SIMILAR PATTERNS OF AMINO ACIDS FOR 5V5Z_A_1YNA602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLY A 318
THR A 492
PRO A 307
 None
 0.59A 5v5zA-1dlcA:
0.8		 5v5zA-1dlcA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		3 GLY A  55
THR A 420
PRO A 423
 None
 0.59A 5v5zA-1gkrA:
0.0		 5v5zA-1gkrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h29 HIGH-MOLECULAR-WEIGH
T CYTOCHROME C

(Desulfovibrio
vulgaris) 		PF02085
(Cytochrom_CIII) 		3 GLY A 396
THR A 328
PRO A 279
 None
 0.51A 5v5zA-1h29A:
0.0		 5v5zA-1h29A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm6 ANNEXIN 1

(Sus scrofa) 		PF00191
(Annexin) 		3 GLY A 344
THR A  41
PRO A  38
 None
 0.46A 5v5zA-1hm6A:
0.0		 5v5zA-1hm6A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		3 GLY A 458
THR A 415
PRO A 342
 None
 0.60A 5v5zA-1ii2A:
0.0		 5v5zA-1ii2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		3 GLY A 468
THR A 426
PRO A 354
 None
 0.57A 5v5zA-1j3bA:
0.0		 5v5zA-1j3bA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLY A 319
THR A 495
PRO A 308
 None
 0.61A 5v5zA-1ji6A:
0.0		 5v5zA-1ji6A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9g CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF03167
(UDG) 		3 GLY A  33
THR A  96
PRO A  48
 None
 0.63A 5v5zA-1l9gA:
0.0		 5v5zA-1l9gA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE

(Mycobacterium
tuberculosis) 		PF02548
(Pantoate_transf) 		3 GLY A 228
THR A  19
PRO A  56
 None
 0.65A 5v5zA-1oy0A:
0.0		 5v5zA-1oy0A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		3 GLY A  69
THR A 227
PRO A 135
 None
 0.62A 5v5zA-1pweA:
undetectable		 5v5zA-1pweA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyd PINORESINOL-LARICIRE
SINOL REDUCTASE

(Thuja plicata) 		PF05368
(NmrA) 		3 GLY A 107
THR A 213
PRO A 151
 None
 0.64A 5v5zA-1qydA:
undetectable		 5v5zA-1qydA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 GLY A 492
THR A 344
PRO A 481
 None
 0.62A 5v5zA-1ry2A:
undetectable		 5v5zA-1ry2A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLY A 301
THR A 394
PRO A 331
 MYR  A1001 ( 3.9A)
None
MYR  A1001 ( 4.6A)
 0.58A 5v5zA-1v26A:
undetectable		 5v5zA-1v26A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 GLY A 781
THR A 715
PRO A 752
 None
 0.53A 5v5zA-1vbgA:
undetectable		 5v5zA-1vbgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yht DSPB

(Aggregatibacter
actinomycetemcomitans) 		PF00728
(Glyco_hydro_20) 		3 GLY A 219
THR A 122
PRO A 118
 None
 0.60A 5v5zA-1yhtA:
undetectable		 5v5zA-1yhtA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		3 GLY A 201
THR A  95
PRO A 156
 None
SEP  A  92 ( 4.1A)
None
 0.60A 5v5zA-1zefA:
undetectable		 5v5zA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzh CYTOCHROME C
PEROXIDASE

(Rhodobacter
capsulatus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 GLY A 211
THR A  70
PRO A  84
 None
None
HEC  A 802 (-4.2A)
 0.63A 5v5zA-1zzhA:
undetectable		 5v5zA-1zzhA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bej SEGREGATION PROTEIN

(Thermus
thermophilus) 		PF13614
(AAA_31) 		3 GLY A 164
THR A  93
PRO A 100
 None
 0.55A 5v5zA-2bejA:
undetectable		 5v5zA-2bejA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1u DI-HAEM CYTOCHROME C
PEROXIDASE

(Paracoccus
pantotrophus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 GLY A 222
THR A  81
PRO A  95
 None
None
HEC  A 401 (-4.3A)
 0.64A 5v5zA-2c1uA:
undetectable		 5v5zA-2c1uA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C

