SIMILAR PATTERNS OF AMINO ACIDS FOR 5V5Z_A_1YNA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ILE A  55
PHE A 106
GLY A 134
LEU A  66
PHE A 101
 None
 1.28A 5v5zA-1hkkA:
undetectable		 5v5zA-1hkkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus) 		PF00079
(Serpin) 		5 PHE B 370
ILE A 252
PHE A 291
PHE A  51
PHE B 384
 None
 1.28A 5v5zA-1hleB:
undetectable		 5v5zA-1hleB:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03372
(Exo_endo_phos) 		5 PHE A 686
ILE A 660
TYR A 688
PHE A 695
HIS A 827
 None
 1.28A 5v5zA-1i9zA:
undetectable		 5v5zA-1i9zA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		5 TYR A  42
PHE A 687
ILE A  20
PHE A 107
GLY A  32
 None
 1.31A 5v5zA-1kehA:
undetectable		 5v5zA-1kehA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		5 PHE A  61
ILE A  41
PHE A 127
GLY A  65
THR A  69
 None
 1.33A 5v5zA-1oa1A:
undetectable		 5v5zA-1oa1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		5 ILE A  72
PHE A  99
GLY A  81
THR A  78
MET A 107
 None
COA  A 500 (-3.6A)
None
None
COA  A 500 (-4.6A)
 1.18A 5v5zA-1q6yA:
undetectable		 5v5zA-1q6yA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE

(Oxalobacter
formigenes) 		PF02515
(CoA_transf_3) 		5 ILE A  70
PHE A  97
GLY A  79
THR A  76
MET A 105
 None
CAO  A 429 (-3.8A)
None
None
CAO  A 429 (-3.7A)
 1.11A 5v5zA-1vgqA:
0.0		 5v5zA-1vgqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ILE A  55
PHE A 106
GLY A 134
LEU A  66
PHE A 101
 None
 1.26A 5v5zA-1wb0A:
undetectable		 5v5zA-1wb0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkg SYNTHETIC CONSTRUCT
ANKYRIN REPEAT
PROTEIN E3_19

(synthetic
construct) 		PF12796
(Ank_2) 		5 ILE A  95
GLY A  91
THR A 123
LEU A 119
HIS A 118
 None
 1.38A 5v5zA-2bkgA:
undetectable		 5v5zA-2bkgA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ed6 25KDA STRUCTURAL
PROTEIN VP25

(White spot
syndrome virus) 		PF12175
(WSS_VP) 		5 PHE A 171
PHE A  65
GLY A 136
PHE A 177
MET A 192
 None
 1.29A 5v5zA-2ed6A:
undetectable		 5v5zA-2ed6A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		5 TYR A 598
ILE A 518
TYR A 596
GLY A 621
HIS A 646
 None
 1.37A 5v5zA-2g28A:
undetectable		 5v5zA-2g28A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq6 SEROLOGICALLY
DEFINED COLON CANCER
ANTIGEN 10

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A  54
ILE A 161
PHE A 115
PHE A 130
THR A 137
 None
 1.25A 5v5zA-2hq6A:
undetectable		 5v5zA-2hq6A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		5 PHE A 333
ILE A 307
GLY A 343
THR A  53
PHE A 244
 None
None
None
None
NHE  A   1 (-3.6A)
 1.19A 5v5zA-2ichA:
undetectable		 5v5zA-2ichA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 ILE A 242
PHE A 146
LEU A 291
HIS A 290
PHE A 132
 None
 1.33A 5v5zA-2ip2A:
undetectable		 5v5zA-2ip2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP

(Murid
betaherpesvirus
1) 		PF04843
(Herpes_teg_N) 		5 TYR A 193
ILE A 135
PHE A 191
THR A 152
LEU A 122
 None
 1.34A 5v5zA-2j7qA:
undetectable		 5v5zA-2j7qA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m83 PROTEIN PHOSPHATASE
1 REGULATORY SUBUNIT
3A

