SIMILAR PATTERNS OF AMINO ACIDS FOR 5VC0_A_RITA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus) 		PF00191
(Annexin) 		5 ASP A 218
ARG A 243
LEU A 253
ILE A 109
ALA A 234
 None
 1.14A 5vc0A-1aowA:
0.0		 5vc0A-1aowA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT

(Shigella
dysenteriae) 		PF00161
(RIP) 		5 PHE A  95
PHE A  50
LEU A 238
PHE A 257
ALA A 168
 None
 1.05A 5vc0A-1dm0A:
undetectable		 5vc0A-1dm0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foe T-LYMPHOMA INVASION
AND METASTASIS
INDUCING PROTEIN 1

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 ASP A1327
PHE A1331
ILE A1335
ALA A1299
ILE A1249
 None
 1.20A 5vc0A-1foeA:
0.0		 5vc0A-1foeA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ASP 1 173
SER 1 140
LEU 1  33
PHE 1 107
ALA 1 183
 None
 1.11A 5vc0A-1gt91:
undetectable		 5vc0A-1gt91:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		5 SER A  53
LEU A  19
ILE A   4
ALA A  67
ALA A  58
 None
 1.12A 5vc0A-1m33A:
0.0		 5vc0A-1m33A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 PHE A  80
ILE A 243
ALA A 123
ILE A 296
ALA A 293
 None
 1.09A 5vc0A-1mlzA:
0.0		 5vc0A-1mlzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onf GLUTATHIONE
REDUCTASE

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ARG A 196
ILE A 172
PHE A 170
ILE A 186
ALA A 187
 None
None
None
FAD  A 500 ( 4.3A)
None
 1.19A 5vc0A-1onfA:
0.0		 5vc0A-1onfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		5 PHE A 230
LEU A 216
ILE A 166
ILE A 174
ALA A 172
 None
 1.19A 5vc0A-1qcxA:
0.0		 5vc0A-1qcxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Nostoc sp. PCC
7120) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 PHE A 172
LEU A 204
PHE A 174
ALA A 238
ILE A  99
 None
 1.20A 5vc0A-1vquA:
0.0		 5vc0A-1vquA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		5 ASP A 277
LEU A 114
PHE A  28
PHE A 111
ALA A 210
 None
 1.06A 5vc0A-1wzaA:
undetectable		 5vc0A-1wzaA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypf GMP REDUCTASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		5 ASP A  26
PHE A  36
ILE A  65
ILE A 204
ALA A 224
 None
 1.18A 5vc0A-1ypfA:
undetectable		 5vc0A-1ypfA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z4e TRANSCRIPTIONAL
REGULATOR

(Bacillus
halodurans) 		PF00583
(Acetyltransf_1) 		5 ARG A 135
PHE A 136
LEU A  70
ILE A 111
ALA A 144
 None
 1.07A 5vc0A-1z4eA:
undetectable		 5vc0A-1z4eA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 PHE A 260
LEU A 158
ILE A 104
ALA A 102
ALA A 205
 None
 1.03A 5vc0A-1zr6A:
undetectable		 5vc0A-1zr6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 PHE A 370
PHE A  90
ALA A  91
ILE A  77
ALA A  78
 None
 1.09A 5vc0A-2dkhA:
undetectable		 5vc0A-2dkhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dll INTERFERON
REGULATORY FACTOR 4

(Homo sapiens) 		PF00605
(IRF) 		5 ASP A 102
LEU A  82
PHE A  56
ALA A  53
ALA A  42
 None
 1.19A 5vc0A-2dllA:
undetectable		 5vc0A-2dllA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ARG X 153
PHE X 168
PHE X 253
ALA X 119
ILE X 146
 PTR  X 160 ( 3.7A)
None
None
None
None
 1.20A 5vc0A-2dq7X:
undetectable		 5vc0A-2dq7X:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 ASP A  59
LEU A 104
ALA A 140
ILE A 262
ALA A 261
 None
 1.10A 5vc0A-2hz7A:
undetectable		 5vc0A-2hz7A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1s HYPOTHETICAL PROTEIN

(Methanosarcina
mazei) 		PF07929
(PRiA4_ORF3) 		5 ARG A 137
PHE A 181
PHE A 176
ILE A  26
ALA A  40
 None
 1.05A 5vc0A-2i1sA:
undetectable		 5vc0A-2i1sA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 SER A 114
LEU A 205
ILE A 121
ALA A 145
ILE A 190
 None
 1.10A 5vc0A-2ia2A:
undetectable		 5vc0A-2ia2A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdc GLYPHOSATE
N-ACETYLTRANSFERASE

(Bacillus
licheniformis) 		PF00583
(Acetyltransf_1) 		5 PHE A 123
LEU A  98
PHE A  56
ILE A  53
ALA A  76
 None
None
None
None
CAO  A1147 (-4.1A)
 1.15A 5vc0A-2jdcA:
undetectable		 5vc0A-2jdcA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 PHE A1154
PHE A1402
ILE A1333
ILE A1386
ALA A1383
 None
 1.16A 5vc0A-2nlkA:
undetectable		 5vc0A-2nlkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q07 UNCHARACTERIZED
PROTEIN AF0587

(Archaeoglobus
fulgidus) 		PF01472
(PUA) 		5 PHE A 246
SER A 275
LEU A 262
PHE A 247
ILE A 401
 None
 1.17A 5vc0A-2q07A:
undetectable		 5vc0A-2q07A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A 156
ASP A 118
LEU A 387
ALA A 449
ALA A 201
 None
 1.19A 5vc0A-2qo3A:
undetectable		 5vc0A-2qo3A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 ASP A 208
PHE A 246
ILE A  86
ILE A 194
ALA A 190
 None
 1.20A 5vc0A-2qpsA:
undetectable		 5vc0A-2qpsA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 ARG A 350
LEU A 171
ILE A 176
ALA A 164
ALA A 193
 None
 1.16A 5vc0A-2uvfA:
undetectable		 5vc0A-2uvfA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyo HYPOTHETICAL PROTEIN
ML2640

