SIMILAR PATTERNS OF AMINO ACIDS FOR 5VC0_A_RITA602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		4 ILE A  18
LEU A   6
PHE A 153
THR A  33
 None
 1.04A 5vc0A-1b5fA:
0.0		 5vc0A-1b5fA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		4 ILE 1  97
LEU 3  25
PHE 3  28
ARG 1 116
 MYR  1 900 ( 4.4A)
None
None
None
 0.92A 5vc0A-1bev1:
0.0		 5vc0A-1bev1:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 ILE A  97
LEU A  50
PHE A  32
THR A  60
 None
 1.03A 5vc0A-1czfA:
0.0		 5vc0A-1czfA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		4 ILE A  36
PHE A 166
THR A  22
THR A 147
 None
 0.94A 5vc0A-1efvA:
0.0		 5vc0A-1efvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 527
PHE A 267
THR A 357
THR A 272
 None
 0.89A 5vc0A-1eovA:
0.9		 5vc0A-1eovA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6f PLACENTAL LACTOGEN

(Ovis aries) 		PF00103
(Hormone_1) 		4 ILE A 121
LEU A 172
THR A 102
THR A  62
 None
 0.94A 5vc0A-1f6fA:
undetectable		 5vc0A-1f6fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		4 ARG A 133
ILE A 120
THR A 407
THR A 304
 None
None
None
HEM  A 800 (-3.4A)
 1.01A 5vc0A-1itkA:
0.0		 5vc0A-1itkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A 107
LEU A  50
PHE A  47
THR A 154
 None
 1.00A 5vc0A-1kfiA:
0.0		 5vc0A-1kfiA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 LEU A  73
PHE A  70
THR A 191
THR A 247
 None
 0.97A 5vc0A-1kgpA:
0.1		 5vc0A-1kgpA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 ILE A 117
LEU A 665
PHE A 741
ARG A  66
 None
 0.88A 5vc0A-1obhA:
undetectable		 5vc0A-1obhA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		5 ILE A 106
LEU A 172
PHE A 174
THR A 178
ARG A 153
 None
 1.21A 5vc0A-1og6A:
undetectable		 5vc0A-1og6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 ARG A 142
LEU A 157
PHE A 153
ARG A 149
 None
 0.92A 5vc0A-1q3bA:
undetectable		 5vc0A-1q3bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ILE A  69
LEU A  51
PHE A 104
ARG A  18
 None
 1.00A 5vc0A-1qhoA:
undetectable		 5vc0A-1qhoA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		4 LEU A  63
PHE A  60
THR A 181
THR A 237
 None
 1.03A 5vc0A-1r2fA:
undetectable		 5vc0A-1r2fA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 644
LEU A 453
THR A 699
THR A 655
 None
 1.03A 5vc0A-1r8wA:
undetectable		 5vc0A-1r8wA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ILE A 446
LEU A 439
PHE A 410
THR A 348
 None
 0.99A 5vc0A-1ry2A:
undetectable		 5vc0A-1ry2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE A 193
LEU A 175
PHE A 219
ARG A 144
 None
 0.75A 5vc0A-1smaA:
undetectable		 5vc0A-1smaA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		4 ARG A 177
ILE A 121
PHE A  93
THR A  84
 None
 0.92A 5vc0A-1t8wA:
undetectable		 5vc0A-1t8wA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 ILE A   5
LEU A  14
THR A 156
ARG A 266
 None
 0.99A 5vc0A-1tp7A:
undetectable		 5vc0A-1tp7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Thermotoga
maritima) 		PF13393
(tRNA-synt_His) 		4 ILE C 113
LEU C 212
PHE C 211
THR C 218
 None
 1.04A 5vc0A-1usyC:
undetectable		 5vc0A-1usyC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Thermotoga
maritima) 		PF13393
(tRNA-synt_His) 		4 ILE C 113
LEU C 249
THR C 230
THR C 244
 None
 1.00A 5vc0A-1usyC:
undetectable		 5vc0A-1usyC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 LEU A  68
PHE A  65
THR A 186
THR A 242
 None
 0.97A 5vc0A-1uzrA:
undetectable		 5vc0A-1uzrA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdq BACTERIAL SULFITE
OXIDASE

