SIMILAR PATTERNS OF AMINO ACIDS FOR 5UXD_A_ZITA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)

(Serratia
marcescens) 		PF00583
(Acetyltransf_1) 		4 GLU A 105
TYR A 143
ALA A 134
GLY A 138
 None
 0.99A 5uxdA-1bo4A:
0.0		 5uxdA-1bo4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cen CELLULASE CELC

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 GLU A  55
TYR A  63
ALA A  92
GLY A  94
 None
 0.98A 5uxdA-1cenA:
0.0		 5uxdA-1cenA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxj CLASS II CHITINASE

(Canavalia
ensiformis) 		PF00182
(Glyco_hydro_19) 		4 PHE A  42
ALA A 130
GLY A 128
TYR A 124
 None
 0.71A 5uxdA-1dxjA:
undetectable		 5uxdA-1dxjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF01180
(DHO_dh) 		4 TYR A 155
ALA A 189
GLY A 187
TYR A 186
 None
 1.10A 5uxdA-1f76A:
0.0		 5uxdA-1f76A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg2 CLATHRIN ASSEMBLY
PROTEIN SHORT FORM

(Rattus
norvegicus) 		PF07651
(ANTH) 		4 PHE A 143
ALA A 210
GLY A 214
TYR A 211
 None
 0.91A 5uxdA-1hg2A:
undetectable		 5uxdA-1hg2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		4 TYR A  87
PHE A  91
ALA A  97
GLY A 148
 None
 0.85A 5uxdA-1oduA:
0.0		 5uxdA-1oduA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLU A  91
ALA A  62
GLY A  60
TYR A  56
 None
 1.09A 5uxdA-1pvdA:
0.0		 5uxdA-1pvdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 GLU A  35
TYR A 252
ALA A  60
GLY A  58
 SO4  A 905 ( 4.7A)
None
None
SAH  A 887 (-3.0A)
 0.86A 5uxdA-1r6aA:
0.2		 5uxdA-1r6aA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t7s BAG-1 COCHAPERONE

(Caenorhabditis
elegans) 		PF02179
(BAG) 		4 GLU A  98
TYR A  97
ALA A  84
GLY A 156
 None
 0.89A 5uxdA-1t7sA:
undetectable		 5uxdA-1t7sA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 GLU A  59
PHE A  97
ALA A 161
GLY A   8
 None
 0.96A 5uxdA-1ub7A:
undetectable		 5uxdA-1ub7A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugp NITRILE HYDRATASE
BETA SUBUNIT

(Pseudonocardia
thermophila) 		PF02211
(NHase_beta) 		4 PHE B  37
ALA B 122
GLY B 125
TYR B 124
 None
 0.98A 5uxdA-1ugpB:
undetectable		 5uxdA-1ugpB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 GLU A 368
ALA A 282
GLY A 124
TYR A 125
 None
 1.00A 5uxdA-1xrcA:
undetectable		 5uxdA-1xrcA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bov MONO-ADP-RIBOSYLTRAN
SFERASE C3
RAS-RELATED PROTEIN
RAL-A

(Clostridium
botulinum;
Homo sapiens) 		PF00071
(Ras)
PF03496
(ADPrib_exo_Tox) 		4 GLU A 147
ALA B1057
GLY B1059
TYR B1063
 None
 1.04A 5uxdA-2bovA:
undetectable		 5uxdA-2bovA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		4 GLU A 144
ALA A 120
GLY A 123
TYR A 122
 None
 0.92A 5uxdA-2c20A:
undetectable		 5uxdA-2c20A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN

(Mus musculus) 		PF04564
(U-box)
PF12895
(ANAPC3) 		4 ALA A  48
GLY A  51
TYR A  50
TYR A  63
 None
 1.05A 5uxdA-2c2lA:
undetectable		 5uxdA-2c2lA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		4 PHE A 157
ALA A 191
GLY A 168
TYR A 167
 None
 0.92A 5uxdA-2ghbA:
undetectable		 5uxdA-2ghbA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF03054
(tRNA_Me_trans) 		4 PHE A 109
ALA A 130
GLY A 172
TYR A 129
 None
 1.01A 5uxdA-2hmaA:
undetectable		 5uxdA-2hmaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 PHE A 116
GLY A 158
TYR A 235
TYR A 234
 None
 0.98A 5uxdA-2hzkA:
undetectable		 5uxdA-2hzkA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihm DNA POLYMERASE MU

