2akjA:
undetectable		 5vceA-2akjA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b30 PVIVAX HYPOTHETICAL
PROTEIN

(Plasmodium
vivax) 		PF08282
(Hydrolase_3) 		5 PHE A  34
ILE A  66
PHE A  79
ALA A  53
ALA A 288
 None
 1.11A 5vceA-2b30A:
undetectable		 5vceA-2b30A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ILE A 703
ALA A 652
THR A 636
ILE A 626
ALA A 625
 None
 0.92A 5vceA-2bucA:
undetectable		 5vceA-2bucA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A 297
THR A 308
ILE A 307
ALA A 247
GLU A 245
 None
 0.91A 5vceA-2dzdA:
undetectable		 5vceA-2dzdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 PHE A 366
PHE A 336
ALA A 337
ILE A 382
ALA A   9
 None
 0.96A 5vceA-2fa0A:
undetectable		 5vceA-2fa0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ILE A 703
ALA A 652
THR A 636
ILE A 626
ALA A 625
 None
 0.89A 5vceA-2g5tA:
undetectable		 5vceA-2g5tA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		5 PHE A  11
ILE A  60
ILE A  64
ILE A   4
GLU A  76
 None
None
None
None
DND  A 998 ( 4.6A)
 1.13A 5vceA-2h29A:
undetectable		 5vceA-2h29A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j28 50S RIBOSOMAL
PROTEIN L2

(Escherichia
coli) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		5 ILE C  90
ALA C 105
ILE C 115
ALA C  75
GLU C  99
 None
None
None
None
G  B1491 ( 3.5A)
 0.99A 5vceA-2j28C:
undetectable		 5vceA-2j28C:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		5 PHE A 402
ALA A 193
THR A 196
ILE A 199
GLU A 122
 NAI  A1501 (-3.9A)
NAI  A1501 (-4.3A)
None
None
None
 1.12A 5vceA-2j6lA:
undetectable		 5vceA-2j6lA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		6 PHE A 228
ILE A 289
PHE A 296
ALA A 297
THR A 330
ILE A 329
 None
 1.46A 5vceA-2jirA:
undetectable		 5vceA-2jirA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ILE A 704
ALA A 653
THR A 637
ILE A 627
ALA A 626
 None
 0.90A 5vceA-2oaeA:
undetectable		 5vceA-2oaeA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 SER A  76
ILE A 117
ALA A   9
THR A  39
ALA A  66
 None
 1.13A 5vceA-2pwzA:
undetectable		 5vceA-2pwzA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqx METALLOPROTEINASE

(Serratia
proteamaculans) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
PF16485
(PLN_propep) 		5 PHE A 311
ALA A 312
THR A 315
ILE A 292
ALA A 289
 None
 0.85A 5vceA-2vqxA:
undetectable		 5vceA-2vqxA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		5 ILE A 541
ILE A 539
ALA A 251
THR A 255
ILE A 229
 None
 1.10A 5vceA-2ww8A:
undetectable		 5vceA-2ww8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 ILE A  44
ALA A  77
ILE A  56
ALA A  55
GLU A  49
 None
 1.05A 5vceA-2wzfA:
undetectable		 5vceA-2wzfA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 ILE A  44
ALA A  77
ILE A  56
ALA A  55
GLU A  49
 None
 0.92A 5vceA-2wzgA:
undetectable		 5vceA-2wzgA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		5 ILE A  65
ILE A  20
ALA A  82
ALA A 369
GLU A  29
 None
 1.13A 5vceA-2ychA:
undetectable		 5vceA-2ychA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli) 		PF00595
(PDZ)
PF13365
(Trypsin_2) 		5 ILE A 104
ILE A 102
ALA A 100
ILE A 179
ALA A 168
 None
 1.13A 5vceA-2zleA:
undetectable		 5vceA-2zleA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayn RHODOPSIN

(Todarodes
pacificus) 		PF00001
(7tm_1) 		5 SER A 263
ILE A 266
ILE A 129
ALA A  69
THR A  67
 None
 1.04A 5vceA-3aynA:
undetectable		 5vceA-3aynA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens) 		PF01522
(Polysacc_deac_1) 		5 ILE A 276
PHE A 275
ALA A 279
ILE A  27
ALA A  28
 None
 1.01A 5vceA-3cl6A:
undetectable		 5vceA-3cl6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzb PREPHENATE
DEHYDROGENASE

(Streptococcus
thermophilus) 		PF02153
(PDH) 		5 ILE A  22
ILE A  68
ALA A  97
ALA A 126
GLU A 142
 None
 1.02A 5vceA-3dzbA:
undetectable		 5vceA-3dzbA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5d PUTATIVE GLYOXALASE
I

(Listeria
monocytogenes) 		PF00903
(Glyoxalase) 		5 ILE A  74
ILE A  76
THR A  88
ILE A  98
ALA A  99
 None
 1.09A 5vceA-3e5dA:
undetectable		 5vceA-3e5dA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6g ALPHA-ISOPROPYLMALAT
E SYNTHASE

(Leptospira
interrogans) 		no annotation 6 ILE B 448
ALA B 499
THR B 496
ILE B 399
ALA B 409
GLU B 422
 None
 1.47A 5vceA-3f6gB:
undetectable		 5vceA-3f6gB:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1