(Escherichia
coli) 		PF00174
(Oxidored_molyb) 		4 ARG A 194
ILE A 206
LEU A  70
THR A  65
 MTE  A 301 (-2.8A)
None
None
None
 0.91A 5vc0A-1xdqA:
undetectable		 5vc0A-1xdqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq1 PUTATIVE TROPINONE
REDUCATSE

(Arabidopsis
thaliana) 		PF13561
(adh_short_C2) 		4 ILE A  97
LEU A  93
PHE A  89
THR A  66
 None
 0.93A 5vc0A-1xq1A:
undetectable		 5vc0A-1xq1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		4 ILE A 354
LEU A 302
THR A 197
THR A 306
 None
 0.95A 5vc0A-2a0uA:
undetectable		 5vc0A-2a0uA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 ILE A 307
LEU A 267
THR A 274
ARG A 303
 None
 1.04A 5vc0A-2amlA:
0.4		 5vc0A-2amlA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 ILE A 909
LEU A 881
PHE A 876
THR A 901
 None
 0.94A 5vc0A-2b5mA:
undetectable		 5vc0A-2b5mA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv6 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MGRA

(Staphylococcus
aureus) 		PF01047
(MarR) 		4 ARG A  84
ILE A  96
LEU A  64
THR A  37
 SO4  A1142 (-3.4A)
None
None
None
 1.00A 5vc0A-2bv6A:
undetectable		 5vc0A-2bv6A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01156
(IU_nuc_hydro) 		4 ILE A 189
LEU A 109
THR A 125
THR A 116
 None
 0.95A 5vc0A-2c40A:
undetectable		 5vc0A-2c40A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		4 LEU A 184
PHE A 183
THR A 131
THR A 189
 SAH  A 300 (-3.8A)
SAH  A 300 (-4.9A)
SAH  A 300 (-3.4A)
None
 1.00A 5vc0A-2cbfA:
undetectable		 5vc0A-2cbfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG C 272
ILE C 271
LEU C 360
THR C 292
 None
 0.94A 5vc0A-2d3tC:
undetectable		 5vc0A-2d3tC:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dcp HYPOTHETICAL PROTEIN
(RAFL09-17-B18)

(Arabidopsis
thaliana) 		PF01417
(ENTH) 		4 ARG A  57
ILE A  54
LEU A  32
THR A 120
 None
 0.90A 5vc0A-2dcpA:
undetectable		 5vc0A-2dcpA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eeo ASPARTATE
1-DECARBOXYLASE

(Thermus
thermophilus) 		PF02261
(Asp_decarbox) 		4 ILE B  49
LEU B  87
THR A  16
ARG B 113
 None
 1.04A 5vc0A-2eeoB:
undetectable		 5vc0A-2eeoB:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 ILE A 171
LEU A 197
THR A 218
THR A 230
 None
 1.03A 5vc0A-2i0kA:
undetectable		 5vc0A-2i0kA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00977
(His_biosynth) 		4 ILE A 177
LEU A 132
PHE A 117
ARG A 154
 None
 0.97A 5vc0A-2lleA:
undetectable		 5vc0A-2lleA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzt PROTEIN HRB1

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		4 ILE A 448
LEU A 392
THR A 416
ARG A 453
 None
 1.03A 5vc0A-2mztA:
undetectable		 5vc0A-2mztA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE A  79
LEU A 110
PHE A 322
ARG A  37
 None
 0.99A 5vc0A-2og2A:
undetectable		 5vc0A-2og2A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		4 ILE A 167
LEU A 364
THR A  65
ARG A   7
 None
 0.95A 5vc0A-2q09A:
undetectable		 5vc0A-2q09A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q50 GLYOXYLATE
REDUCTASE/HYDROXYPYR
UVATE REDUCTASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ARG A 171
ILE A 168
THR A 121
THR A 301
 None
 0.83A 5vc0A-2q50A:
undetectable		 5vc0A-2q50A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA

(Mus musculus;
Paraburkholderia
xenovorans) 		PF01007
(IRK) 		4 ILE A 245
LEU A 180
PHE A   8
ARG A  14
 None
 0.88A 5vc0A-2qksA:
undetectable		 5vc0A-2qksA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		4 ARG A 391
LEU A 437
PHE A 439
THR A 417
 None
 0.86A 5vc0A-2qmiA:
undetectable		 5vc0A-2qmiA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ILE A  38
LEU A  77
THR A  58
ARG A  91
 None
 0.98A 5vc0A-2r9vA:
undetectable		 5vc0A-2r9vA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8s CLATHRIN INTERACTOR
1

