SIMILAR PATTERNS OF AMINO ACIDS FOR 5V0V_A_8QSA615

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b79 DNAB HELICASE

(Escherichia
coli) 		PF00772
(DnaB) 		4 VAL A  99
HIS A  66
LEU A  83
ILE A  67
 None
 0.86A 5v0vA-1b79A:
undetectable		 5v0vA-1b79A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwu RIBOSOMAL PROTEIN L1

(Methanothermococcus
thermolithotrophicus) 		PF00687
(Ribosomal_L1) 		4 LEU A 151
VAL A  48
LEU A 163
ILE A 181
 None
 0.96A 5v0vA-1dwuA:
undetectable		 5v0vA-1dwuA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyp CHALCONE-FLAVONONE
ISOMERASE 1

(Medicago sativa) 		PF02431
(Chalcone) 		4 LEU A  78
ARG A  82
LEU A  75
ILE A  84
 None
 1.00A 5v0vA-1eypA:
undetectable		 5v0vA-1eypA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g61 TRANSLATION
INITIATION FACTOR 6

(Methanocaldococcus
jannaschii) 		PF01912
(eIF-6) 		4 LEU A2071
VAL A2097
LEU A2020
ILE A2084
 None
 1.02A 5v0vA-1g61A:
undetectable		 5v0vA-1g61A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 LEU A  82
TYR A 205
VAL A 208
ILE A  72
 None
 0.99A 5v0vA-1h81A:
undetectable		 5v0vA-1h81A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
HIS A 198
LEU A 168
ILE A 178
 None
 0.95A 5v0vA-1harA:
0.3		 5v0vA-1harA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		4 LEU A  42
VAL A 367
LEU A 418
ILE A 383
 None
None
None
PGO  A 902 ( 4.3A)
 1.02A 5v0vA-1hqsA:
undetectable		 5v0vA-1hqsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 LEU A 204
VAL A 207
LEU A 287
ILE A 256
 None
 1.01A 5v0vA-1kywA:
0.0		 5v0vA-1kywA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 TYR A 231
VAL A  61
LEU A 296
ILE A 322
 None
 0.92A 5v0vA-1m1cA:
0.0		 5v0vA-1m1cA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 LEU A  58
ARG A  62
LEU A 197
ILE A  64
 None
 0.96A 5v0vA-1nj1A:
0.4		 5v0vA-1nj1A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o75 47 KDA MEMBRANE
ANTIGEN

(Treponema
pallidum) 		PF14888
(PBP-Tp47_c)
PF14889
(PBP-Tp47_a) 		4 LEU A 386
VAL A 379
LEU A 343
ILE A 350
 None
 0.98A 5v0vA-1o75A:
undetectable		 5v0vA-1o75A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP) 		4 VAL A 384
ARG A 421
LEU A 107
ILE A 379
 None
 0.92A 5v0vA-1o7fA:
2.3		 5v0vA-1o7fA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 TYR A  25
ARG A 222
LEU A  56
ILE A 165
 None
FMN  A1730 (-2.8A)
None
None
 0.86A 5v0vA-1o94A:
undetectable		 5v0vA-1o94A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oht CG14704 PROTEIN

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 VAL A 155
ARG A 156
HIS A 152
ILE A  40
 None
None
ZN  A1185 (-3.1A)
None
 0.80A 5v0vA-1ohtA:
undetectable		 5v0vA-1ohtA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		4 LEU A 228
HIS A 222
LEU A 263
ILE A 273
 None
 0.94A 5v0vA-1osnA:
undetectable		 5v0vA-1osnA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qas PHOSPHOLIPASE C
DELTA-1

(Rattus
norvegicus) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 LEU A 387
TYR A 329
VAL A 369
ILE A 354
 None
 0.88A 5v0vA-1qasA:
0.8		 5v0vA-1qasA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo4 PEROXIDASE

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		4 TYR A   7
ARG A 123
LEU A  87
ILE A 295
 None
 0.92A 5v0vA-1qo4A:
undetectable		 5v0vA-1qo4A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus) 		PF00149
(Metallophos) 		4 LEU A  45
TYR A 201
VAL A 258
LEU A 204
 None
 1.02A 5v0vA-1s8eA:
undetectable		 5v0vA-1s8eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0y TUBULIN FOLDING
COFACTOR B

(Caenorhabditis
elegans) 		PF14560
(Ubiquitin_2) 		4 VAL A  73
ARG A  74
LEU A  57
ILE A  79
 None
 0.98A 5v0vA-1t0yA:
undetectable		 5v0vA-1t0yA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5i C_TERMINAL DOMAIN OF
A PROBABLE
ATP-DEPENDENT RNA
HELICASE