(Oryctolagus
cuniculus) 		PF03370
(CBM_21) 		5 ILE A 174
TYR A 172
GLY A 146
THR A 135
LEU A 231
 None
 1.20A 5v5zA-2m83A:
undetectable		 5v5zA-2m83A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		5 PHE A 326
PHE A 319
GLY A 196
LEU A 199
MET A 269
 None
 1.15A 5v5zA-2o7rA:
undetectable		 5v5zA-2o7rA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ILE A 375
PHE A 238
GLY A 268
PHE A  66
MET A 232
 None
 1.40A 5v5zA-2qo3A:
undetectable		 5v5zA-2qo3A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 PHE B 226
ILE B 161
PHE B 195
LEU B 130
HIS B  58
 None
 1.22A 5v5zA-2uzxB:
undetectable		 5v5zA-2uzxB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		5 PHE A 333
GLY A 194
THR A 192
LEU A  23
HIS A  26
 None
 1.22A 5v5zA-2x4gA:
undetectable		 5v5zA-2x4gA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmr PROTEIN NDRG2

(Homo sapiens) 		PF03096
(Ndr) 		5 ILE A  51
PHE A 296
GLY A 151
LEU A 154
MET A 244
 None
 1.20A 5v5zA-2xmrA:
undetectable		 5v5zA-2xmrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE

(Plesiocystis
pacifica) 		PF00561
(Abhydrolase_1) 		5 PHE A 210
PHE A 100
GLY A  54
LEU A 105
PHE A  30
 None
 1.05A 5v5zA-2xt0A:
undetectable		 5v5zA-2xt0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		5 PHE A  80
PHE A 190
THR A  68
LEU A 251
MET A  71
 None
 1.31A 5v5zA-3d5eA:
undetectable		 5v5zA-3d5eA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 198
TYR A 207
GLY A 158
THR A 223
HIS A 251
 None
 1.30A 5v5zA-3gazA:
undetectable		 5v5zA-3gazA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0u PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		5 PHE A  27
ILE A  14
PHE A 125
THR A 110
LEU A 106
 None
 1.24A 5v5zA-3h0uA:
undetectable		 5v5zA-3h0uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		5 PHE A 154
ILE A 320
PHE A 338
GLY A  54
LEU A  59
 None
 1.28A 5v5zA-3i3vA:
undetectable		 5v5zA-3i3vA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		5 PHE A 154
ILE A 320
PHE A 351
GLY A  54
LEU A  59
 None
 1.05A 5v5zA-3i3vA:
undetectable		 5v5zA-3i3vA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6y ESTERASE APC40077

(Oleispira
antarctica) 		PF00756
(Esterase) 		5 TYR A  97
PHE A 105
GLY A 183
HIS A 147
MET A 149
 None
 1.42A 5v5zA-3i6yA:
undetectable		 5v5zA-3i6yA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 PHE A 322
ILE A  77
PHE A 306
PHE A 346
PHE A 333
 None
 1.19A 5v5zA-3iv0A:
undetectable		 5v5zA-3iv0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksx NITRATE TRANSPORT
PROTEIN

(Xanthomonas
citri) 		PF09084
(NMT1) 		5 ILE A  80
PHE A 227
GLY A  84
LEU A 235
PHE A  55
 None
 1.24A 5v5zA-3ksxA:
undetectable		 5v5zA-3ksxA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		6 TYR A 102
TYR A 115
PHE A 104
THR A 294
LEU A 355
MET A 459
 HEM  A 481 (-4.7A)
HEM  A 481 ( 4.9A)
None
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.4A)
TPF  A 490 (-4.7A)
 1.07A 5v5zA-3l4dA:
39.9		 5v5zA-3l4dA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		6 TYR A 102
TYR A 115
PHE A 289
PHE A 104
THR A 294
LEU A 355
 HEM  A 481 (-4.7A)
HEM  A 481 ( 4.9A)
TPF  A 490 (-4.3A)
None
TPF  A 490 ( 3.5A)
TPF  A 490 (-4.4A)
 1.22A 5v5zA-3l4dA:
39.9		 5v5zA-3l4dA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ls2 S-FORMYLGLUTATHIONE
HYDROLASE

(Pseudoalteromonas
haloplanktis) 		PF00756
(Esterase) 		5 TYR A  96
PHE A 104
GLY A 182
HIS A 146
MET A 148
 None
 1.37A 5v5zA-3ls2A:
undetectable		 5v5zA-3ls2A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		5 ILE A 468
PHE A 472
PHE A 436
GLY A 158
PHE A 167
 None
 1.41A 5v5zA-3mzsA:
29.5		 5v5zA-3mzsA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00287
(Na_K-ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
 None
 1.13A 5v5zA-3n23B:
undetectable		 5v5zA-3n23B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2e SHIKIMATE KINASE