(Schizosaccharomyces
pombe) 		PF04857
(CAF1) 		5 PHE A 109
ILE A  84
ALA A 241
THR A 104
ILE A  22
 None
 1.11A 5vceA-3g10A:
undetectable		 5vceA-3g10A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g40 NA-K-CL
COTRANSPORTER

(Methanosarcina
acetivorans) 		no annotation 5 ILE A 631
ILE A 722
ALA A 748
ILE A 585
ALA A 494
 None
 1.13A 5vceA-3g40A:
undetectable		 5vceA-3g40A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)

(Clostridium
acetobutylicum) 		PF13377
(Peripla_BP_3) 		5 ILE A 307
ILE A 127
PHE A 151
ALA A 129
ILE A  80
 None
 1.09A 5vceA-3g85A:
undetectable		 5vceA-3g85A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A 293
THR A 304
ILE A 303
ALA A 243
GLU A 241
 None
 0.95A 5vceA-3g8dA:
undetectable		 5vceA-3g8dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvn HEMOLYSIN

(Streptococcus
suis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 PHE A  37
ILE A 256
PHE A 242
ILE A 117
ALA A 370
 None
 0.84A 5vceA-3hvnA:
undetectable		 5vceA-3hvnA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3li9 HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE

(Methanosarcina
mazei) 		PF02743
(dCache_1) 		5 SER A 291
ILE A 259
ALA A  51
ILE A 212
ALA A 209
 None
 1.02A 5vceA-3li9A:
undetectable		 5vceA-3li9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 PHE A 604
ILE A 472
ILE A 457
ALA A 459
GLU A 432
 None
 1.03A 5vceA-3lk6A:
undetectable		 5vceA-3lk6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne2 PROBABLE AQUAPORIN
AQPM

(Archaeoglobus
fulgidus) 		PF00230
(MIP) 		5 PHE A 109
ILE A 105
ILE A  88
ALA A 233
THR A 155
 None
 1.08A 5vceA-3ne2A:
undetectable		 5vceA-3ne2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2

(Helicobacter
mustelae) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE C 401
PHE C 441
ILE C 405
ALA C 129
ILE C  85
 None
 1.11A 5vceA-3qgkC:
undetectable		 5vceA-3qgkC:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT

(Legionella
pneumophila) 		PF01596
(Methyltransf_3) 		5 PHE A 137
ILE A  89
ALA A 144
ILE A 168
ALA A 167
 None
 1.07A 5vceA-3r3hA:
undetectable		 5vceA-3r3hA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K

(Escherichia
coli) 		no annotation 5 SER J  40
ILE J  56
ALA J  12
THR J  16
ILE K  37
 None
 1.01A 5vceA-3rkoJ:
undetectable		 5vceA-3rkoJ:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II

(Bacillus
anthracis) 		PF00155
(Aminotran_1_2) 		5 ILE A  85
ALA A  94
THR A  97
ALA A 252
GLU A 247
 None
 1.10A 5vceA-3t32A:
undetectable		 5vceA-3t32A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7c CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 ILE A 143
ILE A 152
ALA A 102
THR A  13
ILE A  37
 None
 0.93A 5vceA-3t7cA:
undetectable		 5vceA-3t7cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Francisella
tularensis) 		PF01380
(SIS) 		5 ILE A 481
PHE A 407
ALA A 415
THR A 418
ILE A 316
 None
 1.09A 5vceA-3tbfA:
undetectable		 5vceA-3tbfA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 363
ALA A 422
ILE A 282
ALA A 242
GLU A 166
 None
None
None
None
MG  A 430 ( 4.7A)
 1.11A 5vceA-3tqpA:
2.1		 5vceA-3tqpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 PHE A  22
ALA A 292
THR A 298
ALA A 323
GLU A 339
 None
 1.12A 5vceA-3vomA:
undetectable		 5vceA-3vomA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		5 PHE A 118
ILE A 126
ALA A 130
THR A 133
GLU A   3
 None
 1.04A 5vceA-3vvlA:
undetectable		 5vceA-3vvlA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 PHE A 619
ILE A 750
PHE A 727
ALA A 644
ILE A 349
 None
 0.94A 5vceA-3welA:
undetectable		 5vceA-3welA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 ILE A 357
ILE A 487
ALA A 489
ILE A 570
ALA A 367
 None
 1.08A 5vceA-3zukA:
undetectable		 5vceA-3zukA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dna PROBABLE GLUTATHIONE
REDUCTASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A  11
PHE A 324
ALA A 321
ALA A  25
GLU A 109
 FAD  A 500 (-4.8A)
None
None
None
None
 1.12A 5vceA-4dnaA:
undetectable		 5vceA-4dnaA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 PHE A 191
ILE A 189
PHE A 203
ALA A 158
GLU A 171
 None
 1.06A 5vceA-4fdwA:
undetectable		 5vceA-4fdwA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgs PROBABLE
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 ILE A 176
ILE A 174
ALA A 128
ILE A   9
ALA A  10
 None
 1.11A 5vceA-4fgsA:
undetectable		 5vceA-4fgsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		5 PHE A 279
ILE A 269
ILE A 266
ILE A 415
ALA A 401
 None
 1.13A 5vceA-4h7nA:
undetectable		 5vceA-4h7nA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkt INOSITOL
2-DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 PHE A   5
PHE A 290
ILE A  89
THR A  70
ALA A  33
 None
 1.06A 5vceA-4hktA:
undetectable		 5vceA-4hktA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		5 SER A 436
ILE A 417
ALA A 419
ALA A 426
GLU A 433
 None
 1.03A 5vceA-4hwvA:
undetectable		 5vceA-4hwvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 123
SER A 116
ILE A 115
PHE A 224
ALA A 138
 None
BHF  A 602 (-3.2A)
BHF  A 602 (-4.7A)
BHF  A 602 (-3.3A)
None
 1.13A 5vceA-4i8vA:
31.3		 5vceA-4i8vA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij4 CHITINASE A