(Homo sapiens) 		PF00271
(Helicase_C) 		4 TYR A 371
VAL A 403
LEU A 262
ILE A 411
 None
 1.00A 5v0vA-1t5iA:
undetectable		 5v0vA-1t5iA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA

(Leishmania
major) 		PF02580
(Tyr_Deacylase) 		5 LEU A  86
VAL A 133
ARG A 137
LEU A  15
ILE A  96
 None
 1.45A 5v0vA-1tc5A:
undetectable		 5v0vA-1tc5A:
14.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 115
TYR A 138
ARG A 145
HIS A 146
LEU A 182
 None
 0.61A 5v0vA-1tf0A:
46.0		 5v0vA-1tf0A:
76.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA

(Bacillus
subtilis) 		PF02590
(SPOUT_MTase) 		4 LEU A 139
VAL A 142
LEU A  11
ILE A   5
 None
 1.03A 5v0vA-1to0A:
undetectable		 5v0vA-1to0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Mus musculus) 		PF00005
(ABC_tran)
PF14396
(CFTR_R) 		4 LEU A 468
HIS A 484
LEU A 441
ILE A 482
 None
 0.99A 5v0vA-1xfaA:
undetectable		 5v0vA-1xfaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjv PROTECTION OF
TELOMERES 1

(Homo sapiens) 		PF02765
(POT1)
PF16686
(POT1PC) 		4 VAL A 222
HIS A 226
LEU A 164
ILE A 275
 None
 0.86A 5v0vA-1xjvA:
undetectable		 5v0vA-1xjvA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		4 LEU A2427
TYR A2309
LEU A2279
ILE A2282
 None
 0.99A 5v0vA-1xktA:
2.5		 5v0vA-1xktA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 TYR A 371
VAL A 403
LEU A 262
ILE A 411
 None
 0.67A 5v0vA-1xtjA:
undetectable		 5v0vA-1xtjA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 LEU A 331
VAL A 323
LEU A 336
ILE A 353
 None
 1.03A 5v0vA-1z7eA:
undetectable		 5v0vA-1z7eA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjc AMINOPEPTIDASE AMPS

(Staphylococcus
aureus) 		PF02073
(Peptidase_M29) 		4 TYR A  11
VAL A 179
LEU A 103
ILE A 249
 None
 1.00A 5v0vA-1zjcA:
undetectable		 5v0vA-1zjcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au5 CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF11472
(DUF3206) 		4 LEU A 112
ARG A  88
LEU A  22
ILE A  90
 None
 1.00A 5v0vA-2au5A:
2.4		 5v0vA-2au5A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 VAL A 718
ARG A 721
LEU A 701
ILE A 686
 None
 1.01A 5v0vA-2b3xA:
undetectable		 5v0vA-2b3xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9l PROPHENOLOXIDASE
ACTIVATING FACTOR

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		4 LEU A 257
VAL A 195
LEU A 209
ILE A 214
 None
 0.89A 5v0vA-2b9lA:
undetectable		 5v0vA-2b9lA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		4 LEU A 331
VAL A 323
LEU A 336
ILE A 353
 None
 0.99A 5v0vA-2bllA:
undetectable		 5v0vA-2bllA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bm3 SCAFFOLDING DOCKERIN
BINDING PROTEIN A

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		4 LEU A  97
VAL A  72
ARG A  70
ILE A  30
 None
 0.89A 5v0vA-2bm3A:
undetectable		 5v0vA-2bm3A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 234
VAL A 261
HIS A 263
LEU A 280
ILE A 274
 None
 1.25A 5v0vA-2bvgA:
2.1		 5v0vA-2bvgA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi9 OUTER MEMBRANE
PROTEIN

(Bartonella
henselae) 		PF04430
(DUF498) 		4 LEU A 123
VAL A  62
LEU A  83
ILE A  96
 None
 0.99A 5v0vA-2fi9A:
undetectable		 5v0vA-2fi9A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG

(Homo sapiens) 		PF04078
(Rcd1) 		4 LEU A  36
VAL A  84
LEU A  13
ILE A  47
 None
 1.00A 5v0vA-2fv2A:
undetectable		 5v0vA-2fv2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L2
SUBUNIT

