SIMILAR PATTERNS OF AMINO ACIDS FOR 5V3H_A_SAMA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		5 LYS A 157
ARG A 163
GLU A  47
ASN A 286
PHE A 153
 None
SO4  A 343 ( 4.8A)
SO4  A 343 (-3.3A)
SO4  A 343 (-3.7A)
None
 1.14A 5v3hA-2r0vA:
1.9		 5v3hA-2r0vA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		8 LYS A  17
ARG A  19
HIS A 135
ASN A 180
ASN A 205
HIS A 206
TYR A 252
PHE A 272
 SFG  A 491 (-4.7A)
SFG  A 491 (-3.9A)
SFG  A 491 (-3.8A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
SFG  A 491 (-3.7A)
 0.54A 5v3hA-3n71A:
37.9		 5v3hA-3n71A:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		10 LYS A  17
ARG A  19
GLU A 135
HIS A 137
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
PHE A 260
 None
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
SAM  A 501 (-3.6A)
 0.35A 5v3hA-5kjmA:
53.6		 5v3hA-5kjmA:
99.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo sapiens) 		PF00856
(SET) 		5 LYS A 226
ARG A 228
ASN A 298
HIS A 299
TYR A 336
 SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
 0.75A 5v3hA-5tegA:
8.0		 5v3hA-5tegA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 7 GLU A 130
CYH A 180
ASN A 181
ASN A 205
HIS A 206
TYR A 239
PHE A 259
 SAM  A 502 (-4.9A)
SAM  A 502 (-4.1A)
SAM  A 502 ( 4.1A)
SAM  A 502 (-3.1A)
None
8HR  A 501 ( 4.0A)
SAM  A 502 (-3.5A)
 0.59A 5v3hA-5xxgA:
39.9		 5v3hA-5xxgA:
undetectable