SIMILAR PATTERNS OF AMINO ACIDS FOR 5VC3_A_DB8A601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  70
LYS A  85
VAL A 110
ASN A 186
 None
 0.88A 5vc3A-1gngA:
24.5		 5vc3A-1gngA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 588
LYS A 608
VAL A 638
ASN A 729
 None
 0.89A 5vc3A-1lufA:
23.4		 5vc3A-1lufA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  78
LYS A  93
VAL A 118
ASN A 191
 STU  A 401 (-4.7A)
STU  A 401 ( 4.5A)
None
STU  A 401 (-4.5A)
 0.95A 5vc3A-1nxkA:
21.0		 5vc3A-1nxkA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 377
LYS A 391
VAL A 419
ASN A 487
 None
 1.22A 5vc3A-1snxA:
23.9		 5vc3A-1snxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 352
LYS A 369
VAL A 399
ASN A 466
 STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-4.2A)
 0.61A 5vc3A-1u59A:
24.5		 5vc3A-1u59A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 VAL A 259
LYS A 274
VAL A 307
ASN A 374
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
BI1  A1000 (-4.4A)
None
 0.85A 5vc3A-1zrzA:
25.2		 5vc3A-1zrzA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap9 ACETYLGLUTAMATE
KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		4 VAL A  68
LYS A  36
VAL A 159
ASN A 192
 None
 1.39A 5vc3A-2ap9A:
undetectable		 5vc3A-2ap9A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		4 VAL A  55
LYS A  58
VAL A 260
ASN A 304
 None
 1.31A 5vc3A-2cw6A:
undetectable		 5vc3A-2cw6A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz6 ENDOPLASMIC
RETICULUM TO NUCLEUS
SIGNALLING 1 ISOFORM
1 VARIANT

(Homo sapiens) 		PF13360
(PQQ_2) 		4 VAL A 240
LYS A 239
VAL A 226
ASN A 244
 None
 1.32A 5vc3A-2hz6A:
undetectable		 5vc3A-2hz6A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 VAL A 436
LYS A 454
VAL A 484
ASN A 551
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
None
None
 0.95A 5vc3A-2j0jA:
23.2		 5vc3A-2j0jA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  37
LYS A  52
VAL A  82
ASN A 149
 QPP  A1314 ( 4.6A)
None
None
None
 0.91A 5vc3A-2jc6A:
21.2		 5vc3A-2jc6A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL X  78
LYS X  93
VAL X 118
ASN X 191
 None
F10  X 401 (-4.3A)
None
None
 0.75A 5vc3A-2p3gX:
20.1		 5vc3A-2p3gX:
25.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 313
LYS A 328
VAL A 360
ASN A 431
 770  A 901 ( 4.7A)
770  A 901 (-4.6A)
770  A 901 ( 4.7A)
None
 0.34A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 647
LYS A 665
VAL A 695
ASN A 763
 IHZ  A1001 ( 4.4A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
 1.03A 5vc3A-3dkoA:
22.4		 5vc3A-3dkoA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		4 VAL A  34
LYS A  49
VAL A  77
ASN A 156
 None
 0.89A 5vc3A-3e3pA:
16.7		 5vc3A-3e3pA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  67
LYS A  82
VAL A 113
ASN A 184
 None
STU  A   1 ( 4.2A)
None
STU  A   1 ( 4.9A)
 1.01A 5vc3A-3fmeA:
22.5		 5vc3A-3fmeA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6z POLYCOMB PROTEIN
SFMBT

(Drosophila
melanogaster) 		PF02820
(MBT) 		4 VAL A 939
LYS A 938
VAL A 807
ASN A 811
 None
 1.16A 5vc3A-3h6zA:
undetectable		 5vc3A-3h6zA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 VAL A  67
LYS A  82
VAL A 113
ASN A 180
 None
 0.78A 5vc3A-3iecA:
22.9		 5vc3A-3iecA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1013
LYS A1033
VAL A1063
ASN A1140
 None
CCX  A   1 ( 3.7A)
CCX  A   1 (-4.1A)
None
 0.99A 5vc3A-3lw0A:
22.7		 5vc3A-3lw0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 848
LYS A 868
VAL A 899
ASN A1033
 4TT  A2001 ( 4.5A)
None
None
None
 0.89A 5vc3A-3vidA:
21.8		 5vc3A-3vidA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 848
LYS A 868
VAL A 899
ASN A1033
 LEV  A1201 ( 4.9A)
None
None
GOL  A1210 (-3.6A)
 0.81A 5vc3A-3wzdA:
22.6		 5vc3A-3wzdA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 568
LYS A 588
VAL A 617
ASN A 697
 None
 0.59A 5vc3A-4at3A:
22.6		 5vc3A-4at3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  27
LYS A  42
VAL A  73
ASN A 140
 38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
None
 0.99A 5vc3A-4bgqA:
26.3		 5vc3A-4bgqA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A  25
LYS A  40
VAL A  72
ASN A 139
 None
 0.86A 5vc3A-4d28A:
22.0		 5vc3A-4d28A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 VAL A 525
LYS A 482
VAL A 291
ASN A 517
 None
 1.31A 5vc3A-4ddwA:
undetectable		 5vc3A-4ddwA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		4 VAL A  52
LYS A  66
VAL A  91
ASN A 167
 None
 1.06A 5vc3A-4e7wA:
23.6		 5vc3A-4e7wA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 523
LYS A 543
VAL A 572
ASN A 654
 None
 0.62A 5vc3A-4f0iA:
16.1		 5vc3A-4f0iA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  37
LYS A  52
VAL A  84
ASN A 151
 STU  A 401 ( 4.9A)
None
None
STU  A 401 ( 4.8A)
 0.46A 5vc3A-4fr4A:
24.6		 5vc3A-4fr4A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A  50
LYS A  63
VAL A  90
ASN A 161
 1UL  A 501 ( 4.9A)
None
None
None
 0.92A 5vc3A-4l52A:
22.6		 5vc3A-4l52A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 VAL A 635
LYS A 650
VAL A 685
ASN A 751
 None
 0.93A 5vc3A-4otdA:
24.7		 5vc3A-4otdA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  60
LYS A  74
VAL A 104
ASN A 181
 KSA  A 405 ( 4.9A)
None
None
KSA  A 405 (-4.0A)
 0.68A 5vc3A-4wsqA:
25.3		 5vc3A-4wsqA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkp KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF01344
(Kelch_1) 		4 VAL A 439
LYS A 442
VAL A 460
ASN A 515
 None
 1.32A 5vc3A-5nkpA:
2.4		 5vc3A-5nkpA:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 124
LYS A 139
VAL A 171
ASN A 238
 H8H  A 401 (-4.7A)
H8H  A 401 (-4.9A)
None
EDO  A 402 (-3.9A)
 0.37A 5vc3A-5vcxA:
24.0		 5vc3A-5vcxA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 226
LYS A 241
VAL A 273
ASN A 344
 8X7  A 501 ( 4.5A)
PO4  A 502 (-3.6A)
8X7  A 501 ( 4.6A)
8X7  A 501 ( 4.7A)
 0.44A 5vc3A-5vdkA:
34.0		 5vc3A-5vdkA:
62.29