(Lumbricus
terrestris) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		4 LEU N 182
VAL N 193
LEU N 147
ILE N 130
 None
 0.76A 5v0vA-2gtlN:
undetectable		 5v0vA-2gtlN:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 LEU A 199
VAL A 195
HIS A  44
LEU A 206
ILE A 192
 None
 1.47A 5v0vA-2h4tA:
2.1		 5v0vA-2h4tA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4j PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Helicobacter
pylori) 		PF00486
(Trans_reg_C) 		4 LEU A  53
TYR A 111
LEU A  40
ILE A  85
 None
 0.94A 5v0vA-2k4jA:
undetectable		 5v0vA-2k4jA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 LEU A 267
VAL A 220
LEU A 346
ILE A 230
 None
 0.85A 5v0vA-2mbgA:
2.3		 5v0vA-2mbgA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nef NEGATIVE FACTOR
(F-PROTEIN)

(Human
immunodeficiency
virus 1) 		PF00469
(F-protein) 		4 LEU A 189
TYR A  81
VAL A  85
HIS A  89
 None
 0.99A 5v0vA-2nefA:
undetectable		 5v0vA-2nefA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 TYR A  51
VAL A  55
HIS A  58
ILE A  85
 None
 0.93A 5v0vA-2o8rA:
1.4		 5v0vA-2o8rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 340
HIS A 336
LEU A 365
ILE A 348
 None
 1.00A 5v0vA-2og9A:
2.0		 5v0vA-2og9A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 TYR A 275
VAL A 273
LEU A 263
ILE A 240
 TYR  A 275 ( 1.3A)
VAL  A 273 ( 0.6A)
LEU  A 263 ( 0.6A)
ILE  A 240 ( 0.7A)
 0.69A 5v0vA-2ogsA:
undetectable		 5v0vA-2ogsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP

(Escherichia
coli) 		PF00072
(Response_reg) 		4 LEU A  76
VAL A  50
LEU A  91
ILE A  63
 None
 0.94A 5v0vA-2pl1A:
undetectable		 5v0vA-2pl1A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvq GLUTATHIONE
S-TRANSFERASE

(Ochrobactrum
anthropi) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 200
HIS A  15
LEU A 186
ILE A  16
 None
 0.88A 5v0vA-2pvqA:
undetectable		 5v0vA-2pvqA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 LEU A 311
VAL A 563
ARG A 564
ILE A 477
 None
 0.99A 5v0vA-2q3zA:
undetectable		 5v0vA-2q3zA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 LEU A 200
HIS A 212
LEU A 160
ILE A 210
 None
 1.02A 5v0vA-2qagA:
undetectable		 5v0vA-2qagA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		4 LEU A  10
VAL A  44
LEU A 111
ILE A 101
 None
 1.01A 5v0vA-2qm1A:
1.9		 5v0vA-2qm1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyb MEMBRANE PROTEIN,
PUTATIVE

(Geobacter
sulfurreducens) 		PF13185
(GAF_2) 		4 LEU A 134
VAL A 126
LEU A 142
ILE A 111
 None
 0.99A 5v0vA-2qybA:
undetectable		 5v0vA-2qybA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		4 LEU A 851
HIS A 752
LEU A 544
ILE A 756
 None
 0.95A 5v0vA-2r4fA:
undetectable		 5v0vA-2r4fA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 325
ARG A 316
LEU A 264
ILE A 314
 None
 0.93A 5v0vA-2vd5A:
3.2		 5v0vA-2vd5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 LEU A 441
ARG A 268
LEU A 421
ILE A 266
 None
 0.98A 5v0vA-2vsqA:
1.0		 5v0vA-2vsqA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		4 ARG A 329
HIS A 120
LEU A 375
ILE A 336
 None
 0.98A 5v0vA-2wknA:
undetectable		 5v0vA-2wknA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 LEU A  62
VAL A  64
HIS A  26
LEU A  37
ILE A  30
 None
 1.40A 5v0vA-2wyhA:
1.6		 5v0vA-2wyhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 LEU A 516
TYR A  89
ARG A  80
ILE A  27
 None
 0.94A 5v0vA-2x3kA:
undetectable		 5v0vA-2x3kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 VAL A 559
ARG A 527
LEU A 543
ILE A 536
 None
 0.89A 5v0vA-2xpiA:
undetectable		 5v0vA-2xpiA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A 173
VAL A 197
HIS A 201
ILE A 249
 None
 0.84A 5v0vA-2z1qA:
undetectable		 5v0vA-2z1qA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		4 TYR A 149
VAL A 148
ARG A 205
ILE A 164
 None
None
SO4  A 512 (-4.1A)
None
 0.84A 5v0vA-2zm2A:
undetectable		 5v0vA-2zm2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zw4 BLEOMYCIN
ACETYLTRANSFERASE

