SIMILAR PATTERNS OF AMINO ACIDS FOR 5VC0_A_RITA602_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aow | ANNEXIN IV (Bos taurus) |
PF00191(Annexin) | 5 | ASP A 218ARG A 243LEU A 253ILE A 109ALA A 234 | None | 1.14A | 5vc0A-1aowA:0.0 | 5vc0A-1aowA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dm0 | SHIGA TOXIN ASUBUNIT (Shigelladysenteriae) |
PF00161(RIP) | 5 | PHE A 95PHE A 50LEU A 238PHE A 257ALA A 168 | None | 1.05A | 5vc0A-1dm0A:undetectable | 5vc0A-1dm0A:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1foe | T-LYMPHOMA INVASIONAND METASTASISINDUCING PROTEIN 1 (Mus musculus) |
PF00169(PH)PF00621(RhoGEF) | 5 | ASP A1327PHE A1331ILE A1335ALA A1299ILE A1249 | None | 1.20A | 5vc0A-1foeA:0.0 | 5vc0A-1foeA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gt9 | KUMAMOLYSIN (Bacillussubtilis) |
PF00082(Peptidase_S8) | 5 | ASP 1 173SER 1 140LEU 1 33PHE 1 107ALA 1 183 | None | 1.11A | 5vc0A-1gt91:undetectable | 5vc0A-1gt91:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m33 | BIOH PROTEIN (Escherichiacoli) |
PF00561(Abhydrolase_1) | 5 | SER A 53LEU A 19ILE A 4ALA A 67ALA A 58 | None | 1.12A | 5vc0A-1m33A:0.0 | 5vc0A-1m33A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mlz | 7,8-DIAMINO-PELARGONIC ACIDAMINOTRANSFERASE (Escherichiacoli) |
PF00202(Aminotran_3) | 5 | PHE A 80ILE A 243ALA A 123ILE A 296ALA A 293 | None | 1.09A | 5vc0A-1mlzA:0.0 | 5vc0A-1mlzA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1onf | GLUTATHIONEREDUCTASE (Plasmodiumfalciparum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ARG A 196ILE A 172PHE A 170ILE A 186ALA A 187 | NoneNoneNoneFAD A 500 ( 4.3A)None | 1.19A | 5vc0A-1onfA:0.0 | 5vc0A-1onfA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qcx | PECTIN LYASE B (Aspergillusniger) |
PF00544(Pec_lyase_C) | 5 | PHE A 230LEU A 216ILE A 166ILE A 174ALA A 172 | None | 1.19A | 5vc0A-1qcxA:0.0 | 5vc0A-1qcxA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vqu | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE 2 (Nostoc sp. PCC7120) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | PHE A 172LEU A 204PHE A 174ALA A 238ILE A 99 | None | 1.20A | 5vc0A-1vquA:0.0 | 5vc0A-1vquA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wza | ALPHA-AMYLASE A (Halothermothrixorenii) |
PF00128(Alpha-amylase) | 5 | ASP A 277LEU A 114PHE A 28PHE A 111ALA A 210 | None | 1.06A | 5vc0A-1wzaA:undetectable | 5vc0A-1wzaA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ypf | GMP REDUCTASE (Bacillusanthracis) |
PF00478(IMPDH) | 5 | ASP A 26PHE A 36ILE A 65ILE A 204ALA A 224 | None | 1.18A | 5vc0A-1ypfA:undetectable | 5vc0A-1ypfA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z4e | TRANSCRIPTIONALREGULATOR (Bacillushalodurans) |
PF00583(Acetyltransf_1) | 5 | ARG A 135PHE A 136LEU A 70ILE A 111ALA A 144 | None | 1.07A | 5vc0A-1z4eA:undetectable | 5vc0A-1z4eA:14.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zr6 | GLUCOOLIGOSACCHARIDEOXIDASE (Sarocladiumstrictum) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | PHE A 260LEU A 158ILE A 104ALA A 102ALA A 205 | None | 1.03A | 5vc0A-1zr6A:undetectable | 5vc0A-1zr6A:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dkh | 3-HYDROXYBENZOATEHYDROXYLASE (Comamonastestosteroni) |
