SIMILAR PATTERNS OF AMINO ACIDS FOR 5UXD_B_ZITB501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6j NITROGEN REGULATORY
IIA PROTEIN

(Escherichia
coli) 		PF00359
(PTS_EIIA_2) 		5 ILE A  65
LEU A 124
VAL A 127
GLU A  58
ALA A  31
 None
 1.12A 5uxdB-1a6jA:
undetectable		 5uxdB-1a6jA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 ASP A 301
VAL A 157
PHE A 250
ALA A 167
GLY A 165
 None
 1.09A 5uxdB-1fw8A:
undetectable		 5uxdB-1fw8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ILE A  56
LEU A 291
GLU A 131
ALA A  91
GLY A  92
 None
None
HIS  A 450 ( 3.0A)
None
None
 1.12A 5uxdB-1httA:
0.2		 5uxdB-1httA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
ASP A  11
LEU A  74
GLY A 282
TYR A 281
 None
 1.12A 5uxdB-1jedA:
0.0		 5uxdB-1jedA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A 329
LEU A 320
PHE A 377
ALA A 375
GLY A 309
 None
None
None
FAD  A 701 (-3.8A)
FAD  A 701 (-3.4A)
 1.11A 5uxdB-1jscA:
0.0		 5uxdB-1jscA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7p PHOSPHOSERINE
PHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF12710
(HAD) 		5 ASP A 167
LEU A   7
VAL A  94
ALA A 120
GLY A 101
 SEP  A 770 ( 4.4A)
None
None
None
SEP  A 770 ( 4.4A)
 1.11A 5uxdB-1l7pA:
undetectable		 5uxdB-1l7pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		5 ASP A 289
LEU A 235
VAL A 247
PHE A 258
GLY A 302
 None
 1.13A 5uxdB-1mppA:
0.0		 5uxdB-1mppA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 284
ASP A 271
LEU A 139
PHE A 299
GLY A 302
 None
 1.06A 5uxdB-1mx3A:
0.0		 5uxdB-1mx3A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 136
ASP A  64
LEU A 100
VAL A 105
GLY A 142
 None
 0.96A 5uxdB-1qlbA:
0.0		 5uxdB-1qlbA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
ASP A  11
LEU A  74
GLY A 282
TYR A 281
 None
 1.13A 5uxdB-1r6xA:
undetectable		 5uxdB-1r6xA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		5 LEU A 180
ASP A 206
LEU A 371
ALA A 168
GLY A 164
 None
 1.09A 5uxdB-2amxA:
undetectable		 5uxdB-2amxA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		5 LEU A 141
LEU A  67
VAL A  66
ALA A  36
GLY A  38
 None
 1.03A 5uxdB-2bbzA:
undetectable		 5uxdB-2bbzA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 LEU A 122
ASP A 121
LEU A  82
TYR A  79
TYR A 223
 None
None
None
None
1DO  A1655 (-3.9A)
 1.01A 5uxdB-2cfzA:
undetectable		 5uxdB-2cfzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzr GENERAL
TRANSCRIPTION FACTOR
II-I REPEAT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02946
(GTF2I) 		5 ILE A  69
LEU A  15
ASP A  14
ALA A  23
GLY A  21
 None
 1.13A 5uxdB-2dzrA:
undetectable		 5uxdB-2dzrA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		5 LEU A 141
LEU A  67
VAL A  66
ALA A  36
GLY A  38
 None
 1.05A 5uxdB-2f1sA:
undetectable		 5uxdB-2f1sA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11

(Brucella suis) 		PF00437
(T2SSE) 		5 ILE A 199
LEU A 214
PHE A 269
ALA A 273
GLY A 276
 None
 1.06A 5uxdB-2gzaA:
undetectable		 5uxdB-2gzaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		5 LEU A 257
VAL A 281
PHE A 166
GLY A 236
TYR A 234
 None
 1.07A 5uxdB-2ixnA:
undetectable		 5uxdB-2ixnA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ome C-TERMINAL-BINDING
PROTEIN 2