(Gemmabryum
coronatum) 		PF00182
(Glyco_hydro_19) 		5 PHE A  12
ILE A  58
ALA A 136
THR A 135
ALA A 126
 None
 1.10A 5vceA-4ij4A:
0.4		 5vceA-4ij4A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 5 ILE A 341
ILE A 421
ALA A 406
ILE A  23
ALA A 385
 None
None
ACT  A 826 (-4.3A)
None
None
 1.06A 5vceA-4lgnA:
undetectable		 5vceA-4lgnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		5 ILE A 171
PHE A 189
ILE A 175
ILE A 284
ALA A 283
 None
 1.01A 5vceA-4mr0A:
undetectable		 5vceA-4mr0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A 293
THR A 304
ILE A 303
ALA A 243
GLU A 241
 None
 0.95A 5vceA-4mv3A:
undetectable		 5vceA-4mv3A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Anaerococcus
prevotii) 		PF03480
(DctP) 		5 PHE A 115
ILE A 328
PHE A 109
ILE A 130
GLU A 119
 None
 1.11A 5vceA-4n91A:
0.0		 5vceA-4n91A:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		10 PHE A 108
SER A 119
ILE A 120
PHE A 241
ILE A 301
ALA A 305
THR A 309
ILE A 369
ALA A 370
GLU A 374
 2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
2QH  A 602 (-4.5A)
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
HEM  A 601 (-4.7A)
2QH  A 602 ( 3.1A)
2QH  A 602 ( 4.8A)
 0.61A 5vceA-4ny4A:
57.8		 5vceA-4ny4A:
98.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		7 SER A 119
ILE A 120
ARG A 212
PHE A 241
ILE A 301
THR A 309
ILE A 369
 2QH  A 602 (-3.9A)
None
2QH  A 602 (-4.0A)
2QH  A 602 (-4.5A)
None
2QH  A 602 ( 3.7A)
HEM  A 601 (-4.7A)
 1.24A 5vceA-4ny4A:
57.8		 5vceA-4ny4A:
98.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		5 ILE A 100
ILE A 124
ALA A 161
ILE A 194
GLU A 231
 None
 1.13A 5vceA-4ov4A:
undetectable		 5vceA-4ov4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po5 ALLOPHYCOCYANIN
SUBUNIT ALPHA-B

(Synechocystis
sp. PCC 6803) 		PF00502
(Phycobilisome) 		5 ILE A 156
PHE A 153
THR A 149
ILE A  39
ALA A  40
 None
 1.08A 5vceA-4po5A:
2.3		 5vceA-4po5A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 ILE A 111
PHE A  26
ILE A  61
ALA A  22
ALA A 156
 None
None
None
None
EDO  A 505 ( 4.9A)
 0.99A 5vceA-4pv4A:
undetectable		 5vceA-4pv4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		5 PHE A 399
ALA A 191
THR A 194
ILE A 197
GLU A 120
 NAD  A 601 (-3.9A)
NAD  A 601 (-4.2A)
None
None
None
 1.07A 5vceA-4pxnA:
undetectable		 5vceA-4pxnA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3k MGS-M1

(unidentified) 		PF00326
(Peptidase_S9)
PF07859
(Abhydrolase_3) 		5 ILE A 110
ALA A 123
THR A 158
ILE A 189
GLU A 192
 None
 1.07A 5vceA-4q3kA:
undetectable		 5vceA-4q3kA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tjv VACUOLAR-SORTING
RECEPTOR 1

(Arabidopsis
thaliana) 		PF02225
(PA) 		5 ILE A 159
ILE A 151
ALA A 149
ILE A 146
ALA A 113
 None
 0.99A 5vceA-4tjvA:
undetectable		 5vceA-4tjvA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ILE A 304
PHE A 273
ILE A 302
THR A 264
ALA A 356
 None
 1.10A 5vceA-4tr6A:
undetectable		 5vceA-4tr6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A  83
ILE A 227
ALA A 255
ILE A 264
ALA A 267
 None
 1.08A 5vceA-4yzoA:
0.2		 5vceA-4yzoA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5s ALDEHYDE
DECARBONYLASE

(Synechocystis
sp. PCC 6803) 		PF11266
(Ald_deCOase) 		5 ILE A 109
PHE A 117
ALA A 118
ILE A  27
ALA A  83
 None
 1.09A 5vceA-4z5sA:
undetectable		 5vceA-4z5sA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7s CYSTEINE DESULFURASE

(Thermococcus
onnurineus) 		PF00266
(Aminotran_5) 		5 PHE A  82
ILE A  80
ILE A  73
ALA A 195
GLU A  88
 None
 1.03A 5vceA-5b7sA:
undetectable		 5vceA-5b7sA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep5 THIOESTERASE