PF01494(FAD_binding_3)PF07976(Phe_hydrox_dim) | 5 | PHE A 370PHE A 90ALA A 91ILE A 77ALA A 78 | None | 1.09A | 5vc0A-2dkhA:undetectable | 5vc0A-2dkhA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dll | INTERFERONREGULATORY FACTOR 4 (Homo sapiens) |
PF00605(IRF) | 5 | ASP A 102LEU A 82PHE A 56ALA A 53ALA A 42 | None | 1.19A | 5vc0A-2dllA:undetectable | 5vc0A-2dllA:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ARG X 153PHE X 168PHE X 253ALA X 119ILE X 146 | PTR X 160 ( 3.7A)NoneNoneNoneNone | 1.20A | 5vc0A-2dq7X:undetectable | 5vc0A-2dq7X:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hz7 | GLUTAMINYL-TRNASYNTHETASE (Deinococcusradiodurans) |
PF00749(tRNA-synt_1c)PF03950(tRNA-synt_1c_C) | 5 | ASP A 59LEU A 104ALA A 140ILE A 262ALA A 261 | None | 1.10A | 5vc0A-2hz7A:undetectable | 5vc0A-2hz7A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i1s | HYPOTHETICAL PROTEIN (Methanosarcinamazei) |
PF07929(PRiA4_ORF3) | 5 | ARG A 137PHE A 181PHE A 176ILE A 26ALA A 40 | None | 1.05A | 5vc0A-2i1sA:undetectable | 5vc0A-2i1sA:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ia2 | PUTATIVETRANSCRIPTIONALREGULATOR (Rhodococcusjostii) |
PF01614(IclR)PF09339(HTH_IclR) | 5 | SER A 114LEU A 205ILE A 121ALA A 145ILE A 190 | None | 1.10A | 5vc0A-2ia2A:undetectable | 5vc0A-2ia2A:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jdc | GLYPHOSATEN-ACETYLTRANSFERASE (Bacilluslicheniformis) |
PF00583(Acetyltransf_1) | 5 | PHE A 123LEU A 98PHE A 56ILE A 53ALA A 76 | NoneNoneNoneNoneCAO A1147 (-4.1A) | 1.15A | 5vc0A-2jdcA:undetectable | 5vc0A-2jdcA:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nlk | PROTEIN TYROSINEPHOSPHATASE,RECEPTOR TYPE, GVARIANT (FRAGMENT) (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | PHE A1154PHE A1402ILE A1333ILE A1386ALA A1383 | None | 1.16A | 5vc0A-2nlkA:undetectable | 5vc0A-2nlkA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q07 | UNCHARACTERIZEDPROTEIN AF0587 (Archaeoglobusfulgidus) |
PF01472(PUA) | 5 | PHE A 246SER A 275LEU A 262PHE A 247ILE A 401 | None | 1.17A | 5vc0A-2q07A:undetectable | 5vc0A-2q07A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qo3 | ERYAII ERYTHROMYCINPOLYKETIDE SYNTHASEMODULES 3 AND 4 (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | PHE A 156ASP A 118LEU A 387ALA A 449ALA A 201 | None | 1.19A | 5vc0A-2qo3A:undetectable | 5vc0A-2qo3A:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qps | ALPHA-AMYLASE TYPE AISOZYME (Hordeum vulgare) |
PF00128(Alpha-amylase)PF07821(Alpha-amyl_C2) | 5 | ASP A 208PHE A 246ILE A 86ILE A 194ALA A 190 | None | 1.20A | 5vc0A-2qpsA:undetectable | 5vc0A-2qpsA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uvf | EXOPOLYGALACTURONASE (Yersiniaenterocolitica) |
PF00295(Glyco_hydro_28)PF12708(Pectate_lyase_3) | 5 | ARG A 350LEU A 171ILE A 176ALA A 164ALA A 193 | None | 1.16A | 5vc0A-2uvfA:undetectable | 5vc0A-2uvfA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uyo | HYPOTHETICAL PROTEINML2640 (Mycobacteriumleprae) |