(Mycobacterium
leprae) 		PF04072
(LCM) 		5 ASP A  38
PHE A  91
LEU A 189
ILE A 214
ILE A 131
 None
 1.12A 5vc0A-2uyoA:
undetectable		 5vc0A-2uyoA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ASP A 377
ARG A 234
ILE A 347
ALA A 170
ALA A 279
 None
None
GOL  A1421 (-3.9A)
None
IPA  A1423 (-4.5A)
 1.00A 5vc0A-2wgeA:
undetectable		 5vc0A-2wgeA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akk CTKA

(Helicobacter
pylori) 		PF07804
(HipA_C) 		5 PHE A 145
PHE A 140
ILE A 282
ILE A  63
ALA A  60
 None
 1.13A 5vc0A-3akkA:
undetectable		 5vc0A-3akkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 ILE A 162
PHE A 165
ALA A 166
ILE A 126
ALA A 108
 None
 1.19A 5vc0A-3blwA:
undetectable		 5vc0A-3blwA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpj GTP-BINDING PROTEIN
YPT31/YPT8

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 LEU B 150
ILE B 124
ALA B 166
ILE B 171
ALA B  64
 None
 1.17A 5vc0A-3cpjB:
undetectable		 5vc0A-3cpjB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		5 PHE A 277
LEU A  74
ALA A  67
ILE A 312
ALA A 308
 None
 1.17A 5vc0A-3czeA:
undetectable		 5vc0A-3czeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1n POU DOMAIN, CLASS 6,
TRANSCRIPTION FACTOR
1

(Homo sapiens) 		PF00046
(Homeobox)
PF00157
(Pou) 		5 ILE I 147
PHE I 150
ALA I 151
ILE I 185
ALA I 184
 None
 1.12A 5vc0A-3d1nI:
undetectable		 5vc0A-3d1nI:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		5 LEU A 100
ILE A 107
PHE A 105
ILE A 300
ALA A 296
 None
 1.15A 5vc0A-3d4uA:
undetectable		 5vc0A-3d4uA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		5 ASP A 159
LEU A  34
ILE A 326
PHE A 408
ALA A 409
 None
 1.15A 5vc0A-3d6kA:
undetectable		 5vc0A-3d6kA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		5 ASP A 259
LEU A 493
ILE A  10
ALA A  69
ALA A 123
 None
 1.18A 5vc0A-3e2dA:
undetectable		 5vc0A-3e2dA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee1 EFFECTOR PROTEIN
VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		5 ASP A 178
ARG A 389
LEU A 349
ALA A 394
ILE A 292
 None
 1.04A 5vc0A-3ee1A:
undetectable		 5vc0A-3ee1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		6 ASP A 241
ARG A 268
LEU A  84
ILE A 105
ALA A 108
ALA A 300
 None
 1.39A 5vc0A-3eezA:
undetectable		 5vc0A-3eezA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		PF00616
(RasGAP) 		5 PHE A1262
PHE A1265
ILE A1209
ILE A1228
ALA A1229
 None
 1.12A 5vc0A-3fayA:
undetectable		 5vc0A-3fayA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		5 SER A 328
LEU A 278
PHE A 118
ILE A 365
ALA A 364
 None
None
PLP  A 500 (-4.9A)
None
None
 1.13A 5vc0A-3if2A:
undetectable		 5vc0A-3if2A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lms CARBOXYPEPTIDASE B2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 ARG A 291
LEU A 100
PHE A 105
ILE A 300
ALA A 296
 None
 1.09A 5vc0A-3lmsA:
undetectable		 5vc0A-3lmsA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		5 ARG A 455
LEU A 445
ILE A 411
ALA A 401
ILE A 467
 None
 1.18A 5vc0A-3mwtA:
undetectable		 5vc0A-3mwtA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 ARG B 586
ILE B 682
ALA B 872
ILE B 571
ALA B 574
 None
 1.09A 5vc0A-3o8oB:
undetectable		 5vc0A-3o8oB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osl CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		5 LEU A 212
ILE A 219
PHE A 217
ILE A 415
ALA A 411
 None
 1.15A 5vc0A-3oslA:
undetectable		 5vc0A-3oslA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 ASP A 139
PHE A 144
LEU A  19
ALA A  12
ILE A   6
 None
 1.17A 5vc0A-3qsgA:
undetectable		 5vc0A-3qsgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		5 SER X  79
LEU X 276
ALA X 423
ILE X  84
ALA X  83
 None
 1.18A 5vc0A-3ss7X:
undetectable		 5vc0A-3ss7X:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 179
ARG A 113
LEU A 294
ALA A 102
ILE A 303
 None
 1.08A 5vc0A-3tcsA:
undetectable		 5vc0A-3tcsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 355
ARG A  49
ILE A  84
ALA A  80
ALA A 119
 None
 1.12A 5vc0A-3ugvA:
undetectable		 5vc0A-3ugvA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		5 LEU A 287
ILE A 346
ALA A 350
ILE A 360
ALA A 276
 None
 1.04A 5vc0A-3uhjA:
undetectable		 5vc0A-3uhjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		5 PHE A 293
ILE A 316
ALA A 119
ILE A 142
ALA A 143
 None
 1.21A 5vc0A-3vpzA:
undetectable		 5vc0A-3vpzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh0 PROTOGLOBIN

