SIMILAR PATTERNS OF AMINO ACIDS FOR 5V02_R_657R201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5c ENDOPOLYGALACTURONAS
E

(Chondrostereum
purpureum) 		PF00295
(Glyco_hydro_28) 		5 ALA A  11
LEU A  35
VAL A  34
LEU A  22
ILE A  49
 None
 1.07A 5v02B-1k5cA:
undetectable
5v02R-1k5cA:
undetectable		 5v02B-1k5cA:
12.84
5v02R-1k5cA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1

(Rattus
norvegicus) 		PF13649
(Methyltransf_25) 		5 ALA A 265
LEU A 266
VAL A 267
LEU A 335
MET A 301
 None
 1.04A 5v02B-1or8A:
undetectable
5v02R-1or8A:
undetectable		 5v02B-1or8A:
15.26
5v02R-1or8A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A 249
VAL A 247
MET A 204
VAL A 198
ILE A 173
 None
 1.07A 5v02B-1tufA:
undetectable
5v02R-1tufA:
undetectable		 5v02B-1tufA:
13.61
5v02R-1tufA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		5 ALA A 231
LEU A 235
LEU A 403
VAL A 425
ILE A 407
 None
 1.12A 5v02B-1vl4A:
undetectable
5v02R-1vl4A:
undetectable		 5v02B-1vl4A:
12.76
5v02R-1vl4A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Nostoc sp. PCC
7120) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 ALA A  33
LEU A  36
MET A  70
GLU A  72
VAL A  73
 None
 1.10A 5v02B-1vquA:
undetectable
5v02R-1vquA:
undetectable		 5v02B-1vquA:
12.57
5v02R-1vquA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9z VP9

(Banna virus) 		PF08978
(Reoviridae_Vp9) 		5 ALA A 108
LEU A 107
VAL A 132
VAL A 112
ILE A 128
 None
 1.08A 5v02B-1w9zA:
undetectable
5v02R-1w9zA:
undetectable		 5v02B-1w9zA:
16.61
5v02R-1w9zA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd5 HYPOTHETICAL PROTEIN
TT1426

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 LEU A 125
VAL A 126
LEU A 140
GLU A 171
VAL A 172
 None
 1.06A 5v02B-1wd5A:
undetectable
5v02R-1wd5A:
undetectable		 5v02B-1wd5A:
16.75
5v02R-1wd5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 382
VAL A 381
LEU A 360
VAL A 321
ILE A 280
 None
 1.06A 5v02B-1y4uA:
undetectable
5v02R-1y4uA:
undetectable		 5v02B-1y4uA:
10.59
5v02R-1y4uA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A  28
LEU A  38
GLU A  71
VAL A  72
ILE A  34
 None
 1.00A 5v02B-1ykwA:
undetectable
5v02R-1ykwA:
undetectable		 5v02B-1ykwA:
13.79
5v02R-1ykwA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 ALA A 228
LEU A 227
LEU A  93
GLU A 232
ILE A 247
 None
 1.11A 5v02B-2e0xA:
undetectable
5v02R-2e0xA:
undetectable		 5v02B-2e0xA:
14.66
5v02R-2e0xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		5 ALA A  14
LEU A  17
LEU A  61
VAL A 139
ILE A 105
 None
 1.02A 5v02B-2e87A:
4.2
5v02R-2e87A:
undetectable		 5v02B-2e87A:
14.29
5v02R-2e87A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		5 ALA A 522
LEU A 525
VAL A 526
GLU A 337
ILE A 327
 None
 0.82A 5v02B-2et6A:
undetectable
5v02R-2et6A:
undetectable		 5v02B-2et6A:
9.95
5v02R-2et6A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		5 LEU A  32
MET A  51
GLU A  54
VAL A  55
ILE A  63
 None
 0.93A 5v02B-2f2pA:
undetectable
5v02R-2f2pA:
12.2		 5v02B-2f2pA:
18.99
5v02R-2f2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		5 MET A  51
GLU A  54
VAL A  55
ILE A  63
MET A  72
 None
 1.00A 5v02B-2f2pA:
undetectable
5v02R-2f2pA:
12.2		 5v02B-2f2pA:
18.99
5v02R-2f2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		5 LEU A 382
VAL A 381
LEU A 360
VAL A 321
ILE A 280
 None
 1.08A 5v02B-2gq0A:
undetectable
5v02R-2gq0A:
undetectable		 5v02B-2gq0A:
19.14
5v02R-2gq0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20