(Staphylococcus
aureus) 		PF03061
(4HBT) 		5 ILE A  90
ALA A  72
THR A 112
ILE A 103
ALA A  85
 None
 1.08A 5vceA-5ep5A:
undetectable		 5vceA-5ep5A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0k UNCHARACTERIZED
PROTEIN

(Pedobacter
heparinus) 		PF16265
(DUF4918) 		5 ILE A 103
PHE A 116
ILE A 122
ILE A 200
ALA A 202
 None
 1.07A 5vceA-5h0kA:
undetectable		 5vceA-5h0kA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0k UNCHARACTERIZED
PROTEIN

(Pedobacter
heparinus) 		PF16265
(DUF4918) 		5 ILE A 103
PHE A 116
ILE A 122
ILE A 200
GLU A 204
 None
 0.94A 5vceA-5h0kA:
undetectable		 5vceA-5h0kA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17

(Sphingomonas
sp. PAMC 26605) 		PF00067
(p450) 		5 ILE A  79
ALA A  76
THR A  74
ILE A  73
ALA A  93
 None
None
D12  A 502 (-3.5A)
None
None
 0.97A 5vceA-5h1zA:
28.0		 5vceA-5h1zA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 ILE A 542
ILE A 534
ALA A 340
ILE A 328
ALA A 329
 None
 1.10A 5vceA-5h3kA:
undetectable		 5vceA-5h3kA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC

(Zea mays) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		6 SER A 302
PHE A 209
ALA A 210
THR A 213
ILE A 344
GLU A 394
 None
 1.49A 5vceA-5h8yA:
undetectable		 5vceA-5h8yA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		5 ILE A 109
PHE A 117
ALA A 118
ILE A  27
ALA A  83
 None
OCD  A 500 (-3.9A)
OCD  A 500 (-3.6A)
OCD  A 500 ( 4.6A)
None
 1.12A 5vceA-5k52A:
undetectable		 5vceA-5k52A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf2 PREDICTED
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00583
(Acetyltransf_1) 		5 PHE A 136
ILE A  78
ALA A 100
ILE A   3
ALA A  47
 None
 1.13A 5vceA-5kf2A:
undetectable		 5vceA-5kf2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 ILE A1472
ILE A1398
PHE A1452
ILE A1498
ALA A1499
 None
 1.03A 5vceA-5m5pA:
undetectable		 5vceA-5m5pA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A  29
ILE A  35
ALA A  11
ILE A  15
ALA A 246
 None
None
None
NAD  A 334 (-3.4A)
None
 1.11A 5vceA-5mdhA:
undetectable		 5vceA-5mdhA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 5 SER A  50
ILE A 122
THR A 777
ILE A 790
ALA A  44
 PO4  A1002 (-4.4A)
None
None
None
None
 1.12A 5vceA-5mz9A:
undetectable		 5vceA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 SER A 454
ILE A 453
ILE A 319
ILE A 476
GLU A 471
 None
 1.05A 5vceA-5uv2A:
undetectable		 5vceA-5uv2A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 ILE A 557
PHE A 569
ALA A 600
ILE A 617
GLU A 582
 None
 0.95A 5vceA-5ve8A:
undetectable		 5vceA-5ve8A:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 7 SER A 119
PHE A 241
ILE A 301
PHE A 304
ALA A 305
THR A 309
ALA A 370
 RIT  A 602 (-3.7A)
RIT  A 602 (-3.9A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.74A 5vceA-5veuA:
53.9		 5vceA-5veuA:
82.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 5 PHE G 176
PHE G 159
ILE G 307
ALA G 316
ALA G 204
 None
 1.07A 5vceA-5wduG:
undetectable		 5vceA-5wduG:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		5 SER A 288
ILE A 293
ALA A 355
ILE A 256
ALA A 252
 None
 1.05A 5vceA-5xn8A:
undetectable		 5vceA-5xn8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 5 PHE B 272
SER B 229
ILE B 547
ARG B 533
GLU B 269
 None
 1.12A 5vceA-5y31B:
undetectable		 5vceA-5y31B:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y33 ALGINATE LYASE

(Flavobacterium
sp. UMI-01) 		no annotation 5 ILE A 104
ILE A 120
ALA A 236
ILE A   6
ALA A   4
 None
 1.07A 5vceA-5y33A:
undetectable		 5vceA-5y33A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 PHE B 195
ILE B 191
ILE B 217
ALA B  70
ILE B 213
 None
None
None
FAD  B 401 ( 4.0A)
FAD  B 401 (-3.5A)
 1.08A 5vceA-5y6qB:
undetectable		 5vceA-5y6qB:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ

(Pyrococcus
furiosus) 		no annotation 5 ILE L  70
ILE J  40
ALA J  44
THR J  47
ALA L 134
 NFU  L 401 ( 4.8A)
None
None
None
None
 0.95A 5vceA-6cfwL:
undetectable		 5vceA-6cfwL:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F

(Pyrococcus
furiosus) 		no annotation 5 PHE F  23
ILE B  62
ILE B  58
ALA B  55
ALA A  19
 None
 1.07A 5vceA-6cfwF:
undetectable		 5vceA-6cfwF:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 5 PHE A  92
PHE A 323
ILE A 478
ILE A 170
GLU A 289
 None
HEM  A 604 ( 3.9A)
None
None
None
 1.05A 5vceA-6ercA:
undetectable		 5vceA-6ercA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		4 ARG A 223
PHE B 145
ILE B 149
THR B 265
 None
 1.13A 5vceA-1abrA:
0.0		 5vceA-1abrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b24 PROTEIN (I-DMOI)

