SIMILAR PATTERNS OF AMINO ACIDS FOR 5V37_A_SAMA504_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		5 GLY A 211
ASN A 212
GLU A 175
ASN A  74
TYR A 181
 None
 1.30A 5v37A-1ac5A:
undetectable		 5v37A-1ac5A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 980
ASN A 106
GLU A 979
ASN A 558
HIS A 975
 None
None
None
None
MGD  A1019 (-4.8A)
 1.46A 5v37A-1kqfA:
undetectable		 5v37A-1kqfA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt6 SET9

(Homo sapiens) 		PF00856
(SET)
PF02493
(MORN) 		5 GLY A 227
ASN A 265
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.0A)
SAH  A   1 (-3.6A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.4A)
 0.35A 5v37A-1mt6A:
6.7		 5v37A-1mt6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whs SERINE
CARBOXYPEPTIDASE II

(Triticum
aestivum) 		PF00450
(Peptidase_S10) 		5 GLY A 175
ASN A 176
GLU A 145
ASN A  51
TYR A 151
 None
None
ACY  A 460 ( 4.3A)
ACY  A 460 (-3.8A)
None
 1.33A 5v37A-1whsA:
undetectable		 5v37A-1whsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atf CYSTEINE DIOXYGENASE
TYPE I

(Mus musculus) 		PF05995
(CDO_I) 		5 GLY A 100
ASN A 101
GLU A 149
ASN A 144
HIS A  81
 None
 1.17A 5v37A-2atfA:
undetectable		 5v37A-2atfA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE

(Vespula
vulgaris) 		PF01630
(Glyco_hydro_56) 		5 GLU A 243
ASN A 205
ASN A 187
TYR A 184
PHE A 186
 None
 1.42A 5v37A-2atmA:
undetectable		 5v37A-2atmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		6 GLY A  81
ASN A 242
HIS A 243
TYR A 287
TYR A 300
PHE A 302
 SAM  A 801 (-3.7A)
SAM  A 801 (-2.9A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.8A)
None
SAM  A 801 (-3.9A)
 0.58A 5v37A-2h21A:
9.9		 5v37A-2h21A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 ARG A 150
GLY A 151
ASN A 219
HIS A 220
TYR A 261
 None
SAM  A 304 (-3.5A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
 1.18A 5v37A-2r3aA:
5.8		 5v37A-2r3aA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7

(Homo sapiens) 		PF00856
(SET) 		5 GLY A 227
ASN A 265
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.33A 5v37A-3cboA:
7.8		 5v37A-3cboA:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		5 GLY A  16
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 None
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 1.18A 5v37A-3n71A:
38.2		 5v37A-3n71A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		7 GLY A  18
ASN A 180
ASN A 205
HIS A 206
TYR A 252
TYR A 270
PHE A 272
 SFG  A 491 ( 4.2A)
SFG  A 491 (-4.3A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
None
SFG  A 491 (-3.7A)
 0.51A 5v37A-3n71A:
38.2		 5v37A-3n71A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		5 GLY A  20
ASN A 180
HIS A 206
TYR A 252
TYR A 270
 None
SFG  A 491 (-4.3A)
None
SFG  A 491 (-4.8A)
None
 1.15A 5v37A-3n71A:
38.2		 5v37A-3n71A:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		6 GLY A  74
ASN A 251
HIS A 252
TYR A 285
TYR A 297
PHE A 299
 SAM  A 484 (-3.4A)
SAM  A 484 (-3.1A)
None
SAM  A 484 (-4.8A)
None
SAM  A 484 (-3.5A)
 0.47A 5v37A-3rc0A:
12.2		 5v37A-3rc0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsj BONT/F

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 ARG A1017
GLY A1019
ASN A1020
GLU A1071
PHE A 934
 None
 1.48A 5v37A-3rsjA:
undetectable		 5v37A-3rsjA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 GLY A 104
ASN A 277
HIS A 278
TYR A 312
PHE A 326
 SAM  A1000 ( 4.5A)
SAM  A1000 (-3.2A)
None
SAM  A1000 (-4.8A)
SAM  A1000 (-3.6A)
 0.51A 5v37A-3smtA:
12.2		 5v37A-3smtA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 GLU A 627
ASN A 631
ASN A 684
TYR A 630
PHE A 629
 None
 1.43A 5v37A-4gl2A:
2.3		 5v37A-4gl2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ARG A  59
GLY A 295
ASN A 296
GLU A 292
HIS A 268
 CP  A 401 (-3.6A)
None
None
None
None
 1.13A 5v37A-4nf2A:
undetectable		 5v37A-4nf2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2i NON-LEE ENCODED TYPE
III EFFECTOR C