(Saccharomyces
cerevisiae) 		PF08612
(Med20) 		5 ALA A 207
LEU A 208
VAL A 205
LEU A 142
ILE A  37
 None
 1.01A 5v02B-2hzsA:
undetectable
5v02R-2hzsA:
undetectable		 5v02B-2hzsA:
19.62
5v02R-2hzsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 382
VAL A 381
LEU A 360
VAL A 321
ILE A 280
 None
 1.09A 5v02B-2iopA:
undetectable
5v02R-2iopA:
undetectable		 5v02B-2iopA:
10.74
5v02R-2iopA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ALA A 105
LEU A 108
LEU A 247
VAL A 275
ILE A 243
 None
 0.96A 5v02B-2ip4A:
undetectable
5v02R-2ip4A:
undetectable		 5v02B-2ip4A:
12.44
5v02R-2ip4A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 384
LEU A 347
GLU A 401
VAL A 399
ILE A 411
 None
 1.05A 5v02B-2iuuA:
undetectable
5v02R-2iuuA:
undetectable		 5v02B-2iuuA:
11.79
5v02R-2iuuA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2

(Homo sapiens) 		no annotation 5 LEU B  72
MET B  91
VAL B  95
ILE B 103
MET B 112
 None
 0.53A 5v02B-2jjzB:
undetectable
5v02R-2jjzB:
4.7		 5v02B-2jjzB:
19.75
5v02R-2jjzB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 ALA A 168
MET A  51
GLU A  54
VAL A  55
ILE A  63
 None
 0.97A 5v02B-2n6aA:
undetectable
5v02R-2n6aA:
7.3		 5v02B-2n6aA:
18.82
5v02R-2n6aA:
83.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 LEU A  32
MET A  51
GLU A  54
VAL A  55
ILE A  63
 None
 1.12A 5v02B-2n6aA:
undetectable
5v02R-2n6aA:
7.3		 5v02B-2n6aA:
18.82
5v02R-2n6aA:
83.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oh1 ACETYLTRANSFERASE,
GNAT FAMILY

(Listeria
monocytogenes) 		no annotation 5 ALA A  79
LEU A 119
GLU A  70
VAL A  15
ILE A   6
 None
 1.12A 5v02B-2oh1A:
undetectable
5v02R-2oh1A:
undetectable		 5v02B-2oh1A:
20.67
5v02R-2oh1A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 383
VAL A 382
LEU A 391
VAL A 470
ILE A 444
 None
 1.12A 5v02B-2q27A:
undetectable
5v02R-2q27A:
undetectable		 5v02B-2q27A:
11.03
5v02R-2q27A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		5 LEU A  92
VAL A  93
LEU A 104
GLU A 111
ILE A 160
 None
 0.96A 5v02B-2q6kA:
undetectable
5v02R-2q6kA:
undetectable		 5v02B-2q6kA:
14.69
5v02R-2q6kA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg3 UPF0130 PROTEIN
AF_2059

(Archaeoglobus
fulgidus) 		PF02676
(TYW3) 		5 ALA A 116
LEU A 180
LEU A 184
VAL A 101
ILE A  34
 None
 1.07A 5v02B-2qg3A:
undetectable
5v02R-2qg3A:
undetectable		 5v02B-2qg3A:
18.78
5v02R-2qg3A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1