(Methanosarcina
acetivorans) 		PF11563
(Protoglobin) 		5 ASP A 129
ARG A  92
LEU A 184
ALA A 177
ILE A 149
 None
HEM  A 200 (-4.6A)
None
None
HEM  A 200 (-4.3A)
 0.92A 5vc0A-3zh0A:
undetectable		 5vc0A-3zh0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjl PROTOGLOBIN

(Methanosarcina
acetivorans) 		PF11563
(Protoglobin) 		5 ASP A 129
ARG A  92
LEU A 184
ALA A 177
ILE A 149
 None
HEM  A 200 (-4.4A)
None
None
HEM  A 200 ( 4.6A)
 0.86A 5vc0A-3zjlA:
undetectable		 5vc0A-3zjlA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		5 LEU A 156
ILE A  96
ALA A 132
ILE A 264
ALA A 265
 None
 1.21A 5vc0A-4c1nA:
undetectable		 5vc0A-4c1nA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1d HYDANTOIN TRANSPORT
PROTEIN

(Microbacterium
liquefaciens) 		PF02133
(Transp_cyt_pur) 		5 LEU A 301
PHE A 149
ALA A 177
ILE A  41
ALA A  38
 None
None
None
None
NA  A1471 (-4.9A)
 1.09A 5vc0A-4d1dA:
undetectable		 5vc0A-4d1dA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e54 DNA DAMAGE-BINDING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		5 SER B 297
LEU B 324
ALA B 317
ILE B 269
ALA B 259
 None
 1.08A 5vc0A-4e54B:
undetectable		 5vc0A-4e54B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		5 ASP A 111
PHE A 114
LEU A 249
ILE A  30
ALA A  31
 None
 1.19A 5vc0A-4ei8A:
undetectable		 5vc0A-4ei8A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ASP A 614
LEU A 745
ILE A 642
ALA A 629
ILE A 603
 ASP  A 614 ( 0.6A)
LEU  A 745 ( 0.5A)
ILE  A 642 ( 0.6A)
ALA  A 629 ( 0.0A)
ILE  A 603 ( 0.6A)
 1.15A 5vc0A-4flxA:
undetectable		 5vc0A-4flxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE

(Rhodobacter
sphaeroides) 		PF02230
(Abhydrolase_2) 		5 ARG A 139
LEU A 231
ILE A 185
PHE A 236
ALA A 179
 None
 1.18A 5vc0A-4ftwA:
undetectable		 5vc0A-4ftwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ARG A 472
PHE A 391
ALA A 501
ILE A 460
ALA A 461
 None
 1.18A 5vc0A-4h7uA:
undetectable		 5vc0A-4h7uA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ASP A 379
ILE A 133
PHE A 564
ALA A 563
ALA A 555
 None
 1.17A 5vc0A-4h7uA:
undetectable		 5vc0A-4h7uA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I

(Escherichia
coli) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		5 PHE A 236
LEU A 309
PHE A 164
ALA A 312
ALA A 320
 None
 1.08A 5vc0A-4js5A:
undetectable		 5vc0A-4js5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 ASP A 473
PHE A 134
PHE A 436
ILE A  68
ALA A  40
 None
 1.12A 5vc0A-4jsoA:
undetectable		 5vc0A-4jsoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		5 ARG A 260
SER A 299
ILE A 300
ILE A 269
ALA A 268
 None
 1.14A 5vc0A-4k6nA:
undetectable		 5vc0A-4k6nA:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ASP A  76
ARG A 106
LEU A 211
ILE A 369
ALA A 370
 None
None
None
HEM  A 601 (-4.7A)
2QH  A 602 ( 3.1A)
 0.97A 5vc0A-4ny4A:
53.4		 5vc0A-4ny4A:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		8 ASP A  76
ARG A 106
PHE A 108
SER A 119
ILE A 301
ALA A 305
ILE A 369
ALA A 370
 None
None
2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
2QH  A 602 ( 3.6A)
HEM  A 601 (-4.7A)
2QH  A 602 ( 3.1A)
 0.62A 5vc0A-4ny4A:
53.4		 5vc0A-4ny4A:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		7 ASP A  76
ARG A 106
PHE A 108
SER A 119
ILE A 301
PHE A 304
ALA A 305
 None
None
2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
2QH  A 602 (-3.3A)
2QH  A 602 ( 3.6A)
 1.16A 5vc0A-4ny4A:
53.4		 5vc0A-4ny4A:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 PHE A  57
PHE A 108
SER A 119
ILE A 301
ALA A 305
 None
2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
2QH  A 602 ( 3.6A)
 1.00A 5vc0A-4ny4A:
53.4		 5vc0A-4ny4A:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		6 SER A 119
LEU A 210
ILE A 301
ALA A 305
ILE A 369
ALA A 370
 2QH  A 602 (-3.9A)
None
None
2QH  A 602 ( 3.6A)
HEM  A 601 (-4.7A)
2QH  A 602 ( 3.1A)
 0.97A 5vc0A-4ny4A:
53.4		 5vc0A-4ny4A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 ASP A 304
LEU A 272
ILE A 326
ILE A 389
ALA A 396
 None
 1.18A 5vc0A-4oj5A:
undetectable		 5vc0A-4oj5A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E
TYPE II SECRETION
SYSTEM PROTEIN L

(Vibrio
vulnificus) 		PF00437
(T2SSE)
PF05134
(T2SSL) 		5 ASP X  95
ARG X 116
ILE A 331
ALA A 340
ILE A 318
 None
 1.20A 5vc0A-4phtX:
undetectable		 5vc0A-4phtX:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq0 FACT COMPLEX SUBUNIT
POB3