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 GLU A 165
TYR A 234
ALA A 251
GLY A 247
 None
None
None
NA  A 900 ( 4.9A)
 1.07A 5uxdA-2ihmA:
2.7		 5uxdA-2ihmA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m26 HCF C-TERMINAL CHAIN
1

(Mus musculus) 		no annotation 4 GLU A  53
ALA A 110
GLY A 108
TYR A 107
 None
 1.09A 5uxdA-2m26A:
undetectable		 5uxdA-2m26A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m2a FKBP-TYPE 16 KDA
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Escherichia
coli) 		PF00254
(FKBP_C) 		4 GLU A  26
PHE A  15
ALA A  70
GLY A  72
 None
 0.93A 5uxdA-2m2aA:
undetectable		 5uxdA-2m2aA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9x REDUCTASE, ASSEMBLY
PROTEIN

(Archaeoglobus
fulgidus) 		PF02613
(Nitrate_red_del) 		4 TYR A 140
PHE A 143
ALA A  23
GLY A  21
 None
 0.78A 5uxdA-2o9xA:
undetectable		 5uxdA-2o9xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 GLU A 310
PHE A 314
ALA A 109
GLY A 107
 GLU  A 310 ( 0.6A)
PHE  A 314 ( 1.3A)
ALA  A 109 ( 0.0A)
GLY  A 107 ( 0.0A)
 1.05A 5uxdA-2ogsA:
undetectable		 5uxdA-2ogsA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		4 GLU A  64
PHE A  62
ALA A  49
GLY A 201
 None
None
NAD  A 358 (-3.1A)
None
 1.07A 5uxdA-2q1tA:
undetectable		 5uxdA-2q1tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		4 GLU A  31
ALA A 165
GLY A 168
TYR A 167
 None
 1.07A 5uxdA-2rfzA:
undetectable		 5uxdA-2rfzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Paraburkholderia
phymatum) 		PF13377
(Peripla_BP_3) 		4 PHE A 267
ALA A 281
GLY A 253
TYR A 254
 None
 1.10A 5uxdA-2rgyA:
undetectable		 5uxdA-2rgyA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLU A  89
ALA A  60
GLY A  58
TYR A  54
 GLU  A  89 ( 0.5A)
ALA  A  60 ( 0.0A)
GLY  A  58 ( 0.0A)
TYR  A  54 ( 1.3A)
 1.02A 5uxdA-2vbfA:
undetectable		 5uxdA-2vbfA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		4 TYR A  22
PHE A 145
ALA A 158
GLY A 162
 None
 0.96A 5uxdA-2veoA:
undetectable		 5uxdA-2veoA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 GLU A 370
ALA A 406
GLY A 410
TYR A 407
 None
 1.09A 5uxdA-2wzsA:
undetectable		 5uxdA-2wzsA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 TYR A 296
PHE A 297
ALA A 379
GLY A 377
 None
None
ZN  A1946 ( 4.2A)
None
 1.07A 5uxdA-2yd0A:
1.8		 5uxdA-2yd0A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak4 NADH-DEPENDENT
QUINUCLIDINONE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 TYR A 216
PHE A 188
ALA A 145
GLY A 149
 None
 0.81A 5uxdA-3ak4A:
undetectable		 5uxdA-3ak4A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3atg GLUCANASE

(Cellulosimicrobium
cellulans) 		PF00722
(Glyco_hydro_16) 		4 GLU A  63
ALA A  30
GLY A  29
TYR A  41
 None
 1.07A 5uxdA-3atgA:
undetectable		 5uxdA-3atgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLU A 241
TYR A 239
ALA A 318
GLY A 284
 None
GLC  A1002 (-3.7A)
None
None
 0.67A 5uxdA-3bc9A:
undetectable		 5uxdA-3bc9A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqh L-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE ULAE

