SIMILAR PATTERNS OF AMINO ACIDS FOR 5VC3_A_DB8A601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 202
ALA A 220
GLU A 236
TYR A 268
GLY A 272
ASP A 332
 None
 0.85A 5vc3A-1k9aA:
25.4		 5vc3A-1k9aA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLU A 209
ILE A 211
GLY A 212
ALA A 230
TYR A 282
GLY A 286
ASP A 290
 None
PY1  A 700 (-3.6A)
None
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
None
 0.74A 5vc3A-1py5A:
18.6		 5vc3A-1py5A:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
ALA A 642
GLU A 661
TYR A 693
CYH A 694
GLY A 697
ASP A 829
 None
 0.79A 5vc3A-1rjbA:
21.9		 5vc3A-1rjbA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 621
GLU A 640
TYR A 672
CYH A 673
GLY A 676
ASP A 810
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.9A)
 0.96A 5vc3A-1t46A:
18.2		 5vc3A-1t46A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 596
ALA A 621
TYR A 672
CYH A 673
GLY A 676
ASP A 677
 None
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
None
 1.07A 5vc3A-1t46A:
18.2		 5vc3A-1t46A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 596
ALA A 621
TYR A 672
CYH A 673
GLY A 676
ASP A 810
 None
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.9A)
 0.93A 5vc3A-1t46A:
18.2		 5vc3A-1t46A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
GLU A  76
CYH A 108
GLY A 110
ASP A 114
ASP A 169
 None
 0.73A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
GLU A  76
TYR A 107
CYH A 108
GLY A 110
ASP A 169
 None
 0.62A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
ALA A  55
GLU A  76
CYH A 108
GLY A 110
ASP A 114
 None
 1.08A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
ALA A  55
GLU A  76
TYR A 107
CYH A 108
GLY A 110
 None
 0.97A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
GLY A  35
ALA A  55
CYH A 108
GLY A 110
ASP A 114
 None
 0.91A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
GLY A  35
ALA A  55
TYR A 107
CYH A 108
GLY A 110
 None
 0.62A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
GLU A  55
TYR A  86
CYH A  87
GLY A  90
ASP A 148
 HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.7A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-3.9A)
 0.66A 5vc3A-1zltA:
24.9		 5vc3A-1zltA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLU A  55
TYR A  86
CYH A  87
GLY A  90
ASP A  94
ASP A 148
 None
HYM  A 400 (-4.7A)
HYM  A 400 (-4.2A)
None
None
HYM  A 400 (-3.9A)
 0.88A 5vc3A-1zltA:
24.9		 5vc3A-1zltA:
25.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLU B 271
ILE B 273
GLY B 274
GLU B 308
CYH B 369
PHE B 421
ASP B 432
 None
 1.09A 5vc3A-2a1aB:
25.0		 5vc3A-2a1aB:
32.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE B 273
GLY B 274
GLU B 308
CYH B 369
GLY B 372
PHE B 421
ASP B 432
 None
 0.88A 5vc3A-2a1aB:
25.0		 5vc3A-2a1aB:
32.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
GLU A  76
TYR A 107
CYH A 108
GLY A 110
ASP A 114
ASP A 169
 STU  A 400 (-3.2A)
None
STU  A 400 (-4.5A)
STU  A 400 (-4.0A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.3A)
STU  A 400 (-3.6A)
 0.85A 5vc3A-2gcdA:
27.4		 5vc3A-2gcdA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
ALA A  55
GLU A  76
TYR A 107
CYH A 108
GLY A 110
ASP A 114
 STU  A 400 (-4.2A)
STU  A 400 (-3.2A)
None
STU  A 400 (-4.5A)
STU  A 400 (-4.0A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.3A)
 1.09A 5vc3A-2gcdA:
27.4		 5vc3A-2gcdA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
GLY A  35
ALA A  55
TYR A 107
CYH A 108
GLY A 110
ASP A 114
 STU  A 400 (-4.2A)
STU  A 400 (-3.3A)
STU  A 400 (-3.2A)
STU  A 400 (-4.5A)
STU  A 400 (-4.0A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.3A)
 0.79A 5vc3A-2gcdA:
27.4		 5vc3A-2gcdA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 428