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		5 LEU A 470
ILE A 412
PHE A 414
ALA A 401
ALA A 383
 None
 1.10A 5vc0A-4pq0A:
undetectable		 5vc0A-4pq0A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9d BENZOYLFORMATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 PHE A  24
ILE A 432
PHE A 456
ALA A 430
ILE A 415
 None
 1.10A 5vc0A-4q9dA:
undetectable		 5vc0A-4q9dA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		5 PHE A 100
LEU A  31
PHE A   7
ALA A 141
ALA A 103
 None
 1.18A 5vc0A-4rhhA:
undetectable		 5vc0A-4rhhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 ASP A 135
LEU A 244
PHE A 239
ILE A 230
ALA A 181
 SAH  A 502 (-2.7A)
None
None
None
None
 1.16A 5vc0A-4rvhA:
undetectable		 5vc0A-4rvhA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 SER A 410
LEU A 671
ALA A 353
ILE A 359
ALA A 358
 None
 1.05A 5vc0A-4uozA:
undetectable		 5vc0A-4uozA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe3 CYTOCHROME P-450

(Streptomyces
antibioticus) 		PF00067
(p450) 		5 ASP A 143
SER A 175
LEU A 361
ALA A 244
ILE A 397
 None
None
None
HEM  A 501 ( 3.5A)
CL6  A 502 (-4.8A)
 1.21A 5vc0A-4xe3A:
27.0		 5vc0A-4xe3A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 ARG A 249
SER A 267
ILE A 359
ILE A 367
ALA A 368
 None
 1.10A 5vc0A-4xhjA:
undetectable		 5vc0A-4xhjA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk2 ALDO/KETO REDUCTASE

(Polaromonas sp.
JS666) 		PF00248
(Aldo_ket_red) 		5 PHE A 160
LEU A  88
ILE A 155
ILE A 210
ALA A 209
 None
 1.09A 5vc0A-4xk2A:
undetectable		 5vc0A-4xk2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 ASP A 537
ARG A 270
ILE A 414
PHE A 415
ILE A 422
 None
None
None
CU  A 802 ( 4.9A)
None
 1.18A 5vc0A-4yzwA:
undetectable		 5vc0A-4yzwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztk CELL DIVISION
PROTEIN
FTSI/PENICILLIN
BINDING PROTEIN 2

(Legionella
pneumophila) 		PF00905
(Transpeptidase) 		5 PHE A 480
ILE A 352
ALA A 380
ILE A 376
ALA A 369
 None
 1.14A 5vc0A-4ztkA:
undetectable		 5vc0A-4ztkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		5 PHE A 212
PHE A 338
SER A 264
PHE A 270
ALA A 271
 None
 1.11A 5vc0A-4zxwA:
undetectable		 5vc0A-4zxwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 ASP A 293
ARG A 131
LEU A 430
ILE A 466
ILE A 171
 None
 1.16A 5vc0A-5e7pA:
undetectable		 5vc0A-5e7pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 LEU A 890
ILE A 918
ALA A 895
ILE A 904
ALA A 765
 None
 1.16A 5vc0A-5h42A:
undetectable		 5vc0A-5h42A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 PHE A 393
ILE A 179
ALA A 373
ILE A 426
ALA A 434
 None
 1.10A 5vc0A-5h7nA:
undetectable		 5vc0A-5h7nA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbh 30S RIBOSOMAL
PROTEIN US7

(Pyrococcus
abyssi) 		PF00177
(Ribosomal_S7) 		5 ILE H 111
PHE H 108
ALA H 107
ILE H  71
ALA H 166
 None
 1.03A 5vc0A-5jbhH:
undetectable		 5vc0A-5jbhH:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 ASP A 393
SER A 566
PHE A 538
ALA A 588
ALA A 555
 None
 1.12A 5vc0A-5m11A:
undetectable		 5vc0A-5m11A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1q PHAGE TERMINASE
LARGE SUBUNIT

(Thermus phage
G20c) 		PF17289
(Terminase_6C) 		5 ILE A 291
PHE A 304
ALA A 293
ILE A 355
ALA A 356
 None
 1.14A 5vc0A-5m1qA:
undetectable		 5vc0A-5m1qA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		5 ASP A 820
ARG A 763
LEU A 339
PHE A 785
ALA A 784
 None
 1.18A 5vc0A-5mtzA:
undetectable		 5vc0A-5mtzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB

(Shigella
flexneri) 		PF00006
(ATP-synt_ab) 		5 LEU A  91
ILE A 229
ALA A 232
ILE A 298
ALA A 300
 None
 0.91A 5vc0A-5swjA:
undetectable		 5vc0A-5swjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		6 ASP A 380
PHE A 399
SER A 351
ILE A 474
PHE A 471
ALA A 470
 None
 1.42A 5vc0A-5u47A:
undetectable		 5vc0A-5u47A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		5 PHE A  80
ILE A 243
ALA A 123
ILE A 296
ALA A 293
 None
 1.18A 5vc0A-5uc7A:
undetectable		 5vc0A-5uc7A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wez TIR CHAPERONE
TRANSLOCATED INTIMIN
RECEPTOR TIR

(Escherichia
coli) 		no annotation 5 LEU A 109
ILE A  21
PHE A  12
ALA A  13
ILE B  38
 None
 1.16A 5vc0A-5wezA:
undetectable		 5vc0A-5wezA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		5 PHE A 624
PHE A 601
PHE A 573
ILE A 511
ALA A 554
 None
 1.20A 5vc0A-5xmcA:
undetectable		 5vc0A-5xmcA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		5 SER A 288
ILE A 293
ALA A 355
ILE A 256
ALA A 252
 None
 1.13A 5vc0A-5xn8A:
undetectable		 5vc0A-5xn8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		5 ASP A 999
ARG A 960
PHE A 961
ALA A 326
ALA A 921
 None
 1.18A 5vc0A-5y7oA:
undetectable		 5vc0A-5y7oA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 5 PHE A 624
LEU A 540
ALA A 412
ILE A 560
ALA A 595
 None
 1.00A 5vc0A-5z9sA:
undetectable		 5vc0A-5z9sA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbb -

(-) 		no annotation 5 PHE A 406
LEU A  12
ALA A  57
ILE A  27
ALA A 416
 None
 1.21A 5vc0A-5zbbA:
undetectable		 5vc0A-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bja ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 5 ARG A 344
ILE A 331
PHE A 330
ILE A 314
ALA A 315
 None
 1.09A 5vc0A-6bjaA:
undetectable		 5vc0A-6bjaA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eio ANTIFREEZE PROTEIN

(uncultured
bacterium) 		no annotation 5 ASP A 225
LEU A 250
ALA A  55
ILE A 217
ALA A 218
 None
 1.10A 5vc0A-6eioA:
undetectable		 5vc0A-6eioA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 5 SER A 592
ILE A 534
PHE A 535
ILE A 612
ALA A 613
 None
 1.10A 5vc0A-6et7A:
undetectable		 5vc0A-6et7A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 5 PHE M 149
LEU M 238
ILE M 230
ALA M 233
ALA M 287
 None
 0.99A 5vc0A-6g2jM:
undetectable		 5vc0A-6g2jM:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		4 ILE A  18
LEU A   6
PHE A 153
THR A  33
 None
 1.04A 5vc0A-1b5fA:
0.0		 5vc0A-1b5fA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		4 ILE 1  97
LEU 3  25
PHE 3  28
ARG 1 116
 MYR  1 900 ( 4.4A)
None
None
None
 0.92A 5vc0A-1bev1:
0.0		 5vc0A-1bev1:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 ILE A  97
LEU A  50
PHE A  32
THR A  60
 None
 1.03A 5vc0A-1czfA:
0.0		 5vc0A-1czfA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		4 ILE A  36
PHE A 166
THR A  22
THR A 147
 None
 0.94A 5vc0A-1efvA:
0.0		 5vc0A-1efvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 527
PHE A 267
THR A 357
THR A 272
 None
 0.89A 5vc0A-1eovA:
0.9		 5vc0A-1eovA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6f PLACENTAL LACTOGEN

(Ovis aries) 		PF00103
(Hormone_1) 		4 ILE A 121
LEU A 172
THR A 102
THR A  62
 None
 0.94A 5vc0A-1f6fA:
undetectable		 5vc0A-1f6fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		4 ARG A 133
ILE A 120
THR A 407
THR A 304
 None
None
None
HEM  A 800 (-3.4A)
 1.01A 5vc0A-1itkA:
0.0		 5vc0A-1itkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A 107
LEU A  50
PHE A  47
THR A 154
 None
 1.00A 5vc0A-1kfiA:
0.0		 5vc0A-1kfiA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 LEU A  73
PHE A  70
THR A 191
THR A 247
 None
 0.97A 5vc0A-1kgpA:
0.1		 5vc0A-1kgpA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 ILE A 117
LEU A 665
PHE A 741
ARG A  66
 None
 0.88A 5vc0A-1obhA:
undetectable		 5vc0A-1obhA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		5 ILE A 106
LEU A 172
PHE A 174
THR A 178
ARG A 153
 None
 1.21A 5vc0A-1og6A:
undetectable		 5vc0A-1og6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 ARG A 142
LEU A 157
PHE A 153
ARG A 149
 None
 0.92A 5vc0A-1q3bA:
undetectable		 5vc0A-1q3bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ILE A  69
LEU A  51
PHE A 104
ARG A  18
 None
 1.00A 5vc0A-1qhoA:
undetectable		 5vc0A-1qhoA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		4 LEU A  63
PHE A  60
THR A 181
THR A 237
 None
 1.03A 5vc0A-1r2fA:
undetectable		 5vc0A-1r2fA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 644
LEU A 453
THR A 699
THR A 655
 None
 1.03A 5vc0A-1r8wA:
undetectable		 5vc0A-1r8wA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ILE A 446
LEU A 439
PHE A 410
THR A 348
 None
 0.99A 5vc0A-1ry2A:
undetectable		 5vc0A-1ry2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE A 193
LEU A 175
PHE A 219
ARG A 144
 None
 0.75A 5vc0A-1smaA:
undetectable		 5vc0A-1smaA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		4 ARG A 177
ILE A 121
PHE A  93
THR A  84
 None
 0.92A 5vc0A-1t8wA:
undetectable		 5vc0A-1t8wA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 ILE A   5
LEU A  14
THR A 156
ARG A 266
 None
 0.99A 5vc0A-1tp7A:
undetectable		 5vc0A-1tp7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Thermotoga
maritima) 		PF13393
(tRNA-synt_His) 		4 ILE C 113
LEU C 212
PHE C 211
THR C 218
 None
 1.04A 5vc0A-1usyC:
undetectable		 5vc0A-1usyC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Thermotoga
maritima) 		PF13393
(tRNA-synt_His) 		4 ILE C 113
LEU C 249
THR C 230
THR C 244
 None
 1.00A 5vc0A-1usyC:
undetectable		 5vc0A-1usyC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 LEU A  68
PHE A  65
THR A 186
THR A 242
 None
 0.97A 5vc0A-1uzrA:
undetectable		 5vc0A-1uzrA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdq BACTERIAL SULFITE
OXIDASE