(Citrobacter
rodentium) 		PF13678
(Peptidase_M85) 		5 GLY A 238
ASN A 240
GLU A 143
ASN A 242
TYR A 136
 None
 1.36A 5v37A-4o2iA:
undetectable		 5v37A-4o2iA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 GLY B 260
GLU B 503
ASN B 506
HIS B 467
PHE B 509
 None
None
None
CLA  B1231 (-3.9A)
CLA  B1223 (-4.4A)
 1.37A 5v37A-4rkuB:
undetectable		 5v37A-4rkuB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT

(Anolis
carolinensis) 		no annotation 5 GLY A 520
CYH A 560
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
CJD  A 708 (-3.8A)
CJD  A 708 (-3.5A)
None
None
 1.06A 5v37A-4w2rA:
5.6		 5v37A-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfv VIOF

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N) 		5 ASN A 222
CYH A 195
ASN A 192
TYR A 224
PHE A 234
 None
 1.28A 5v37A-4yfvA:
undetectable		 5v37A-4yfvA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		5 ARG A 786
GLY A 787
ASN A 788
ASN A 822
TYR A 814
 None
 1.43A 5v37A-5kcaA:
undetectable		 5v37A-5kcaA:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		8 GLY A  18
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
PHE A 260
 SAM  A 501 ( 4.1A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
SAM  A 501 (-3.6A)
 0.46A 5v37A-5kjmA:
43.4		 5v37A-5kjmA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		8 GLY A  18
GLU A 135
CYH A 181
ASN A 182
ASN A 206
HIS A 207
TYR A 240
TYR A 258
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 0.69A 5v37A-5kjmA:
43.4		 5v37A-5kjmA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		6 GLY A  20
CYH A 181
ASN A 182
HIS A 207
TYR A 240
TYR A 258
 None
SAM  A 501 ( 3.4A)
SAM  A 501 ( 3.8A)
None
6TM  A 502 ( 3.6A)
6TM  A 502 ( 4.2A)
 1.22A 5v37A-5kjmA:
43.4		 5v37A-5kjmA:
32.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 ARG A 300
GLY A 301
ASN A 302
ASN A 336
TYR A 328
 None
 1.35A 5v37A-5l2eA:
undetectable		 5v37A-5l2eA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET)
PF11616
(EZH2_WD-Binding) 		5 GLY A 623
CYH A 663
ASN A 688
HIS A 689
TYR A 726
 74D  A 809 ( 3.9A)
74D  A 809 (-3.6A)
74D  A 809 (-3.0A)
None
None
 1.22A 5v37A-5ls6A:
6.5		 5v37A-5ls6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 5 GLY A 426
ASN A 425
ASN A 315
HIS A 359
TYR A 347
 None
 1.44A 5v37A-5nqdA:
undetectable		 5v37A-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wg6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,POLYCOMB
PROTEIN SUZ12
(E.C.2.1.1.43)
CHIMERA

(Homo sapiens) 		no annotation 5 GLY A 625
CYH A 695
ASN A 694
ASN A 688
HIS A 689
 A9G  A9009 ( 4.9A)
None
None
A9G  A9009 (-3.1A)
None
 1.21A 5v37A-5wg6A:
6.3		 5v37A-5wg6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 12 ARG A  14
GLY A  15
ASN A  16
GLU A 130
ASN A 132
CYH A 180
ASN A 181
ASN A 205
HIS A 206
TYR A 239
TYR A 257
PHE A 259
 SAM  A 502 (-4.8A)
SAM  A 502 ( 3.9A)
SAM  A 502 (-4.4A)
SAM  A 502 (-4.9A)
SAM  A 502 (-3.2A)
SAM  A 502 (-4.1A)
SAM  A 502 ( 4.1A)
SAM  A 502 (-3.1A)
None
8HR  A 501 ( 4.0A)
None
SAM  A 502 (-3.5A)
 0.54A 5v37A-5xxgA:
64.0		 5v37A-5xxgA:
undetectable