(Gallus gallus) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		5 ALA A  78
LEU A  81
VAL A  82
LEU A  97
ILE A 118
 MYR  A   1 (-3.5A)
None
MYR  A   1 ( 4.6A)
None
None
 1.07A 5v02B-2r2iA:
undetectable
5v02R-2r2iA:
7.1		 5v02B-2r2iA:
21.11
5v02R-2r2iA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 5 ALA C 228
LEU C 232
LEU C 126
GLU C  48
VAL C  46
 None
 1.12A 5v02B-3amjC:
undetectable
5v02R-3amjC:
undetectable		 5v02B-3amjC:
13.05
5v02R-3amjC:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 ALA A 329
LEU A 331
VAL A 332
LEU A 323
ILE A 271
 None
 1.12A 5v02B-3aqpA:
2.1
5v02R-3aqpA:
undetectable		 5v02B-3aqpA:
8.91
5v02R-3aqpA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b32 CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		5 LEU A  32
MET A  51
GLU A  54
VAL A  55
ILE A  63
 None
 0.69A 5v02B-3b32A:
undetectable
5v02R-3b32A:
12.6		 5v02B-3b32A:
20.00
5v02R-3b32A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqt UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF04994
(TfoX_C) 		5 ALA A  57
LEU A  58
LEU A  20
VAL A  50
ILE A  43
 None
 1.04A 5v02B-3bqtA:
undetectable
5v02R-3bqtA:
undetectable		 5v02B-3bqtA:
26.50
5v02R-3bqtA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 ALA A  72
LEU A  74
LEU A  88
VAL A  98
ILE A 127
 None
 1.09A 5v02B-3ciaA:
undetectable
5v02R-3ciaA:
undetectable		 5v02B-3ciaA:
10.50
5v02R-3ciaA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4o DIPICOLINATE
SYNTHASE SUBUNIT A

(Bacillus
halodurans) 		PF01262
(AlaDh_PNT_C)
PF16924
(DpaA_N) 		5 ALA A 281
LEU A 284
VAL A 285
GLU A  18
ILE A   9
 None
 0.88A 5v02B-3d4oA:
undetectable
5v02R-3d4oA:
undetectable		 5v02B-3d4oA:
18.62
5v02R-3d4oA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		6 LEU A 335
MET A 354
GLU A 357
VAL A 358
ILE A 366
MET A 375
 None
 0.87A 5v02B-3evrA:
undetectable
5v02R-3evrA:
12.4		 5v02B-3evrA:
12.59
5v02R-3evrA:
38.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 144
LEU A 141
VAL A 140
LEU A  13
ILE A  98
 None
 1.12A 5v02B-3eyaA:
undetectable
5v02R-3eyaA:
undetectable		 5v02B-3eyaA:
11.52
5v02R-3eyaA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f84 CFA/I FIMBRIAL
SUBUNIT B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A  76
VAL A  75
LEU A 128
GLU A 103
ILE A 106
 None
 1.13A 5v02B-3f84A:
undetectable
5v02R-3f84A:
undetectable		 5v02B-3f84A:
17.89
5v02R-3f84A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		5 LEU A 234
LEU A 104
GLU A  92
VAL A  79
ILE A   8
 None
None
None
FAD  A 298 (-4.0A)
None
 1.07A 5v02B-3fbsA:
undetectable
5v02R-3fbsA:
undetectable		 5v02B-3fbsA:
14.63
5v02R-3fbsA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gud NECK APPENDAGE
PROTEIN

(Bacillus virus
GA1) 		PF13884
(Peptidase_S74) 		5 ALA A 682
LEU A 687
VAL A 688
LEU A 727
VAL A 642
 None
 1.02A 5v02B-3gudA:
undetectable
5v02R-3gudA:
undetectable		 5v02B-3gudA:
20.61
5v02R-3gudA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gx8 MONOTHIOL
GLUTAREDOXIN-5,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		5 ALA A  82
LEU A  49
VAL A  48
VAL A  85
ILE A 104
 None
 0.91A 5v02B-3gx8A:
undetectable
5v02R-3gx8A:
undetectable		 5v02B-3gx8A:
22.05
5v02R-3gx8A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A   7
LEU A 232
VAL A 231
VAL A   4
ILE A 175
 None
 1.13A 5v02B-3hhdA:
undetectable
5v02R-3hhdA:
undetectable		 5v02B-3hhdA:
7.45
5v02R-3hhdA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9y SENSOR PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 5 LEU A 313
VAL A 314
LEU A 115
VAL A  58
ILE A  99
 None
 1.07A 5v02B-3i9yA:
4.2
5v02R-3i9yA:
undetectable		 5v02B-3i9yA:
18.84
5v02R-3i9yA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifk CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		5 LEU A  32
MET A  51
VAL A  55
ILE A  63
MET A  72
 None
 0.63A 5v02B-3ifkA:
undetectable
5v02R-3ifkA:
12.4		 5v02B-3ifkA:
20.19
5v02R-3ifkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j6d PROTEIN PRGH

