SIMILAR PATTERNS OF AMINO ACIDS FOR 5V3C_A_AMHA402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		5 ASP A 130
GLN A 169
GLY A 195
GLY A 196
VAL A 198
 G  D 915 ( 3.0A)
G  D 915 ( 3.9A)
G  D 915 ( 4.2A)
G  D 915 ( 4.2A)
None
 0.98A 5v3cA-1j2bA:
38.8		 5v3cA-1j2bA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqh PAPILLOMAVIRUS
TRANSCRIPTION FACTOR
E2

(Alphapapillomavirus
7) 		PF00508
(PPV_E2_N) 		5 ASP A  96
GLY A 113
GLY A 114
ALA A 133
VAL A 132
 None
 1.16A 5v3cA-1qqhA:
undetectable		 5v3cA-1qqhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A 148
GLY A 173
GLY A 174
ALA A 298
VAL A 299
 None
 1.43A 5v3cA-1uxiA:
2.0		 5v3cA-1uxiA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 CYH A 383
GLY A 296
GLY A 294
ALA A 330
VAL A 327
 COA  A1001 ( 4.6A)
None
None
None
None
 1.29A 5v3cA-1wl4A:
0.0		 5v3cA-1wl4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		5 ASP A  40
GLY A 204
GLY A 205
ALA A 287
VAL A 288
 None
 1.16A 5v3cA-1yloA:
0.0		 5v3cA-1yloA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		6 ASP A 142
CYH A 144
GLN A 184
GLY A 210
GLY A 211
MET A 241
 None
EDO  A 404 (-3.4A)
EDO  A 404 ( 4.0A)
EDO  A 404 (-3.4A)
EDO  A 404 (-3.0A)
EDO  A 404 (-4.4A)
 0.64A 5v3cA-2ashA:
53.9		 5v3cA-2ashA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		5 ASP A 142
CYH A 144
GLN A 184
GLY A 211
MET A 241
 None
EDO  A 404 (-3.4A)
EDO  A 404 ( 4.0A)
EDO  A 404 (-3.0A)
EDO  A 404 (-4.4A)
 1.25A 5v3cA-2ashA:
53.9		 5v3cA-2ashA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA

(Human
mastadenovirus
C) 		PF01686
(Adeno_Penton_B) 		5 ASP A 380
GLN A 476
GLY A 473
GLY A 474
ALA A 106
 None
 1.35A 5v3cA-2c6sA:
undetectable		 5v3cA-2c6sA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE

(Leishmania
major) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 TYR A 147
GLY A 145
GLY A 143
ALA A 140
VAL A 116
 None
 1.45A 5v3cA-2hfsA:
0.0		 5v3cA-2hfsA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		5 TYR A 182
GLN A 240
GLY A 237
GLY A 236
MET A 188
 None
 0.86A 5v3cA-2osyA:
12.3		 5v3cA-2osyA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8v CLASS III CHITINASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		5 TYR A 177
ASP A 176
GLY A 168
ALA A 163
VAL A 162
 None
 1.11A 5v3cA-2y8vA:
7.3		 5v3cA-2y8vA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE

(Thermus
thermophilus) 		no annotation 5 GLN A  54
GLY A  51
GLY A  50
ALA A  48
VAL A  95
 None
 1.35A 5v3cA-2yvsA:
undetectable		 5v3cA-2yvsA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 ASP A 846
GLY A 210
GLY A 211
ALA A 186
VAL A 185
 None
 1.33A 5v3cA-3egwA:
undetectable		 5v3cA-3egwA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		5 ASP A  16
GLY A  10
GLY A   9
ALA A   5
VAL A  33
 EDO  A 256 (-3.5A)
None
None
None
None
 1.10A 5v3cA-3ks5A:
8.9		 5v3cA-3ks5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		5 GLN A 404
GLY A 390
GLY A 400
ALA A 373
VAL A 372
 None
 1.26A 5v3cA-3qnqA:
undetectable		 5v3cA-3qnqA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		5 GLY A 142
GLY A 145
ALA A 149
VAL A 148
MET A  80
 None
 1.21A 5v3cA-3qnqA:
undetectable		 5v3cA-3qnqA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 TYR A 333
ASP A 332
GLY A 360
GLY A 336
ALA A 340
 None
 1.45A 5v3cA-3sutA:
5.8		 5v3cA-3sutA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		5 ASP A  82
GLY A  43
GLY A 106
ALA A 110
VAL A 109
 None
 1.43A 5v3cA-3ti7A:
undetectable		 5v3cA-3ti7A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		5 CYH A  88
GLY A  18
GLY A  20
ALA A 229
VAL A  23
 None
 1.45A 5v3cA-3tpcA:
3.7		 5v3cA-3tpcA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A

(Burkholderia
thailandensis) 		PF06026
(Rib_5-P_isom_A) 		5 TYR A 173
ASP A 183
GLY A 104
GLY A 105
ALA A 107
 None
None
K  A 238 ( 4.8A)
K  A 238 (-3.9A)
K  A 238 (-4.2A)
 1.46A 5v3cA-3u7jA:
2.3		 5v3cA-3u7jA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uko ALCOHOL
DEHYDROGENASE
CLASS-3

