SIMILAR PATTERNS OF AMINO ACIDS FOR 5V0V_A_8QPA613_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 ALA A 237
VAL A 300
SER A 298
GLY A 122
 None
 0.99A 5v0vA-1b41A:
0.0		 5v0vA-1b41A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)

(Malus domestica) 		PF00155
(Aminotran_1_2) 		4 ARG A 333
ALA A 328
PHE A  98
THR A 236
 None
 0.85A 5v0vA-1b8gA:
0.0		 5v0vA-1b8gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bfo CAMPATH-1G ANTIBODY

(Rattus rattus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE A 118
SER A 116
THR A 114
GLY B 147
 None
 1.01A 5v0vA-1bfoA:
undetectable		 5v0vA-1bfoA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvn PROTEIN
(TENDAMISTAT)

(Streptomyces
tendae) 		PF01356
(A_amylase_inhib) 		4 ALA T 867
VAL T 835
THR T 841
GLY T 857
 None
 0.96A 5v0vA-1bvnT:
undetectable		 5v0vA-1bvnT:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		4 ALA A 237
VAL A 300
SER A 298
GLY A 122
 None
 0.92A 5v0vA-1c2oA:
2.2		 5v0vA-1c2oA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cij PROTEIN (HALOALKANE
DEHALOGENASE)

(Xanthobacter
autotrophicus) 		PF00561
(Abhydrolase_1) 		5 ARG A   6
LYS A  90
ALA A   4
VAL A  92
SER A 214
 None
 1.40A 5v0vA-1cijA:
undetectable		 5v0vA-1cijA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs6 AXONIN-1

(Gallus gallus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 VAL A 242
PHE A 236
THR A 171
GLY A 155
 None
 0.94A 5v0vA-1cs6A:
undetectable		 5v0vA-1cs6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ARG A  22
ALA A  60
THR A  25
GLY A  58
 None
 1.00A 5v0vA-1e8cA:
0.0		 5v0vA-1e8cA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		4 ALA A 229
PHE A 298
SER A 208
GLY A 202
 None
None
None
FAD  A 399 (-3.1A)
 1.02A 5v0vA-1efpA:
0.0		 5v0vA-1efpA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		5 ARG A 292
ALA A 190
VAL A 163
THR A 187
GLY A 206
 None
 1.35A 5v0vA-1f1xA:
undetectable		 5v0vA-1f1xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq3 GRANZYME B

(Homo sapiens) 		PF00089
(Trypsin) 		4 ALA A 139
VAL A 138
THR A 189
GLY A 197
 None
 0.98A 5v0vA-1fq3A:
undetectable		 5v0vA-1fq3A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1

(Escherichia
coli) 		PF05785
(CNF1) 		4 VAL A 833
PHE A 787
THR A 802
GLY A 842
 None
 0.94A 5v0vA-1hq0A:
0.0		 5v0vA-1hq0A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1

(Saccharomyces
cerevisiae) 		PF00398
(RrnaAD) 		4 LYS A 179
ALA A 182
SER A 174
GLY A 215
 None
 0.88A 5v0vA-1i4wA:
0.0		 5v0vA-1i4wA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		4 ARG A 377
ALA A 303
VAL A 264
SER A 262
 None
 0.85A 5v0vA-1inpA:
0.4		 5v0vA-1inpA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jj7 PEPTIDE TRANSPORTER
TAP1

(Homo sapiens) 		PF00005
(ABC_tran) 		4 ARG A 515
SER A 509
THR A 558
GLY A 718
 ADP  A 752 (-4.0A)
None
None
None
 0.95A 5v0vA-1jj7A:
undetectable		 5v0vA-1jj7A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ALA A 346
VAL A 323
THR A 343
GLY A 315
 None
 0.96A 5v0vA-1k0gA:
undetectable		 5v0vA-1k0gA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 ALA A 522
VAL A 537
THR A 559
GLY A 494
 None
 1.02A 5v0vA-1kb0A:
undetectable		 5v0vA-1kb0A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		4 ARG A1011
ALA A 967
VAL A 970
THR A 827
 None
 0.80A 5v0vA-1no7A:
undetectable		 5v0vA-1no7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Leishmania
major) 		PF00581
(Rhodanese)
PF09122
(DUF1930) 		4 ALA A 259
SER A 182
THR A 211
GLY A 254
 None
None
None
SO3  A1374 (-3.3A)
 0.91A 5v0vA-1okgA:
undetectable		 5v0vA-1okgA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		4 ALA A 164
VAL A 163
THR A 136
GLY A 168
 None
 0.90A 5v0vA-1p9hA:
undetectable		 5v0vA-1p9hA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psq PROBABLE THIOL
PEROXIDASE