(Salmonella
enterica) 		PF09480
(PrgH) 		5 ALA A 281
LEU A 282
LEU A 236
VAL A 289
ILE A 248
 None
 1.02A 5v02B-3j6dA:
undetectable
5v02R-3j6dA:
undetectable		 5v02B-3j6dA:
15.64
5v02R-3j6dA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtl PROTEASOME SUBUNIT
BETA

(Thermoplasma
acidophilum) 		PF00227
(Proteasome) 		5 ALA H  52
LEU H  55
VAL H  56
LEU H  87
ILE H 113
 None
 0.68A 5v02B-3jtlH:
undetectable
5v02R-3jtlH:
undetectable		 5v02B-3jtlH:
20.30
5v02R-3jtlH:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyn QUINONE
OXIDOREDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  86
LEU A 106
VAL A 107
LEU A 101
GLU A  64
 None
 0.85A 5v02B-3jynA:
undetectable
5v02R-3jynA:
undetectable		 5v02B-3jynA:
15.38
5v02R-3jynA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k21 CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Plasmodium
falciparum) 		PF13499
(EF-hand_7) 		5 LEU A 144
MET A 168
VAL A 172
ILE A 180
MET A 189
 None
 0.67A 5v02B-3k21A:
undetectable
5v02R-3k21A:
7.6		 5v02B-3k21A:
22.04
5v02R-3k21A:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lps TOPOISOMERASE IV
SUBUNIT B

(Xanthomonas
oryzae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 LEU A 246
LEU A 228
GLU A 110
VAL A 111
ILE A  84
 None
 1.06A 5v02B-3lpsA:
undetectable
5v02R-3lpsA:
undetectable		 5v02B-3lpsA:
12.37
5v02R-3lpsA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 ALA A 324
LEU A 325
LEU A  52
GLU A 320
ILE A 329
 None
 1.09A 5v02B-3maxA:
undetectable
5v02R-3maxA:
undetectable		 5v02B-3maxA:
12.79
5v02R-3maxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpi GLUTARYL-COA
DEHYDROGENASE

(Desulfococcus
multivorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A 166
LEU A 169
VAL A 168
LEU A 215
ILE A 197
 None
 1.12A 5v02B-3mpiA:
1.5
5v02R-3mpiA:
undetectable		 5v02B-3mpiA:
14.36
5v02R-3mpiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oby PROTEIN PELOTA
HOMOLOG