GLY A 429
ALA A 452
CYH A 502
GLY A 505
ASP A 564
 BII  A1687 (-3.8A)
BII  A1687 ( 3.8A)
BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
BII  A1687 (-3.6A)
None
 0.79A 5vc3A-2jkmA:
23.2		 5vc3A-2jkmA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 589
ALA A 614
GLU A 633
TYR A 665
CYH A 666
GLY A 669
ASP A 796
 None
 0.96A 5vc3A-2ogvA:
15.5		 5vc3A-2ogvA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 589
ALA A 614
TYR A 665
CYH A 666
GLY A 669
ASP A 670
 None
 1.17A 5vc3A-2ogvA:
15.5		 5vc3A-2ogvA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 GLU A  23
ALA A  46
GLU A  73
GLY A 109
ASP A 113
ASP A 167
 None
ATP  A 381 (-3.5A)
None
None
None
MN  A 382 (-2.0A)
 1.12A 5vc3A-2phkA:
19.7		 5vc3A-2phkA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		7 ILE B  47
GLY B  48
ALA B  67
GLU B  85
TYR B 116
GLY B 120
ASP B 182
 None
 0.82A 5vc3A-2qkwB:
19.2		 5vc3A-2qkwB:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 681
GLY A 682
ALA A 705
GLU A 724
TYR A 755
GLY A 759
ASP A 818
 None
 0.84A 5vc3A-2r2pA:
25.3		 5vc3A-2r2pA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  82
GLY A  83
ALA A 103
GLU A 124
TYR A 155
ASP A 216
 None
ANP  A1480 ( 4.3A)
ANP  A1480 ( 3.9A)
None
ANP  A1480 ( 4.9A)
ANP  A1480 (-3.5A)
 0.92A 5vc3A-2v55A:
22.3		 5vc3A-2v55A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  82
GLY A  83
GLU A 124
TYR A 155
GLY A 159
ASP A 216
 None
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 4.9A)
None
ANP  A1480 (-3.5A)
 0.82A 5vc3A-2v55A:
22.3		 5vc3A-2v55A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  14
GLY A  15
TYR A  88
CYH A  89
GLY A  92
PHE A 148
 None
 0.66A 5vc3A-2w5hA:
24.2		 5vc3A-2w5hA:
28.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  47
GLU A  66
TYR A  97
GLY A 101
ASP A 105
ASP A 158
 J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-3.2A)
J60  A1294 ( 4.6A)
 0.63A 5vc3A-2xikA:
20.4		 5vc3A-2xikA:
30.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 627
GLY A 628
ALA A 651
TYR A 701
GLY A 705
ASP A 764
 None
None
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
None
 0.79A 5vc3A-2xyuA:
23.6		 5vc3A-2xyuA:
26.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 326
GLU A 346
ASN A 376
TYR A 378
CYH A 379
GLY A 382
PHE A 433
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
770  A 901 (-3.8A)
 0.77A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 326
GLU A 346
TYR A 378
CYH A 379
GLY A 382
ASP A 386
PHE A 433
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
None
770  A 901 (-4.0A)
770  A 901 (-3.8A)
 0.57A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLU A 303
ILE A 305
ALA A 326
GLU A 346
ASN A 376
TYR A 378
CYH A 379
GLY A 382
PHE A 433
 None
770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
 0.89A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLU A 303
ILE A 305
ALA A 326
GLU A 346
TYR A 378
CYH A 379
GLY A 382
ASP A 386
PHE A 433
 None
770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
None
770  A 901 (-4.0A)
 0.80A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLU A 303
ILE A 305
GLY A 306
ALA A 326
ASN A 376
TYR A 378
CYH A 379
GLY A 382
PHE A 433
 None
770  A 901 (-3.8A)
770  A 901 ( 4.6A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
 0.49A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A1084
GLY A1085
ALA A1108
GLU A1127
TYR A1159
GLY A1163
 CKK  A1500 ( 4.4A)
None
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
CKK  A1500 ( 4.5A)
 0.96A 5vc3A-3c1xA:
21.7		 5vc3A-3c1xA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 202
ALA A 220
GLU A 236
TYR A 268
GLY A 272
ASP A 332
 None
 0.85A 5vc3A-3d7uA:
