SIMILAR PATTERNS OF AMINO ACIDS FOR 5V96_A_ADNA502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		4 GLU A 154
THR A 153
THR A  66
LEU A  59
 None
None
SO4  A 207 (-4.7A)
None
 1.43A 5v96A-1k7jA:
undetectable		 5v96A-1k7jA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		4 GLU A 440
THR A 441
THR A  32
LEU A 176
 None
 1.42A 5v96A-1khwA:
undetectable		 5v96A-1khwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovw ENDOGLUCANASE I

(Fusarium
oxysporum) 		PF00840
(Glyco_hydro_7) 		4 GLU A 227
THR A 224
THR A 179
LEU A 220
 None
 1.42A 5v96A-1ovwA:
undetectable		 5v96A-1ovwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		4 GLU A 338
THR A 441
THR A 473
LEU A 331
 None
 1.47A 5v96A-1ukcA:
undetectable		 5v96A-1ukcA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		4 GLU A 132
THR A 130
THR A  80
LEU A 111
 None
 0.97A 5v96A-1v72A:
2.6		 5v96A-1v72A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		4 GLU A  32
THR A  35
THR A  76
LEU A 101
 None
 1.33A 5v96A-1vbjA:
undetectable		 5v96A-1vbjA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.35A 5v96A-1z1wA:
undetectable		 5v96A-1z1wA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cp9 ELONGATION FACTOR
TS, MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 GLU A  32
THR A  33
THR A  20
LEU A  38
 None
 1.45A 5v96A-2cp9A:
undetectable		 5v96A-2cp9A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		4 GLU A 102
THR A 103
THR A 196
LEU A  93
 None
 1.47A 5v96A-2ow4A:
undetectable		 5v96A-2ow4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
aureus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 GLU A 511
THR A 512
THR A 455
LEU A 522
 None
 1.28A 5v96A-2wqdA:
0.3		 5v96A-2wqdA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		4 GLU A 424
THR A 420
THR A 398
LEU A 403
 None
 1.42A 5v96A-2x98A:
undetectable		 5v96A-2x98A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 GLU A  68
THR A  66
THR A 175
LEU A 164
 MG  A1904 ( 4.7A)
None
None
None
 1.37A 5v96A-2ztsA:
undetectable		 5v96A-2ztsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF02847
(MA3) 		4 GLU B 165
THR B 169
THR B 219
LEU B 209
 None
 1.31A 5v96A-2zu6B:
undetectable		 5v96A-2zu6B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 GLU A 435
THR A 437
THR A 406
LEU A 374
 None
 1.01A 5v96A-3a0fA:
undetectable		 5v96A-3a0fA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiq PROGRAMMED CELL
DEATH PROTEIN 4

(Mus musculus) 		PF02847
(MA3) 		4 GLU C 165
THR C 169
THR C 219
LEU C 209
 None
 1.43A 5v96A-3eiqC:
undetectable		 5v96A-3eiqC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD

(Bacillus
subtilis) 		PF07451
(SpoVAD) 		4 GLU A 115
THR A 116
THR A  91
LEU A  85
 None
 1.41A 5v96A-3lm6A:
undetectable		 5v96A-3lm6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd1 PRECORRIN-6A
SYNTHASE/COBF
PROTEIN

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		4 GLU A  90
THR A  91
THR A 121
LEU A   4
 None
 1.27A 5v96A-3nd1A:
undetectable		 5v96A-3nd1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 GLU A 198
THR A 195
THR A 248
LEU A 169
 None
 0.91A 5v96A-3nowA:
undetectable		 5v96A-3nowA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 GLU A 117
THR A  14
THR A  32
LEU A 102
 None
 1.11A 5v96A-3othA:
4.7		 5v96A-3othA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r20 CYTIDYLATE KINASE

(Mycolicibacterium
smegmatis) 		PF02224
(Cytidylate_kin) 		4 GLU A 130
THR A  36
THR A 136
LEU A 194
 DPO  A 230 ( 4.8A)
None
None
None
 1.34A 5v96A-3r20A:
2.4		 5v96A-3r20A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r50 IPOMOELIN

(Ipomoea batatas) 		PF01419
(Jacalin) 		4 GLU A  76
THR A  77
THR A  63
LEU A  72
 None
 0.91A 5v96A-3r50A:
undetectable		 5v96A-3r50A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 GLU A 369
THR A 372
THR A 145
LEU A  44
 None
 1.26A 5v96A-3rd8A:
undetectable		 5v96A-3rd8A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrp PROBABLE FUMARATE
HYDRATASE FUM

(Mycobacteroides
abscessus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 GLU A 370
THR A 373
THR A 146
LEU A  43
 None
 1.26A 5v96A-3rrpA:
undetectable		 5v96A-3rrpA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY

(Cupriavidus
pinatubonensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLU A 107
THR A 108
THR A 116
LEU A 151
 None
 1.42A 5v96A-3s2gA:
10.6		 5v96A-3s2gA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT

(Cryptococcus
neoformans) 		PF01239
(PPTA) 		4 GLU A  64
THR A  63
THR A  85
LEU A 118
 None
 1.49A 5v96A-3sfyA:
undetectable		 5v96A-3sfyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		4 GLU A 287
THR A  33
THR A 298
LEU A 263
 None
 1.36A 5v96A-3tbhA:
5.5		 5v96A-3tbhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 GLU A 524
THR A 523
THR A 488
LEU A 880
 None
 1.35A 5v96A-3u44A:
undetectable		 5v96A-3u44A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 GLU A 352
THR A 353
THR A 301
LEU A 383
 None
 1.41A 5v96A-3wdjA:
2.6		 5v96A-3wdjA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE

(Pectobacterium
carotovorum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 230
THR A 258
THR A 192
LEU A 217
 None
 1.50A 5v96A-4e4fA:
undetectable		 5v96A-4e4fA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.24A 5v96A-4fr4A:
undetectable		 5v96A-4fr4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 GLU A 557
THR A 695
THR A 487
LEU A 540
 None
 1.33A 5v96A-4igdA:
undetectable		 5v96A-4igdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le7 PYOCIN L1

(Pseudomonas
aeruginosa) 		PF01453
(B_lectin) 		4 GLU A 137
THR A 136
THR A 167
LEU A 213
 None
 1.44A 5v96A-4le7A:
undetectable		 5v96A-4le7A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		4 GLU X  94
THR X  95
THR X  69
LEU X 104
 None
 1.30A 5v96A-4li3X:
3.6		 5v96A-4li3X:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.14A 5v96A-4nq8A:
undetectable		 5v96A-4nq8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 825
THR A 829
THR A 772
LEU A 799
 None
 1.45A 5v96A-4pj6A:
undetectable		 5v96A-4pj6A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLU A 312
THR A 316
THR A 272
LEU A 268
 None
 1.50A 5v96A-4rsmA:
5.0		 5v96A-4rsmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN

(Homo sapiens) 		PF00628
(PHD) 		4 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.08A 5v96A-4up5A:
undetectable		 5v96A-4up5A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy4 SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 29
SYNTAXIN-17
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 8

(Homo sapiens) 		PF00957
(Synaptobrevin)
no annotation 		4 GLU B 215
THR B 218
THR A  54
LEU D 244
 None
 1.45A 5v96A-4wy4B:
undetectable		 5v96A-4wy4B:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 GLU A 315
THR A 316
THR A 446
LEU A 292
 None
 1.30A 5v96A-4ye5A:
undetectable		 5v96A-4ye5A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 332
THR A 333
THR A 488
LEU A 293
 None
 1.16A 5v96A-5agaA:
undetectable		 5v96A-5agaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyu CONSERVED MEMBRANE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF05108
(T7SS_ESX1_EccB) 		4 GLU A 166
THR A 154
THR A 150
LEU A 371
 None
 1.35A 5v96A-5cyuA:
undetectable		 5v96A-5cyuA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e25 BRANCHED-CHAIN
AMINOTRANSFERASE

(Geoglobus
acetivorans) 		PF01063
(Aminotran_4) 		4 GLU A 286
THR A 283
THR A 246
LEU A 275
 None
 1.40A 5v96A-5e25A:
undetectable		 5v96A-5e25A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 GLU A 482
THR A 484
THR A 686
LEU A 394
 None
 1.24A 5v96A-5ehkA:
undetectable		 5v96A-5ehkA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLU A 435
THR A 343
THR A1177
LEU A 556
 None
 1.28A 5v96A-5epgA:
undetectable		 5v96A-5epgA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4g VCP-LIKE ATPASE

(Thermoplasma
acidophilum) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		4 GLU A 568
THR A 611
THR A 585
LEU A 592
 None
 1.50A 5v96A-5g4gA:
undetectable		 5v96A-5g4gA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 GLU A2264
THR A2294
THR A2384
LEU A2538
 None
 1.37A 5v96A-5h64A:
undetectable		 5v96A-5h64A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 4 GLU B 196
THR B 197
THR B 158
LEU B 175
 None
 1.48A 5v96A-5hzgB:
undetectable		 5v96A-5hzgB:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLU A  57
THR A  58
THR A 212
LEU A 401
 SAH  A 502 (-3.7A)
SAH  A 502 (-4.2A)
NAD  A 501 ( 4.1A)
NAD  A 501 (-4.1A)
 0.46A 5v96A-5utuA:
55.9		 5v96A-5utuA:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLU A 557
THR A 554
THR A 478
LEU A 432
 EDO  A 701 (-3.8A)
None
None
None
 1.27A 5v96A-5vrbA:
2.5		 5v96A-5vrbA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG

(Saccharomyces
cerevisiae) 		PF10345
(Cohesin_load) 		4 GLU A  79
THR A  80
THR A  69
LEU A 116
 None
 1.47A 5v96A-5w94A:
undetectable		 5v96A-5w94A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		4 GLU A 562
THR A 568
THR A 190
LEU A 683
 None
 1.32A 5v96A-5wx1A:
2.7		 5v96A-5wx1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 GLU A 270
THR A 269
THR A 152
LEU A 411
 FUM  A 702 (-4.7A)
FUM  A 702 (-3.4A)
None
FAD  A 701 (-3.7A)
 1.40A 5v96A-5xmjA:
2.1		 5v96A-5xmjA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Burkholderia
cenocepacia) 		no annotation 4 GLU A  60
THR A  61
THR A  52
LEU A 105
 None
 1.46A 5v96A-5y89A:
3.2		 5v96A-5y89A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 GLU A 220
THR A  70
THR A 177
LEU A 166
 None
 1.48A 5v96A-5za2A:
undetectable		 5v96A-5za2A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.26A 5v96A-6c66G:
undetectable		 5v96A-6c66G:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 4 GLU A 318
THR A 306
THR A 282
LEU A  39
 None
 1.31A 5v96A-6d0nA:
undetectable		 5v96A-6d0nA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 4 GLU A1003
THR A1004
THR A1644
LEU A1000
 None
 1.36A 5v96A-6fayA:
undetectable		 5v96A-6fayA:
12.24