PF04072(LCM) | 5 | ASP A 38PHE A 91LEU A 189ILE A 214ILE A 131 | None | 1.12A | 5vc0A-2uyoA:undetectable | 5vc0A-2uyoA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wge | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 1 (Mycobacteriumtuberculosis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ASP A 377ARG A 234ILE A 347ALA A 170ALA A 279 | NoneNoneGOL A1421 (-3.9A)NoneIPA A1423 (-4.5A) | 1.00A | 5vc0A-2wgeA:undetectable | 5vc0A-2wgeA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3akk | CTKA (Helicobacterpylori) |
PF07804(HipA_C) | 5 | PHE A 145PHE A 140ILE A 282ILE A 63ALA A 60 | None | 1.13A | 5vc0A-3akkA:undetectable | 5vc0A-3akkA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3blw | ISOCITRATEDEHYDROGENASE [NAD]SUBUNIT 1 (Saccharomycescerevisiae) |
PF00180(Iso_dh) | 5 | ILE A 162PHE A 165ALA A 166ILE A 126ALA A 108 | None | 1.19A | 5vc0A-3blwA:undetectable | 5vc0A-3blwA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpj | GTP-BINDING PROTEINYPT31/YPT8 (Saccharomycescerevisiae) |
PF00071(Ras) | 5 | LEU B 150ILE B 124ALA B 166ILE B 171ALA B 64 | None | 1.17A | 5vc0A-3cpjB:undetectable | 5vc0A-3cpjB:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cze | SUCROSE HYDROLASE (Xanthomonascitri) |
PF00128(Alpha-amylase) | 5 | PHE A 277LEU A 74ALA A 67ILE A 312ALA A 308 | None | 1.17A | 5vc0A-3czeA:undetectable | 5vc0A-3czeA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1n | POU DOMAIN, CLASS 6,TRANSCRIPTION FACTOR1 (Homo sapiens) |
PF00046(Homeobox)PF00157(Pou) | 5 | ILE I 147PHE I 150ALA I 151ILE I 185ALA I 184 | None | 1.12A | 5vc0A-3d1nI:undetectable | 5vc0A-3d1nI:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d4u | CARBOXYPEPTIDASE B2 (Bos taurus) |
PF00246(Peptidase_M14) | 5 | LEU A 100ILE A 107PHE A 105ILE A 300ALA A 296 | None | 1.15A | 5vc0A-3d4uA:undetectable | 5vc0A-3d4uA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6k | PUTATIVEAMINOTRANSFERASE (Corynebacteriumdiphtheriae) |
PF12897(Aminotran_MocR) | 5 | ASP A 159LEU A 34ILE A 326PHE A 408ALA A 409 | None | 1.15A | 5vc0A-3d6kA:undetectable | 5vc0A-3d6kA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e2d | ALKALINE PHOSPHATASE (Vibrio sp.G15-21) |
PF00245(Alk_phosphatase) | 5 | ASP A 259LEU A 493ILE A 10ALA A 69ALA A 123 | None | 1.18A | 5vc0A-3e2dA:undetectable | 5vc0A-3e2dA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ee1 | EFFECTOR PROTEINVIRA (Shigellaflexneri) |
PF06872(EspG) | 5 | ASP A 178ARG A 389LEU A 349ALA A 394ILE A 292 | None | 1.04A | 5vc0A-3ee1A:undetectable | 5vc0A-3ee1A:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eez | PUTATIVE MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Ruegeriapomeroyi) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 6 | ASP A 241ARG A 268LEU A 84ILE A 105ALA A 108ALA A 300 | None | 1.39A | 5vc0A-3eezA:undetectable | 5vc0A-3eezA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fay | RASGTPASE-ACTIVATING-LIKE PROTEIN IQGAP1 (Homo sapiens) |