20.2		 5vc3A-3d7uA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A 148
ILE A 150
GLY A 151
ALA A 169
GLY A 226
ASP A 294
 None
VIN  A6331 (-4.0A)
VIN  A6331 (-3.5A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.0A)
 1.02A 5vc3A-3dtcA:
16.8		 5vc3A-3dtcA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLU A 207
ALA A 228
GLU A 243
TYR A 281
GLY A 285
ASP A 351
 None
ADP  A 900 (-3.4A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 ( 2.7A)
 1.03A 5vc3A-3g2fA:
11.1		 5vc3A-3g2fA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLU A 207
ILE A 209
ALA A 228
TYR A 281
GLY A 285
ASP A 351
 None
ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 ( 2.7A)
 1.01A 5vc3A-3g2fA:
11.1		 5vc3A-3g2fA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLU A 207
ILE A 209
GLY A 210
ALA A 228
TYR A 281
GLY A 285
 None
ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.4A)
None
ADP  A 900 ( 4.2A)
 1.01A 5vc3A-3g2fA:
11.1		 5vc3A-3g2fA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 859
GLU A 878
TYR A 911
CYH A 912
GLY A 915
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.9A)
8ST  A2001 (-3.8A)
None
None
 0.83A 5vc3A-3hngA:
22.1		 5vc3A-3hngA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 834
ALA A 859
TYR A 911
CYH A 912
GLY A 915
ASP A1040
 None
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.9A)
8ST  A2001 (-3.8A)
None
None
 0.82A 5vc3A-3hngA:
22.1		 5vc3A-3hngA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ILE A  59
GLY A  60
ALA A  80
TYR A 131
GLY A 135
ASP A 193
 None
 0.85A 5vc3A-3iecA:
22.9		 5vc3A-3iecA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ILE A  59
GLY A  60
GLU A 100
TYR A 131
GLY A 135
ASP A 193
 None
 1.00A 5vc3A-3iecA:
22.9		 5vc3A-3iecA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
GLU A 244
TYR A 281
GLY A 285
ASP A 289
ASP A 350
 LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-3.7A)
LDN  A   1 (-3.9A)
 0.83A 5vc3A-3mdyA:
23.5		 5vc3A-3mdyA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ILE A 210
GLY A 211
ALA A 229
TYR A 281
GLY A 285
ASP A 289
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.7A)
LDN  A   1 (-3.6A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-3.7A)
 0.79A 5vc3A-3mdyA:
23.5		 5vc3A-3mdyA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLU A 206
GLY A 209
ALA A 227
GLU A 242
TYR A 279
GLY A 283
ASP A 287
ASP A 348
 None
None
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-3.8A)
None
 0.75A 5vc3A-3my0A:
25.1		 5vc3A-3my0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 GLU A 555
ALA A 576
GLU A 596
TYR A 627
GLY A 631
ASP A 694
 None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-3.5A)
 1.14A 5vc3A-3ppzA:
25.7		 5vc3A-3ppzA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 GLU A 555
ILE A 557
GLY A 558
ALA A 576
GLU A 596
TYR A 627
GLY A 631
 None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
 1.24A 5vc3A-3ppzA:
25.7		 5vc3A-3ppzA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLU A 623
ILE A 625
GLY A 626
ALA A 649
GLU A 668
GLY A 703
ASP A 762
 None
 0.76A 5vc3A-3zfxA:
25.8		 5vc3A-3zfxA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A  95
ILE A  97
GLY A  98
ALA A 121
GLY A 175
ASP A 234
 None
30K  A1365 (-4.5A)
30K  A1365 ( 3.9A)
30K  A1365 (-3.2A)
30K  A1365 (-3.5A)
30K  A1365 (-3.3A)
 0.68A 5vc3A-4aw5A:
24.0		 5vc3A-4aw5A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  69
ALA A  89
GLU A 110
CYH A 142
PHE A 192
ASP A 203
 9ZP  A1333 (-3.6A)
9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
None
 0.83A 5vc3A-4b6lA:
28.1		 5vc3A-4b6lA:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLU A 212
GLY A 215
ALA A 233
GLU A 248
TYR A 285
GLY A 289
ASP A 293
 EDO  A1515 (-3.8A)
None
TAK  A1507 (-3.3A)