(Desulfurococcus
mucosus) 		PF14528
(LAGLIDADG_3) 		4 ARG A 140
PHE A 109
ILE A 177
THR A 176
 None
 1.12A 5vceA-1b24A:
0.4		 5vceA-1b24A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b47 CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		4 ARG A 256
PHE A 248
ILE A 228
THR A 227
 None
 1.11A 5vceA-1b47A:
0.3		 5vceA-1b47A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		4 ARG A  61
PHE A  47
ILE A 290
THR A  56
 None
 1.02A 5vceA-1dy6A:
0.0		 5vceA-1dy6A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1glv GLUTATHIONE SYNTHASE

(Escherichia
coli) 		PF02951
(GSH-S_N)
PF02955
(GSH-S_ATP) 		4 ARG A 291
PHE A 297
ILE A 301
THR A 302
 None
 1.17A 5vceA-1glvA:
0.0		 5vceA-1glvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4r MERLIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ARG A 200
PHE A 162
ILE A 188
THR A 189
 None
 1.02A 5vceA-1h4rA:
0.0		 5vceA-1h4rA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 ARG A 319
PHE A 311
ILE A 300
THR A 302
 None
 0.99A 5vceA-1kl7A:
0.0		 5vceA-1kl7A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ARG A 161
PHE A 296
PHE A 298
THR A 139
 None
FAD  A 500 (-4.7A)
None
None
 1.09A 5vceA-1np7A:
0.0		 5vceA-1np7A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		4 PHE A 150
PHE A 151
ILE A 144
THR A 143
 None
 1.08A 5vceA-1o9jA:
undetectable		 5vceA-1o9jA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ARG A 588
PHE A 542
ILE A 452
THR A 455
 None
 1.06A 5vceA-1pl0A:
undetectable		 5vceA-1pl0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqg INSULIN RECEPTOR
SUBSTRATE 1

(Homo sapiens) 		PF00169
(PH)
PF02174
(IRS) 		4 ARG A 213
PHE A 236
PHE A 222
ILE A 253
 None
 1.10A 5vceA-1qqgA:
undetectable		 5vceA-1qqgA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		4 PHE A 470
PHE A 465
ILE A 693
THR A 690
 None
 1.14A 5vceA-1w8jA:
undetectable		 5vceA-1w8jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0p HYPOTHETICAL PROTEIN
TLL0078

(Thermosynechococcus
elongatus) 		PF04940
(BLUF) 		4 ARG A 105
PHE A 232
PHE A 230
THR A 187
 None
 1.09A 5vceA-1x0pA:
undetectable		 5vceA-1x0pA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus) 		PF00909
(Ammonium_transp) 		4 PHE A 202
PHE A 204
ILE A 260
THR A 261
 None
 1.10A 5vceA-2b2iA:
0.2		 5vceA-2b2iA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 ARG A 348
PHE A 337
PHE A 350
ILE A 363
 None
 1.10A 5vceA-2c11A:
undetectable		 5vceA-2c11A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb4 MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		no annotation 4 ARG A  76
PHE A 140
PHE A 200
ILE A  41
 None
 1.11A 5vceA-2cb4A:
undetectable		 5vceA-2cb4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 ARG A  79
PHE A  86
ILE A  29
THR A  28
 None
 0.92A 5vceA-2ct8A:
undetectable		 5vceA-2ct8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwo RNA SILENCING
SUPPRESSOR

(Beet yellows
virus) 		PF11479
(Suppressor_P21) 		4 ARG A 130
PHE A 109
ILE A 116
THR A 117
 None
 0.83A 5vceA-2cwoA:
undetectable		 5vceA-2cwoA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czq CUTINASE-LIKE
PROTEIN

(Cryptococcus
sp. S-2) 		PF01083
(Cutinase) 		4 ARG A  65
ARG A  66
ILE A  43
THR A  42
 None
CIT  A 501 (-3.7A)
None
CIT  A 501 (-3.3A)
 1.11A 5vceA-2czqA:
undetectable		 5vceA-2czqA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B

(Rattus
norvegicus) 		no annotation 4 ARG B 388
PHE B 399
ILE B 348
THR B 349
 None
 1.13A 5vceA-2dwzB:
undetectable		 5vceA-2dwzB:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5i HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN
L-LIKE

(Mus musculus) 		PF00076
(RRM_1) 		4 ARG A 246
PHE A 250
ILE A 229
THR A 230
 None
 1.10A 5vceA-2e5iA:
undetectable		 5vceA-2e5iA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efo 150AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR

(Sulfurisphaera
tokodaii) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		4 ARG A 112
PHE A 119
ILE A  66
THR A  67
 None
 1.09A 5vceA-2efoA:
undetectable		 5vceA-2efoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eia EIAV CAPSID PROTEIN
P26

(Equine
infectious
anemia virus) 		PF00607
(Gag_p24) 		4 ARG A  18
PHE A  41
ILE A  27
THR A  26
 None
 1.08A 5vceA-2eiaA:
undetectable		 5vceA-2eiaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6e TOXIN A

(Clostridioides
difficile) 		no annotation 4 ARG A  26
PHE A  23
PHE A  35
ILE A  32
 None
 1.16A 5vceA-2f6eA:
undetectable		 5vceA-2f6eA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he3 GLUTATHIONE
PEROXIDASE 2