(Homo sapiens) 		PF01417
(ENTH) 		4 ARG E 102
ILE E 105
LEU E  86
ARG E  96
 None
 1.03A 5vc0A-2v8sE:
undetectable		 5vc0A-2v8sE:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ILE A 377
LEU A 349
PHE A  47
THR A  53
 None
 0.75A 5vc0A-2vqrA:
undetectable		 5vc0A-2vqrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ILE A 377
LEU A 349
PHE A  47
THR A  53
 None
 0.78A 5vc0A-2w8sA:
undetectable		 5vc0A-2w8sA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 ILE A 481
LEU A 402
THR A 345
ARG A 412
 None
 1.00A 5vc0A-2yevA:
undetectable		 5vc0A-2yevA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 ILE A 491
LEU A 518
PHE A 551
THR A 573
 None
 0.94A 5vc0A-2zj8A:
undetectable		 5vc0A-2zj8A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 ARG A  95
ILE A  99
LEU A 125
ARG A  88
 None
None
None
SAH  A 801 (-3.9A)
 1.04A 5vc0A-2zwaA:
undetectable		 5vc0A-2zwaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A  84
THR A  55
THR A  67
ARG A  75
 None
 1.04A 5vc0A-3b2dA:
undetectable		 5vc0A-3b2dA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frq REPRESSOR PROTEIN
MPHR(A)

(Escherichia
coli) 		PF00440
(TetR_N) 		4 ARG A 133
ILE A 130
LEU A 177
PHE A 181
 None
 1.03A 5vc0A-3frqA:
undetectable		 5vc0A-3frqA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwz INNER MEMBRANE
PROTEIN YBAL

(Escherichia
coli) 		PF02254
(TrkA_N) 		4 ARG A 514
ILE A 489
THR A 525
ARG A 537
 AMP  A 601 (-3.0A)
AMP  A 601 (-3.6A)
None
None
 1.02A 5vc0A-3fwzA:
undetectable		 5vc0A-3fwzA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Clostridioides
difficile) 		PF01380
(SIS) 		5 ILE A 287
LEU A 204
THR A 281
THR A 232
ARG A 211
 None
 1.41A 5vc0A-3g68A:
undetectable		 5vc0A-3g68A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqs ADENYLATE
CYCLASE-LIKE PROTEIN

(Chlamydia
trachomatis) 		PF16697
(Yop-YscD_cpl) 		4 ILE A  45
LEU A   7
PHE A  19
THR A  26
 None
 1.01A 5vc0A-3gqsA:
undetectable		 5vc0A-3gqsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		4 ILE A  33
LEU B  25
PHE B  28
ARG A  52
 None
 1.01A 5vc0A-3j2jA:
undetectable		 5vc0A-3j2jA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		4 ARG A 574
ILE A 554
THR A 689
ARG A 641
 None
 0.98A 5vc0A-3jbyA:
undetectable		 5vc0A-3jbyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		4 ILE A 285
LEU A 134
PHE A 427
THR A 178
 None
 1.02A 5vc0A-3kswA:
30.7		 5vc0A-3kswA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 ARG A 380
LEU A 301
THR A 310
THR A 369
 None
 0.98A 5vc0A-3l8aA:
undetectable		 5vc0A-3l8aA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 LEU A  73
PHE A  70
THR A 191
THR A 247
 None
 0.97A 5vc0A-3mjoA:
undetectable		 5vc0A-3mjoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 4 LEU B  63
PHE B  60
THR B 181
THR B 237
 None
 1.03A 5vc0A-3n3bB:
undetectable		 5vc0A-3n3bB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN

(Geobacter
sulfurreducens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ILE A 177
LEU A 241
PHE A 265
THR A  96
 None
None
None
NAP  A 301 (-4.1A)
 1.01A 5vc0A-3pduA:
undetectable		 5vc0A-3pduA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		4 ARG A 176
LEU A 263
THR A 161
THR A  39
 PLM  A 702 (-3.9A)
PLM  A 702 ( 4.8A)
PLM  A 702 ( 4.8A)
None
 1.03A 5vc0A-3pl5A:
undetectable		 5vc0A-3pl5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psq HYPOTHETICAL
EXPORTED PROTEIN