(Streptococcus
pneumoniae) 		PF08534
(Redoxin) 		4 ALA A 128
VAL A 129
PHE A 153
THR A  79
 None
 1.01A 5v0vA-1psqA:
undetectable		 5v0vA-1psqA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		4 LYS A  76
ALA A  79
SER A  71
GLY A 124
 None
 1.00A 5v0vA-1quaA:
undetectable		 5v0vA-1quaA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 ARG A 621
LYS A 606
ALA A 605
GLY A 600
 None
None
None
ANP  A 911 (-2.9A)
 0.97A 5v0vA-1qvrA:
2.0		 5v0vA-1qvrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7h YKOF

(Bacillus
subtilis) 		PF07615
(Ykof) 		4 ARG A  52
ALA A  11
THR A  81
GLY A  85
 None
 0.94A 5v0vA-1s7hA:
undetectable		 5v0vA-1s7hA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sf8 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		4 LYS A 552
ALA A 555
VAL A 561
THR A 548
 None
 0.91A 5v0vA-1sf8A:
undetectable		 5v0vA-1sf8A:
13.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 ARG A 209
ALA A 213
VAL A 216
PHE A 228
SER A 232
THR A 236
GLY A 328
 DKA  A1001 ( 4.6A)
DKA  A1001 ( 4.0A)
None
DKA  A1001 (-4.4A)
DKA  A1001 (-3.5A)
None
DKA  A1001 ( 4.1A)
 0.93A 5v0vA-1tf0A:
46.0		 5v0vA-1tf0A:
76.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 LYS A 212
ALA A 213
VAL A 216
PHE A 228
SER A 232
THR A 236
GLY A 328
 None
DKA  A1001 ( 4.0A)
None
DKA  A1001 (-4.4A)
DKA  A1001 (-3.5A)
None
DKA  A1001 ( 4.1A)
 0.50A 5v0vA-1tf0A:
46.0		 5v0vA-1tf0A:
76.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ARG A 107
ALA A 109
PHE A 347
GLY A 221
 None
 0.90A 5v0vA-1u0uA:
undetectable		 5v0vA-1u0uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 ALA A 627
VAL A 562
THR A 579
GLY A 612
 None
 1.02A 5v0vA-1u1hA:
undetectable		 5v0vA-1u1hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		4 ALA A 338
PHE A 271
SER A 298
GLY A 288
 None
 0.96A 5v0vA-1up2A:
undetectable		 5v0vA-1up2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ARG A 169
ALA A 173
SER A 139
GLY A 130
 GTP  A 500 (-3.5A)
None
None
GTP  A 500 (-3.5A)
 0.98A 5v0vA-1w5eA:
undetectable		 5v0vA-1w5eA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 ALA A 143
SER A  33
THR A 151
GLY A  36
 None
 0.96A 5v0vA-1wuuA:
undetectable		 5v0vA-1wuuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 ARG A  60
PHE A 179
THR A 160
GLY A 106
 HEM  A 901 (-3.9A)
None
PQQ  A 801 (-2.6A)
HEM  A 901 (-3.3A)
 0.95A 5v0vA-1yiqA:
2.2		 5v0vA-1yiqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zem XYLITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF13561
(adh_short_C2) 		4 ALA A 163
SER A 144
THR A 142
GLY A 158
 None
NAD  A2263 (-3.3A)
NAD  A2263 (-3.7A)
None
 0.76A 5v0vA-1zemA:
undetectable		 5v0vA-1zemA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6n PROTEINASE K

(Serratia sp.
GF96) 		PF00082
(Peptidase_S8) 		4 ARG A  52
ALA A  35
VAL A 128
GLY A 232
 None
 0.99A 5v0vA-2b6nA:
undetectable		 5v0vA-2b6nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bht CYSTEINE SYNTHASE B