PF00616(RasGAP) | 5 | PHE A1262PHE A1265ILE A1209ILE A1228ALA A1229 | None | 1.12A | 5vc0A-3fayA:undetectable | 5vc0A-3fayA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3if2 | AMINOTRANSFERASE (Psychrobacterarcticus) |
PF00155(Aminotran_1_2) | 5 | SER A 328LEU A 278PHE A 118ILE A 365ALA A 364 | NoneNonePLP A 500 (-4.9A)NoneNone | 1.13A | 5vc0A-3if2A:undetectable | 5vc0A-3if2A:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lms | CARBOXYPEPTIDASE B2 (Homo sapiens) |
PF00246(Peptidase_M14) | 5 | ARG A 291LEU A 100PHE A 105ILE A 300ALA A 296 | None | 1.09A | 5vc0A-3lmsA:undetectable | 5vc0A-3lmsA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwt | NUCLEOPROTEIN (Lassamammarenavirus) |
PF00843(Arena_nucleocap)PF17290(Arena_ncap_C) | 5 | ARG A 455LEU A 445ILE A 411ALA A 401ILE A 467 | None | 1.18A | 5vc0A-3mwtA:undetectable | 5vc0A-3mwtA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8o | 6-PHOSPHOFRUCTOKINASE SUBUNIT BETA (Saccharomycescerevisiae) |
PF00365(PFK) | 5 | ARG B 586ILE B 682ALA B 872ILE B 571ALA B 574 | None | 1.09A | 5vc0A-3o8oB:undetectable | 5vc0A-3o8oB:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3osl | CARBOXYPEPTIDASE B2 (Bos taurus) |
PF00246(Peptidase_M14) | 5 | LEU A 212ILE A 219PHE A 217ILE A 415ALA A 411 | None | 1.15A | 5vc0A-3oslA:undetectable | 5vc0A-3oslA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qsg | NAD-BINDINGPHOSPHOGLUCONATEDEHYDROGENASE-LIKEPROTEIN (Alicyclobacillusacidocaldarius) |
PF03807(F420_oxidored)PF09130(DUF1932) | 5 | ASP A 139PHE A 144LEU A 19ALA A 12ILE A 6 | None | 1.17A | 5vc0A-3qsgA:undetectable | 5vc0A-3qsgA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ss7 | D-SERINE DEHYDRATASE (Escherichiacoli) |
PF00291(PALP) | 5 | SER X 79LEU X 276ALA X 423ILE X 84ALA X 83 | None | 1.18A | 5vc0A-3ss7X:undetectable | 5vc0A-3ss7X:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tcs | RACEMASE, PUTATIVE (Roseobacterdenitrificans) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ASP A 179ARG A 113LEU A 294ALA A 102ILE A 303 | None | 1.08A | 5vc0A-3tcsA:undetectable | 5vc0A-3tcsA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ugv | ENOLASE (alphaproteobacteriumBAL199) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ASP A 355ARG A 49ILE A 84ALA A 80ALA A 119 | None | 1.12A | 5vc0A-3ugvA:undetectable | 5vc0A-3ugvA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uhj | PROBABLE GLYCEROLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00465(Fe-ADH) | 5 | LEU A 287ILE A 346ALA A 350ILE A 360ALA A 276 | None | 1.04A | 5vc0A-3uhjA:undetectable | 5vc0A-3uhjA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vpz | GLUCOKINASE (Pseudoalteromonassp. AS-131) |
PF02685(Glucokinase) | 5 | PHE A 293ILE A 316ALA A 119ILE A 142ALA A 143 | None | 1.21A | 5vc0A-3vpzA:undetectable | 5vc0A-3vpzA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zh0 | PROTOGLOBIN (Methanosarcinaacetivorans) |
PF11563(Protoglobin) | 5 | ASP A 129ARG A 92LEU A 184ALA A 177ILE A 149 | NoneHEM A 200 (-4.6A)NoneNoneHEM A 200 (-4.3A) | 0.92A | 5vc0A-3zh0A:undetectable | 5vc0A-3zh0A:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zjl | PROTOGLOBIN (Methanosarcinaacetivorans) |