(Streptomyces
verticillus) 		PF13302
(Acetyltransf_3) 		4 LEU A  19
VAL A 116
HIS A 119
LEU A  22
 None
 1.01A 5v0vA-2zw4A:
undetectable		 5v0vA-2zw4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b79 TOXIN SECRETION
ATP-BINDING PROTEIN

(Vibrio
parahaemolyticus) 		PF03412
(Peptidase_C39) 		4 LEU A  71
VAL A  93
LEU A 111
ILE A 105
 None
 0.92A 5v0vA-3b79A:
undetectable		 5v0vA-3b79A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 LEU A 252
VAL A 110
LEU A 245
ILE A 201
 None
 0.88A 5v0vA-3bf8A:
undetectable		 5v0vA-3bf8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 167
VAL A  84
LEU A 151
ILE A 141
 None
 0.89A 5v0vA-3coiA:
undetectable		 5v0vA-3coiA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)

(Escherichia
coli;
Homo sapiens) 		PF00085
(Thioredoxin) 		4 LEU A 386
HIS A 350
LEU A 397
ILE A 349
 None
CL  A   1 (-4.5A)
None
None
 0.85A 5v0vA-3dxbA:
undetectable		 5v0vA-3dxbA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		4 LEU A 500
VAL A  26
HIS A  31
ILE A 330
 None
 0.89A 5v0vA-3e1tA:
undetectable		 5v0vA-3e1tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 LEU A 584
VAL A 962
LEU A 998
ILE A 926
 None
 0.72A 5v0vA-3eh1A:
undetectable		 5v0vA-3eh1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehd UNCHARACTERIZED
CONSERVED PROTEIN

(Enterococcus
faecalis) 		PF05014
(Nuc_deoxyrib_tr) 		4 LEU A  22
VAL A  71
LEU A  29
ILE A   4
 None
 0.91A 5v0vA-3ehdA:
undetectable		 5v0vA-3ehdA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0i ARSENATE REDUCTASE

(Vibrio cholerae) 		PF03960
(ArsC) 		4 LEU A  50
TYR A   6
VAL A  98
LEU A  43
 None
 0.90A 5v0vA-3f0iA:
undetectable		 5v0vA-3f0iA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 LEU A  61
VAL A  73
LEU A  52
ILE A  43
 None
 0.90A 5v0vA-3h8fA:
undetectable		 5v0vA-3h8fA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 LEU A 202
ARG A 206
LEU A 485
ILE A 211
 None
 0.93A 5v0vA-3hhsA:
undetectable		 5v0vA-3hhsA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		4 LEU A 178
VAL A 181
LEU A 171
ILE A 135
 None
 0.92A 5v0vA-3hveA:
undetectable		 5v0vA-3hveA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 LEU T 236
VAL T 228
LEU T 275
ILE T 272
 None
 0.90A 5v0vA-3icqT:
1.6		 5v0vA-3icqT:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE

(Bacillus
anthracis) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 543
VAL A 537
LEU A 548
ILE A 486
 None
 0.92A 5v0vA-3icsA:
undetectable		 5v0vA-3icsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		4 LEU A 411
VAL A 313
LEU A 386
ILE A 302
 None
None
EDO  A 466 ( 4.9A)
None
 0.97A 5v0vA-3ij3A:
undetectable		 5v0vA-3ij3A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT E

(Saccharomyces
cerevisiae) 		no annotation 4 LEU K 132
VAL K 190
LEU K 169
ILE K 125
 None
 0.98A 5v0vA-3j9tK:
undetectable		 5v0vA-3j9tK:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ja7 PORTAL PROTEIN GP20

(Escherichia
virus T4) 		PF07230
(Peptidase_S80) 		4 LEU A 174
VAL A 417
LEU A 177
ILE A 156
 None
 1.00A 5v0vA-3ja7A:
undetectable		 5v0vA-3ja7A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		4 LEU A 242
VAL A 262
LEU A 390
ILE A 418
 None
 1.01A 5v0vA-3javA:
undetectable		 5v0vA-3javA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP3