(Saccharomyces
cerevisiae) 		PF03737
(RraA-like) 		3 GLY A 164
THR A  35
PRO A  32
 None
 0.57A 5v5zA-2c5qA:
undetectable		 5v5zA-2c5qA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		3 GLY A 219
THR A 317
PRO A 267
 None
 0.61A 5v5zA-2cyaA:
undetectable		 5v5zA-2cyaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgq BRUNO-LIKE 6, RNA
BINDING PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		3 GLY A 131
THR A  93
PRO A 124
 None
 0.40A 5v5zA-2dgqA:
undetectable		 5v5zA-2dgqA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLY A 382
THR A 173
PRO A 196
 None
NAD  A1403 (-3.0A)
NAD  A1403 ( 4.0A)
 0.61A 5v5zA-2dphA:
undetectable		 5v5zA-2dphA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 GLY A 328
THR A 480
PRO A 470
 None
 0.66A 5v5zA-2e7zA:
undetectable		 5v5zA-2e7zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 GLY A  89
THR A 201
PRO A 223
 None
 0.41A 5v5zA-2fpqA:
0.3		 5v5zA-2fpqA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Pseudomonas sp.
101) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 GLY A 377
THR A 282
PRO A 256
 None
NAD  A 394 (-4.8A)
NAD  A 394 (-3.7A)
 0.63A 5v5zA-2nadA:
undetectable		 5v5zA-2nadA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oum 50S RIBOSOMAL
PROTEIN L1

(Thermus
thermophilus) 		PF00687
(Ribosomal_L1) 		3 GLY A 159
THR A 217
PRO A 174
 None
 0.66A 5v5zA-2oumA:
undetectable		 5v5zA-2oumA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 GLY A 204
THR A 222
PRO A 219
 None
 0.65A 5v5zA-2pa6A:
undetectable		 5v5zA-2pa6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2por PORIN

(Rhodobacter
capsulatus) 		PF13609
(Porin_4) 		3 GLY A 233
THR A 106
PRO A 103
 C8E  A 548 ( 4.4A)
None
None
 0.61A 5v5zA-2porA:
undetectable		 5v5zA-2porA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 GLY A  63
THR A  35
PRO A  17
 None
 0.60A 5v5zA-2pwhA:
undetectable		 5v5zA-2pwhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 GLY A 353
THR A 162
PRO A 294
 None
 0.58A 5v5zA-2q3zA:
undetectable		 5v5zA-2q3zA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 GLY A 477
THR A 950
PRO A 945
 None
 0.62A 5v5zA-2vdcA:
undetectable		 5v5zA-2vdcA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhd CYTOCHROME C551
PEROXIDASE

(Pseudomonas
aeruginosa) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 GLY A 208
THR A  67
PRO A  81
 None
None
HEC  A 401 (-4.5A)
 0.64A 5v5zA-2vhdA:
undetectable		 5v5zA-2vhdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF13599
(Pentapeptide_4) 		3 GLY A 207
THR A 167
PRO A 186
 None
None
CL  A1212 ( 4.1A)
 0.65A 5v5zA-2w7zA:
undetectable		 5v5zA-2w7zA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLY C 270
THR C 249
PRO C 254
 None
 0.63A 5v5zA-2wtkC:
undetectable		 5v5zA-2wtkC:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE

(Plesiocystis
pacifica) 		PF00561
(Abhydrolase_1) 		3 GLY A 246
THR A 187
PRO A 184
 None
 0.65A 5v5zA-2xt0A:
undetectable		 5v5zA-2xt0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzi EXTRACELLULAR
SIALIDASE/NEURAMINID
ASE, PUTATIVE