(Escherichia
coli) 		PF00291
(PALP) 		4 ALA A 277
VAL A 170
THR A 167
GLY A 262
 None
 0.84A 5v0vA-2bhtA:
undetectable		 5v0vA-2bhtA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01156
(IU_nuc_hydro) 		4 ALA A 182
VAL A 181
THR A 129
GLY A 277
 None
 0.94A 5v0vA-2c40A:
undetectable		 5v0vA-2c40A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Methanothermobacter
thermautotrophicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		4 ALA C 371
VAL C 370
THR C 376
GLY C 335
 None
 0.99A 5v0vA-2d6fC:
undetectable		 5v0vA-2d6fC:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzk UBX
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00789
(UBX) 		4 ARG A  40
ALA A  44
VAL A  47
GLY A  52
 None
 0.99A 5v0vA-2dzkA:
undetectable		 5v0vA-2dzkA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 ARG A  31
SER A 100
THR A  98
GLY A  58
 None
 0.90A 5v0vA-2e4uA:
undetectable		 5v0vA-2e4uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ARG A 314
ALA A 309
PHE A 569
SER A 566
 None
 0.82A 5v0vA-2e7zA:
undetectable		 5v0vA-2e7zA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		4 ALA A  38
VAL A  48
THR A  42
GLY A 121
 CO  A 210 ( 4.3A)
None
None
None
 0.98A 5v0vA-2f7nA:
2.9		 5v0vA-2f7nA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		4 ARG A  76
VAL A 115
SER A 118
GLY A  83
 None
 0.87A 5v0vA-2gfiA:
undetectable		 5v0vA-2gfiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		4 ARG A 170
VAL A 115
SER A 118
GLY A  83
 None
 0.98A 5v0vA-2gfiA:
undetectable		 5v0vA-2gfiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 VAL A 276
PHE A  88
THR A 245
GLY A 124
 ACP  A 700 (-4.1A)
ACP  A 700 (-3.2A)
None
ACP  A 700 (-3.1A)
 1.00A 5v0vA-2hcbA:
undetectable		 5v0vA-2hcbA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE

(Leishmania
major) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ARG A 121
ALA A 159
SER A  39
GLY A 162
 None
 1.01A 5v0vA-2hfsA:
2.6		 5v0vA-2hfsA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg6 HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09634
(DUF2025) 		4 ALA A  42
VAL A  41
SER A  36
GLY A  20
 None
 0.83A 5v0vA-2hg6A:
undetectable		 5v0vA-2hg6A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 ALA A  48
PHE A  86
THR A  94
GLY A 355
 None
 0.80A 5v0vA-2hz7A:
undetectable		 5v0vA-2hz7A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 LYS A1061
PHE A1014
SER A1018
GLY A1056
 None
 1.01A 5v0vA-2ix8A:
2.9		 5v0vA-2ix8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1
TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 4

(Homo sapiens;
Mus musculus) 		PF04099
(Sybindin) 		4 ARG C  23
PHE C  64
THR C  86
GLY D 122
 None
 1.01A 5v0vA-2j3tC:
2.0		 5v0vA-2j3tC:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus) 		PF00696
(AA_kinase) 		4 ALA A 127
VAL A 126
THR A 119
GLY A  38
 None
None
UTP  A1227 (-2.8A)
None
 0.86A 5v0vA-2j4lA:
2.2		 5v0vA-2j4lA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4r EXOPOLYPHOSPHATASE

(Aquifex
aeolicus) 		PF02541
(Ppx-GppA) 		4 ALA A  84
VAL A 111
PHE A  99
THR A  87
 None
None
None
G4P  A1307 (-3.7A)
 0.84A 5v0vA-2j4rA:
undetectable		 5v0vA-2j4rA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om5 CONTACTIN 2

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 VAL A 238
PHE A 232
THR A 167
GLY A 151
 None
 1.02A 5v0vA-2om5A:
undetectable		 5v0vA-2om5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 ARG A 667
ALA A 155
THR A 161
GLY A 459
 None
ADP  A1789 (-4.2A)
None
VO4  A1791 (-3.3A)
 0.90A 5v0vA-2v26A:
1.8		 5v0vA-2v26A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		4 ARG A 288
ALA A 408
THR A  29
GLY A 335
 2HP  A 601 (-3.2A)
None
None
None
 0.90A 5v0vA-2x1mA:
undetectable		 5v0vA-2x1mA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		4 ALA A 229
VAL A 228
PHE A 293
THR A 289
 None
 1.00A 5v0vA-2xrmA:
undetectable		 5v0vA-2xrmA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd7 PTPRD PROTEIN

(Homo sapiens) 		PF07679
(I-set) 		4 ARG A 179
ALA A 203
SER A 206
GLY A 151
 None
 0.91A 5v0vA-2yd7A:
undetectable		 5v0vA-2yd7A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		4 ARG A 256
ALA A 260
VAL A 263
GLY A 333
 None
 0.92A 5v0vA-2yrrA:
undetectable		 5v0vA-2yrrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuf NGFI-A-BINDING
PROTEIN 1