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		4 ILE A 123
LEU A 137
PHE A 140
THR A 172
 None
 0.97A 5vc0A-3psqA:
undetectable		 5vc0A-3psqA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		4 ILE A  83
LEU A 264
THR A 381
ARG A  26
 None
 1.01A 5vc0A-3qnqA:
undetectable		 5vc0A-3qnqA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp7 FLAVOPROTEIN
MONOOXYGENASE

(Klebsiella
pneumoniae) 		PF01494
(FAD_binding_3) 		4 ARG A 263
ILE A 264
PHE A 217
ARG A 235
 None
 1.00A 5vc0A-3rp7A:
undetectable		 5vc0A-3rp7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		4 LEU A 295
PHE A 333
THR A 222
THR A 493
 None
 0.99A 5vc0A-3up4A:
undetectable		 5vc0A-3up4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens) 		PF00362
(Integrin_beta) 		4 ILE B 326
LEU B 159
THR B 167
ARG B 259
 None
 0.99A 5vc0A-3v4vB:
undetectable		 5vc0A-3v4vB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		4 ILE A 583
LEU A 541
THR A 521
ARG A 574
 None
 0.93A 5vc0A-3vmnA:
undetectable		 5vc0A-3vmnA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		4 ILE A 116
LEU A  89
THR A 130
ARG A 124
 None
 1.01A 5vc0A-3vqrA:
undetectable		 5vc0A-3vqrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN
V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 ILE D  14
THR D  39
THR D 228
ARG A 191
 None
 0.96A 5vc0A-3w3aD:
undetectable		 5vc0A-3w3aD:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 ARG A  89
LEU A 204
THR A 189
ARG A 217
 None
 0.99A 5vc0A-3zbyA:
17.5		 5vc0A-3zbyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE A 134
LEU A 165
PHE A 377
ARG A  92
 None
 1.04A 5vc0A-4ak9A:
undetectable		 5vc0A-4ak9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 ARG A  53
ILE A 118
LEU A  99
THR A 152
 None
 0.82A 5vc0A-4bjuA:
undetectable		 5vc0A-4bjuA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		4 ARG B 142
LEU B  29
PHE B 230
THR B 168
 None
 0.81A 5vc0A-4ckeB:
undetectable		 5vc0A-4ckeB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 ILE A 102
LEU A 591
THR A 192
ARG A 179
 None
None
None
GOL  A 701 (-3.5A)
 1.02A 5vc0A-4dwsA:
undetectable		 5vc0A-4dwsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 ILE A 285
LEU A 134
PHE A 427
THR A 178
 None
HEM  A 501 ( 4.7A)
None
None
 1.01A 5vc0A-4g3jA:
34.6		 5vc0A-4g3jA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		4 ILE A 140
LEU A 188
THR A 193
ARG A 275
 None
HEM  A 401 (-4.1A)
K  A 402 (-3.4A)
None
 0.91A 5vc0A-4gedA:
undetectable		 5vc0A-4gedA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E

(Geobacillus
stearothermophilus) 		PF00365
(PFK) 		4 ILE A  45
LEU A 112
PHE A 117
ARG A   3
 None
 0.99A 5vc0A-4i4iA:
undetectable		 5vc0A-4i4iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		4 ILE A  39
LEU A 337
THR A  51
ARG A 302
 None
None
None
SO4  A 401 (-2.6A)
 0.96A 5vc0A-4kdsA:
undetectable		 5vc0A-4kdsA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjz TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		4 ILE A 391
LEU A 377
THR A 381
ARG A 453
 None
 1.03A 5vc0A-4kjzA:
undetectable		 5vc0A-4kjzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH

(Lechevalieria
aerocolonigenes) 		PF04820
(Trp_halogenase) 		4 ILE A 346
PHE A 462
THR A 394
ARG A 387
 None
 1.01A 5vc0A-4lu6A:
undetectable		 5vc0A-4lu6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhb PUTATIVE ALDO/KETO
REDUCTASE