(Aspergillus
fumigatus) 		PF13088
(BNR_2) 		3 GLY A 356
THR A 126
PRO A  61
 None
 0.67A 5v5zA-2xziA:
undetectable		 5v5zA-2xziA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0h PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 GLY A  59
THR A 281
PRO A 127
 C8E  A1402 (-3.7A)
None
None
 0.57A 5v5zA-2y0hA:
undetectable		 5v5zA-2y0hA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I
PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02847
(MA3) 		3 GLY A  79
THR B 254
PRO A 108
 None
 0.54A 5v5zA-2zu6A:
undetectable		 5v5zA-2zu6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLY A 162
THR A  55
PRO A  45
 None
None
FAD  A 446 ( 4.5A)
 0.65A 5v5zA-3cgdA:
undetectable		 5v5zA-3cgdA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		3 GLY A 305
THR A 312
PRO A 260
 None
 0.65A 5v5zA-3dc8A:
undetectable		 5v5zA-3dc8A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doh ESTERASE

(Thermotoga
maritima) 		PF02230
(Abhydrolase_2) 		3 GLY A 288
THR A 163
PRO A 234
 None
 0.53A 5v5zA-3dohA:
undetectable		 5v5zA-3dohA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		3 GLY A 194
THR A  88
PRO A 147
 None
 0.64A 5v5zA-3g0iA:
undetectable		 5v5zA-3g0iA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilr HEPARIN LYASE I

(Bacteroides
thetaiotaomicron) 		PF14099
(Polysacc_lyase) 		3 GLY A 349
THR A 277
PRO A 228
 None
 0.50A 5v5zA-3ilrA:
undetectable		 5v5zA-3ilrA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtv PAPAIN-LIKE CYSTEINE
PROTEASE

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05411
(Peptidase_C32) 		3 GLY A 170
THR A 117
PRO A  86
 None
 0.52A 5v5zA-3mtvA:
undetectable		 5v5zA-3mtvA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 GLY X 435
THR X 330
PRO X 327
 None
 0.61A 5v5zA-3rwkX:
undetectable		 5v5zA-3rwkX:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		3 GLY A 218
THR A 445
PRO A 450
 None
NDP  A 801 (-3.4A)
None
 0.58A 5v5zA-3slkA:
undetectable		 5v5zA-3slkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 GLY A 462
THR A 384
PRO A 340
 None
 0.63A 5v5zA-3ue3A:
undetectable		 5v5zA-3ue3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 GLY A  64
THR A  36
PRO A  18
 None
 0.58A 5v5zA-3wy2A:
undetectable		 5v5zA-3wy2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 GLY A 230
THR A  89
PRO A 103
 None
None
HEC  A 423 (-4.2A)
 0.57A 5v5zA-4aalA:
undetectable		 5v5zA-4aalA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axv MPAA

(Vibrio
campbellii) 		PF04952
(AstE_AspA) 		3 GLY A  20
THR A  87
PRO A  80
 None
 0.65A 5v5zA-4axvA:
undetectable		 5v5zA-4axvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		3 GLY A 434
THR A 756
PRO A 760
 None
 0.53A 5v5zA-4ckbA:
undetectable		 5v5zA-4ckbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		3 GLY A 437
THR A 559
PRO A 441
 None
 0.63A 5v5zA-4cvcA:
undetectable		 5v5zA-4cvcA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLY A 485
THR A 526
PRO A 416
 None
 0.66A 5v5zA-4d8mA:
undetectable		 5v5zA-4d8mA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Thermobifida
fusca) 		PF02011
(Glyco_hydro_48) 		3 GLY A 114
THR A 282
PRO A 107
 None
 0.66A 5v5zA-4jjjA:
undetectable		 5v5zA-4jjjA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE

(Roseobacter
denitrificans) 		PF03480
(DctP) 		3 GLY A 127
THR A  90
PRO A 142
 None
 0.67A 5v5zA-4pc9A:
undetectable		 5v5zA-4pc9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		3 GLY A 303
THR A 240
PRO A 335
 None
 0.66A 5v5zA-4qgkA:
undetectable		 5v5zA-4qgkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Pectobacterium
atrosepticum) 		PF13416
(SBP_bac_8) 		3 GLY A 343
THR A 144
PRO A 354
 None
GOL  A 501 ( 4.6A)
None
 0.63A 5v5zA-4ry1A:
undetectable		 5v5zA-4ry1A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN

(Zobellia
galactanivorans) 		no annotation 3 GLY A 182
THR A 287
PRO A 232
 None
 0.58A 5v5zA-4u6dA:
undetectable		 5v5zA-4u6dA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		3 GLY A 794
THR A 689
PRO A 779
 None
 0.51A 5v5zA-4uwaA:
undetectable		 5v5zA-4uwaA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x04 SOLUTE BINDING
PROTEIN

(Citrobacter
koseri) 		PF03480
(DctP) 		3 GLY A 127
THR A 152
PRO A 239
 None
 0.60A 5v5zA-4x04A:
undetectable		 5v5zA-4x04A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
no annotation 		3 GLY A 275
THR D 146
PRO D 133
 None
 0.62A 5v5zA-4x28A:
undetectable		 5v5zA-4x28A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN

(Clostridioides
difficile) 		PF02661
(Fic) 		3 GLY A 173
THR A 112
PRO A 164
 None
 0.52A 5v5zA-4x2dA:
1.6		 5v5zA-4x2dA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		3 GLY A 394
THR A 234
PRO A 230
 None
 0.49A 5v5zA-4xiiA:
undetectable		 5v5zA-4xiiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 GLY A 378
THR A 283
PRO A 257
 None
None
NDP  A 401 (-3.5A)
 0.66A 5v5zA-4xybA:
undetectable		 5v5zA-4xybA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		3 GLY A 242
THR A 416
PRO A 144
 None
 0.62A 5v5zA-4y23A:
undetectable		 5v5zA-4y23A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yep LAMININ SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00052
(Laminin_B) 		3 GLY A1315
THR A1344
PRO A1272
 None
 0.50A 5v5zA-4yepA:
undetectable		 5v5zA-4yepA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeq LAMININ SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00052
(Laminin_B) 		3 GLY U 140
THR U 169
PRO U  97
 None
 0.57A 5v5zA-4yeqU:
undetectable		 5v5zA-4yeqU:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 GLY A 350
THR A 281
PRO A 385
 None
 0.57A 5v5zA-4yweA:
undetectable		 5v5zA-4yweA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		3 GLY I 187
THR I 324
PRO I 380
 None
 0.60A 5v5zA-4zoqI:
undetectable		 5v5zA-4zoqI:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 3 GLY A 354
THR A 279
PRO A 365
 None
 0.61A 5v5zA-5ah0A:
undetectable		 5v5zA-5ah0A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aid MEP2

(Candida
albicans) 		PF00909
(Ammonium_transp) 		3 GLY A  32
THR A  10
PRO A 115
 None
 0.63A 5v5zA-5aidA:
undetectable		 5v5zA-5aidA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqn BOTULINUM NEUROTOXIN
TYPE D,BOTULINUM
NEUROTOXIN TYPE D

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		3 GLY A  89
THR A 201
PRO A 223
 None
 0.50A 5v5zA-5bqnA:
undetectable		 5v5zA-5bqnA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1m MU-TYPE OPIOID
RECEPTOR

(Mus musculus) 		PF00001
(7tm_1) 		3 GLY A  52
THR A 311
PRO A  58
 None
None
YCM  A  57 ( 2.6A)
 0.61A 5v5zA-5c1mA:
1.3		 5v5zA-5c1mA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		3 GLY A 611
THR A 844
PRO A 994
 None
 0.66A 5v5zA-5d0fA:
1.3		 5v5zA-5d0fA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE

(Chromohalobacter
salexigens) 		PF00120
(Gln-synt_C) 		3 GLY A 258
THR A 326
PRO A 323
 None
 0.66A 5v5zA-5dm3A:
undetectable		 5v5zA-5dm3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		3 GLY A 177
THR A  70
PRO A 132
 None
 0.66A 5v5zA-5f4zA:
undetectable		 5v5zA-5f4zA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		3 GLY A  65
THR A 122
PRO A 230
 X2N  A 590 ( 4.0A)
None
X2N  A 590 (-4.2A)
 0.48A 5v5zA-5fsaA:
54.9		 5v5zA-5fsaA:
90.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fws KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		3 GLY A  42
THR A 195
PRO A  93
 None
 0.60A 5v5zA-5fwsA:
undetectable		 5v5zA-5fwsA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fww KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		3 GLY B  42
THR B 195
PRO B  93
 None
 0.65A 5v5zA-5fwwB:
undetectable		 5v5zA-5fwwB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		3 GLY A 622
THR A 531
PRO A 556
 None
 0.57A 5v5zA-5haxA:
undetectable		 5v5zA-5haxA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		3 GLY A  73
THR A 130
PRO A 238
 None
 0.34A 5v5zA-5hs1A:
54.1		 5v5zA-5hs1A:
64.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		3 GLY A  35
THR A 283
PRO A 215
 None
 0.62A 5v5zA-5i5lA:
undetectable		 5v5zA-5i5lA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		3 GLY A  74
THR A 131
PRO A 239
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.9A)
1YN  A 602 ( 4.8A)
 0.39A 5v5zA-5jlcA:
53.5		 5v5zA-5jlcA:
62.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 GLY A 528
THR A 384
PRO A 414
 None
None
6R9  A 704 (-3.3A)
 0.62A 5v5zA-5k8fA:
undetectable		 5v5zA-5k8fA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldy IG DOMAIN PROTEIN
GROUP 1 DOMAIN
PROTEIN

(Yersinia
pseudotuberculosis) 		PF09134
(Invasin_D3) 		3 GLY A1888
THR A1810
PRO A1838
 None
 0.58A 5v5zA-5ldyA:
undetectable		 5v5zA-5ldyA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 GLY A 779
THR A 713
PRO A 750
 None
 0.59A 5v5zA-5lu4A:
undetectable		 5v5zA-5lu4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9f ORF68

(Staphylococcus
virus K) 		no annotation 3 GLY A 315
THR A 331
PRO A 288
 None
 0.65A 5v5zA-5m9fA:
undetectable		 5v5zA-5m9fA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		3 GLY A 264
THR A 124
PRO A 144
 None
 0.65A 5v5zA-5mscA:
undetectable		 5v5zA-5mscA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		3 GLY A  16
THR A   2
PRO A  30
 None
 0.62A 5v5zA-5tufA:
undetectable		 5v5zA-5tufA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		3 GLY A 521
THR A 179
PRO A 174
 None
CL  A 603 (-4.7A)
None
 0.62A 5v5zA-5u8zA:
undetectable		 5v5zA-5u8zA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM

(Brucella
abortus) 		PF04069
(OpuAC) 		3 GLY A 219
THR A 121
PRO A 244
 None
 0.56A 5v5zA-5uveA:
undetectable		 5v5zA-5uveA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wya ISOLEUCINE
2-EPIMERASE

(Lactobacillus
buchneri) 		PF00202
(Aminotran_3) 		3 GLY A 340
THR A  38
PRO A 411
 None
 0.67A 5v5zA-5wyaA:
undetectable		 5v5zA-5wyaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		3 GLY G 248
THR G  55
PRO G 122
 None
 0.58A 5v5zA-5x5yG:
1.2		 5v5zA-5x5yG:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 GLY A 251
THR A 199
PRO A 242
 None
 0.53A 5v5zA-5xfmA:
undetectable		 5v5zA-5xfmA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 3 GLY A 103
THR A   8
PRO A  57
 None
 0.53A 5v5zA-5xmdA:
undetectable		 5v5zA-5xmdA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3o SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2) 		3 GLY A1096
THR A1124
PRO A 752
 None
 0.61A 5v5zA-6b3oA:
undetectable		 5v5zA-6b3oA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c96 TWO PORE CALCIUM
CHANNEL PROTEIN 1

(Mus musculus) 		no annotation 3 GLY A 592
THR A 138
PRO A 129
 None
 0.64A 5v5zA-6c96A:
undetectable		 5v5zA-6c96A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 3 GLY A  41
THR A 151
PRO A 301
 None
 0.66A 5v5zA-6cj7A:
undetectable		 5v5zA-6cj7A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
8, MITOCHONDRIAL

(Mus musculus) 		no annotation 3 GLY I  65
THR I 145
PRO B 157
 None
 0.66A 5v5zA-6g72I:
undetectable		 5v5zA-6g72I:
9.35