(Helicobacter
pylori) 		PF01202
(SKI) 		5 PHE A  56
ILE A  36
GLY A  79
LEU A  88
MET A  84
 None
None
None
None
OSA  A1001 (-4.6A)
 1.22A 5v5zA-3n2eA:
undetectable		 5v5zA-3n2eA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 507
PHE A 511
PHE A 475
GLY A 196
PHE A 205
 None
 1.31A 5v5zA-3na0A:
17.8		 5v5zA-3na0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyb POLY(A) RNA
POLYMERASE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		5 PHE A 447
ILE A 443
PHE A 379
LEU A 394
PHE A 345
 None
 1.38A 5v5zA-3nybA:
undetectable		 5v5zA-3nybA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 ILE A 496
PHE A 671
GLY A 680
LEU A 718
PHE A 538
 None
ADP  A 764 (-3.8A)
None
None
ADP  A 764 (-4.0A)
 1.35A 5v5zA-3o8lA:
undetectable		 5v5zA-3o8lA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 PHE A 424
PHE A 109
GLY A 269
LEU A  34
PHE A 162
 None
None
None
MHI  A 516 (-3.7A)
None
 1.13A 5v5zA-3o9pA:
undetectable		 5v5zA-3o9pA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		5 TYR A 444
PHE A 422
GLY A 148
PHE A 429
MET A 151
 None
 1.23A 5v5zA-3oqqA:
undetectable		 5v5zA-3oqqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		5 ILE A 261
TYR A 268
GLY A  42
LEU A  47
HIS A  48
 None
 1.40A 5v5zA-3p8aA:
undetectable		 5v5zA-3p8aA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei) 		no annotation 5 PHE A 213
ILE A 195
PHE A 177
GLY A 251
LEU A 155
 None
 1.25A 5v5zA-3picA:
undetectable		 5v5zA-3picA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13416
(SBP_bac_8) 		5 PHE A 219
PHE A 216
GLY A 239
THR A 244
LEU A 229
 PHE  A 219 ( 1.3A)
PHE  A 216 ( 1.3A)
GLY  A 239 ( 0.0A)
THR  A 244 ( 0.8A)
LEU  A 229 ( 0.5A)
 1.23A 5v5zA-3pu5A:
undetectable		 5v5zA-3pu5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 PHE A 272
ILE A 295
TYR A 290
GLY A 248
PHE A 257
 None
 1.33A 5v5zA-3t5bA:
undetectable		 5v5zA-3t5bA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 PHE A1115
GLY A1209
THR A1207
LEU A1187
PHE A1052
 None
 1.38A 5v5zA-3topA:
undetectable		 5v5zA-3topA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 PHE A  48
ILE A  47
TYR A 299
GLY A 228
HIS A 158
 None
 1.33A 5v5zA-3tqoA:
undetectable		 5v5zA-3tqoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uow GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 TYR A 273
PHE A 282
PHE A 406
THR A 307
LEU A 423
 None
 1.28A 5v5zA-3uowA:
undetectable		 5v5zA-3uowA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 PHE D 193
GLY D 416
LEU D 160
HIS D 157
PHE D 194
 None
 1.18A 5v5zA-3vr5D:
undetectable		 5v5zA-3vr5D:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 ILE A  48
GLY A 162
THR A 160
LEU A 129
PHE A  38
 SO4  A 603 (-4.9A)
None
None
None
None
 1.18A 5v5zA-3wfoA:
undetectable		 5v5zA-3wfoA:
25.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(Aquifex
aeolicus;
synthetic
construct) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 ILE A  48
GLY A 162
THR A 160
LEU A 129
PHE A  38
 None
 1.15A 5v5zA-3wfpA:
undetectable		 5v5zA-3wfpA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 ILE A 823
GLY A 733
THR A 281
LEU A 502
PHE A 833
 None
 1.17A 5v5zA-3zuqA:
undetectable		 5v5zA-3zuqA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		5 PHE A 380
TYR A 197
GLY A 249
THR A 522
PHE A 110
 None
 1.16A 5v5zA-4ainA:
undetectable		 5v5zA-4ainA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6g PUTATIVE ESTERASE

