SIMILAR PATTERNS OF AMINO ACIDS FOR 5V0I_A_TRPA402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 GLY A 229
VAL A  72
ILE A  11
VAL A 270
GLN A  17
 None
 1.29A 5v0iA-1bh6A:
undetectable		 5v0iA-1bh6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 GLY A 229
VAL A  72
ILE A  11
VAL A 270
GLN A  17
 None
 1.20A 5v0iA-1c3lA:
undetectable		 5v0iA-1c3lA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		9 GLY A   7
GLN A   9
VAL A  40
HIS A  43
MET A 129
ASP A 132
ILE A 133
VAL A 141
GLN A 147
 None
 0.50A 5v0iA-1d2rA:
42.5		 5v0iA-1d2rA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		5 GLY A   7
VAL A  40
HIS A  43
MET A 129
VAL A 143
 None
 1.27A 5v0iA-1d2rA:
42.5		 5v0iA-1d2rA:
57.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLN A 440
MET A 472
ASP A 469
ILE A 468
VAL A 431
 None
 1.42A 5v0iA-1fprA:
undetectable		 5v0iA-1fprA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		5 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.73A 5v0iA-1j1uA:
19.0		 5v0iA-1j1uA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi4 HYPOTHETICAL PROTEIN
YHBO

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		5 VAL A  53
HIS A  10
ASP A  76
ILE A  75
VAL A  64
 None
 1.43A 5v0iA-1oi4A:
undetectable		 5v0iA-1oi4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		5 GLY A 255
GLN A 184
ASP A 248
ILE A 249
VAL A 259
 None
 1.21A 5v0iA-1r76A:
undetectable		 5v0iA-1r76A:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		5 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.95A 5v0iA-2a4mA:
33.3		 5v0iA-2a4mA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.68A 5v0iA-2cybA:
20.6		 5v0iA-2cybA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2el7 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		6 GLY A   7
GLN A   9
VAL A  42
ASP A 136
ILE A 137
VAL A 145
 None
 0.97A 5v0iA-2el7A:
33.4		 5v0iA-2el7A:
40.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2el7 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		5 GLY A   7
GLN A   9
VAL A  42
VAL A 145
GLN A 151
 None
 1.01A 5v0iA-2el7A:
33.4		 5v0iA-2el7A:
40.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima) 		PF00579
(tRNA-synt_1b) 		6 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
GLN A 151
 TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
TRP  A 401 (-3.5A)
 0.41A 5v0iA-2g36A:
33.3		 5v0iA-2g36A:
36.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w01 ADENYLATE CYCLASE

(Synechocystis
sp. PCC 6803) 		PF00211
(Guanylate_cyc) 		5 GLY A 515
GLN A 519
MET A 475
ILE A 479
VAL A 496
 None
 1.40A 5v0iA-2w01A:
undetectable		 5v0iA-2w01A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 GLY A 597
GLN A 601
ASP A 572
ILE A 571
GLN A 576
 None
ALF  A1855 (-3.0A)
MG  A1856 ( 4.0A)
None
None
 1.22A 5v0iA-2xzlA:
undetectable		 5v0iA-2xzlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.13A 5v0iA-2xzoA:
undetectable		 5v0iA-2xzoA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		8 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
SO4  A1363 ( 3.2A)
 0.59A 5v0iA-2yy5A:
36.6		 5v0iA-2yy5A:
38.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 GLY A  76
ASP A 195
ILE A 196
VAL A 212
GLN A 218
 TRP  A 377 (-3.6A)
TRP  A 377 (-3.6A)
None
None
None
 1.25A 5v0iA-3a05A:
22.8		 5v0iA-3a05A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00239
(Resolvase) 		5 GLY A  45
MET A  66
ASP A  69
ILE A  70
VAL A  77
 None
 1.45A 5v0iA-3guvA:
undetectable		 5v0iA-3guvA:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00579
(tRNA-synt_1b) 		6 GLY A   6
GLN A   8
MET A 128
ILE A 132
VAL A 140
GLN A 146
 None
 1.20A 5v0iA-3m5wA:
34.7		 5v0iA-3m5wA:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00579
(tRNA-synt_1b) 		7 GLY A   6
HIS A  42
MET A 128
ASP A 131
ILE A 132
VAL A 140
GLN A 146
 None
 0.51A 5v0iA-3m5wA:
34.7		 5v0iA-3m5wA:
39.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 365
VAL A 120
ASP A 184
ILE A 183
VAL A 371
 None
 1.41A 5v0iA-3moiA:
undetectable		 5v0iA-3moiA:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n9i TRYPTOPHANYL-TRNA
SYNTHETASE