(Archaeoglobus
fulgidus) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 LEU A 286
VAL A 287
GLU A 309
VAL A 308
ILE A 282
 None
 0.89A 5v02B-3obyA:
undetectable
5v02R-3obyA:
undetectable		 5v02B-3obyA:
15.86
5v02R-3obyA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00218
(IGPS) 		5 ALA A 183
LEU A 179
LEU A 210
VAL A 169
ILE A 206
 None
 1.14A 5v02B-3t44A:
undetectable
5v02R-3t44A:
undetectable		 5v02B-3t44A:
17.23
5v02R-3t44A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 LEU A 326
MET A 345
VAL A 349
ILE A 357
MET A 366
 None
 0.75A 5v02B-3u0kA:
undetectable
5v02R-3u0kA:
11.4		 5v02B-3u0kA:
12.05
5v02R-3u0kA:
33.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ALA A 308
LEU A 174
LEU A 237
MET A 240
VAL A 246
 None
 1.13A 5v02B-3u0oA:
undetectable
5v02R-3u0oA:
undetectable		 5v02B-3u0oA:
14.70
5v02R-3u0oA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 ALA A1038
LEU A1040
LEU A1054
VAL A1064
ILE A1088
 None
 0.99A 5v02B-3u9wA:
2.5
5v02R-3u9wA:
undetectable		 5v02B-3u9wA:
9.76
5v02R-3u9wA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 LEU A1040
VAL A1101
LEU A1054
VAL A1064
ILE A1088
 None
 1.09A 5v02B-3u9wA:
2.5
5v02R-3u9wA:
undetectable		 5v02B-3u9wA:
9.76
5v02R-3u9wA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		5 LEU A 651
VAL A 650
GLU A 611
VAL A 625
ILE A 898
 None
 0.86A 5v02B-3ux8A:
undetectable
5v02R-3ux8A:
undetectable		 5v02B-3ux8A:
9.60
5v02R-3ux8A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		5 LEU A 651
VAL A 650
LEU A 882
VAL A 625
ILE A 898
 None
 1.14A 5v02B-3ux8A:
undetectable
5v02R-3ux8A:
undetectable		 5v02B-3ux8A:
9.60
5v02R-3ux8A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Thermosynechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ALA A 329
LEU A 326
VAL A 325
VAL A   4
ILE A  31
 None
 1.05A 5v02B-3zdfA:
undetectable
5v02R-3zdfA:
undetectable		 5v02B-3zdfA:
15.13
5v02R-3zdfA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amg SNOGD

(Streptomyces
nogalater) 		PF06722
(DUF1205) 		5 ALA A 382
LEU A 385
VAL A 386
VAL A  43
MET A  13
 None
MLY  A 384 ( 4.3A)
None
None
None
 1.13A 5v02B-4amgA:
undetectable
5v02R-4amgA:
undetectable		 5v02B-4amgA:
12.25
5v02R-4amgA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgj SORTING NEXIN-14

(Homo sapiens) 		PF00787
(PX) 		5 ALA A 627
LEU A 626
LEU A 615
VAL A 543
ILE A 514
 None
 1.06A 5v02B-4bgjA:
undetectable
5v02R-4bgjA:
undetectable		 5v02B-4bgjA:
20.14
5v02R-4bgjA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cta CINA-LIKE PROTEIN

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth)
PF02464
(CinA) 		5 LEU A 165
VAL A 164
LEU A  30
VAL A  65
ILE A  26
 None
 1.07A 5v02B-4ctaA:
undetectable
5v02R-4ctaA:
undetectable		 5v02B-4ctaA:
12.18
5v02R-4ctaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgf SULFATE TRANSPORTER
SULFATE TRANSPORTER
FAMILY PROTEIN

(Wolinella
succinogenes) 		PF01740
(STAS) 		5 ALA A 502
LEU A 503
LEU A 487
VAL A 467
ILE A 459
 None
None
None
FMT  A 602 ( 4.1A)
FMT  A 602 (-4.7A)
 0.93A 5v02B-4dgfA:
undetectable
5v02R-4dgfA:
undetectable		 5v02B-4dgfA:
20.29
5v02R-4dgfA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		5 ALA A 426
LEU A 430
LEU A 322
GLU A 423
VAL A 417
 None
 1.14A 5v02B-4fajA:
undetectable
5v02R-4fajA:
undetectable		 5v02B-4fajA:
11.17
5v02R-4fajA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE

(Rhodobacter
sphaeroides) 		PF02230
(Abhydrolase_2) 		5 ALA A 260
LEU A 259
VAL A 257
LEU A  93
GLU A 264
 None
 1.10A 5v02B-4ftwA:
undetectable
5v02R-4ftwA:
undetectable		 5v02B-4ftwA:
13.68
5v02R-4ftwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gow CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		6 LEU D  32
MET D  51
GLU D  54
VAL D  55
ILE D  63
MET D  72
 LEU  D  32 ( 0.6A)
MET  D  51 ( 0.0A)
GLU  D  54 ( 0.5A)
VAL  D  55 ( 0.6A)
ILE  D  63 ( 0.7A)
MET  D  72 ( 0.0A)
 0.71A 5v02B-4gowD:
undetectable
5v02R-4gowD:
14.5		 5v02B-4gowD:
19.86
5v02R-4gowD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2y RGECO1