(Escherichia
coli) 		PF00174
(Oxidored_molyb) 		4 ARG A 194
ILE A 206
LEU A  70
THR A  65
 MTE  A 301 (-2.8A)
None
None
None
 0.91A 5vc0A-1xdqA:
undetectable		 5vc0A-1xdqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq1 PUTATIVE TROPINONE
REDUCATSE

(Arabidopsis
thaliana) 		PF13561
(adh_short_C2) 		4 ILE A  97
LEU A  93
PHE A  89
THR A  66
 None
 0.93A 5vc0A-1xq1A:
undetectable		 5vc0A-1xq1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		4 ILE A 354
LEU A 302
THR A 197
THR A 306
 None
 0.95A 5vc0A-2a0uA:
undetectable		 5vc0A-2a0uA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 ILE A 307
LEU A 267
THR A 274
ARG A 303
 None
 1.04A 5vc0A-2amlA:
0.4		 5vc0A-2amlA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 ILE A 909
LEU A 881
PHE A 876
THR A 901
 None
 0.94A 5vc0A-2b5mA:
undetectable		 5vc0A-2b5mA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv6 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MGRA

(Staphylococcus
aureus) 		PF01047
(MarR) 		4 ARG A  84
ILE A  96
LEU A  64
THR A  37
 SO4  A1142 (-3.4A)
None
None
None
 1.00A 5vc0A-2bv6A:
undetectable		 5vc0A-2bv6A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01156
(IU_nuc_hydro) 		4 ILE A 189
LEU A 109
THR A 125
THR A 116
 None
 0.95A 5vc0A-2c40A:
undetectable		 5vc0A-2c40A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		4 LEU A 184
PHE A 183
THR A 131
THR A 189
 SAH  A 300 (-3.8A)
SAH  A 300 (-4.9A)
SAH  A 300 (-3.4A)
None
 1.00A 5vc0A-2cbfA:
undetectable		 5vc0A-2cbfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG C 272
ILE C 271
LEU C 360
THR C 292
 None
 0.94A 5vc0A-2d3tC:
undetectable		 5vc0A-2d3tC:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dcp HYPOTHETICAL PROTEIN
(RAFL09-17-B18)

(Arabidopsis
thaliana) 		PF01417
(ENTH) 		4 ARG A  57
ILE A  54
LEU A  32
THR A 120
 None
 0.90A 5vc0A-2dcpA:
undetectable		 5vc0A-2dcpA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eeo ASPARTATE
1-DECARBOXYLASE

(Thermus
thermophilus) 		PF02261
(Asp_decarbox) 		4 ILE B  49
LEU B  87
THR A  16
ARG B 113
 None
 1.04A 5vc0A-2eeoB:
undetectable		 5vc0A-2eeoB:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 ILE A 171
LEU A 197
THR A 218
THR A 230
 None
 1.03A 5vc0A-2i0kA:
undetectable		 5vc0A-2i0kA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00977
(His_biosynth) 		4 ILE A 177
LEU A 132
PHE A 117
ARG A 154
 None
 0.97A 5vc0A-2lleA:
undetectable		 5vc0A-2lleA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzt PROTEIN HRB1

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		4 ILE A 448
LEU A 392
THR A 416
ARG A 453
 None
 1.03A 5vc0A-2mztA:
undetectable		 5vc0A-2mztA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE A  79
LEU A 110
PHE A 322
ARG A  37
 None
 0.99A 5vc0A-2og2A:
undetectable		 5vc0A-2og2A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		4 ILE A 167
LEU A 364
THR A  65
ARG A   7
 None
 0.95A 5vc0A-2q09A:
undetectable		 5vc0A-2q09A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q50 GLYOXYLATE
REDUCTASE/HYDROXYPYR
UVATE REDUCTASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ARG A 171
ILE A 168
THR A 121
THR A 301
 None
 0.83A 5vc0A-2q50A:
undetectable		 5vc0A-2q50A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA

(Mus musculus;
Paraburkholderia
xenovorans) 		PF01007
(IRK) 		4 ILE A 245
LEU A 180
PHE A   8
ARG A  14
 None
 0.88A 5vc0A-2qksA:
undetectable		 5vc0A-2qksA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		4 ARG A 391
LEU A 437
PHE A 439
THR A 417
 None
 0.86A 5vc0A-2qmiA:
undetectable		 5vc0A-2qmiA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ILE A  38
LEU A  77
THR A  58
ARG A  91
 None
 0.98A 5vc0A-2r9vA:
undetectable		 5vc0A-2r9vA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8s CLATHRIN INTERACTOR
1

(Homo sapiens) 		PF01417
(ENTH) 		4 ARG E 102
ILE E 105
LEU E  86
ARG E  96
 None
 1.03A 5vc0A-2v8sE:
undetectable		 5vc0A-2v8sE:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ILE A 377
LEU A 349
PHE A  47
THR A  53
 None
 0.75A 5vc0A-2vqrA:
undetectable		 5vc0A-2vqrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ILE A 377
LEU A 349
PHE A  47
THR A  53
 None
 0.78A 5vc0A-2w8sA:
undetectable		 5vc0A-2w8sA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 ILE A 481
LEU A 402
THR A 345
ARG A 412
 None
 1.00A 5vc0A-2yevA:
undetectable		 5vc0A-2yevA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 ILE A 491
LEU A 518
PHE A 551
THR A 573
 None
 0.94A 5vc0A-2zj8A:
undetectable		 5vc0A-2zj8A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 ARG A  95
ILE A  99
LEU A 125
ARG A  88
 None
None
None
SAH  A 801 (-3.9A)
 1.04A 5vc0A-2zwaA:
undetectable		 5vc0A-2zwaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A  84
THR A  55
THR A  67
ARG A  75
 None
 1.04A 5vc0A-3b2dA:
undetectable		 5vc0A-3b2dA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frq REPRESSOR PROTEIN
MPHR(A)