(Homo sapiens) 		PF00255
(GSHPx) 		4 ARG A 168
ARG A 167
PHE A 166
ILE A 182
 None
 0.88A 5vceA-2he3A:
undetectable		 5vceA-2he3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ARG A 589
PHE A 543
ILE A 453
THR A 456
 None
 1.08A 5vceA-2iu3A:
undetectable		 5vceA-2iu3A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4d CRYPTOCHROME DASH

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ARG A 198
PHE A 332
PHE A 334
THR A 176
 None
FAD  A1498 ( 4.8A)
None
None
 1.13A 5vceA-2j4dA:
undetectable		 5vceA-2j4dA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		4 PHE A 101
PHE A 140
ILE A 143
THR A 144
 None
 1.04A 5vceA-2q01A:
undetectable		 5vceA-2q01A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 ARG A 314
PHE A 212
ILE A  32
THR A  28
 CL  A 601 (-3.6A)
None
None
None
 1.04A 5vceA-2r7mA:
undetectable		 5vceA-2r7mA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ARG G1555
PHE G1300
ILE G1292
THR G1293
 None
 0.96A 5vceA-2uv8G:
undetectable		 5vceA-2uv8G:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2u GAMMA CRYSTALLIN C

(Mus musculus) 		PF00030
(Crystall) 		4 ARG A  36
PHE A   6
ILE A   3
THR A   4
 None
 1.15A 5vceA-2v2uA:
undetectable		 5vceA-2v2uA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00155
(Aminotran_1_2) 		4 ARG A 307
ARG A 306
PHE A 374
ILE A  39
 None
SO4  A1401 (-4.0A)
None
None
 1.10A 5vceA-2x5dA:
undetectable		 5vceA-2x5dA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 ARG A1044
PHE B 671
PHE B 673
ILE B 640
 None
 1.06A 5vceA-2y3aA:
undetectable		 5vceA-2y3aA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 ARG A  33
PHE A 225
PHE A 223
THR A 128
 None
None
None
HEM  A 350 (-3.1A)
 1.16A 5vceA-2yp1A:
undetectable		 5vceA-2yp1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 ARG A 169
PHE A 185
PHE A 238
THR A 202
 None
 1.13A 5vceA-2zuyA:
undetectable		 5vceA-2zuyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzj GLUCURONAN LYASE A

(Trichoderma
reesei) 		PF14099
(Polysacc_lyase) 		4 ARG A  60
PHE A 193
PHE A 195
ILE A 158
 None
 1.17A 5vceA-2zzjA:
undetectable		 5vceA-2zzjA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		4 ARG A 584
PHE A 501
ILE A 508
THR A 509
 None
 1.13A 5vceA-3axiA:
undetectable		 5vceA-3axiA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bd9 HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
5

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 ARG A 188
PHE A 331
ILE A 338
THR A 339
 None
 0.99A 5vceA-3bd9A:
undetectable		 5vceA-3bd9A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dul O-METHYLTRANSFERASE,
PUTATIVE

(Bacillus cereus) 		PF01596
(Methyltransf_3) 		4 ARG A  60
ARG A  85
PHE A 136
PHE A 134
 None
 0.79A 5vceA-3dulA:
undetectable		 5vceA-3dulA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 ARG A 156
PHE A 158
ILE A 187
THR A 145
 None
None
None
DPM  A 400 ( 4.8A)
 1.02A 5vceA-3eq1A:
undetectable		 5vceA-3eq1A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7q VALINE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		4 PHE A 114
PHE A 117
ILE A 270
THR A 266
 None
 1.11A 5vceA-3g7qA:
undetectable		 5vceA-3g7qA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq2 SORTING NEXIN-7

(Homo sapiens) 		PF00787
(PX) 		4 ARG A 117
ARG A 118
PHE A 124
ILE A  34
 SO4  A   2 ( 4.7A)
SO4  A   8 (-3.0A)
None
None
 1.04A 5vceA-3iq2A:
undetectable		 5vceA-3iq2A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 ARG A 927
PHE A 921
ILE A 954
THR A 955
 None
 0.92A 5vceA-3nzuA:
undetectable		 5vceA-3nzuA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 ARG A 392
PHE A 259
ILE A 342
THR A 343
 None
 0.90A 5vceA-3ojyA:
undetectable		 5vceA-3ojyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		4 ARG A 373
ARG A 375
PHE A 245
ILE A 283
 None
 1.04A 5vceA-3oksA:
undetectable		 5vceA-3oksA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 PHE A  10
PHE A   8
ILE A 222
THR A 223
 None
 0.92A 5vceA-3q9tA:
undetectable		 5vceA-3q9tA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 249
PHE A 266
ILE A 263
THR A 264
 None
 1.11A 5vceA-3sunA:
undetectable		 5vceA-3sunA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 ARG B 266
PHE B 247
PHE B 243
THR B 274
 None
 0.91A 5vceA-3t5vB:
undetectable		 5vceA-3t5vB:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ud2 ANKYRIN-1

(Homo sapiens) 		no annotation 4 ARG C1010
PHE C1063
ILE C1055
THR C1056
 None
 1.14A 5vceA-3ud2C:
undetectable		 5vceA-3ud2C:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vib MTRR

(Neisseria
gonorrhoeae) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 ARG A 208
PHE A 165
ILE A 140
THR A 141
 None
 1.03A 5vceA-3vibA:
undetectable		 5vceA-3vibA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13