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 290
ASP A 277
LEU A 145
PHE A 305
GLY A 308
 None
 1.01A 5uxdB-2omeA:
undetectable		 5uxdB-2omeA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 LEU A 419
VAL A 413
PHE A 346
ALA A 386
GLY A 389
 None
 1.10A 5uxdB-2wzsA:
undetectable		 5uxdB-2wzsA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 LEU A 530
LEU A 542
PHE A 663
ALA A 666
TYR A 670
 None
 0.98A 5uxdB-3ayfA:
2.7		 5uxdB-3ayfA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfg CLASS A
BETA-LACTAMASE SED1

(Citrobacter
sedlakii) 		PF13354
(Beta-lactamase2) 		5 LEU A 211
ASP A 233
LEU A 162
VAL A 148
ALA A 125
 None
 1.12A 5uxdB-3bfgA:
undetectable		 5uxdB-3bfgA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 112
ASP A 117
LEU A 160
VAL A 156
GLU A 314
 None
 0.92A 5uxdB-3d46A:
undetectable		 5uxdB-3d46A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 112
LEU A 160
VAL A 156
GLU A 314
GLY A 283
 None
 1.00A 5uxdB-3d46A:
undetectable		 5uxdB-3d46A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A 363
LEU A 355
ALA A 145
GLY A 143
TYR A 142
 None
 1.13A 5uxdB-3dtyA:
undetectable		 5uxdB-3dtyA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Deinococcus
geothermalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 204
VAL A 211
GLU A 148
ALA A 142
GLY A 144
 None
 0.86A 5uxdB-3e97A:
undetectable		 5uxdB-3e97A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Salmonella
enterica) 		PF00171
(Aldedh) 		5 LEU A 307
ASP A 306
PHE A 138
ALA A 270
GLY A 259
 None
 1.05A 5uxdB-3efvA:
undetectable		 5uxdB-3efvA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ILE A 181
LEU A 314
LEU A 275
ALA A 176
GLY A 310
 None
 1.02A 5uxdB-3eh2A:
undetectable		 5uxdB-3eh2A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 ILE A  76
VAL A  50
ALA A 197
GLY A 196
TYR A 195
 None
 1.13A 5uxdB-3fahA:
undetectable		 5uxdB-3fahA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy3 HEMOLYSIN

(Proteus
mirabilis) 		PF05860
(Haemagg_act) 		5 ILE A 109
VAL A  56
TYR A  68
GLY A 160
TYR A 172
 None
 1.01A 5uxdB-3fy3A:
undetectable		 5uxdB-3fy3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 ILE A 109
LEU A  92
LEU A 101
ALA A 134
GLY A 138
 None
 1.04A 5uxdB-3glbA:
undetectable		 5uxdB-3glbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 252
VAL A 286
ALA A  98
GLY A  95
TYR A  94
 None
 0.92A 5uxdB-3h2xA:
undetectable		 5uxdB-3h2xA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv9 PROTEIN FIMX