(Escherichia
coli) 		PF00440
(TetR_N) 		4 ARG A 133
ILE A 130
LEU A 177
PHE A 181
 None
 1.03A 5vc0A-3frqA:
undetectable		 5vc0A-3frqA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwz INNER MEMBRANE
PROTEIN YBAL

(Escherichia
coli) 		PF02254
(TrkA_N) 		4 ARG A 514
ILE A 489
THR A 525
ARG A 537
 AMP  A 601 (-3.0A)
AMP  A 601 (-3.6A)
None
None
 1.02A 5vc0A-3fwzA:
undetectable		 5vc0A-3fwzA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Clostridioides
difficile) 		PF01380
(SIS) 		5 ILE A 287
LEU A 204
THR A 281
THR A 232
ARG A 211
 None
 1.41A 5vc0A-3g68A:
undetectable		 5vc0A-3g68A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqs ADENYLATE
CYCLASE-LIKE PROTEIN

(Chlamydia
trachomatis) 		PF16697
(Yop-YscD_cpl) 		4 ILE A  45
LEU A   7
PHE A  19
THR A  26
 None
 1.01A 5vc0A-3gqsA:
undetectable		 5vc0A-3gqsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		4 ILE A  33
LEU B  25
PHE B  28
ARG A  52
 None
 1.01A 5vc0A-3j2jA:
undetectable		 5vc0A-3j2jA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		4 ARG A 574
ILE A 554
THR A 689
ARG A 641
 None
 0.98A 5vc0A-3jbyA:
undetectable		 5vc0A-3jbyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		4 ILE A 285
LEU A 134
PHE A 427
THR A 178
 None
 1.02A 5vc0A-3kswA:
30.7		 5vc0A-3kswA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 ARG A 380
LEU A 301
THR A 310
THR A 369
 None
 0.98A 5vc0A-3l8aA:
undetectable		 5vc0A-3l8aA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 LEU A  73
PHE A  70
THR A 191
THR A 247
 None
 0.97A 5vc0A-3mjoA:
undetectable		 5vc0A-3mjoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 4 LEU B  63
PHE B  60
THR B 181
THR B 237
 None
 1.03A 5vc0A-3n3bB:
undetectable		 5vc0A-3n3bB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN

(Geobacter
sulfurreducens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ILE A 177
LEU A 241
PHE A 265
THR A  96
 None
None
None
NAP  A 301 (-4.1A)
 1.01A 5vc0A-3pduA:
undetectable		 5vc0A-3pduA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		4 ARG A 176
LEU A 263
THR A 161
THR A  39
 PLM  A 702 (-3.9A)
PLM  A 702 ( 4.8A)
PLM  A 702 ( 4.8A)
None
 1.03A 5vc0A-3pl5A:
undetectable		 5vc0A-3pl5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psq HYPOTHETICAL
EXPORTED PROTEIN

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		4 ILE A 123
LEU A 137
PHE A 140
THR A 172
 None
 0.97A 5vc0A-3psqA:
undetectable		 5vc0A-3psqA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		4 ILE A  83
LEU A 264
THR A 381
ARG A  26
 None
 1.01A 5vc0A-3qnqA:
undetectable		 5vc0A-3qnqA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp7 FLAVOPROTEIN
MONOOXYGENASE

(Klebsiella
pneumoniae) 		PF01494
(FAD_binding_3) 		4 ARG A 263
ILE A 264
PHE A 217
ARG A 235
 None
 1.00A 5vc0A-3rp7A:
undetectable		 5vc0A-3rp7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		4 LEU A 295
PHE A 333
THR A 222
THR A 493
 None
 0.99A 5vc0A-3up4A:
undetectable		 5vc0A-3up4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens) 		PF00362
(Integrin_beta) 		4 ILE B 326
LEU B 159
THR B 167
ARG B 259
 None
 0.99A 5vc0A-3v4vB:
undetectable		 5vc0A-3v4vB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		4 ILE A 583
LEU A 541
THR A 521
ARG A 574
 None
 0.93A 5vc0A-3vmnA:
undetectable		 5vc0A-3vmnA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		4 ILE A 116
LEU A  89
THR A 130
ARG A 124
 None
 1.01A 5vc0A-3vqrA:
undetectable		 5vc0A-3vqrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN
V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 ILE D  14
THR D  39
THR D 228
ARG A 191
 None
 0.96A 5vc0A-3w3aD:
undetectable		 5vc0A-3w3aD:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 ARG A  89
LEU A 204
THR A 189
ARG A 217
 None
 0.99A 5vc0A-3zbyA:
17.5		 5vc0A-3zbyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE A 134
LEU A 165
PHE A 377
ARG A  92
 None
 1.04A 5vc0A-4ak9A:
undetectable		 5vc0A-4ak9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 ARG A  53
ILE A 118
LEU A  99
THR A 152
 None
 0.82A 5vc0A-4bjuA:
undetectable		 5vc0A-4bjuA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		4 ARG B 142
LEU B  29
PHE B 230
THR B 168
 None
 0.81A 5vc0A-4ckeB:
undetectable		 5vc0A-4ckeB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 ILE A 102
LEU A 591
THR A 192
ARG A 179
 None
None
None
GOL  A 701 (-3.5A)
 1.02A 5vc0A-4dwsA:
undetectable		 5vc0A-4dwsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 ILE A 285
LEU A 134
PHE A 427
THR A 178
 None
HEM  A 501 ( 4.7A)
None
None
 1.01A 5vc0A-4g3jA:
34.6		 5vc0A-4g3jA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		4 ILE A 140
LEU A 188
THR A 193
ARG A 275
 None
HEM  A 401 (-4.1A)
K  A 402 (-3.4A)
None
 0.91A 5vc0A-4gedA:
undetectable		 5vc0A-4gedA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E