None
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
None
 0.77A 5vc3A-4c02A:
24.8		 5vc3A-4c02A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  89
ALA A 109
GLU A 130
TYR A 161
CYH A 162
PHE A 212
ASP A 223
 1C7  A 401 ( 4.8A)
1C7  A 401 (-3.2A)
None
1C7  A 401 (-3.5A)
1C7  A 401 (-4.1A)
1C7  A 401 (-4.0A)
None
 0.81A 5vc3A-4i6fA:
25.2		 5vc3A-4i6fA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A 130
GLY A 133
ALA A 156
GLU A 177
GLY A 211
ASP A 270
 None
1G0  A 401 ( 4.2A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.5A)
None
 0.97A 5vc3A-4id7A:
25.6		 5vc3A-4id7A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		6 GLY A  46
ALA A  66
GLU A  87
CYH A 119
PHE A 169
ASP A 180
 None
 0.89A 5vc3A-4j7bA:
26.3		 5vc3A-4j7bA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A  40
ALA A  61
GLU A  77
TYR A 106
GLY A 110
ASP A 175
 None
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.2A)
 1.13A 5vc3A-4l52A:
22.6		 5vc3A-4l52A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLU A  31
GLY A  34
ALA A  54
GLU A  70
TYR A 101
CYH A 102
GLY A 105
 None
None
GOL  A 404 ( 3.1A)
None
GOL  A 404 ( 4.9A)
GOL  A 403 (-4.0A)
GOL  A 404 (-3.6A)
 0.99A 5vc3A-4lg4A:
20.2		 5vc3A-4lg4A:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  34
ALA A  54
TYR A 101
CYH A 102
GLY A 105
ASP A 109
 None
GOL  A 404 ( 3.1A)
GOL  A 404 ( 4.9A)
GOL  A 403 (-4.0A)
GOL  A 404 (-3.6A)
None
 0.65A 5vc3A-4lg4A:
20.2		 5vc3A-4lg4A:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLU A  76
GLY A  79
ALA A  99
GLU A 117
GLY A 151
ASP A 213
 None
STU  A 601 (-3.6A)
STU  A 601 (-3.3A)
None
STU  A 601 (-3.4A)
STU  A 601 (-4.3A)
 1.08A 5vc3A-4mvfA:
22.8		 5vc3A-4mvfA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  79
ALA A  99
GLU A 117
CYH A 149
GLY A 151
ASP A 213
 STU  A 601 (-3.6A)
STU  A 601 (-3.3A)
None
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.3A)
 0.85A 5vc3A-4mvfA:
22.8		 5vc3A-4mvfA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLU B  28
ALA B  51
GLU B  70
TYR B 101
GLY B 105
ASP B 109
ASP B 162
 None
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
None
None
ADP  B 500 ( 3.4A)
 0.90A 5vc3A-4o27B:
27.2		 5vc3A-4o27B:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLU B  28
GLY B  31
ALA B  51
TYR B 101
GLY B 105
ASP B 109
ASP B 162
 None
ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.7A)
None
None
ADP  B 500 ( 3.4A)
 0.95A 5vc3A-4o27B:
27.2		 5vc3A-4o27B:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 928
GLU A 947
TYR A 980
GLY A 984
ASP A 988
ASP A1041
 2TT  A1202 ( 3.9A)
None
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
None
2TT  A1202 (-4.6A)
 0.79A 5vc3A-4oliA:
22.9		 5vc3A-4oliA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 619
GLY A 620
ALA A 644
GLU A 663
TYR A 694
ASP A 757
 None
 0.82A 5vc3A-4p2kA:
25.5		 5vc3A-4p2kA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 619
GLY A 620
ALA A 644
GLU A 663
TYR A 694
GLY A 698
 None
 0.92A 5vc3A-4p2kA:
25.5		 5vc3A-4p2kA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
TYR A 693
CYH A 694
GLY A 697
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
None
P30  A1001 (-3.4A)
None
 0.83A 5vc3A-4rt7A:
17.7		 5vc3A-4rt7A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 617
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
None
P30  A1001 (-3.4A)
None
 0.70A 5vc3A-4rt7A:
17.7		 5vc3A-4rt7A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
TYR A 693
CYH A 694
GLY A 697
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
None
 1.06A 5vc3A-4xufA:
16.8		 5vc3A-4xufA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 617
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 698