(Gallus gallus;
Rattus
norvegicus;
Discosoma sp.) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 LEU A 335
MET A 354
GLU A 357
VAL A 358
MET A 375
 None
 0.89A 5v02B-4i2yA:
undetectable
5v02R-4i2yA:
6.8		 5v02B-4i2yA:
13.51
5v02R-4i2yA:
33.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		5 ALA A  55
LEU A  54
LEU A  93
GLU A  59
ILE A  63
 None
 0.77A 5v02B-4iwhA:
undetectable
5v02R-4iwhA:
undetectable		 5v02B-4iwhA:
11.78
5v02R-4iwhA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwq CALCIUM-DEPENDENT
PROTEIN KINASE

(Plasmodium
berghei) 		PF13499
(EF-hand_7) 		5 LEU A 150
MET A 174
VAL A 178
ILE A 186
MET A 195
 None
 0.71A 5v02B-4jwqA:
undetectable
5v02R-4jwqA:
11.2		 5v02B-4jwqA:
21.57
5v02R-4jwqA:
31.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A 467
GLU A 491
VAL A 492
ILE A 500
MET A 509
 None
 0.70A 5v02B-4mvfA:
undetectable
5v02R-4mvfA:
5.3		 5v02B-4mvfA:
12.65
5v02R-4mvfA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		5 ALA A 321
LEU A 322
LEU A 328
GLU A 367
VAL A 365
 None
 1.11A 5v02B-4ohtA:
1.4
5v02R-4ohtA:
undetectable		 5v02B-4ohtA:
12.75
5v02R-4ohtA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4o DNA POLYMERASE BETA

(Leishmania
infantum) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		5 ALA A 110
LEU A 113
LEU A 135
VAL A 102
ILE A 143
 None
 1.11A 5v02B-4p4oA:
undetectable
5v02R-4p4oA:
undetectable		 5v02B-4p4oA:
12.47
5v02R-4p4oA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pii N-GLYCOSYLASE/DNA
LYASE

(Pyrococcus
furiosus) 		PF09171
(AGOG) 		5 ALA A  48
LEU A  51
VAL A  52
LEU A 133
GLU A 108
 None
 0.97A 5v02B-4piiA:
undetectable
5v02R-4piiA:
undetectable		 5v02B-4piiA:
20.40
5v02R-4piiA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqo SORTING NEXIN-14

(Homo sapiens) 		PF00787
(PX) 		5 ALA A 680
LEU A 679
LEU A 668
VAL A 593
ILE A 567
 None
 1.06A 5v02B-4pqoA:
undetectable
5v02R-4pqoA:
undetectable		 5v02B-4pqoA:
19.23
5v02R-4pqoA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q57 CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 LEU A  32
MET A  51
GLU A  54
VAL A  55
MET A  72
 None
 1.12A 5v02B-4q57A:
undetectable
5v02R-4q57A:
12.8		 5v02B-4q57A:
17.65
5v02R-4q57A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ALA A 416
LEU A 417
LEU A 427
GLU A 412
ILE A 442
 None
 1.06A 5v02B-4r6gA:
undetectable
5v02R-4r6gA:
undetectable		 5v02B-4r6gA:
9.80
5v02R-4r6gA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqx SORTASE

(Streptococcus
mutans) 		PF04203
(Sortase) 		5 ALA A 135
LEU A 136
LEU A 166
GLU A 199
ILE A 164
 None
None
None
ACY  A 302 ( 4.9A)
None
 0.69A 5v02B-4tqxA:
undetectable
5v02R-4tqxA:
undetectable		 5v02B-4tqxA:
18.45
5v02R-4tqxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trg SIDC