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 ILE A 511
LEU A 458
VAL A 476
ALA A 497
GLY A 501
 None
GOL  A 906 (-4.0A)
None
None
None
 1.08A 5uxdB-3hv9A:
undetectable		 5uxdB-3hv9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		5 ILE A  31
ASP A 111
LEU A  22
VAL A   6
ALA A 297
 None
 1.08A 5uxdB-3i3lA:
undetectable		 5uxdB-3i3lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 223
LEU A 247
ASP A 249
LEU A 183
GLY A 325
 None
None
MG  A 386 (-3.1A)
None
None
 1.09A 5uxdB-3i6eA:
undetectable		 5uxdB-3i6eA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 221
LEU A 245
ASP A 247
LEU A 181
GLY A 321
 None
None
MG  A 381 (-3.1A)
None
None
 1.14A 5uxdB-3i6tA:
undetectable		 5uxdB-3i6tA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
mutans) 		PF01791
(DeoC) 		5 LEU A 256
VAL A 252
PHE A 263
PHE A 234
ALA A 233
 None
None
None
None
EDO  A 339 ( 3.7A)
 0.83A 5uxdB-3iv3A:
undetectable		 5uxdB-3iv3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		5 LEU A 220
LEU A 252
VAL A 248
PHE A 259
ALA A 229
 None
 1.01A 5uxdB-3jrkA:
undetectable		 5uxdB-3jrkA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		5 LEU A 252
VAL A 248
PHE A 259
PHE A 230
ALA A 229
 None
 0.85A 5uxdB-3jrkA:
undetectable		 5uxdB-3jrkA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		5 LEU A 255
VAL A 251
PHE A 262
PHE A 233
ALA A 232
 None
 0.81A 5uxdB-3myoA:
undetectable		 5uxdB-3myoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 431
LEU A 420
GLU A 162
GLY A 131
TYR A 132
 None
None
ZN  A 501 (-3.9A)
None
None
 1.04A 5uxdB-3pfeA:
undetectable		 5uxdB-3pfeA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE

(Campylobacter
jejuni) 		PF00709
(Adenylsucc_synt) 		5 ASP A 282
LEU A 325
VAL A 262
TYR A 389
TYR A 364
 PGE  A 422 ( 4.9A)
None
None
None
None
 1.07A 5uxdB-3r7tA:
undetectable		 5uxdB-3r7tA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		5 LEU X 142
ASP X 143
LEU X  63
PHE X 158
GLY X 138
 None
 1.13A 5uxdB-3ss7X:
undetectable		 5uxdB-3ss7X:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swo GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  56
GLU A  95
ALA A  90
GLY A  88
TYR A  87
 None
 0.89A 5uxdB-3swoA:
2.2		 5uxdB-3swoA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		5 LEU A 194
LEU A 179
VAL A 181
PHE A 134
GLY A 127
 None
 1.03A 5uxdB-3t5tA:
undetectable		 5uxdB-3t5tA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr6 O-METHYLTRANSFERASE

(Coxiella
burnetii) 		PF01596
(Methyltransf_3) 		5 ILE A 211
LEU A 217
ALA A  76
GLY A  73
TYR A  74
 None
 1.11A 5uxdB-3tr6A:
undetectable		 5uxdB-3tr6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2g 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ILE A 164
LEU A 187
LEU A 246
ALA A 195
GLY A 193
 None
 0.96A 5uxdB-3v2gA:
undetectable		 5uxdB-3v2gA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF16420
(ATG7_N) 		5 ILE A 427
ASP A 421
LEU A 435
VAL A 457
ALA A 591
 None
 1.11A 5uxdB-3vh1A:
undetectable		 5uxdB-3vh1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		5 ASP A 120
LEU A 269
VAL A 268
ALA A  69
GLY A  67
 None
 1.14A 5uxdB-3wg6A:
undetectable		 5uxdB-3wg6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 ILE A   4
LEU A 407
VAL A 366
ALA A 246
GLY A 248
 None
 1.12A 5uxdB-3zh4A:
undetectable		 5uxdB-3zh4A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 150
LEU A 188
LEU A 323
PHE A 313
GLY A 247
 None
 0.99A 5uxdB-4b6lA:
4.5		 5uxdB-4b6lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bof ARGININE DEIMINASE

(Streptococcus
pyogenes) 		PF02274
(Amidinotransf) 		5 LEU A 177
ASP A 212
LEU A 232
VAL A 226
GLY A 205
 None
 1.09A 5uxdB-4bofA:
undetectable		 5uxdB-4bofA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans;
Homo sapiens) 		PF10275
(Peptidase_C65) 		5 ASP A 104
LEU A 160
VAL A  44
PHE A 139
ALA A 225
 None
 1.13A 5uxdB-4dhzA:
3.2		 5uxdB-4dhzA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 ILE A 124
VAL A 162
PHE A 262
PHE A 266
GLY A 290
 None
None
HEM  A 501 (-4.4A)
None
None
 0.89A 5uxdB-4dxyA:
undetectable		 5uxdB-4dxyA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gox POLYKETIDE SYNTHASE