(Neisseria
meningitidis) 		PF00756
(Esterase) 		5 TYR A  94
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.27A 5v5zA-4b6gA:
undetectable		 5v5zA-4b6gA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		5 PHE A 134
ILE A 105
GLY A  98
THR A 387
PHE A 320
 None
None
None
XYP  A1002 ( 4.8A)
None
 1.37A 5v5zA-4c1tA:
undetectable		 5v5zA-4c1tA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 ILE A 445
PHE A 438
PHE A 473
GLY A  18
LEU A 223
 None
 1.25A 5v5zA-4dshA:
undetectable		 5v5zA-4dshA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13

(Candida
albicans) 		PF09084
(NMT1) 		5 ILE A  39
TYR A  22
PHE A 220
GLY A  60
LEU A  83
 None
 1.38A 5v5zA-4eswA:
undetectable		 5v5zA-4eswA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		5 TYR A 103
PHE A 290
PHE A 105
THR A 295
LEU A 356
 VNT  A 502 ( 4.8A)
VNT  A 502 (-4.4A)
VNT  A 502 (-4.8A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
 1.30A 5v5zA-4g3jA:
40.2		 5v5zA-4g3jA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		6 TYR A 103
TYR A 116
PHE A 105
THR A 295
LEU A 356
MET A 460
 VNT  A 502 ( 4.8A)
HEM  A 501 ( 4.5A)
VNT  A 502 (-4.8A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
VNT  A 502 (-4.9A)
 1.33A 5v5zA-4g3jA:
40.2		 5v5zA-4g3jA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 PHE A 327
ILE A 360
GLY A 242
LEU A 249
HIS A 252
 None
None
ATP  A 502 (-3.3A)
None
None
 1.41A 5v5zA-4gniA:
undetectable		 5v5zA-4gniA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN

(Plasmodium
falciparum) 		PF02861
(Clp_N) 		5 ILE A  68
PHE A 131
THR A  96
LEU A 117
HIS A 116
 None
 1.21A 5v5zA-4irfA:
undetectable		 5v5zA-4irfA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 TYR A 108
ILE A 109
PHE A 436
GLY A 102
LEU A 447
 None
 1.23A 5v5zA-4jsoA:
undetectable		 5v5zA-4jsoA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A4447
PHE A4610
GLY A4535
HIS A4647
PHE A4547
 None
 1.19A 5v5zA-4opeA:
undetectable		 5v5zA-4opeA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CWC27 HOMOLOG

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A  54
ILE A 161
PHE A 115
PHE A 130
THR A 137
 None
 1.26A 5v5zA-4r3eA:
undetectable		 5v5zA-4r3eA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27

(Chaetomium
thermophilum) 		PF00160
(Pro_isomerase) 		5 PHE A  54
ILE A 189
PHE A 141
PHE A 156
THR A 164
 None
 1.39A 5v5zA-4r3fA:
undetectable		 5v5zA-4r3fA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE

(Geobacillus
thermodenitrificans) 		no annotation 5 TYR A 227
PHE A 194
PHE A 171
LEU A 182
HIS A 180
 None
 1.16A 5v5zA-4rh0A:
undetectable		 5v5zA-4rh0A:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uym 14-ALPHA STEROL
DEMETHYLASE

(Aspergillus
fumigatus) 		PF00067
(p450) 		5 TYR A 122
PHE A 130
TYR A 136
PHE A 229
HIS A 374
 VOR  A 590 (-3.8A)
VOR  A 590 (-4.6A)
HEM  A 580 (-4.6A)
None
None
 1.06A 5v5zA-4uymA:
50.2		 5v5zA-4uymA:
45.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE

(Burkholderia
pseudomallei) 		PF01063
(Aminotran_4) 		5 TYR A  44
ILE A  53
PHE A 289
GLY A  40
PHE A 290
 None
None
None
ALA  A 401 ( 3.7A)
None
 1.33A 5v5zA-4whxA:
undetectable		 5v5zA-4whxA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		5 ILE A  55
GLY A  45
LEU A 210
PHE A 102
MET A  74
 None
 1.29A 5v5zA-4xhbA:
undetectable		 5v5zA-4xhbA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		5 TYR A 608
ILE A 638
TYR A 598
PHE A 626
GLY A 670
 None
 1.35A 5v5zA-4yw5A:
undetectable		 5v5zA-4yw5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A2550
PHE A2713
GLY A2638
HIS A2753
PHE A2650
 None
 1.28A 5v5zA-4z37A:
undetectable		 5v5zA-4z37A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B

(Homo sapiens) 		PF00229
(TNF) 		5 PHE A 136
PHE A  86
GLY A 408
LEU A  56
PHE A 109
 None
None
None
None
144  A 501 (-4.7A)
 1.18A 5v5zA-4zchA:
undetectable		 5v5zA-4zchA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00632
(HECT) 		5 TYR A 661
ILE A 765
PHE A 752
GLY A 643
LEU A 652
 None
 1.43A 5v5zA-5c91A:
undetectable		 5v5zA-5c91A:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		12 TYR A 118
PHE A 126
ILE A 131
TYR A 132
PHE A 228
PHE A 233
GLY A 307
THR A 311
LEU A 376
HIS A 377
PHE A 380
MET A 508
 X2N  A 590 ( 4.0A)
X2N  A 590 (-4.8A)
X2N  A 590 (-4.2A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.9A)
X2N  A 590 (-4.3A)
X2N  A 590 (-3.5A)
HEM  A 580 (-3.6A)
X2N  A 590 (-4.3A)
X2N  A 590 (-4.3A)
X2N  A 590 ( 4.8A)
X2N  A 590 (-4.8A)
 0.56A 5v5zA-5fsaA:
54.9		 5v5zA-5fsaA:
90.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		5 TYR A2221
PHE A2251
ILE A2250
PHE A2284
PHE A2168
 None
 1.19A 5v5zA-5fu7A:
undetectable		 5v5zA-5fu7A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		5 TYR A  53
ILE A  93
PHE A  28
GLY A  23
LEU A 380
 GCS  A 801 (-4.8A)
None
None
None
None
 1.41A 5v5zA-5gsmA:
undetectable		 5v5zA-5gsmA:
22.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 PHE A 134
TYR A 126
PHE A 236
GLY A 314
THR A 318
 VOR  A 602 (-4.7A)
VOR  A 602 ( 3.8A)
VOR  A 602 (-4.4A)
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
 1.13A 5v5zA-5hs1A:
54.1		 5v5zA-5hs1A:
64.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 TYR A 126
ILE A 139
TYR A 140
PHE A 241
LEU A 383
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
None
HEM  A 601 (-4.0A)
 1.25A 5v5zA-5hs1A:
54.1		 5v5zA-5hs1A:
64.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		11 TYR A 126
PHE A 134
ILE A 139
TYR A 140
PHE A 236
PHE A 241
GLY A 314
THR A 318
LEU A 380
HIS A 381
PHE A 384
 VOR  A 602 ( 3.8A)
VOR  A 602 (-4.7A)
VOR  A 602 (-4.3A)
HEM  A 601 (-4.3A)
VOR  A 602 (-4.4A)
None
VOR  A 602 (-3.0A)
HEM  A 601 (-3.4A)
VOR  A 602 (-4.0A)
None
None
 0.53A 5v5zA-5hs1A:
54.1		 5v5zA-5hs1A:
64.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 PHE A 422
ILE A 397
TYR A 402
GLY A 418
HIS A 282
 None
 1.40A 5v5zA-5ikrA:
undetectable		 5v5zA-5ikrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		5 ILE A 406
GLY A 389
THR A 431
LEU A 363
PHE A 381
 None
 1.39A 5v5zA-5j5uA:
undetectable		 5v5zA-5j5uA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 PHE A 135
TYR A 127
PHE A 237
GLY A 315
THR A 319
 1YN  A 602 ( 4.6A)
1YN  A 602 ( 3.8A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
 1.16A 5v5zA-5jlcA:
53.5		 5v5zA-5jlcA:
62.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 TYR A 127
ILE A 140
TYR A 141
PHE A 242
LEU A 384
 1YN  A 602 ( 3.8A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 ( 4.5A)
HEM  A 601 (-3.6A)
 1.21A 5v5zA-5jlcA:
53.5		 5v5zA-5jlcA:
62.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		12 TYR A 127
PHE A 135
ILE A 140
TYR A 141
PHE A 237
PHE A 242
GLY A 315
THR A 319
LEU A 381
HIS A 382
PHE A 385
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.5A)
 0.66A 5v5zA-5jlcA:
53.5		 5v5zA-5jlcA:
62.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlv SYNAPTIC VESICLE
GLYCOPROTEIN 2C