(Yersinia pestis) 		PF00579
(tRNA-synt_1b) 		9 GLY A  21
GLN A  23
VAL A  54
HIS A  57
MET A 144
ASP A 147
ILE A 148
VAL A 156
GLN A 162
 GOL  A1001 (-3.6A)
None
GOL  A1001 (-4.6A)
GOL  A1001 ( 4.7A)
GOL  A1001 (-3.9A)
GOL  A1001 (-3.9A)
None
None
None
 0.19A 5v0iA-3n9iA:
45.2		 5v0iA-3n9iA:
83.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3prh TRYPTOPHANYL-TRNA
SYNTHETASE

(Bacillus
subtilis) 		PF00579
(tRNA-synt_1b) 		8 GLY A   8
GLN A  10
VAL A  41
HIS A  44
MET A 130
ASP A 133
ILE A 134
GLN A 148
 None
 0.60A 5v0iA-3prhA:
40.8		 5v0iA-3prhA:
49.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3prh TRYPTOPHANYL-TRNA
SYNTHETASE

(Bacillus
subtilis) 		PF00579
(tRNA-synt_1b) 		8 GLY A   8
GLN A  10
VAL A  41
HIS A  44
MET A 130
ASP A 133
ILE A 134
VAL A 142
 None
 0.49A 5v0iA-3prhA:
40.8		 5v0iA-3prhA:
49.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)

(Mycobacterium
ulcerans) 		PF01053
(Cys_Met_Meta_PP) 		5 VAL A 298
ASP A 165
ILE A 169
VAL A 153
GLN A 192
 None
 1.46A 5v0iA-3qi6A:
undetectable		 5v0iA-3qi6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 283
VAL A 174
HIS A 173
ASP A 203
ILE A 314
 None
 1.42A 5v0iA-3qo6A:
undetectable		 5v0iA-3qo6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 GLY A  80
GLN A  77
VAL A 106
ILE A  63
GLN A  78
 None
 1.30A 5v0iA-3qsgA:
undetectable		 5v0iA-3qsgA:
25.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		7 GLN A  11
VAL A  42
MET A 132
ASP A 135
ILE A 136
VAL A 144
GLN A 150
 TRP  A 401 (-3.2A)
TRP  A 401 (-4.7A)
TRP  A 401 (-4.0A)
TRP  A 401 (-4.0A)
None
TRP  A 401 (-4.9A)
TRP  A 401 (-3.8A)
 0.93A 5v0iA-3sz3A:
43.5		 5v0iA-3sz3A:
67.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		7 GLY A   9
GLN A  11
VAL A  42
MET A 132
ASP A 135
ILE A 136
VAL A 144
 TRP  A 401 (-3.8A)
TRP  A 401 (-3.2A)
TRP  A 401 (-4.7A)
TRP  A 401 (-4.0A)
TRP  A 401 (-4.0A)
None
TRP  A 401 (-4.9A)
 0.56A 5v0iA-3sz3A:
43.5		 5v0iA-3sz3A:
67.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		5 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.18A 5v0iA-3vexA:
undetectable		 5v0iA-3vexA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.35A 5v0iA-4ay1A:
undetectable		 5v0iA-4ay1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krt AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25)
PF08239
(SH3_3) 		5 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
 None
None
EPE  A 401 (-3.3A)
None
None
 1.43A 5v0iA-4krtA:
undetectable		 5v0iA-4krtA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kru AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25) 		5 GLY A 190
MET A 193
ASP A 192
ILE A  12
VAL A 187
 None
None
NDG  A 501 (-4.0A)
None
None
 1.32A 5v0iA-4kruA:
undetectable		 5v0iA-4kruA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 GLN B 412
VAL B 408
ASP B 197
ILE B 404
VAL B 436
 None
 1.20A 5v0iA-4r3zB:
undetectable		 5v0iA-4r3zB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpm UNCHARACTERIZED
PROTEIN YCR075W-A