(Synechococcus
sp. PCC 7002) 		PF13469
(Sulfotransfer_3) 		5 ILE A 157
ASP A 132
LEU A 229
VAL A 228
GLY A 265
 None
 1.03A 5uxdB-4goxA:
undetectable		 5uxdB-4goxA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 170
LEU A 208
LEU A 343
PHE A 333
GLY A 267
 None
 0.95A 5uxdB-4i6fA:
4.4		 5uxdB-4i6fA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 LEU A 216
VAL A  62
PHE A 206
ALA A 256
GLY A 259
 None
None
LLP  A 205 ( 4.8A)
None
None
 1.09A 5uxdB-4isyA:
undetectable		 5uxdB-4isyA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix1 HYPOTHETICAL PROTEIN

(Rhodococcus
opacus) 		no annotation 5 ASP A 232
LEU A  71
VAL A  76
GLU A  24
PHE A  44
 None
 1.08A 5uxdB-4ix1A:
undetectable		 5uxdB-4ix1A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmj RNA/RNP
COMPLEX-1-INTERACTIN
G PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A  66
LEU A  78
VAL A  82
TYR A  73
PHE A  44
 None
 0.94A 5uxdB-4jmjA:
undetectable		 5uxdB-4jmjA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE

(Xanthomonas
oryzae) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ILE A   9
LEU A 119
VAL A  39
ALA A  82
GLY A  81
 None
 0.97A 5uxdB-4l1kA:
undetectable		 5uxdB-4l1kA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0g PROTEIN PHOSPHATASE
2C 37

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 LEU A 389
ASP A 388
VAL A 225
ALA A 252
GLY A 250
 None
 1.06A 5uxdB-4n0gA:
undetectable		 5uxdB-4n0gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7y METHIONINE
GAMMA-LYASE

(Citrobacter
freundii) 		PF01053
(Cys_Met_Meta_PP) 		5 ILE A  89
LEU A  96
GLU A 156
TYR A 154
PHE A 133
 LLP  A 210 ( 4.3A)
None
LLP  A 210 ( 3.7A)
None
None
 1.13A 5uxdB-4p7yA:
undetectable		 5uxdB-4p7yA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 ASP A 430
LEU A 314
VAL A 412
ALA A 424
GLY A 426
 None
 1.10A 5uxdB-4qmeA:
0.2		 5uxdB-4qmeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27

(Chaetomium
thermophilum) 		PF00160
(Pro_isomerase) 		5 ILE A 192
LEU A  45
ASP A  46
LEU A 124
VAL A  26
 EDO  A 302 (-3.8A)
EDO  A 308 ( 4.7A)
None
None
None
 1.11A 5uxdB-4r3fA:
undetectable		 5uxdB-4r3fA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ILE A 447
LEU A 425
LEU A 572
GLU A 530
GLY A 433
 None
 1.01A 5uxdB-4ra4A:
4.8		 5uxdB-4ra4A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ILE A2611
LEU A2667
LEU A2602
ALA A2587
GLY A2673
 None
 1.05A 5uxdB-4rh7A:
undetectable		 5uxdB-4rh7A:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster) 		PF03283
(PAE) 		5 LEU A 387
LEU A 370
VAL A 373
PHE A 273
GLY A 125
 None
 1.07A 5uxdB-4uzjA:
undetectable		 5uxdB-4uzjA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER

(Escherichia
coli) 		PF01554
(MatE) 		5 ILE A 147
LEU A 138
GLU A 153
ALA A 214
GLY A 212
 None
None
None
OLC  A 506 ( 3.9A)
None
 0.99A 5uxdB-4z3nA:
undetectable		 5uxdB-4z3nA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		5 ILE A 245
LEU A 249
LEU A 181
GLU A 484
ALA A 327
 None
 1.06A 5uxdB-5aq1A:
undetectable		 5uxdB-5aq1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 5 ILE B  32
LEU B   6
LEU B  70
ALA B 138
GLY B 136
 None
 1.10A 5uxdB-5co4B:
undetectable		 5uxdB-5co4B:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm7 50S RIBOSOMAL
PROTEIN L5