 None
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
None
 1.17A 5vc3A-4xufA:
16.8		 5vc3A-4xufA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 617
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 829
 None
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
None
 0.77A 5vc3A-4xufA:
16.8		 5vc3A-4xufA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  22
GLY A  23
ALA A  44
TYR A  94
CYH A  95
GLY A  98
 51W  A 401 (-3.9A)
51W  A 401 (-3.3A)
51W  A 401 (-3.4A)
51W  A 401 ( 3.4A)
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
 0.74A 5vc3A-5ci7A:
26.2		 5vc3A-5ci7A:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLU A  55
ALA A  77
TYR A 132
CYH A 133
GLY A 136
ASP A 198
 None
IDV  A 401 (-3.6A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.0A)
 0.82A 5vc3A-5i3oA:
15.2		 5vc3A-5i3oA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
GLU A  61
CYH A  93
GLY A  96
ASP A 100
ASP A 154
 6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.68A 5vc3A-5j5tA:
23.1		 5vc3A-5j5tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  22
ALA A  43
GLU A  61
CYH A  93
GLY A  96
ASP A 100
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.83A 5vc3A-5j5tA:
23.1		 5vc3A-5j5tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  22
GLY A  23
ALA A  43
CYH A  93
GLY A  96
ASP A 100
 6G2  A 901 (-3.8A)
None
6G2  A 901 (-3.2A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.59A 5vc3A-5j5tA:
23.1		 5vc3A-5j5tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 396
GLY A 397
ALA A 417
GLU A 436
GLY A 471
ASP A 533
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.8A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-3.6A)
GUI  A 701 ( 4.8A)
 0.83A 5vc3A-5jznA:
28.1		 5vc3A-5jznA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 276
GLY A 277
ALA A 297
GLU A 315
TYR A 346
GLY A 350
ASP A 407
 IPW  A 601 (-4.0A)
IPW  A 601 ( 3.9A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
None
 0.77A 5vc3A-5kbrA:
25.2		 5vc3A-5kbrA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU B 670
ILE B 672
GLY B 673
ALA B 690
CYH B 742
ASP B 803
 None
6U7  B1001 ( 4.8A)
None
6U7  B1001 (-3.6A)
6U7  B1001 (-3.5A)
6U7  B1001 (-4.6A)
 0.65A 5vc3A-5kkrB:
20.5		 5vc3A-5kkrB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU B 670
ILE B 672
GLY B 673
ALA B 690
PHE B 793
ASP B 803
 None
6U7  B1001 ( 4.8A)
None
6U7  B1001 (-3.6A)
6U7  B1001 (-4.3A)
6U7  B1001 (-4.6A)
 0.99A 5vc3A-5kkrB:
20.5		 5vc3A-5kkrB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
GLY A 890
ALA A 909
GLU A 927
GLY A 962
ASP A 966
ASP A1027
 None
ATP  A1200 ( 4.6A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.9A)
ATP  A1200 (-4.1A)
 0.84A 5vc3A-5lpyA:
25.1		 5vc3A-5lpyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 889
ALA A 909
GLU A 927
GLY A 962
ASP A 966
ASP A1027
 ADP  A1200 (-4.7A)
ADP  A1200 (-3.5A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.2A)
ADP  A1200 (-3.4A)
 0.71A 5vc3A-5lpzA:
25.0		 5vc3A-5lpzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 889
GLY A 890
ALA A 909
GLU A 927
GLY A 962
ASP A1027
 ADP  A1200 (-4.7A)
ADP  A1200 ( 4.0A)
ADP  A1200 (-3.5A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-3.4A)
 0.82A 5vc3A-5lpzA:
25.0		 5vc3A-5lpzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 8 GLU A  15
ILE A  17
GLY A  18
ALA A  38
GLU A  57
TYR A  88
CYH A  89
ASP A 150
 None
7LV  A 401 (-4.3A)
7LV  A 401 ( 3.9A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.2A)
 0.92A 5vc3A-5tvtA:
25.9		 5vc3A-5tvtA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 7 ILE A  17
GLY A  18
GLU A  57
TYR A  88
CYH A  89
GLY A  92
ASP A 150
 7LV  A 401 (-4.3A)