(Legionella
pneumophila) 		no annotation 5 LEU A 279
LEU A 314
GLU A 262
VAL A 233
ILE A 310
 None
 1.01A 5v02B-4trgA:
4.2
5v02R-4trgA:
undetectable		 5v02B-4trgA:
11.07
5v02R-4trgA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuu CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00571
(CBS) 		5 ALA A 446
VAL A 459
LEU A 510
VAL A 449
ILE A 455
 SAM  A1546 ( 3.7A)
None
None
None
None
 1.11A 5v02B-4uuuA:
undetectable
5v02R-4uuuA:
undetectable		 5v02B-4uuuA:
19.50
5v02R-4uuuA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 112
LEU A 256
VAL A 257
LEU A 358
ILE A 275
 None
 1.14A 5v02B-4wyrA:
undetectable
5v02R-4wyrA:
undetectable		 5v02B-4wyrA:
12.97
5v02R-4wyrA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 ALA A2188
LEU A2185
LEU A2106
VAL A2163
ILE A2077
 None
 1.10A 5v02B-5fbyA:
1.9
5v02R-5fbyA:
undetectable		 5v02B-5fbyA:
12.50
5v02R-5fbyA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ALA A 445
LEU A 442
VAL A 441
LEU A 426
ILE A 405
 None
 1.08A 5v02B-5gpqA:
undetectable
5v02R-5gpqA:
undetectable		 5v02B-5gpqA:
11.56
5v02R-5gpqA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		5 ALA A1459
LEU A1460
VAL A1461
LEU A1487
GLU A1455
 None
 1.11A 5v02B-5h64A:
3.7
5v02R-5h64A:
undetectable		 5v02B-5h64A:
3.63
5v02R-5h64A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d ZPA963,CALMODULIN

(Caenorhabditis
elegans;
synthetic
construct) 		PF02216
(B)
PF13499
(EF-hand_7) 		5 LEU E 177
MET E 196
GLU E 199
VAL E 200
ILE E 208
 None
 0.91A 5v02B-5h7dE:
undetectable
5v02R-5h7dE:
9.2		 5v02B-5h7dE:
17.50
5v02R-5h7dE:
58.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihl 3H56-5 DOMAIN
ANTIBODY (DAB)

(Homo sapiens) 		PF07686
(V-set) 		5 ALA B  93
VAL B  37
LEU B  78
MET B  34
ILE B  69
 ALA  B  93 ( 0.0A)
VAL  B  37 ( 0.6A)
LEU  B  78 ( 0.6A)
MET  B  34 ( 0.0A)
ILE  B  69 ( 0.7A)
 1.13A 5v02B-5ihlB:
undetectable
5v02R-5ihlB:
undetectable		 5v02B-5ihlB:
15.45
5v02R-5ihlB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbh 30S RIBOSOMAL
PROTEIN US7

(Pyrococcus
abyssi) 		PF00177
(Ribosomal_S7) 		5 ALA H 126
LEU H 123
VAL H 122
LEU H  67
GLU H 187
 None
 1.08A 5v02B-5jbhH:
undetectable
5v02R-5jbhH:
undetectable		 5v02B-5jbhH:
21.40
5v02R-5jbhH:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 5 ALA C 242
LEU C 241
LEU C 305
VAL C 250
ILE C 303
 None
 1.05A 5v02B-5jnfC:
undetectable
5v02R-5jnfC:
undetectable		 5v02B-5jnfC:
9.73
5v02R-5jnfC:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		5 ALA A 258
LEU A 342
LEU A 244
GLU A 301
ILE A 240
 None
 1.10A 5v02B-5l2rA:
undetectable
5v02R-5l2rA:
undetectable		 5v02B-5l2rA:
10.26
5v02R-5l2rA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Streptomyces
venezuelae) 		PF00982
(Glyco_transf_20) 		5 ALA A 379
LEU A 380
VAL A 381
LEU A 429
GLU A 421
 None
 1.13A 5v02B-5lqdA:
undetectable
5v02R-5lqdA:
undetectable		 5v02B-5lqdA:
10.97
5v02R-5lqdA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 ALA B   7
LEU B 232
VAL B 231
VAL B   4
ILE B 175
 None
 1.13A 5v02B-5my0B:
undetectable
5v02R-5my0B:
undetectable		 5v02B-5my0B:
undetectable
5v02R-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 5 LEU A 194
VAL A 195
LEU A 170
VAL A 208
ILE A 248
 None
 1.07A 5v02B-5n0oA:
undetectable
5v02R-5n0oA:
undetectable		 5v02B-5n0oA:
undetectable
5v02R-5n0oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S5

