SIMILAR PATTERNS OF AMINO ACIDS FOR 5VC0_A_RITA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus)
PF00191
(Annexin)
5 ASP A 218
ARG A 243
LEU A 253
ILE A 109
ALA A 234
None
1.14A 5vc0A-1aowA:
0.0
5vc0A-1aowA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT


(Shigella
dysenteriae)
PF00161
(RIP)
5 PHE A  95
PHE A  50
LEU A 238
PHE A 257
ALA A 168
None
1.05A 5vc0A-1dm0A:
undetectable
5vc0A-1dm0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foe T-LYMPHOMA INVASION
AND METASTASIS
INDUCING PROTEIN 1


(Mus musculus)
PF00169
(PH)
PF00621
(RhoGEF)
5 ASP A1327
PHE A1331
ILE A1335
ALA A1299
ILE A1249
None
1.20A 5vc0A-1foeA:
0.0
5vc0A-1foeA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis)
PF00082
(Peptidase_S8)
5 ASP 1 173
SER 1 140
LEU 1  33
PHE 1 107
ALA 1 183
None
1.11A 5vc0A-1gt91:
undetectable
5vc0A-1gt91:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli)
PF00561
(Abhydrolase_1)
5 SER A  53
LEU A  19
ILE A   4
ALA A  67
ALA A  58
None
1.12A 5vc0A-1m33A:
0.0
5vc0A-1m33A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE


(Escherichia
coli)
PF00202
(Aminotran_3)
5 PHE A  80
ILE A 243
ALA A 123
ILE A 296
ALA A 293
None
1.09A 5vc0A-1mlzA:
0.0
5vc0A-1mlzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onf GLUTATHIONE
REDUCTASE


(Plasmodium
falciparum)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ARG A 196
ILE A 172
PHE A 170
ILE A 186
ALA A 187
None
None
None
FAD  A 500 ( 4.3A)
None
1.19A 5vc0A-1onfA:
0.0
5vc0A-1onfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger)
PF00544
(Pec_lyase_C)
5 PHE A 230
LEU A 216
ILE A 166
ILE A 174
ALA A 172
None
1.19A 5vc0A-1qcxA:
0.0
5vc0A-1qcxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2


(Nostoc sp. PCC
7120)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
5 PHE A 172
LEU A 204
PHE A 174
ALA A 238
ILE A  99
None
1.20A 5vc0A-1vquA:
0.0
5vc0A-1vquA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii)
PF00128
(Alpha-amylase)
5 ASP A 277
LEU A 114
PHE A  28
PHE A 111
ALA A 210
None
1.06A 5vc0A-1wzaA:
undetectable
5vc0A-1wzaA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypf GMP REDUCTASE

(Bacillus
anthracis)
PF00478
(IMPDH)
5 ASP A  26
PHE A  36
ILE A  65
ILE A 204
ALA A 224
None
1.18A 5vc0A-1ypfA:
undetectable
5vc0A-1ypfA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z4e TRANSCRIPTIONAL
REGULATOR


(Bacillus
halodurans)
PF00583
(Acetyltransf_1)
5 ARG A 135
PHE A 136
LEU A  70
ILE A 111
ALA A 144
None
1.07A 5vc0A-1z4eA:
undetectable
5vc0A-1z4eA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE


(Sarocladium
strictum)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 PHE A 260
LEU A 158
ILE A 104
ALA A 102
ALA A 205
None
1.03A 5vc0A-1zr6A:
undetectable
5vc0A-1zr6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE


(Comamonas
testosteroni)
PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim)
5 PHE A 370
PHE A  90
ALA A  91
ILE A  77
ALA A  78
None
1.09A 5vc0A-2dkhA:
undetectable
5vc0A-2dkhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dll INTERFERON
REGULATORY FACTOR 4