(Parechovirus B) 		PF00073
(Rhv) 		4 LEU C 145
VAL C 102
LEU C 209
ILE C  96
 None
 0.95A 5v0vA-3jb4C:
undetectable		 5v0vA-3jb4C:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		4 LEU A2392
ARG A2397
HIS A2401
LEU A2324
 None
 1.01A 5v0vA-3jbzA:
3.3		 5v0vA-3jbzA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 LEU A1020
HIS A1049
LEU A 941
ILE A 979
 None
 0.97A 5v0vA-3kg7A:
undetectable		 5v0vA-3kg7A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 4 LEU B 103
VAL B 130
LEU B 265
ILE B 244
 None
 0.89A 5v0vA-3kx2B:
undetectable		 5v0vA-3kx2B:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lft UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF04392
(ABC_sub_bind) 		4 LEU A  56
VAL A 115
LEU A  64
ILE A  71
 None
 1.00A 5v0vA-3lftA:
undetectable		 5v0vA-3lftA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 LEU A 375
VAL A 402
LEU A 353
ILE A 380
 None
 1.01A 5v0vA-3nvsA:
undetectable		 5v0vA-3nvsA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		PF04095
(NAPRTase) 		4 LEU A 107
TYR A  50
VAL A  49
LEU A 353
 CL  A 417 (-4.7A)
None
None
None
 0.97A 5v0vA-3os4A:
undetectable		 5v0vA-3os4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pin PEPTIDE METHIONINE
SULFOXIDE REDUCTASE

(Saccharomyces
cerevisiae) 		PF01625
(PMSR) 		4 LEU B  78
HIS B 179
LEU B  92
ILE B  99
 None
 0.76A 5v0vA-3pinB:
undetectable		 5v0vA-3pinB:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A 355
VAL A 243
LEU A 362
ILE A 235
 None
 0.74A 5v0vA-3popA:
undetectable		 5v0vA-3popA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqj BIOFILM
GROWTH-ASSOCIATED
REPRESSOR

(Xylella
fastidiosa) 		PF12840
(HTH_20) 		4 LEU A  38
VAL A  41
LEU A  29
ILE A  77
 None
 0.95A 5v0vA-3pqjA:
undetectable		 5v0vA-3pqjA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 LEU A1060
VAL A1032
LEU A1102
ILE A1097
 None
 0.90A 5v0vA-3psfA:
2.0		 5v0vA-3psfA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 LEU A1060
VAL A1032
LEU A1102
ILE A1097
 None
 0.84A 5v0vA-3psiA:
2.1		 5v0vA-3psiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzd MYOSIN-X

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF00788
(RA) 		4 LEU A1838
VAL A1854
ARG A1834
ILE A1924
 None
 0.99A 5v0vA-3pzdA:
undetectable		 5v0vA-3pzdA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A 376
VAL A 443
LEU A 383
ILE A 435
 None
 0.89A 5v0vA-3q5iA:
undetectable		 5v0vA-3q5iA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 LEU A 515
ARG A 505
LEU A 449
ILE A 503
 None
 0.97A 5v0vA-3q60A:
1.2		 5v0vA-3q60A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN

(Streptococcus
parasanguinis) 		no annotation 4 LEU A 167
VAL A 288
ARG A 169
ILE A 171
 None
 0.89A 5v0vA-3qkwA:
undetectable		 5v0vA-3qkwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsv MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4

(Mus musculus) 		PF03165
(MH1) 		4 LEU A  57
TYR A  95
VAL A 128
ILE A  74
 None
 0.86A 5v0vA-3qsvA:
1.9		 5v0vA-3qsvA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvl PUTATIVE HYDANTOIN
RACEMASE

(Klebsiella
pneumoniae) 		PF01177
(Asp_Glu_race) 		4 LEU A  85
VAL A  96
ARG A  89
ILE A  64
 None
 0.82A 5v0vA-3qvlA:
undetectable		 5v0vA-3qvlA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Sphaerobacter
thermophilus) 		PF12697
(Abhydrolase_6) 		4 LEU A  97
ARG A  54
LEU A 106
ILE A  78
 None
 0.91A 5v0vA-3r0vA:
undetectable		 5v0vA-3r0vA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbn DNA MISMATCH REPAIR
PROTEIN MLH1

(Homo sapiens) 		PF16413
(Mlh1_C) 		4 LEU A  92
TYR A 179
VAL A 253
ILE A 219
 None
 0.94A 5v0vA-3rbnA:
undetectable		 5v0vA-3rbnA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A  64
VAL A 217
LEU A  71
ILE A 219
 None
 0.99A 5v0vA-3ri6A:
undetectable		 5v0vA-3ri6A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00215
(OMPdecase) 		4 LEU A  59
VAL A  31
LEU A  78
ILE A  55
 None
 0.93A 5v0vA-3ru6A:
undetectable		 5v0vA-3ru6A:
19.86