7LV  A 401 ( 3.9A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.2A)
 0.88A 5vc3A-5tvtA:
25.9		 5vc3A-5tvtA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  98
ALA A 119
GLU A 140
TYR A 171
GLY A 175
ASP A 232
 None
 0.82A 5vc3A-5u7qA:
23.4		 5vc3A-5u7qA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  98
GLY A  99
ALA A 119
TYR A 171
GLY A 175
ASP A 176
 None
 1.11A 5vc3A-5u7qA:
23.4		 5vc3A-5u7qA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  98
GLY A  99
ALA A 119
TYR A 171
GLY A 175
ASP A 232
 None
 0.79A 5vc3A-5u7qA:
23.4		 5vc3A-5u7qA:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 137
GLU A 157
CYH A 190
GLY A 191
PHE A 240
ASP A 251
 H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
H8H  A 401 (-4.3A)
EDO  A 402 ( 2.9A)
 0.97A 5vc3A-5vcxA:
24.0		 5vc3A-5vcxA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLU A 216
ILE A 218
ALA A 239
GLU A 259
TYR A 291
GLY A 295
PHE A 346
ASP A 380
 8X7  A 501 ( 4.9A)
8X7  A 501 ( 4.0A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.8A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.6A)
8X7  A 501 (-3.7A)
8X7  A 501 (-4.8A)
 0.98A 5vc3A-5vdkA:
34.0		 5vc3A-5vdkA:
62.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		10 GLU A 216
ILE A 218
GLY A 219
ALA A 239
ASN A 289
TYR A 291
CYH A 292
GLY A 295
PHE A 346
ASP A 380
 8X7  A 501 ( 4.9A)
8X7  A 501 ( 4.0A)
8X7  A 501 ( 3.8A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.2A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.6A)
8X7  A 501 (-3.7A)
8X7  A 501 (-4.8A)
 0.69A 5vc3A-5vdkA:
34.0		 5vc3A-5vdkA:
62.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 GLU A  26
ALA A  49
GLU A  69
TYR A  98
GLY A 102
ASP A 161
 None
VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
VX6  A 402 (-3.5A)
VX6  A 402 (-4.3A)
 0.76A 5vc3A-5wnmA:
24.4		 5vc3A-5wnmA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 GLY A  29
ALA A  49
GLU A  69
TYR A  98
GLY A 102
ASP A 161
 VX6  A 402 ( 4.2A)
VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
VX6  A 402 (-3.5A)
VX6  A 402 (-4.3A)
 0.80A 5vc3A-5wnmA:
24.4		 5vc3A-5wnmA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 6 ILE A  75
GLY A  76
ALA A  95
TYR A 143
GLY A 147
ASP A 151
 ANP  A1000 (-4.2A)
ANP  A1000 ( 3.8A)
ANP  A1000 (-3.2A)
ANP  A1000 (-4.3A)
None
ANP  A1000 ( 4.9A)
 0.84A 5vc3A-5xd6A:
20.3		 5vc3A-5xd6A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 GLY A  34
ALA A  54
TYR A 101
CYH A 102
GLY A 105
ASP A 109
 ANP  A 501 ( 3.9A)
ANP  A 501 ( 3.7A)
ANP  A 501 ( 4.2A)
ANP  A 501 (-4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-2.6A)
 0.63A 5vc3A-6ao5A:
22.4		 5vc3A-6ao5A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 ILE A 218
GLY A 219
ALA A 237
GLU A 259
GLY A 294
ASP A 298
 DL1  A 601 (-4.0A)
DL1  A 601 ( 4.1A)
DL1  A 601 (-3.4A)
None
DL1  A 601 (-3.5A)
DL1  A 601 ( 4.9A)
 0.58A 5vc3A-6bfnA:
24.7		 5vc3A-6bfnA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 ILE A 171
GLY A 172
ALA A 192
GLU A 236
GLY A 273
ASP A 330
 BI9  A 501 (-4.0A)
BI9  A 501 (-3.6A)
BI9  A 501 (-3.3A)
NH4  A 506 (-3.0A)
BI9  A 501 (-3.3A)
None
 0.88A 5vc3A-6bqlA:
26.5		 5vc3A-6bqlA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 7 GLY A 193
ALA A 211
GLU A 233
TYR A 264
GLY A 268
ASP A 272
ASP A 329
 CJT  A 502 ( 3.9A)
CJT  A 502 (-3.4A)
CJT  A 502 (-3.9A)
CJT  A 502 (-4.5A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-3.3A)
CJT  A 502 ( 4.0A)
 0.89A 5vc3A-6f3dA:
19.0		 5vc3A-6f3dA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 GLU U  18
GLY U  21
ALA U  42
CYH U  94
GLY U  97
ASP U 157
 None
DB8  U 301 ( 4.9A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-3.6A)
 0.74A 5vc3A-6fdyU:
26.0		 5vc3A-6fdyU:
undetectable