(Homo sapiens)
PF00605
(IRF)
5 ASP A 102
LEU A  82
PHE A  56
ALA A  53
ALA A  42
None
1.19A 5vc0A-2dllA:
undetectable
5vc0A-2dllA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ARG X 153
PHE X 168
PHE X 253
ALA X 119
ILE X 146
PTR  X 160 ( 3.7A)
None
None
None
None
1.20A 5vc0A-2dq7X:
undetectable
5vc0A-2dq7X:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE


(Deinococcus
radiodurans)
PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
5 ASP A  59
LEU A 104
ALA A 140
ILE A 262
ALA A 261
None
1.10A 5vc0A-2hz7A:
undetectable
5vc0A-2hz7A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1s HYPOTHETICAL PROTEIN

(Methanosarcina
mazei)
PF07929
(PRiA4_ORF3)
5 ARG A 137
PHE A 181
PHE A 176
ILE A  26
ALA A  40
None
1.05A 5vc0A-2i1sA:
undetectable
5vc0A-2i1sA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Rhodococcus
jostii)
PF01614
(IclR)
PF09339
(HTH_IclR)
5 SER A 114
LEU A 205
ILE A 121
ALA A 145
ILE A 190
None
1.10A 5vc0A-2ia2A:
undetectable
5vc0A-2ia2A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdc GLYPHOSATE
N-ACETYLTRANSFERASE


(Bacillus
licheniformis)
PF00583
(Acetyltransf_1)
5 PHE A 123
LEU A  98
PHE A  56
ILE A  53
ALA A  76
None
None
None
None
CAO  A1147 (-4.1A)
1.15A 5vc0A-2jdcA:
undetectable
5vc0A-2jdcA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)


(Homo sapiens)
PF00102
(Y_phosphatase)
5 PHE A1154
PHE A1402
ILE A1333
ILE A1386
ALA A1383
None
1.16A 5vc0A-2nlkA:
undetectable
5vc0A-2nlkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q07 UNCHARACTERIZED
PROTEIN AF0587


(Archaeoglobus
fulgidus)
PF01472
(PUA)
5 PHE A 246
SER A 275
LEU A 262
PHE A 247
ILE A 401
None
1.17A 5vc0A-2q07A:
undetectable
5vc0A-2q07A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4


(Saccharopolyspora
erythraea)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 PHE A 156
ASP A 118
LEU A 387
ALA A 449
ALA A 201
None
1.19A 5vc0A-2qo3A:
undetectable
5vc0A-2qo3A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME


(Hordeum vulgare)
PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2)
5 ASP A 208
PHE A 246
ILE A  86
ILE A 194
ALA A 190
None
1.20A 5vc0A-2qpsA:
undetectable
5vc0A-2qpsA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica)
PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3)
5 ARG A 350
LEU A 171
ILE A 176
ALA A 164
ALA A 193
None
1.16A 5vc0A-2uvfA:
undetectable
5vc0A-2uvfA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyo HYPOTHETICAL PROTEIN
ML2640


(Mycobacterium
leprae)
PF04072
(LCM)
5 ASP A  38
PHE A  91
LEU A 189
ILE A 214
ILE A 131
None
1.12A 5vc0A-2uyoA:
undetectable
5vc0A-2uyoA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ASP A 377
ARG A 234
ILE A 347
ALA A 170
ALA A 279
None
None
GOL  A1421 (-3.9A)
None
IPA  A1423 (-4.5A)
1.00A 5vc0A-2wgeA:
undetectable
5vc0A-2wgeA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akk CTKA

(Helicobacter
pylori)
PF07804
(HipA_C)
5 PHE A 145
PHE A 140
ILE A 282
ILE A  63
ALA A  60
None
1.13A 5vc0A-3akkA:
undetectable
5vc0A-3akkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF00180
(Iso_dh)
5 ILE A 162
PHE A 165
ALA A 166
ILE A 126
ALA A 108
None
1.19A 5vc0A-3blwA:
undetectable
5vc0A-3blwA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpj GTP-BINDING PROTEIN
YPT31/YPT8