(Homo sapiens) 		PF04905
(NCD2) 		4 ALA A  15
VAL A  18
SER A 124
THR A 128
 None
 0.85A 5v0vA-2yufA:
2.6		 5v0vA-2yufA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zal L-ASPARAGINASE

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		4 LYS B 179
PHE B 236
THR B 197
GLY B 276
 None
None
ASP  B 501 ( 3.9A)
None
 0.96A 5v0vA-2zalB:
undetectable		 5v0vA-2zalB:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Thermus
thermophilus) 		PF01680
(SOR_SNZ) 		4 ALA A 259
VAL A 258
PHE A 213
GLY A  22
 None
 0.98A 5v0vA-2zbtA:
undetectable		 5v0vA-2zbtA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 ARG A 345
SER A 100
THR A  97
GLY A 246
 None
None
None
A5A  A 801 (-3.3A)
 1.00A 5v0vA-2ztgA:
3.3		 5v0vA-2ztgA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak8 DNA PROTECTION
DURING STARVATION
PROTEIN

(Salmonella
enterica) 		PF00210
(Ferritin) 		4 ALA A  81
VAL A  37
THR A  74
GLY A  93
 None
None
SO4  A 168 (-2.9A)
None
 1.00A 5v0vA-3ak8A:
undetectable		 5v0vA-3ak8A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 4 ARG E  81
ALA E 113
VAL E  67
GLY E  93
 None
 0.99A 5v0vA-3aoeE:
1.4		 5v0vA-3aoeE:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LYS A 119
ALA A 120
VAL A 123
GLY A  28
 None
 0.88A 5v0vA-3b97A:
undetectable		 5v0vA-3b97A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm1 PROTEIN YDJA

(Escherichia
coli) 		PF00881
(Nitroreductase) 		4 LYS A 153
ALA A  94
THR A 137
GLY A 112
 None
 0.87A 5v0vA-3bm1A:
undetectable		 5v0vA-3bm1A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		4 ALA A 185
VAL A 187
PHE A  73
THR A  70
 None
 0.94A 5v0vA-3btzA:
undetectable		 5v0vA-3btzA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		4 ALA A 176
SER A 231
THR A 235
GLY A 131
 None
 1.00A 5v0vA-3ds8A:
undetectable		 5v0vA-3ds8A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 244
SER A 113
THR A 172
GLY A 242
 None
 1.00A 5v0vA-3e60A:
undetectable		 5v0vA-3e60A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ALA A 205
VAL A 113
THR A 201
GLY A 109
 HCB  A   1 (-4.8A)
None
None
HCB  A   1 ( 3.7A)
 1.01A 5v0vA-3ezxA:
2.6		 5v0vA-3ezxA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum) 		PF00082
(Peptidase_S8) 		4 ARG A  54
ALA A  37
VAL A 131
GLY A 235
 None
 0.92A 5v0vA-3f7oA:
undetectable		 5v0vA-3f7oA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PHE A 414
SER A 391
THR A 370
GLY A 112
 None
 0.98A 5v0vA-3fhhA:
undetectable		 5v0vA-3fhhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frn FLAGELLAR PROTEIN
FLGA

(Thermotoga
maritima) 		PF13144
(ChapFlgA) 		4 ALA A  28
VAL A  84
PHE A 122
GLY A  31
 None
 0.92A 5v0vA-3frnA:
undetectable		 5v0vA-3frnA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyq CG6831-PA (TALIN)

(Drosophila
melanogaster) 		no annotation 4 ALA A1990
VAL A1994
THR A2063
GLY A2101
 None
 1.00A 5v0vA-3fyqA:
4.3		 5v0vA-3fyqA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm2 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE

(Corynebacterium
diphtheriae) 		no annotation 4 ALA A 122
PHE A 147
SER A 145
THR A 143
 None
 0.93A 5v0vA-3hm2A:
undetectable		 5v0vA-3hm2A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1j OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00106
(adh_short) 		4 ALA A 172
SER A 153
THR A 151
GLY A 167
 None
ACT  A 248 (-2.4A)
None
None
 0.95A 5v0vA-3i1jA:
undetectable		 5v0vA-3i1jA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 308
VAL A 138
THR A  13
GLY A 329
 None
 1.00A 5v0vA-3ic9A:
3.8		 5v0vA-3ic9A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		4 ALA A  15
SER A 432
THR A 434
GLY A 375
 None
 1.02A 5v0vA-3ik2A:
undetectable		 5v0vA-3ik2A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipo PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YNJE