(Yersinia pestis) 		PF00248
(Aldo_ket_red) 		4 ARG A 235
ILE A 268
LEU A 207
PHE A 200
 None
 0.93A 5vc0A-4mhbA:
undetectable		 5vc0A-4mhbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 ILE A 352
PHE A 293
THR A 298
THR A 335
 None
None
None
MLY  A 336 ( 3.9A)
 1.04A 5vc0A-4nk6A:
undetectable		 5vc0A-4nk6A:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 105
ILE A 120
THR A 224
THR A 309
ARG A 372
 HEM  A 601 ( 2.8A)
None
None
2QH  A 602 ( 3.7A)
None
 0.73A 5vc0A-4ny4A:
53.2		 5vc0A-4ny4A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP1
COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 1 112
LEU 3  25
PHE 3  28
ARG 1 131
 None
 1.00A 5vc0A-4q4y1:
undetectable		 5vc0A-4q4y1:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q58 PLECTIN

(Homo sapiens) 		PF00307
(CH) 		4 ARG A 111
ILE A 120
LEU A  76
ARG A 113
 None
 0.89A 5vc0A-4q58A:
undetectable		 5vc0A-4q58A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		4 ILE A 191
LEU A 222
PHE A 245
THR A 150
 None
None
None
CL  A 420 (-3.8A)
 0.96A 5vc0A-4qb7A:
undetectable		 5vc0A-4qb7A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR

(Homo sapiens) 		PF00021
(UPAR_LY6) 		4 ARG U 239
LEU U 252
PHE U 256
THR U 164
 None
 1.03A 5vc0A-4qtiU:
undetectable		 5vc0A-4qtiU:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		4 ILE A 444
LEU A 143
THR A 195
ARG A 471
 None
 1.02A 5vc0A-4qwwA:
undetectable		 5vc0A-4qwwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli) 		PF04453
(OstA_C) 		4 ARG A 520
THR A 472
THR A 586
ARG A 551
 None
 0.96A 5vc0A-4rhbA:
undetectable		 5vc0A-4rhbA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA

(Bacillus
subtilis) 		PF10747
(SirA) 		4 ILE A  80
LEU A  65
THR A   7
THR A  72
 None
 1.03A 5vc0A-4tpsA:
undetectable		 5vc0A-4tpsA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 ILE B  67
LEU B 115
PHE B 113
THR B 138
 None
 0.99A 5vc0A-4tx2B:
undetectable		 5vc0A-4tx2B:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		4 ILE A 689
LEU A 504
THR A 698
ARG A 434
 None
None
None
PO4  A 802 (-2.9A)
 1.02A 5vc0A-4u1rA:
undetectable		 5vc0A-4u1rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1r ALPHA-1,6-MANNANASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 ILE A 320
LEU A 350
THR A  53
ARG A 375
 None
 1.05A 5vc0A-4v1rA:
undetectable		 5vc0A-4v1rA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		4 ARG A 195
LEU A 109
THR A 171
ARG A 198
 None
 1.01A 5vc0A-4wj3A:
undetectable		 5vc0A-4wj3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww5 EKC/KEOPS COMPLEX
SUBUNIT CGI121

(Saccharomyces
cerevisiae) 		PF08617
(CGI-121) 		4 ILE B  12
LEU B 107
THR B  71
ARG B 179
 None
 1.01A 5vc0A-4ww5B:
undetectable		 5vc0A-4ww5B:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhl CASEIN KINASE I
HOMOLOG HRR25

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ARG A 115
ILE A 116
LEU A 203
PHE A 206
 SO4  A 404 (-2.9A)
None
None
None
 1.01A 5vc0A-4xhlA:
undetectable		 5vc0A-4xhlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN SEH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE C 192
LEU C 128
PHE C 169
ARG C 216
 None
 1.03A 5vc0A-4xmmC:
undetectable		 5vc0A-4xmmC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		4 ILE A 159
LEU A 142
PHE A 109
THR A 222
 None
 1.03A 5vc0A-5b1qA:
undetectable		 5vc0A-5b1qA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9d APRICK PROTEASE

(Rickettsia
conorii) 		PF13975
(gag-asp_proteas) 		4 ARG A 216
LEU A 229
PHE A 220
THR A 141
 None
 1.02A 5vc0A-5c9dA:
undetectable		 5vc0A-5c9dA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		4 ILE A  90
LEU A 318
THR A  60
ARG A 230
 None
 1.04A 5vc0A-5d8gA:
undetectable		 5vc0A-5d8gA:
21.47