(Saccharomyces
cerevisiae)
PF00071
(Ras)
5 LEU B 150
ILE B 124
ALA B 166
ILE B 171
ALA B  64
None
1.17A 5vc0A-3cpjB:
undetectable
5vc0A-3cpjB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri)
PF00128
(Alpha-amylase)
5 PHE A 277
LEU A  74
ALA A  67
ILE A 312
ALA A 308
None
1.17A 5vc0A-3czeA:
undetectable
5vc0A-3czeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1n POU DOMAIN, CLASS 6,
TRANSCRIPTION FACTOR
1


(Homo sapiens)
PF00046
(Homeobox)
PF00157
(Pou)
5 ILE I 147
PHE I 150
ALA I 151
ILE I 185
ALA I 184
None
1.12A 5vc0A-3d1nI:
undetectable
5vc0A-3d1nI:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2

(Bos taurus)
PF00246
(Peptidase_M14)
5 LEU A 100
ILE A 107
PHE A 105
ILE A 300
ALA A 296
None
1.15A 5vc0A-3d4uA:
undetectable
5vc0A-3d4uA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE


(Corynebacterium
diphtheriae)
PF12897
(Aminotran_MocR)
5 ASP A 159
LEU A  34
ILE A 326
PHE A 408
ALA A 409
None
1.15A 5vc0A-3d6kA:
undetectable
5vc0A-3d6kA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21)
PF00245
(Alk_phosphatase)
5 ASP A 259
LEU A 493
ILE A  10
ALA A  69
ALA A 123
None
1.18A 5vc0A-3e2dA:
undetectable
5vc0A-3e2dA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee1 EFFECTOR PROTEIN
VIRA


(Shigella
flexneri)
PF06872
(EspG)
5 ASP A 178
ARG A 389
LEU A 349
ALA A 394
ILE A 292
None
1.04A 5vc0A-3ee1A:
undetectable
5vc0A-3ee1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Ruegeria
pomeroyi)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
6 ASP A 241
ARG A 268
LEU A  84
ILE A 105
ALA A 108
ALA A 300
None
1.39A 5vc0A-3eezA:
undetectable
5vc0A-3eezA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1


(Homo sapiens)
PF00616
(RasGAP)
5 PHE A1262
PHE A1265
ILE A1209
ILE A1228
ALA A1229
None
1.12A 5vc0A-3fayA:
undetectable
5vc0A-3fayA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus)
PF00155
(Aminotran_1_2)
5 SER A 328
LEU A 278
PHE A 118
ILE A 365
ALA A 364
None
None
PLP  A 500 (-4.9A)
None
None
1.13A 5vc0A-3if2A:
undetectable
5vc0A-3if2A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lms CARBOXYPEPTIDASE B2

(Homo sapiens)
PF00246
(Peptidase_M14)
5 ARG A 291
LEU A 100
PHE A 105
ILE A 300
ALA A 296
None
1.09A 5vc0A-3lmsA:
undetectable
5vc0A-3lmsA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus)
PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C)
5 ARG A 455
LEU A 445
ILE A 411
ALA A 401
ILE A 467
None
1.18A 5vc0A-3mwtA:
undetectable
5vc0A-3mwtA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00365
(PFK)
5 ARG B 586
ILE B 682
ALA B 872
ILE B 571
ALA B 574
None
1.09A 5vc0A-3o8oB:
undetectable
5vc0A-3o8oB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osl CARBOXYPEPTIDASE B2

(Bos taurus)
PF00246
(Peptidase_M14)
5 LEU A 212
ILE A 219
PHE A 217
ILE A 415
ALA A 411
None
1.15A 5vc0A-3oslA:
undetectable
5vc0A-3oslA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN


(Alicyclobacillus
acidocaldarius)
PF03807
(F420_oxidored)
PF09130
(DUF1932)
5 ASP A 139
PHE A 144
LEU A  19
ALA A  12
ILE A   6
None
1.17A 5vc0A-3qsgA:
undetectable
5vc0A-3qsgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli)
PF00291
(PALP)
5 SER X  79
LEU X 276
ALA X 423
ILE X  84
ALA X  83
None
1.18A 5vc0A-3ss7X:
undetectable
5vc0A-3ss7X:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ASP A 179
ARG A 113
LEU A 294
ALA A 102
ILE A 303
None
1.08A 5vc0A-3tcsA:
undetectable
5vc0A-3tcsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ASP A 355
ARG A  49
ILE A  84
ALA A  80
ALA A 119
None
1.12A 5vc0A-3ugvA:
undetectable
5vc0A-3ugvA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00465
(Fe-ADH)
5 LEU A 287
ILE A 346
ALA A 350
ILE A 360
ALA A 276
None
1.04A 5vc0A-3uhjA:
undetectable
5vc0A-3uhjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131)
PF02685
(Glucokinase)
5 PHE A 293
ILE A 316
ALA A 119
ILE A 142
ALA A 143
None
1.21A 5vc0A-3vpzA:
undetectable
5vc0A-3vpzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh0 PROTOGLOBIN

(Methanosarcina
acetivorans)
PF11563
(Protoglobin)
5 ASP A 129
ARG A  92
LEU A 184
ALA A 177
ILE A 149
None
HEM  A 200 (-4.6A)
None
None
HEM  A 200 (-4.3A)
0.92A 5vc0A-3zh0A:
undetectable
5vc0A-3zh0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjl PROTOGLOBIN

(Methanosarcina
acetivorans)
PF11563
(Protoglobin)
5 ASP A 129
ARG A  92
LEU A 184
ALA A 177
ILE A 149
None
HEM  A 200 (-4.4A)
None
None
HEM  A 200 ( 4.6A)
0.86A 5vc0A-3zjlA:
undetectable
5vc0A-3zjlA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT


(Carboxydothermus
hydrogenoformans)
PF03599
(CdhD)
PF04060
(FeS)
5 LEU A 156
ILE A  96
ALA A 132
ILE A 264
ALA A 265
None
1.21A 5vc0A-4c1nA:
undetectable
5vc0A-4c1nA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1d HYDANTOIN TRANSPORT
PROTEIN


(Microbacterium
liquefaciens)
PF02133
(Transp_cyt_pur)
5 LEU A 301
PHE A 149
ALA A 177
ILE A  41
ALA A  38
None
None
None
None
NA  A1471 (-4.9A)
1.09A 5vc0A-4d1dA:
undetectable
5vc0A-4d1dA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e54 DNA DAMAGE-BINDING
PROTEIN 2


(Homo sapiens)
PF00400
(WD40)
5 SER B 297
LEU B 324
ALA B 317
ILE B 269
ALA B 259
None
1.08A 5vc0A-4e54B:
undetectable
5vc0A-4e54B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX


(Bacillus cereus)
PF00091
(Tubulin)
5 ASP A 111
PHE A 114
LEU A 249
ILE A  30
ALA A  31
None
1.19A 5vc0A-4ei8A:
undetectable
5vc0A-4ei8A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 ASP A 614
LEU A 745
ILE A 642
ALA A 629
ILE A 603
ASP  A 614 ( 0.6A)
LEU  A 745 ( 0.5A)
ILE  A 642 ( 0.6A)
ALA  A 629 ( 0.0A)
ILE  A 603 ( 0.6A)
1.15A 5vc0A-4flxA:
undetectable
5vc0A-4flxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE


(Rhodobacter
sphaeroides)
PF02230
(Abhydrolase_2)
5 ARG A 139
LEU A 231
ILE A 185
PHE A 236
ALA A 179
None
1.18A 5vc0A-4ftwA:
undetectable
5vc0A-4ftwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE


(Leucoagaricus
meleagris)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 ARG A 472
PHE A 391
ALA A 501
ILE A 460
ALA A 461
None
1.18A 5vc0A-4h7uA:
undetectable
5vc0A-4h7uA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE


(Leucoagaricus
meleagris)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 ASP A 379
ILE A 133
PHE A 564
ALA A 563
ALA A 555
None
1.17A 5vc0A-4h7uA:
undetectable
5vc0A-4h7uA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I


(Escherichia
coli)
PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C)
5 PHE A 236
LEU A 309
PHE A 164
ALA A 312
ALA A 320
None
1.08A 5vc0A-4js5A:
undetectable
5vc0A-4js5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN


(Thermotoga
maritima)
PF00496
(SBP_bac_5)
5 ASP A 473
PHE A 134
PHE A 436
ILE A  68
ALA A  40
None
1.12A 5vc0A-4jsoA:
undetectable
5vc0A-4jsoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE


(Saccharomyces
cerevisiae)
PF01063
(Aminotran_4)
5 ARG A 260
SER A 299
ILE A 300
ILE A 269
ALA A 268
None
1.14A 5vc0A-4k6nA:
undetectable
5vc0A-4k6nA:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
5 ASP A  76
ARG A 106
LEU A 211
ILE A 369
ALA A 370
None
None
None
HEM  A 601 (-4.7A)
2QH  A 602 ( 3.1A)
0.97A 5vc0A-4ny4A:
53.4
5vc0A-4ny4A:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
8 ASP A  76
ARG A 106
PHE A 108
SER A 119
ILE A 301
ALA A 305
ILE A 369
ALA A 370
None
None
2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
2QH  A 602 ( 3.6A)
HEM  A 601 (-4.7A)
2QH  A 602 ( 3.1A)
0.62A 5vc0A-4ny4A:
53.4
5vc0A-4ny4A:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
7 ASP A  76
ARG A 106
PHE A 108
SER A 119
ILE A 301
PHE A 304
ALA A 305
None
None
2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
2QH  A 602 (-3.3A)
2QH  A 602 ( 3.6A)
1.16A 5vc0A-4ny4A:
53.4
5vc0A-4ny4A:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
5 PHE A  57
PHE A 108
SER A 119
ILE A 301
ALA A 305
None
2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
2QH  A 602 ( 3.6A)
1.00A 5vc0A-4ny4A:
53.4
5vc0A-4ny4A:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
6 SER A 119
LEU A 210
ILE A 301
ALA A 305
ILE A 369
ALA A 370
2QH  A 602 (-3.9A)
None
None
2QH  A 602 ( 3.6A)
HEM  A 601 (-4.7A)
2QH  A 602 ( 3.1A)
0.97A 5vc0A-4ny4A:
53.4
5vc0A-4ny4A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120)
no annotation 5 ASP A 304
LEU A 272
ILE A 326
ILE A 389
ALA A 396
None
1.18A 5vc0A-4oj5A:
undetectable
5vc0A-4oj5A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E
TYPE II SECRETION
SYSTEM PROTEIN L


(Vibrio
vulnificus)
PF00437
(T2SSE)
PF05134
(T2SSL)
5 ASP X  95
ARG X 116
ILE A 331
ALA A 340
ILE A 318
None
1.20A 5vc0A-4phtX:
undetectable
5vc0A-4phtX:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq0 FACT COMPLEX SUBUNIT
POB3


(Saccharomyces
cerevisiae)
PF08512
(Rtt106)
5 LEU A 470
ILE A 412
PHE A 414
ALA A 401
ALA A 383
None
1.10A 5vc0A-4pq0A:
undetectable
5vc0A-4pq0A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9d BENZOYLFORMATE
DECARBOXYLASE