PF11563(Protoglobin) | 5 | ASP A 129ARG A 92LEU A 184ALA A 177ILE A 149 | NoneHEM A 200 (-4.4A)NoneNoneHEM A 200 ( 4.6A) | 0.86A | 5vc0A-3zjlA:undetectable | 5vc0A-3zjlA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1n | CARBON MONOXIDEDEHYDROGENASECORRINOID/IRON-SULFUR PROTEIN, GAMMASUBUNIT (Carboxydothermushydrogenoformans) |
PF03599(CdhD)PF04060(FeS) | 5 | LEU A 156ILE A 96ALA A 132ILE A 264ALA A 265 | None | 1.21A | 5vc0A-4c1nA:undetectable | 5vc0A-4c1nA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d1d | HYDANTOIN TRANSPORTPROTEIN (Microbacteriumliquefaciens) |
PF02133(Transp_cyt_pur) | 5 | LEU A 301PHE A 149ALA A 177ILE A 41ALA A 38 | NoneNoneNoneNone NA A1471 (-4.9A) | 1.09A | 5vc0A-4d1dA:undetectable | 5vc0A-4d1dA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e54 | DNA DAMAGE-BINDINGPROTEIN 2 (Homo sapiens) |
PF00400(WD40) | 5 | SER B 297LEU B 324ALA B 317ILE B 269ALA B 259 | None | 1.08A | 5vc0A-4e54B:undetectable | 5vc0A-4e54B:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ei8 | PLASMID REPLICATIONPROTEIN REPX (Bacillus cereus) |
PF00091(Tubulin) | 5 | ASP A 111PHE A 114LEU A 249ILE A 30ALA A 31 | None | 1.19A | 5vc0A-4ei8A:undetectable | 5vc0A-4ei8A:24.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4flx | DNA POLYMERASE 1 (Pyrococcusabyssi) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 5 | ASP A 614LEU A 745ILE A 642ALA A 629ILE A 603 | ASP A 614 ( 0.6A)LEU A 745 ( 0.5A)ILE A 642 ( 0.6A)ALA A 629 ( 0.0A)ILE A 603 ( 0.6A) | 1.15A | 5vc0A-4flxA:undetectable | 5vc0A-4flxA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ftw | PHOSPHOLIPASE/CARBOXYLESTERASE (Rhodobactersphaeroides) |
PF02230(Abhydrolase_2) | 5 | ARG A 139LEU A 231ILE A 185PHE A 236ALA A 179 | None | 1.18A | 5vc0A-4ftwA:undetectable | 5vc0A-4ftwA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7u | PYRANOSEDEHYDROGENASE (Leucoagaricusmeleagris) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ARG A 472PHE A 391ALA A 501ILE A 460ALA A 461 | None | 1.18A | 5vc0A-4h7uA:undetectable | 5vc0A-4h7uA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7u | PYRANOSEDEHYDROGENASE (Leucoagaricusmeleagris) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ASP A 379ILE A 133PHE A 564ALA A 563ALA A 555 | None | 1.17A | 5vc0A-4h7uA:undetectable | 5vc0A-4h7uA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4js5 | EXODEOXYRIBONUCLEASEI (Escherichiacoli) |
PF00929(RNase_T)PF08411(Exonuc_X-T_C) | 5 | PHE A 236LEU A 309PHE A 164ALA A 312ALA A 320 | None | 1.08A | 5vc0A-4js5A:undetectable | 5vc0A-4js5A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jso | OLIGOPEPTIDE ABCTRANSPORTER,PERIPLASMICOLIGOPEPTIDE-BINDINGPROTEIN (Thermotogamaritima) |
PF00496(SBP_bac_5) | 5 | ASP A 473PHE A 134PHE A 436ILE A 68ALA A 40 | None | 1.12A | 5vc0A-4jsoA:undetectable | 5vc0A-4jsoA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6n | AMINODEOXYCHORISMATELYASE (Saccharomycescerevisiae) |