(Mycolicibacterium
smegmatis) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 ALA E 168
LEU E 121
VAL E 110
LEU E 140
VAL E  99
 None
 1.12A 5v02B-5o5jE:
undetectable
5v02R-5o5jE:
undetectable		 5v02B-5o5jE:
15.89
5v02R-5o5jE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oms CYTOCHROME P450

(Amycolatopsis
sp. ATCC 39116) 		no annotation 5 ALA A 255
LEU A 258
VAL A 259
LEU A 373
GLU A 137
 None
 0.89A 5v02B-5omsA:
undetectable
5v02R-5omsA:
undetectable		 5v02B-5omsA:
undetectable
5v02R-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugz PUTATIVE
THIOESTERASE

(Escherichia
coli) 		PF00975
(Thioesterase) 		5 LEU A  59
LEU A   9
MET A  83
GLU A  86
ILE A  74
 None
 0.90A 5v02B-5ugzA:
undetectable
5v02R-5ugzA:
undetectable		 5v02B-5ugzA:
16.48
5v02R-5ugzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 5 ALA A 379
LEU A 380
LEU A 342
VAL A 335
ILE A 259
 None
 1.12A 5v02B-5xepA:
undetectable
5v02R-5xepA:
undetectable		 5v02B-5xepA:
undetectable
5v02R-5xepA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
aureus) 		no annotation 5 ALA A 150
LEU A 215
VAL A 216
LEU A  17
ILE A  19
 None
 1.11A 5v02B-5xexA:
undetectable
5v02R-5xexA:
undetectable		 5v02B-5xexA:
10.38
5v02R-5xexA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US5

(Toxoplasma
gondii) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 ALA C 225
LEU C 177
VAL C 166
LEU C 196
VAL C 147
 None
 1.10A 5v02B-5xxuC:
undetectable
5v02R-5xxuC:
undetectable		 5v02B-5xxuC:
16.36
5v02R-5xxuC:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y8f SEFIR DOMAIN PROTEIN

(Bacillus cereus) 		no annotation 5 ALA A  22
LEU A  21
LEU A  61
VAL A  31
ILE A 141
 None
 1.10A 5v02B-5y8fA:
undetectable
5v02R-5y8fA:
undetectable		 5v02B-5y8fA:
undetectable
5v02R-5y8fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cro LAMBDA CRO REPRESSOR

(Escherichia
virus Lambda) 		PF09048
(Cro) 		5 ALA A  20
LEU A  23
VAL A  25
LEU A  42
ILE A  40
 None
 1.04A 5v02B-6croA:
undetectable
5v02R-6croA:
undetectable		 5v02B-6croA:
25.88
5v02R-6croA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9z SULFATE TRANSPORTER
CYSZ

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		no annotation 5 ALA F 102
LEU F 101
LEU F  22
GLU F 106
VAL F 107
 None
 1.13A 5v02B-6d9zF:
2.5
5v02R-6d9zF:
undetectable		 5v02B-6d9zF:
undetectable
5v02R-6d9zF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpc -

(-) 		no annotation 5 LEU A  12
VAL A  13
GLU A  49
VAL A  48
ILE A   5
 None
 1.08A 5v02B-6gpcA:
undetectable
5v02R-6gpcA:
undetectable		 5v02B-6gpcA:
undetectable
5v02R-6gpcA:
undetectable