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 CYH A 271
GLY A 204
GLY A 207
ALA A 209
VAL A 210
 None
NAD  A 402 (-3.3A)
None
None
None
 0.99A 5v3cA-3ukoA:
3.8		 5v3cA-3ukoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN
PENTON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF01686
(Adeno_Penton_B)
PF03678
(Adeno_hexon_C) 		5 ASP M 354
GLN M 450
GLY M 447
GLY M 448
ALA A 906
 None
 1.35A 5v3cA-3zifM:
undetectable		 5v3cA-3zifM:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 TYR A 530
ASP A 558
GLY A 131
ALA A  82
VAL A  79
 None
 1.31A 5v3cA-3zz1A:
undetectable		 5v3cA-3zz1A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00106
(adh_short) 		5 CYH A  86
GLY A  16
GLY A  18
ALA A 227
VAL A  21
 None
 1.44A 5v3cA-4pn3A:
2.3		 5v3cA-4pn3A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00106
(adh_short) 		5 TYR A 226
CYH A  86
GLY A  16
GLY A  18
VAL A  21
 None
 1.33A 5v3cA-4pn3A:
2.3		 5v3cA-4pn3A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8l UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF00710
(Asparaginase) 		5 ASP A  84
GLY A  18
GLY A 115
ALA A 142
MET A  22
 ASP  A 700 (-3.0A)
ASP  A 700 ( 3.7A)
ASP  A 700 (-3.4A)
None
None
 1.30A 5v3cA-4r8lA:
undetectable		 5v3cA-4r8lA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		5 GLN A 230
GLY A 223
GLY A 192
ALA A 196
VAL A 199
 None
 1.30A 5v3cA-4yhsA:
undetectable		 5v3cA-4yhsA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0u OPLOPHORUS-LUCIFERIN
2-MONOOXYGENASE
CATALYTIC SUBUNIT

(Oplophorus
gracilirostris) 		no annotation 5 TYR A 114
ASP A 108
GLY A  95
ALA A 118
VAL A 127
 None
 1.41A 5v3cA-5b0uA:
undetectable		 5v3cA-5b0uA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwx GLUTAMATE RECEPTOR 4

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 ASP B  48
GLY B  10
GLY B   9
ALA B  72
VAL B  70
 None
 1.29A 5v3cA-5fwxB:
undetectable		 5v3cA-5fwxB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ASP A 558
GLY A 596
GLY A 595
ALA A 695
VAL A 684
 None
 1.38A 5v3cA-5i2tA:
undetectable		 5v3cA-5i2tA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum) 		PF02353
(CMAS) 		5 ASP A 196
GLN A 129
GLY A 128
ALA A 146
VAL A 145
 None
 1.46A 5v3cA-5kpgA:
undetectable		 5v3cA-5kpgA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 CYH A 490
GLN A 382
GLY A 619
GLY A 618
ALA A 178
 None
 1.29A 5v3cA-5nccA:
undetectable		 5v3cA-5nccA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Homo sapiens) 		no annotation 5 TYR A4513
GLY A4516
GLY A4515
ALA A4568
VAL A4569
 None
 1.34A 5v3cA-5o6cA:
undetectable		 5v3cA-5o6cA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 5 ASP A 156
GLN A 203
GLY A 229
ALA A 232
MET A 260
 GGB  A 403 (-3.1A)
None
GGB  A 403 (-3.3A)
GGB  A 403 ( 4.1A)
GGB  A 403 (-3.7A)
 1.33A 5v3cA-5utiA:
58.7		 5v3cA-5utiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 8 TYR A 106
ASP A 156
GLN A 203
GLY A 229
GLY A 230
ALA A 232
VAL A 233
MET A 260
 GGB  A 403 (-3.9A)
GGB  A 403 (-3.1A)
None
GGB  A 403 (-3.3A)
GGB  A 403 (-3.8A)
GGB  A 403 ( 4.1A)
None
GGB  A 403 (-3.7A)
 0.36A 5v3cA-5utiA:
58.7		 5v3cA-5utiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 5 TYR A 106
CYH A 158
GLN A 203
GLY A 229
MET A 260
 GGB  A 403 (-3.9A)
GGB  A 403 (-3.6A)
None
GGB  A 403 (-3.3A)
GGB  A 403 (-3.7A)
 1.26A 5v3cA-5utiA:
58.7		 5v3cA-5utiA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1b EGL NINE HOMOLOG 2

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		5 CYH A 250
GLY A 254
GLY A 245
ALA A 282
VAL A 243
 None
 1.44A 5v3cA-5v1bA:
undetectable		 5v3cA-5v1bA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 CYH A 101
GLN A 103
GLY A 123
GLY A  98
ALA A  95
 SF4  A 501 (-2.2A)
SF4  A 501 (-4.5A)
SF4  A 501 ( 4.3A)
SF4  A 501 ( 4.4A)
None
 1.26A 5v3cA-5vj7A:
undetectable		 5v3cA-5vj7A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqn PROBABLE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		5 ASP A  63
CYH A  64
GLY A  57
ALA A  32
VAL A  31
 None
 1.50A 5v3cA-5wqnA:
2.7		 5v3cA-5wqnA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 ASP A 226
GLY A 187
GLY A 245
ALA A 249
VAL A 248
 None
 1.45A 5v3cA-5yl7A:
undetectable		 5v3cA-5yl7A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 5 ASP A 377
GLY A 481
GLY A 333
ALA A 328
VAL A 339
 None
 1.36A 5v3cA-6f2tA:
undetectable		 5v3cA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71

(Danio rerio) 		no annotation 5 ASP A 661
GLY A 755
GLY A 802
ALA A 813
VAL A 814
 None
 1.16A 5v3cA-6fq3A:
undetectable		 5v3cA-6fq3A:
23.33