(Deinococcus
radiodurans) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 ILE D 154
LEU D 108
PHE D 177
ALA D 166
GLY D 126
 None
 1.13A 5uxdB-5dm7D:
undetectable		 5uxdB-5dm7D:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		5 LEU A  39
VAL A  37
PHE A 271
ALA A 323
GLY A 325
 None
 1.01A 5uxdB-5ereA:
undetectable		 5uxdB-5ereA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 5 ILE A  46
LEU A 395
VAL A 392
ALA A  67
TYR A  75
 None
 1.06A 5uxdB-5fkrA:
2.9		 5uxdB-5fkrA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 5 LEU A 593
VAL A 577
PHE A 617
PHE A 642
ALA A 644
 None
 1.04A 5uxdB-5fkrA:
2.9		 5uxdB-5fkrA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdi CYTOCHROME P450 144

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 ILE A 410
LEU A 404
ASP A 405
LEU A 430
GLY A 309
 None
 1.10A 5uxdB-5hdiA:
undetectable		 5uxdB-5hdiA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Streptococcus
porcinus) 		PF01791
(DeoC) 		5 LEU A 255
VAL A 251
PHE A 262
PHE A 233
ALA A 232
 None
 0.74A 5uxdB-5hjlA:
undetectable		 5uxdB-5hjlA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF01326
(PPDK_N) 		5 ILE A 296
LEU A 279
LEU A  26
ALA A 301
GLY A 303
 None
 1.09A 5uxdB-5hv6A:
1.2		 5uxdB-5hv6A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00567
(TUDOR) 		5 LEU A 451
VAL A 312
GLU A 485
ALA A 492
GLY A 490
 UNX  A 503 ( 4.3A)
UNX  A 503 ( 4.0A)
None
None
None
 1.07A 5uxdB-5j39A:
undetectable		 5uxdB-5j39A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7w THYMIDYLATE SYNTHASE

(Enterococcus
faecalis) 		PF00303
(Thymidylat_synt) 		5 LEU A 214
LEU A  46
VAL A  51
ALA A 257
GLY A 255
 None
 1.13A 5uxdB-5j7wA:
undetectable		 5uxdB-5j7wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		5 ILE A  17
LEU A 364
VAL A 361
ALA A  38
TYR A  46
 None
 1.14A 5uxdB-5jwzA:
3.0		 5uxdB-5jwzA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l01 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		5 ILE A 366
GLU A 340
TYR A 264
ALA A 332
GLY A 331
 6Z4  A 502 (-3.8A)
None
6Z4  A 502 (-4.3A)
FE  A 501 ( 4.6A)
None
 1.08A 5uxdB-5l01A:
undetectable		 5uxdB-5l01A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		5 ILE A  92
LEU A  61
LEU A 183
PHE A 579
GLY A  68
 None
 1.09A 5uxdB-5mtzA:
undetectable		 5uxdB-5mtzA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 5 ILE A 143
LEU A  23
VAL A 167
ALA A  48
GLY A  46
 None
 1.08A 5uxdB-5oc9A:
2.4		 5uxdB-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 5 LEU A 266
LEU A 308
VAL A 284
GLY A 221
TYR A 220
 None
 1.14A 5uxdB-5oenA:
undetectable		 5uxdB-5oenA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		5 ILE A 123
LEU A 166
VAL A  18
GLY A 373
TYR A 376
 None
 1.03A 5uxdB-5svcA:
undetectable		 5uxdB-5svcA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sz8 HEMOLYSIN

(Proteus
mirabilis) 		PF05860
(Haemagg_act) 		5 ILE A 109
VAL A  56
TYR A  68
GLY A 160
TYR A 172
 None
 1.04A 5uxdB-5sz8A:
undetectable		 5uxdB-5sz8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sz8 HEMOLYSIN