(Homo sapiens) 		PF00090
(TSP_1) 		4 ARG A 660
ARG A 659
ILE A 673
THR A 563
 None
 1.01A 5vceA-3vn4A:
undetectable		 5vceA-3vn4A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		4 ARG A 133
PHE A 407
ILE A 379
THR A 378
 None
None
TYQ  A 382 ( 4.9A)
TYQ  A 382 ( 4.0A)
 1.04A 5vceA-3x3yA:
undetectable		 5vceA-3x3yA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9f CELLULOSOMAL-SCAFFOL
DING PROTEIN A

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 ARG A  40
PHE A  78
ILE A  94
THR A  38
 None
 1.00A 5vceA-4b9fA:
undetectable		 5vceA-4b9fA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		4 ARG B 142
PHE B 230
ILE B 171
THR B 168
 None
 0.98A 5vceA-4ckeB:
undetectable		 5vceA-4ckeB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqw CBS
DOMAIN-CONTAINING
PROTEIN CBSX1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00571
(CBS) 		4 ARG A 107
PHE A 111
ILE A 215
THR A  82
 None
 1.16A 5vceA-4gqwA:
undetectable		 5vceA-4gqwA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ARG C 327
PHE C 318
ILE C 286
THR C 282
 None
 1.04A 5vceA-4hb4C:
undetectable		 5vceA-4hb4C:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ARG A 517
PHE A 525
PHE A 527
ILE A 626
 None
 1.08A 5vceA-4hwtA:
undetectable		 5vceA-4hwtA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 4 ARG B 317
PHE B 325
PHE B 323
THR B 264
 None
 1.08A 5vceA-4iu9B:
undetectable		 5vceA-4iu9B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ARG A 275
PHE A 193
ILE A 164
THR A 163
 None
 1.04A 5vceA-4iv5A:
undetectable		 5vceA-4iv5A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		4 ARG A 278
ARG A 279
ILE A  86
THR A  85
 None
 1.13A 5vceA-4j7hA:
undetectable		 5vceA-4j7hA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo5 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 ARG A  57
PHE A  95
ILE A 111
THR A  55
 CL  A 205 (-3.2A)
None
None
None
 1.00A 5vceA-4jo5A:
undetectable		 5vceA-4jo5A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw7 ARSENIC
METHYLTRANSFERASE

(Cyanidioschyzon
sp. 5508) 		PF13847
(Methyltransf_31) 		4 ARG A 308
ARG A 276
PHE A 304
ILE A 328
 None
 1.06A 5vceA-4kw7A:
undetectable		 5vceA-4kw7A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw7 ARSENIC
METHYLTRANSFERASE

(Cyanidioschyzon
sp. 5508) 		PF13847
(Methyltransf_31) 		4 ARG A 308
PHE A 310
PHE A 304
ILE A 327
 None
 1.15A 5vceA-4kw7A:
undetectable		 5vceA-4kw7A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n80 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 306
PHE A 292
ILE A 114
THR A 110
 None
 1.16A 5vceA-4n80A:
undetectable		 5vceA-4n80A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 PHE A 367
PHE A 365
ILE A 433
THR A 431
 None
None
None
C8E  A 702 ( 4.6A)
 1.15A 5vceA-4nreA:
undetectable		 5vceA-4nreA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwb MRNA TURNOVER
PROTEIN 4

(Chaetomium
thermophilum) 		PF00466
(Ribosomal_L10) 		4 ARG A  25
PHE A  66
ILE A  34
THR A  33
 None
 1.07A 5vceA-4nwbA:
undetectable		 5vceA-4nwbA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 105
ARG A 106
PHE A 213
ILE A 223
THR A 224
 HEM  A 601 ( 2.8A)
None
2QH  A 602 (-4.2A)
None
None
 0.50A 5vceA-4ny4A:
57.8		 5vceA-4ny4A:
98.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qc6 BIFUNCTIONAL AAC/APH

(Staphylococcus
warneri) 		PF13523
(Acetyltransf_8) 		4 ARG A 128
PHE A 121
PHE A 123
ILE A  75
 None
 1.16A 5vceA-4qc6A:
undetectable		 5vceA-4qc6A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmf KRR1 SMALL SUBUNIT
PROCESSOME COMPONENT

(Saccharomyces
cerevisiae) 		no annotation 4 ARG D 142
ARG D 144
PHE D 131
ILE D 194
 None
 1.14A 5vceA-4qmfD:
undetectable		 5vceA-4qmfD:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 ARG A 808
PHE A 781
ILE A 704
THR A 702
 None
 1.08A 5vceA-4rt6A:
undetectable		 5vceA-4rt6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 ARG A 250
PHE A 245
ILE A 202
THR A 203
 None
 0.86A 5vceA-4xriA:
undetectable		 5vceA-4xriA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxk PHYCOBILIPROTEIN
APCE

(Nostoc sp. PCC
7120) 		PF00502
(Phycobilisome) 		4 ARG A  37
PHE A  34
ILE A  25
THR A  24
 None
 0.96A 5vceA-4xxkA:
undetectable		 5vceA-4xxkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 ARG A 127
ARG A 128
PHE A 134
ILE A 186
 None
 1.02A 5vceA-4yj1A:
undetectable		 5vceA-4yj1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		4 PHE A  39
PHE A  71
ILE A  80
THR A  79
 None
 1.14A 5vceA-4zi5A:
undetectable		 5vceA-4zi5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 ARG A 623
PHE A 628
ILE A 559
THR A 555
 None
 1.07A 5vceA-5a22A:
undetectable		 5vceA-5a22A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		4 PHE A 150
PHE A 151
ILE A 144
THR A 143
 None
 1.09A 5vceA-5abmA:
undetectable		 5vceA-5abmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B