(Geobacillus
stearothermophilus) 		PF00365
(PFK) 		4 ILE A  45
LEU A 112
PHE A 117
ARG A   3
 None
 0.99A 5vc0A-4i4iA:
undetectable		 5vc0A-4i4iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		4 ILE A  39
LEU A 337
THR A  51
ARG A 302
 None
None
None
SO4  A 401 (-2.6A)
 0.96A 5vc0A-4kdsA:
undetectable		 5vc0A-4kdsA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjz TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		4 ILE A 391
LEU A 377
THR A 381
ARG A 453
 None
 1.03A 5vc0A-4kjzA:
undetectable		 5vc0A-4kjzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH

(Lechevalieria
aerocolonigenes) 		PF04820
(Trp_halogenase) 		4 ILE A 346
PHE A 462
THR A 394
ARG A 387
 None
 1.01A 5vc0A-4lu6A:
undetectable		 5vc0A-4lu6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhb PUTATIVE ALDO/KETO
REDUCTASE

(Yersinia pestis) 		PF00248
(Aldo_ket_red) 		4 ARG A 235
ILE A 268
LEU A 207
PHE A 200
 None
 0.93A 5vc0A-4mhbA:
undetectable		 5vc0A-4mhbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 ILE A 352
PHE A 293
THR A 298
THR A 335
 None
None
None
MLY  A 336 ( 3.9A)
 1.04A 5vc0A-4nk6A:
undetectable		 5vc0A-4nk6A:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 105
ILE A 120
THR A 224
THR A 309
ARG A 372
 HEM  A 601 ( 2.8A)
None
None
2QH  A 602 ( 3.7A)
None
 0.73A 5vc0A-4ny4A:
53.2		 5vc0A-4ny4A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP1
COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 1 112
LEU 3  25
PHE 3  28
ARG 1 131
 None
 1.00A 5vc0A-4q4y1:
undetectable		 5vc0A-4q4y1:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q58 PLECTIN

(Homo sapiens) 		PF00307
(CH) 		4 ARG A 111
ILE A 120
LEU A  76
ARG A 113
 None
 0.89A 5vc0A-4q58A:
undetectable		 5vc0A-4q58A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		4 ILE A 191
LEU A 222
PHE A 245
THR A 150
 None
None
None
CL  A 420 (-3.8A)
 0.96A 5vc0A-4qb7A:
undetectable		 5vc0A-4qb7A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR

(Homo sapiens) 		PF00021
(UPAR_LY6) 		4 ARG U 239
LEU U 252
PHE U 256
THR U 164
 None
 1.03A 5vc0A-4qtiU:
undetectable		 5vc0A-4qtiU:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		4 ILE A 444
LEU A 143
THR A 195
ARG A 471
 None
 1.02A 5vc0A-4qwwA:
undetectable		 5vc0A-4qwwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli) 		PF04453
(OstA_C) 		4 ARG A 520
THR A 472
THR A 586
ARG A 551
 None
 0.96A 5vc0A-4rhbA:
undetectable		 5vc0A-4rhbA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA

(Bacillus
subtilis) 		PF10747
(SirA) 		4 ILE A  80
LEU A  65
THR A   7
THR A  72
 None
 1.03A 5vc0A-4tpsA:
undetectable		 5vc0A-4tpsA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 ILE B  67
LEU B 115
PHE B 113
THR B 138
 None
 0.99A 5vc0A-4tx2B:
undetectable		 5vc0A-4tx2B:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		4 ILE A 689
LEU A 504
THR A 698
ARG A 434
 None
None
None
PO4  A 802 (-2.9A)
 1.02A 5vc0A-4u1rA:
undetectable		 5vc0A-4u1rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1r ALPHA-1,6-MANNANASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 ILE A 320
LEU A 350
THR A  53
ARG A 375
 None
 1.05A 5vc0A-4v1rA:
undetectable		 5vc0A-4v1rA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		4 ARG A 195
LEU A 109
THR A 171
ARG A 198
 None
 1.01A 5vc0A-4wj3A:
undetectable		 5vc0A-4wj3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww5 EKC/KEOPS COMPLEX
SUBUNIT CGI121

(Saccharomyces
cerevisiae) 		PF08617
(CGI-121) 		4 ILE B  12
LEU B 107
THR B  71
ARG B 179
 None
 1.01A 5vc0A-4ww5B:
undetectable		 5vc0A-4ww5B:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhl CASEIN KINASE I
HOMOLOG HRR25

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ARG A 115
ILE A 116
LEU A 203
PHE A 206
 SO4  A 404 (-2.9A)
None
None
None
 1.01A 5vc0A-4xhlA:
undetectable		 5vc0A-4xhlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN SEH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE C 192
LEU C 128
PHE C 169
ARG C 216
 None
 1.03A 5vc0A-4xmmC:
undetectable		 5vc0A-4xmmC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		4 ILE A 159
LEU A 142
PHE A 109
THR A 222
 None
 1.03A 5vc0A-5b1qA:
undetectable		 5vc0A-5b1qA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9d APRICK PROTEASE

(Rickettsia
conorii) 		PF13975
(gag-asp_proteas) 		4 ARG A 216
LEU A 229
PHE A 220
THR A 141
 None
 1.02A 5vc0A-5c9dA:
undetectable		 5vc0A-5c9dA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		4 ILE A  90
LEU A 318
THR A  60
ARG A 230
 None
 1.04A 5vc0A-5d8gA:
undetectable		 5vc0A-5d8gA:
21.47