(Proteus
mirabilis) 		PF05860
(Haemagg_act) 		5 LEU A 181
VAL A 159
PHE A 149
ALA A 125
GLY A  77
 None
 1.11A 5uxdB-5sz8A:
undetectable		 5uxdB-5sz8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h PROTEASOME SUBUNIT
BETA TYPE-7

(Homo sapiens) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 ILE O  34
VAL O 177
PHE O 138
ALA O 134
GLY O 130
 None
 1.10A 5uxdB-5t0hO:
undetectable		 5uxdB-5t0hO:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 ILE A 349
LEU A 331
ALA A 311
GLY A 336
TYR A 310
 None
 0.81A 5uxdB-5tvjA:
undetectable		 5uxdB-5tvjA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01063
(Aminotran_4) 		5 ILE A 246
LEU A 230
GLU A 296
ALA A 302
GLY A 304
 None
 1.13A 5uxdB-5u3fA:
undetectable		 5uxdB-5u3fA:
25.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		6 LEU A 100
VAL A 108
TYR A 198
PHE A 265
ALA A 268
GLY A 271
 None
 0.85A 5uxdB-5uxbA:
32.1		 5uxdB-5uxbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		5 VAL A 108
GLU A 196
TYR A 198
ALA A 268
GLY A 271
 None
 0.67A 5uxdB-5uxbA:
32.1		 5uxdB-5uxbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0e FREE SERINE KINASE

(Thermococcus
kodakarensis) 		PF02195
(ParBc) 		5 ILE A 174
LEU A 117
PHE A 141
GLY A 180
TYR A 179
 None
 0.96A 5uxdB-5x0eA:
undetectable		 5uxdB-5x0eA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn7 PUTATIVE RTX-TOXIN

(Vibrio
vulnificus) 		PF11647
(MLD) 		5 LEU A2495
PHE A2544
ALA A2540
GLY A2536
TYR A2535
 None
 1.09A 5uxdB-5xn7A:
undetectable		 5uxdB-5xn7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 5 ILE A 201
LEU A 199
ASP A 196
LEU A 242
VAL A 260
 None
 1.10A 5uxdB-5y4gA:
undetectable		 5uxdB-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao1 BETA-LACTAMASE
DOMAIN PROTEIN

(Paraburkholderia
phymatum) 		PF00753
(Lactamase_B) 		5 ILE A 221
ASP A 224
LEU A 190
ALA A 103
GLY A 101
 None
CA  A 403 ( 2.2A)
None
None
None
 0.94A 5uxdB-6ao1A:
undetectable		 5uxdB-6ao1A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 5 LEU A 437
GLU A 482
ALA A 560
GLY A 563
TYR A 562
 EDO  A 705 (-4.5A)
None
None
None
None
 1.01A 5uxdB-6au1A:
undetectable		 5uxdB-6au1A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b57 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		no annotation 5 LEU A 451
VAL A 312
GLU A 485
ALA A 492
GLY A 490
 None
 1.02A 5uxdB-6b57A:
undetectable		 5uxdB-6b57A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 ILE A 194
LEU A  66
GLU A 151
ALA A 154
GLY A 156
 None
SO4  A 407 (-4.8A)
None
LLP  A 181 ( 3.3A)
None
 1.01A 5uxdB-6blgA:
undetectable		 5uxdB-6blgA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0b FRIZZLED-2
TOXIN B

(Clostridioides
difficile;
Homo sapiens) 		no annotation 5 LEU A1488
ASP A1490
LEU A1527
VAL A1518
PHE B 128
 None
None
None
None
PAM  B 202 (-3.9A)
 1.04A 5uxdB-6c0bA:
undetectable		 5uxdB-6c0bA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj4 ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		no annotation 5 ILE A 873
LEU A 884
VAL A 898
ALA A1013
GLY A1015
 None
 1.14A 5uxdB-6fj4A:
undetectable		 5uxdB-6fj4A:
11.33