PF01063(Aminotran_4) | 5 | ARG A 260SER A 299ILE A 300ILE A 269ALA A 268 | None | 1.14A | 5vc0A-4k6nA:undetectable | 5vc0A-4k6nA:21.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 5 | ASP A 76ARG A 106LEU A 211ILE A 369ALA A 370 | NoneNoneNoneHEM A 601 (-4.7A)2QH A 602 ( 3.1A) | 0.97A | 5vc0A-4ny4A:53.4 | 5vc0A-4ny4A:99.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 8 | ASP A 76ARG A 106PHE A 108SER A 119ILE A 301ALA A 305ILE A 369ALA A 370 | NoneNone2QH A 602 (-4.4A)2QH A 602 (-3.9A)None2QH A 602 ( 3.6A)HEM A 601 (-4.7A)2QH A 602 ( 3.1A) | 0.62A | 5vc0A-4ny4A:53.4 | 5vc0A-4ny4A:99.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 7 | ASP A 76ARG A 106PHE A 108SER A 119ILE A 301PHE A 304ALA A 305 | NoneNone2QH A 602 (-4.4A)2QH A 602 (-3.9A)None2QH A 602 (-3.3A)2QH A 602 ( 3.6A) | 1.16A | 5vc0A-4ny4A:53.4 | 5vc0A-4ny4A:99.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 5 | PHE A 57PHE A 108SER A 119ILE A 301ALA A 305 | None2QH A 602 (-4.4A)2QH A 602 (-3.9A)None2QH A 602 ( 3.6A) | 1.00A | 5vc0A-4ny4A:53.4 | 5vc0A-4ny4A:99.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 6 | SER A 119LEU A 210ILE A 301ALA A 305ILE A 369ALA A 370 | 2QH A 602 (-3.9A)NoneNone2QH A 602 ( 3.6A)HEM A 601 (-4.7A)2QH A 602 ( 3.1A) | 0.97A | 5vc0A-4ny4A:53.4 | 5vc0A-4ny4A:99.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oj5 | TAILSPIKE PROTEIN (Escherichiavirus CBA120) |
no annotation | 5 | ASP A 304LEU A 272ILE A 326ILE A 389ALA A 396 | None | 1.18A | 5vc0A-4oj5A:undetectable | 5vc0A-4oj5A:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pht | GENERAL SECRETORYPATHWAY PROTEIN ETYPE II SECRETIONSYSTEM PROTEIN L (Vibriovulnificus) |
PF00437(T2SSE)PF05134(T2SSL) | 5 | ASP X 95ARG X 116ILE A 331ALA A 340ILE A 318 | None | 1.20A | 5vc0A-4phtX:undetectable | 5vc0A-4phtX:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pq0 | FACT COMPLEX SUBUNITPOB3 (Saccharomycescerevisiae) |
PF08512(Rtt106) | 5 | LEU A 470ILE A 412PHE A 414ALA A 401ALA A 383 | None | 1.10A | 5vc0A-4pq0A:undetectable | 5vc0A-4pq0A:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9d | BENZOYLFORMATEDECARBOXYLASE (Mycolicibacteriumsmegmatis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | PHE A 24ILE A 432PHE A 456ALA A 430ILE A 415 | None | 1.10A | 5vc0A-4q9dA:undetectable | 5vc0A-4q9dA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rhh | BETA-XYLOSIDASE (Geobacillusstearothermophilus) |
PF03512(Glyco_hydro_52) | 5 | PHE A 100LEU A 31PHE A 7ALA A 141ALA A 103 | None | 1.18A | 5vc0A-4rhhA:undetectable | 5vc0A-4rhhA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvh | D-MYCAROSE3-C-METHYLTRANSFERASE (Streptomycesargillaceus) |
PF08421(Methyltransf_13)PF08484(Methyltransf_14)PF13489(Methyltransf_23) | 5 | ASP A 135LEU A 244PHE A 239ILE A 230ALA A 181 | SAH A 502 (-2.7A)NoneNoneNoneNone | 1.16A | 5vc0A-4rvhA:undetectable | 5vc0A-4rvhA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoz | BETA-GALACTOSIDASE (Bifidobacteriumanimalis) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | SER A 410LEU A 671ALA A 353ILE A 359ALA A 358 | None | 1.05A | 5vc0A-4uozA:undetectable | 5vc0A-4uozA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xe3 | CYTOCHROME P-450 (Streptomycesantibioticus) |