(Mycolicibacterium
smegmatis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 PHE A  24
ILE A 432
PHE A 456
ALA A 430
ILE A 415
None
1.10A 5vc0A-4q9dA:
undetectable
5vc0A-4q9dA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus)
PF03512
(Glyco_hydro_52)
5 PHE A 100
LEU A  31
PHE A   7
ALA A 141
ALA A 103
None
1.18A 5vc0A-4rhhA:
undetectable
5vc0A-4rhhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E


(Streptomyces
argillaceus)
PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23)
5 ASP A 135
LEU A 244
PHE A 239
ILE A 230
ALA A 181
SAH  A 502 (-2.7A)
None
None
None
None
1.16A 5vc0A-4rvhA:
undetectable
5vc0A-4rvhA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
5 SER A 410
LEU A 671
ALA A 353
ILE A 359
ALA A 358
None
1.05A 5vc0A-4uozA:
undetectable
5vc0A-4uozA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe3 CYTOCHROME P-450

(Streptomyces
antibioticus)
PF00067
(p450)
5 ASP A 143
SER A 175
LEU A 361
ALA A 244
ILE A 397
None
None
None
HEM  A 501 ( 3.5A)
CL6  A 502 (-4.8A)
1.21A 5vc0A-4xe3A:
27.0
5vc0A-4xe3A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H


(Human
alphaherpesvirus
3)
PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
5 ARG A 249
SER A 267
ILE A 359
ILE A 367
ALA A 368
None
1.10A 5vc0A-4xhjA:
undetectable
5vc0A-4xhjA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk2 ALDO/KETO REDUCTASE

(Polaromonas sp.
JS666)
PF00248
(Aldo_ket_red)
5 PHE A 160
LEU A  88
ILE A 155
ILE A 210
ALA A 209
None
1.09A 5vc0A-4xk2A:
undetectable
5vc0A-4xk2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
5 ASP A 537
ARG A 270
ILE A 414
PHE A 415
ILE A 422
None
None
None
CU  A 802 ( 4.9A)
None
1.18A 5vc0A-4yzwA:
undetectable
5vc0A-4yzwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztk CELL DIVISION
PROTEIN
FTSI/PENICILLIN
BINDING PROTEIN 2


(Legionella
pneumophila)
PF00905
(Transpeptidase)
5 PHE A 480
ILE A 352
ALA A 380
ILE A 376
ALA A 369
None
1.14A 5vc0A-4ztkA:
undetectable
5vc0A-4ztkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE


(Streptomyces
globisporus)
PF00668
(Condensation)
5 PHE A 212
PHE A 338
SER A 264
PHE A 270
ALA A 271
None
1.11A 5vc0A-4zxwA:
undetectable
5vc0A-4zxwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48


(Mycolicibacterium
smegmatis)
PF00004
(AAA)
PF02359
(CDC48_N)
5 ASP A 293
ARG A 131
LEU A 430
ILE A 466
ILE A 171
None
1.16A 5vc0A-5e7pA:
undetectable
5vc0A-5e7pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN


(Lachnoclostridium
phytofermentans)
PF17167
(Glyco_hydro_36)
5 LEU A 890
ILE A 918
ALA A 895
ILE A 904
ALA A 765
None
1.16A 5vc0A-5h42A:
undetectable
5vc0A-5h42A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG


(Homo sapiens)
PF02758
(PYRIN)
PF13416
(SBP_bac_8)
5 PHE A 393
ILE A 179
ALA A 373
ILE A 426
ALA A 434
None
1.10A 5vc0A-5h7nA:
undetectable
5vc0A-5h7nA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbh 30S RIBOSOMAL
PROTEIN US7


(Pyrococcus
abyssi)
PF00177
(Ribosomal_S7)
5 ILE H 111
PHE H 108
ALA H 107
ILE H  71
ALA H 166
None
1.03A 5vc0A-5jbhH:
undetectable
5vc0A-5jbhH:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93


(Porphyromonas
gingivalis)
no annotation 5 ASP A 393
SER A 566
PHE A 538
ALA A 588
ALA A 555
None
1.12A 5vc0A-5m11A:
undetectable
5vc0A-5m11A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1q PHAGE TERMINASE
LARGE SUBUNIT