(Mus musculus) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		4 ARG A 248
PHE A 240
ILE A 220
THR A 219
 None
 0.89A 5vceA-5axiA:
undetectable		 5vceA-5axiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1

(Homo sapiens) 		PF16213
(DCB) 		4 ARG A 129
PHE A  81
ILE A 134
THR A 133
 None
 1.14A 5vceA-5ee5A:
undetectable		 5vceA-5ee5A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgo CG1507-PB, ISOFORM B

(Drosophila
melanogaster) 		PF04845
(PurA) 		4 ARG A 197
PHE A 206
ILE A 232
THR A 233
 None
 1.04A 5vceA-5fgoA:
undetectable		 5vceA-5fgoA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fud O-ACETYL-ADP-RIBOSE
DEACETYLASE

(Oceanobacillus
iheyensis) 		PF01661
(Macro) 		4 ARG A  84
PHE A  79
ILE A  43
THR A  18
 None
 1.12A 5vceA-5fudA:
undetectable		 5vceA-5fudA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gv1 ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		4 ARG A 207
PHE A 204
ILE A 163
THR A 166
 None
 1.05A 5vceA-5gv1A:
undetectable		 5vceA-5gv1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyg ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		4 ARG A 207
PHE A 204
ILE A 163
THR A 166
 None
 1.12A 5vceA-5gygA:
undetectable		 5vceA-5gygA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6j PIERISIN-1

(Pieris rapae) 		no annotation 4 ARG A  49
PHE A 112
PHE A 168
ILE A  12
 None
 1.03A 5vceA-5h6jA:
undetectable		 5vceA-5h6jA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6n PIERISIN-1

(Pieris rapae) 		no annotation 4 ARG A  49
PHE A 112
PHE A 168
ILE A  12
 None
 1.13A 5vceA-5h6nA:
undetectable		 5vceA-5h6nA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		4 ARG A  40
PHE A 100
ILE A  97
THR A  98
 None
 1.04A 5vceA-5hkeA:
undetectable		 5vceA-5hkeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 ARG A 279
PHE A  27
ILE A  32
THR A  33
 None
 1.08A 5vceA-5jozA:
undetectable		 5vceA-5jozA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40)
PF00443
(UCH) 		4 ARG A 298
PHE C 262
ILE A 212
THR A 213
 None
 0.98A 5vceA-5k1cA:
undetectable		 5vceA-5k1cA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1

(Arabidopsis
thaliana) 		PF00400
(WD40) 		4 PHE A 400
PHE A 398
ILE A 377
THR A 388
 None
 1.08A 5vceA-5kwnA:
undetectable		 5vceA-5kwnA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 ARG b  66
PHE b  39
ILE b  71
THR b  70
 None
 1.08A 5vceA-5l9wb:
undetectable		 5vceA-5l9wb:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 ARG A  36
ARG A  91
ILE A 130
THR A 128
 None
 1.16A 5vceA-5ljoA:
undetectable		 5vceA-5ljoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		4 ARG A 215
ARG A 194
ILE A 250
THR A 251
 None
 1.08A 5vceA-5mulA:
undetectable		 5vceA-5mulA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 4 ARG A  26
ARG A  29
PHE A  57
ILE A  31
 None
 1.07A 5vceA-5o7gA:
undetectable		 5vceA-5o7gA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		4 ARG A 249
PHE A 317
ILE A 292
THR A 293
 None
 0.96A 5vceA-5wx1A:
undetectable		 5vceA-5wx1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US5

(Toxoplasma
gondii) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 ARG C 176
PHE C 218
ILE C 195
THR C 191
 U  21093 ( 3.3A)
None
None
U  2   5 ( 4.8A)
 1.14A 5vceA-5xxuC:
undetectable		 5vceA-5xxuC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT EXO84

(Saccharomyces
cerevisiae) 		no annotation 4 ARG H 636
PHE H 675
ILE H 668
THR H 667
 None
 1.16A 5vceA-5yfpH:
undetectable		 5vceA-5yfpH:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 4 ARG A 517
PHE A 484
ILE A 626
THR A 627
 None
 0.91A 5vceA-5yy3A:
undetectable		 5vceA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S4

(Leishmania
donovani) 		no annotation 4 ARG D 131
PHE D 157
ILE D 128
THR D 141
 U  1 577 ( 2.9A)
None
None
C  1 868 ( 3.7A)
 1.07A 5vceA-6az1D:
undetectable		 5vceA-6az1D:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 4 ARG A  55
PHE A  27
ILE A  36
THR A  59
 None
 1.15A 5vceA-6ci9A:
undetectable		 5vceA-6ci9A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 4 ARG A2008
ARG A2032
PHE A2023
ILE A2050
 None
 1.10A 5vceA-6fayA:
undetectable		 5vceA-6fayA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg9 -

(-) 		no annotation 4 ARG A 183
PHE A 207
PHE A 232
THR A 201
 None
 1.02A 5vceA-6fg9A:
undetectable		 5vceA-6fg9A:
undetectable