(Homo sapiens) 		PF13599
(Pentapeptide_4) 		5 TYR C 497
PHE C 537
PHE C 522
PHE C 481
THR C 530
 None
 1.43A 5v5zA-5jlvC:
undetectable		 5v5zA-5jlvC:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp2 EPIDERMAL GROWTH
FACTOR RECEPTOR
SUBSTRATE 15
F-BAR DOMAIN ONLY
PROTEIN 1

(Danio rerio;
Homo sapiens) 		PF10291
(muHD)
no annotation 		5 TYR A 991
PHE E 636
GLY A 920
THR A 922
PHE E 625
 None
 1.43A 5v5zA-5jp2A:
undetectable		 5v5zA-5jp2A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 TYR A 567
ILE A 566
PHE A 498
GLY A 589
LEU A 510
 None
 1.41A 5v5zA-5jqkA:
undetectable		 5v5zA-5jqkA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 PHE A 367
PHE A 326
THR A 349
LEU A 322
MET A 304
 None
 1.34A 5v5zA-5k8gA:
undetectable		 5v5zA-5k8gA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqc PEPTIDASE M23

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		5 ILE A 143
TYR A 123
PHE A  81
GLY A 140
LEU A 182
 None
 1.04A 5v5zA-5kqcA:
undetectable		 5v5zA-5kqcA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le4 DD_D12_11_D12

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ILE A  62
GLY A  58
THR A  90
LEU A  86
HIS A  85
 None
 1.41A 5v5zA-5le4A:
undetectable		 5v5zA-5le4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb9 PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 PHE A 327
ILE A 360
GLY A 242
LEU A 249
HIS A 252
 None
None
ATP  A 700 (-3.5A)
None
None
 1.40A 5v5zA-5mb9A:
undetectable		 5v5zA-5mb9A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		5 ILE A 380
PHE A 337
GLY A 446
THR A 567
LEU A 265
 None
 1.38A 5v5zA-5medA:
undetectable		 5v5zA-5medA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nge UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		no annotation 5 ILE A 320
PHE A 264
THR A 231
LEU A 228
PHE A 283
 None
 1.21A 5v5zA-5ngeA:
undetectable		 5v5zA-5ngeA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A 115
TYR A 275
GLY A 323
LEU A 327
HIS A 328
 None
None
None
None
CAP  A1001 (-4.0A)
 1.41A 5v5zA-5nv3A:
undetectable		 5v5zA-5nv3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00397
(WW)
PF00632
(HECT) 		5 PHE A 626
ILE A 612
PHE A 579
PHE A 525
PHE A 529
 None
 1.41A 5v5zA-5tj7A:
undetectable		 5v5zA-5tj7A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 ILE A 562
PHE A 613
GLY A 641
LEU A 573
PHE A 608
 None
 1.35A 5v5zA-5wvgA:
undetectable		 5v5zA-5wvgA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 5 ILE A  55
PHE A 107
GLY A 135
LEU A  67
PHE A 102
 None
 1.17A 5v5zA-5xepA:
undetectable		 5v5zA-5xepA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 5 PHE I 577
ILE I 579
PHE I 543
PHE I 468
PHE I 647
 None
 1.23A 5v5zA-6bnpI:
undetectable		 5v5zA-6bnpI:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 PHE A 313
ILE A 734
PHE A 335
PHE A 982
PHE A 977
 None
None
ZQU  A1304 ( 3.8A)
ZQU  A1305 ( 4.6A)
None
 1.20A 5v5zA-6fn1A:
undetectable		 5v5zA-6fn1A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 PHE A 209
ILE A 210
PHE A 166
HIS A 173
MET A 234
 None
 1.38A 5v5zA-6fshA:
28.1		 5v5zA-6fshA:
12.34