(Thermus phage
G20c)
PF17289
(Terminase_6C)
5 ILE A 291
PHE A 304
ALA A 293
ILE A 355
ALA A 356
None
1.14A 5vc0A-5m1qA:
undetectable
5vc0A-5m1qA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae)
PF13691
(Lactamase_B_4)
5 ASP A 820
ARG A 763
LEU A 339
PHE A 785
ALA A 784
None
1.18A 5vc0A-5mtzA:
undetectable
5vc0A-5mtzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB


(Shigella
flexneri)
PF00006
(ATP-synt_ab)
5 LEU A  91
ILE A 229
ALA A 232
ILE A 298
ALA A 300
None
0.91A 5vc0A-5swjA:
undetectable
5vc0A-5swjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X


(Streptococcus
thermophilus)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA)
6 ASP A 380
PHE A 399
SER A 351
ILE A 474
PHE A 471
ALA A 470
None
1.42A 5vc0A-5u47A:
undetectable
5vc0A-5u47A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE


(environmental
samples)
PF00202
(Aminotran_3)
5 PHE A  80
ILE A 243
ALA A 123
ILE A 296
ALA A 293
None
1.18A 5vc0A-5uc7A:
undetectable
5vc0A-5uc7A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wez TIR CHAPERONE
TRANSLOCATED INTIMIN
RECEPTOR TIR


(Escherichia
coli)
no annotation 5 LEU A 109
ILE A  21
PHE A  12
ALA A  13
ILE B  38
None
1.16A 5vc0A-5wezA:
undetectable
5vc0A-5wezA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY


(Mus musculus)
PF00397
(WW)
PF00632
(HECT)
5 PHE A 624
PHE A 601
PHE A 573
ILE A 511
ALA A 554
None
1.20A 5vc0A-5xmcA:
undetectable
5vc0A-5xmcA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE


(unidentified)
PF00465
(Fe-ADH)
5 SER A 288
ILE A 293
ALA A 355
ILE A 256
ALA A 252
None
1.13A 5vc0A-5xn8A:
undetectable
5vc0A-5xn8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii)
PF06427
(UDP-g_GGTase)
5 ASP A 999
ARG A 960
PHE A 961
ALA A 326
ALA A 921
None
1.18A 5vc0A-5y7oA:
undetectable
5vc0A-5y7oA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN


(Bifidobacterium
longum)
no annotation 5 PHE A 624
LEU A 540
ALA A 412
ILE A 560
ALA A 595
None
1.00A 5vc0A-5z9sA:
undetectable
5vc0A-5z9sA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbb -

(-)
no annotation 5 PHE A 406
LEU A  12
ALA A  57
ILE A  27
ALA A 416
None
1.21A 5vc0A-5zbbA:
undetectable
5vc0A-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bja ACETYL-COA
ACETYLTRANSFERASE A


(Ascaris suum)
no annotation 5 ARG A 344
ILE A 331
PHE A 330
ILE A 314
ALA A 315
None
1.09A 5vc0A-6bjaA:
undetectable
5vc0A-6bjaA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eio ANTIFREEZE PROTEIN

(uncultured
bacterium)
no annotation 5 ASP A 225
LEU A 250
ALA A  55
ILE A 217
ALA A 218
None
1.10A 5vc0A-6eioA:
undetectable
5vc0A-6eioA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN


(Idiomarina sp.
A28L)
no annotation 5 SER A 592
ILE A 534
PHE A 535
ILE A 612
ALA A 613
None
1.10A 5vc0A-6et7A:
undetectable
5vc0A-6et7A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4


(Mus musculus)
no annotation 5 PHE M 149
LEU M 238
ILE M 230
ALA M 233
ALA M 287
None
0.99A 5vc0A-6g2jM:
undetectable
5vc0A-6g2jM:
10.36