PF00067(p450) | 5 | ASP A 143SER A 175LEU A 361ALA A 244ILE A 397 | NoneNoneNoneHEM A 501 ( 3.5A)CL6 A 502 (-4.8A) | 1.21A | 5vc0A-4xe3A:27.0 | 5vc0A-4xe3A:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhj | ENVELOPEGLYCOPROTEIN H (Humanalphaherpesvirus3) |
PF02489(Herpes_glycop_H)PF17488(Herpes_glycoH_C) | 5 | ARG A 249SER A 267ILE A 359ILE A 367ALA A 368 | None | 1.10A | 5vc0A-4xhjA:undetectable | 5vc0A-4xhjA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xk2 | ALDO/KETO REDUCTASE (Polaromonas sp.JS666) |
PF00248(Aldo_ket_red) | 5 | PHE A 160LEU A 88ILE A 155ILE A 210ALA A 209 | None | 1.09A | 5vc0A-4xk2A:undetectable | 5vc0A-4xk2A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzw | AGAP004976-PA (Anophelesgambiae) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | ASP A 537ARG A 270ILE A 414PHE A 415ILE A 422 | NoneNoneNone CU A 802 ( 4.9A)None | 1.18A | 5vc0A-4yzwA:undetectable | 5vc0A-4yzwA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ztk | CELL DIVISIONPROTEINFTSI/PENICILLINBINDING PROTEIN 2 (Legionellapneumophila) |
PF00905(Transpeptidase) | 5 | PHE A 480ILE A 352ALA A 380ILE A 376ALA A 369 | None | 1.14A | 5vc0A-4ztkA:undetectable | 5vc0A-4ztkA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxw | C-DOMAIN TYPE IIPEPTIDE SYNTHETASE (Streptomycesglobisporus) |
PF00668(Condensation) | 5 | PHE A 212PHE A 338SER A 264PHE A 270ALA A 271 | None | 1.11A | 5vc0A-4zxwA:undetectable | 5vc0A-4zxwA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7p | CELL DIVISIONCONTROL PROTEINCDC48 (Mycolicibacteriumsmegmatis) |
PF00004(AAA)PF02359(CDC48_N) | 5 | ASP A 293ARG A 131LEU A 430ILE A 466ILE A 171 | None | 1.16A | 5vc0A-5e7pA:undetectable | 5vc0A-5e7pA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h42 | UNCHARACTERIZEDPROTEIN (Lachnoclostridiumphytofermentans) |
PF17167(Glyco_hydro_36) | 5 | LEU A 890ILE A 918ALA A 895ILE A 904ALA A 765 | None | 1.16A | 5vc0A-5h42A:undetectable | 5vc0A-5h42A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7n | NLRP12-PYD WITH MBPTAG (Homo sapiens) |
PF02758(PYRIN)PF13416(SBP_bac_8) | 5 | PHE A 393ILE A 179ALA A 373ILE A 426ALA A 434 | None | 1.10A | 5vc0A-5h7nA:undetectable | 5vc0A-5h7nA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbh | 30S RIBOSOMALPROTEIN US7 (Pyrococcusabyssi) |
PF00177(Ribosomal_S7) | 5 | ILE H 111PHE H 108ALA H 107ILE H 71ALA H 166 | None | 1.03A | 5vc0A-5jbhH:undetectable | 5vc0A-5jbhH:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m11 | IMMUNOREACTIVE 84KDANTIGEN PG93 (Porphyromonasgingivalis) |
no annotation | 5 | ASP A 393SER A 566PHE A 538ALA A 588ALA A 555 | None | 1.12A | 5vc0A-5m11A:undetectable | 5vc0A-5m11A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m1q | PHAGE TERMINASELARGE SUBUNIT (Thermus phageG20c) |
PF17289(Terminase_6C) | 5 | ILE A 291PHE A 304ALA A 293ILE A 355ALA A 356 | None | 1.14A | 5vc0A-5m1qA:undetectable | 5vc0A-5m1qA:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mtz | RIBONUCLEASE Z (Saccharomycescerevisiae) |