(Escherichia
coli) 		PF00581
(Rhodanese) 		4 ARG A 238
ALA A 391
SER A 347
GLY A 386
 NA  A 436 ( 4.0A)
None
None
None
 1.00A 5v0vA-3ipoA:
undetectable		 5v0vA-3ipoA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isl PURINE CATABOLISM
PROTEIN PUCG

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		4 ARG A  98
SER A 206
THR A  72
GLY A  20
 None
None
PLP  A 419 (-3.4A)
None
 0.86A 5v0vA-3islA:
undetectable		 5v0vA-3islA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbk METAVINCULIN

(Homo sapiens) 		PF01044
(Vinculin) 		4 ALA M1003
SER M1016
THR M1020
GLY M1007
 None
 0.96A 5v0vA-3jbkM:
4.2		 5v0vA-3jbkM:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		4 ARG A 355
ALA A  99
THR A 112
GLY A 102
 None
 1.00A 5v0vA-3k40A:
undetectable		 5v0vA-3k40A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 407
VAL A 356
THR A 346
GLY A 422
 None
 0.93A 5v0vA-3l8kA:
4.7		 5v0vA-3l8kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ALA A 235
SER A 427
THR A 429
GLY A 238
 None
None
None
XUL  A7778 ( 4.9A)
 1.01A 5v0vA-3ll3A:
undetectable		 5v0vA-3ll3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ALA B 308
VAL B 252
THR B 314
GLY B 245
 None
 0.83A 5v0vA-3m2rB:
undetectable		 5v0vA-3m2rB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 LYS A 905
ALA A 906
VAL A 909
GLY A 865
 None
 1.00A 5v0vA-3nowA:
undetectable		 5v0vA-3nowA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opu SPAP

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		4 ALA A1174
PHE A1377
THR A1177
GLY A1477
 None
 0.93A 5v0vA-3opuA:
undetectable		 5v0vA-3opuA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ALA A 195
VAL A 208
THR A 203
GLY A 193
 None
None
FAD  A 601 (-4.7A)
FAD  A 601 (-3.3A)
 1.00A 5v0vA-3p4sA:
undetectable		 5v0vA-3p4sA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN

(Geobacter
sulfurreducens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ALA A 279
VAL A 281
SER A 264
GLY A 186
 None
 1.02A 5v0vA-3pduA:
undetectable		 5v0vA-3pduA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 ALA A 163
SER A 143
THR A 141
GLY A 158
 None
None
GOL  A 285 (-4.0A)
None
 0.84A 5v0vA-3pk0A:
undetectable		 5v0vA-3pk0A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q33 HISTONE
ACETYLTRANSFERASE
RTT109

(Saccharomyces
cerevisiae) 		PF08214
(HAT_KAT11) 		4 ARG A  81
VAL A  67
PHE A  53
THR A  49
 None
 0.91A 5v0vA-3q33A:
undetectable		 5v0vA-3q33A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		4 ALA A 373
VAL A 372
SER A 363
GLY A 400
 None
 0.90A 5v0vA-3qnqA:
2.6		 5v0vA-3qnqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE

(Mycobacteroides
abscessus) 		PF13561
(adh_short_C2) 		4 ALA A 176
SER A 156
THR A 154
GLY A 171
 None
PG5  A 273 ( 4.9A)
EDO  A 279 ( 4.7A)
None
 0.85A 5v0vA-3rihA:
undetectable		 5v0vA-3rihA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K

(Escherichia
coli) 		no annotation 4 ALA K  45
VAL K  48
PHE J   5
GLY K   7
 None
 0.93A 5v0vA-3rkoK:
4.6		 5v0vA-3rkoK:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 ALA A  23
VAL A  27
THR A 169
GLY A  56
 GOL  A 496 ( 4.0A)
None
None
None
 0.94A 5v0vA-3rreA:
undetectable		 5v0vA-3rreA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		4 ARG A 290
SER A 363
THR A 386
GLY A 345
 None
 1.01A 5v0vA-3sweA:
undetectable		 5v0vA-3sweA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		4 ARG A 238
ALA A 339
THR A 383
GLY A 352
 None
 0.88A 5v0vA-3tw0A:
undetectable		 5v0vA-3tw0A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		4 ARG A 237
ALA A 222
SER A 110
GLY A 220
 None
 1.01A 5v0vA-3wbhA:
2.3		 5v0vA-3wbhA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ALA A  43
VAL A  42
THR A  36
GLY A  49
 None
 0.88A 5v0vA-3wy2A:
undetectable		 5v0vA-3wy2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 ARG A 187
ALA A  90
SER A  97
GLY A  49
 None
 0.89A 5v0vA-3ziuA:
undetectable		 5v0vA-3ziuA:
20.18