(Saccharomyces
cerevisiae) 		PF11503
(DUF3215) 		5 GLY B  28
GLN B  30
ASP B  34
ILE B  35
VAL B  21
 None
 1.33A 5v0iA-4xpmB:
undetectable		 5v0iA-4xpmB:
13.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		7 GLY A  40
GLN A  42
HIS A  77
ASP A 167
ILE A 168
VAL A 176
GLN A 182
 5BX  A 401 (-3.9A)
5BX  A 401 ( 3.4A)
5BX  A 401 (-3.5A)
5BX  A 401 (-3.9A)
5BX  A 401 ( 4.9A)
None
5BX  A 401 ( 3.0A)
 0.63A 5v0iA-5ekdA:
38.1		 5v0iA-5ekdA:
42.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		7 GLY A  40
VAL A  74
HIS A  77
ASP A 167
ILE A 168
VAL A 176
GLN A 182
 5BX  A 401 (-3.9A)
5BX  A 401 ( 4.9A)
5BX  A 401 (-3.5A)
5BX  A 401 (-3.9A)
5BX  A 401 ( 4.9A)
None
5BX  A 401 ( 3.0A)
 0.34A 5v0iA-5ekdA:
38.1		 5v0iA-5ekdA:
42.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		5 GLY A  40
VAL A  74
HIS A  77
ASP A 167
VAL A 178
 5BX  A 401 (-3.9A)
5BX  A 401 ( 4.9A)
5BX  A 401 (-3.5A)
5BX  A 401 (-3.9A)
ATP  A 402 (-3.2A)
 1.18A 5v0iA-5ekdA:
38.1		 5v0iA-5ekdA:
42.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tev TRYPTOPHAN--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00579
(tRNA-synt_1b) 		6 GLY A   9
HIS A  47
MET A 142
ASP A 145
ILE A 146
VAL A 154
 None
 0.23A 5v0iA-5tevA:
34.2		 5v0iA-5tevA:
33.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v0i TRYPTOPHAN--TRNA
LIGASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
TRP  A 402 (-3.9A)
None
None
TRP  A 402 (-3.1A)
 0.09A 5v0iA-5v0iA:
51.7		 5v0iA-5v0iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v0i TRYPTOPHAN--TRNA
LIGASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		5 GLY A   9
VAL A  42
HIS A  45
MET A 132
VAL A 146
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
None
 1.20A 5v0iA-5v0iA:
51.7		 5v0iA-5v0iA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wte VP3

(Hepatovirus A) 		PF00073
(Rhv) 		5 GLY C 164
GLN C 166
MET C 160
ASP C 161
ILE C 162
 None
 1.40A 5v0iA-5wteC:
undetectable		 5v0iA-5wteC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE

(Haemophilus
influenzae) 		no annotation 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
TRP  A 501 (-3.9A)
None
None
TRP  A 501 (-3.3A)
 0.61A 5v0iA-6dfuA:
45.7		 5v0iA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE

(Haemophilus
influenzae) 		no annotation 5 GLY A   9
VAL A  42
HIS A  45
MET A 132
VAL A 146
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
None
 1.33A 5v0iA-6dfuA:
45.7		 5v0iA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE

(Synechocystis
sp. PCC 6803;
Deinococcus
radiodurans) 		no annotation 5 GLY A 616
GLN A 620
MET A 576
ILE A 580
VAL A 597
 None
 1.34A 5v0iA-6fhtA:
undetectable		 5v0iA-6fhtA:
undetectable