PF13691(Lactamase_B_4) | 5 | ASP A 820ARG A 763LEU A 339PHE A 785ALA A 784 | None | 1.18A | 5vc0A-5mtzA:undetectable | 5vc0A-5mtzA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swj | PROBABLE ATPSYNTHASE SPAL/MXIB (Shigellaflexneri) |
PF00006(ATP-synt_ab) | 5 | LEU A 91ILE A 229ALA A 232ILE A 298ALA A 300 | None | 0.91A | 5vc0A-5swjA:undetectable | 5vc0A-5swjA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u47 | PENICILLIN BINDINGPROTEIN 2X (Streptococcusthermophilus) |
PF00905(Transpeptidase)PF03717(PBP_dimer)PF03793(PASTA) | 6 | ASP A 380PHE A 399SER A 351ILE A 474PHE A 471ALA A 470 | None | 1.42A | 5vc0A-5u47A:undetectable | 5vc0A-5u47A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uc7 | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE (environmentalsamples) |
PF00202(Aminotran_3) | 5 | PHE A 80ILE A 243ALA A 123ILE A 296ALA A 293 | None | 1.18A | 5vc0A-5uc7A:undetectable | 5vc0A-5uc7A:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wez | TIR CHAPERONETRANSLOCATED INTIMINRECEPTOR TIR (Escherichiacoli) |
no annotation | 5 | LEU A 109ILE A 21PHE A 12ALA A 13ILE B 38 | None | 1.16A | 5vc0A-5wezA:undetectable | 5vc0A-5wezA:9.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmc | E3 UBIQUITIN-PROTEINLIGASE ITCHY (Mus musculus) |
PF00397(WW)PF00632(HECT) | 5 | PHE A 624PHE A 601PHE A 573ILE A 511ALA A 554 | None | 1.20A | 5vc0A-5xmcA:undetectable | 5vc0A-5xmcA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xn8 | GLYCEROLDEHYDROGENASE (unidentified) |
PF00465(Fe-ADH) | 5 | SER A 288ILE A 293ALA A 355ILE A 256ALA A 252 | None | 1.13A | 5vc0A-5xn8A:undetectable | 5vc0A-5xn8A:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y7o | UGGT (Thermomycesdupontii) |
PF06427(UDP-g_GGTase) | 5 | ASP A 999ARG A 960PHE A 961ALA A 326ALA A 921 | None | 1.18A | 5vc0A-5y7oA:undetectable | 5vc0A-5y7oA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z9s | GLYCOSYL HYDROLASEFAMILY 3 PROTEIN (Bifidobacteriumlongum) |
no annotation | 5 | PHE A 624LEU A 540ALA A 412ILE A 560ALA A 595 | None | 1.00A | 5vc0A-5z9sA:undetectable | 5vc0A-5z9sA:11.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zbb | - (-) |
no annotation | 5 | PHE A 406LEU A 12ALA A 57ILE A 27ALA A 416 | None | 1.21A | 5vc0A-5zbbA:undetectable | 5vc0A-5zbbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bja | ACETYL-COAACETYLTRANSFERASE A (Ascaris suum) |
no annotation | 5 | ARG A 344ILE A 331PHE A 330ILE A 314ALA A 315 | None | 1.09A | 5vc0A-6bjaA:undetectable | 5vc0A-6bjaA:10.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eio | ANTIFREEZE PROTEIN (unculturedbacterium) |
no annotation | 5 | ASP A 225LEU A 250ALA A 55ILE A 217ALA A 218 | None | 1.10A | 5vc0A-6eioA:undetectable | 5vc0A-6eioA:9.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6et7 | DIGUANYLATE CYCLASE(GGDEF)DOMAIN-CONTAININGPROTEIN (Idiomarina sp.A28L) |
no annotation | 5 | SER A 592ILE A 534PHE A 535ILE A 612ALA A 613 | None | 1.10A | 5vc0A-6et7A:undetectable | 5vc0A-6et7A:10.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN4 (Mus musculus) |
no annotation | 5 | PHE M 149LEU M 238ILE M 230ALA M 233ALA M 287 | None | 0.99A | 5vc0A-6g2jM:undetectable | 5vc0A-6g2jM:10.36 |