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		4 GLU A  42
GLY A 118
TYR A 119
TYR A 122
 None
 0.72A 5uxdA-3cqhA:
undetectable		 5uxdA-3cqhA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 TYR A 414
PHE A 419
ALA A 443
GLY A 441
 None
 0.95A 5uxdA-3e1sA:
undetectable		 5uxdA-3e1sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLU A 554
ALA A 150
GLY A 522
TYR A 154
 None
 1.01A 5uxdA-3e9yA:
undetectable		 5uxdA-3e9yA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edl KINESIN13 MOTOR
DOMAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 PHE D 215
ALA D 183
GLY D 186
TYR D 139
 None
 0.99A 5uxdA-3edlD:
undetectable		 5uxdA-3edlD:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		4 PHE A 447
ALA A 251
GLY A 222
TYR A 271
 None
 0.89A 5uxdA-3eu8A:
undetectable		 5uxdA-3eu8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 4 GLU S 421
TYR L 259
ALA S 502
GLY S 514
 None
 0.68A 5uxdA-3g9kS:
undetectable		 5uxdA-3g9kS:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 175
PHE A  31
GLY A 265
TYR A 242
 None
 1.00A 5uxdA-3gdcA:
undetectable		 5uxdA-3gdcA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		4 PHE A  79
ALA A 116
GLY A 120
TYR A 192
 None
 0.96A 5uxdA-3gwbA:
undetectable		 5uxdA-3gwbA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		4 GLU A 377
TYR A 165
PHE A 381
GLY A 421
 None
 0.87A 5uxdA-3hoaA:
2.4		 5uxdA-3hoaA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		4 GLU A 367
TYR A 154
PHE A 371
GLY A 411
 None
None
None
CL  A 505 ( 4.0A)
 0.85A 5uxdA-3hq2A:
undetectable		 5uxdA-3hq2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV

(Corynebacterium
glutamicum) 		PF00465
(Fe-ADH) 		4 TYR A 153
PHE A  18
ALA A 200
GLY A 204
 None
 1.07A 5uxdA-3iv7A:
undetectable		 5uxdA-3iv7A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		4 GLU A1401
ALA A1429
GLY A1431
TYR A1435
 None
 1.00A 5uxdA-3jbzA:
4.9		 5uxdA-3jbzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb5 TRIPARTITE
MOTIF-CONTAINING
PROTEIN 72

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 ALA A 429
GLY A 414
TYR A 427
TYR A 416
 None
 1.04A 5uxdA-3kb5A:
undetectable		 5uxdA-3kb5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klb PUTATIVE
FLAVOPROTEIN

(Bacteroides
fragilis) 		PF12682
(Flavodoxin_4) 		4 TYR A 103
PHE A 105
GLY A  84
TYR A  10
 None
GOL  A 165 (-4.9A)
None
None
 0.92A 5uxdA-3klbA:
undetectable		 5uxdA-3klbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 4 GLU X 339
ALA X 430
GLY X 473
TYR X 474
 None
 1.07A 5uxdA-3kvnX:
undetectable		 5uxdA-3kvnX:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 GLU A 325
ALA A 203
GLY A 206
TYR A 207
 None
 0.76A 5uxdA-3lmdA:
undetectable		 5uxdA-3lmdA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 PHE A  86
ALA A  35
GLY A  31
TYR A  15
 None
 1.03A 5uxdA-3qfkA:
undetectable		 5uxdA-3qfkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 GLU A 377
ALA A 289
GLY A 127
TYR A 128
 None
 0.92A 5uxdA-3so4A:
undetectable		 5uxdA-3so4A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um9 HALOACID
DEHALOGENASE, TYPE
II

(Polaromonas sp.
JS666) 		PF13419
(HAD_2) 		4 PHE A 173
GLY A  13
TYR A  12
TYR A  16
 None
None
SO4  A 231 (-4.3A)
None
 1.06A 5uxdA-3um9A:
undetectable		 5uxdA-3um9A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 GLU A   4
ALA A   8
GLY A  12
TYR A   7
 None
 1.07A 5uxdA-3uyqA:
undetectable		 5uxdA-3uyqA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 TYR A 124
PHE A 147
ALA A 246
GLY A 514
 None
 1.00A 5uxdA-3wfaA:
undetectable		 5uxdA-3wfaA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Thermosynechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLU A  30
ALA A  70
GLY A  72
TYR A  69
 None
 0.78A 5uxdA-3zdfA:
undetectable		 5uxdA-3zdfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 GLU A 423
TYR A 430
ALA A 531
GLY A 533
 None
DMU  A1774 (-4.7A)
None
K  A1772 ( 4.6A)
 0.93A 5uxdA-4a01A:
1.1		 5uxdA-4a01A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 GLU A 381
TYR A 388
ALA A 489
GLY A 491
 None
 0.96A 5uxdA-4av6A:
1.3		 5uxdA-4av6A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhy ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 TYR A 273
ALA A 256
GLY A 253
TYR A 254
 None
 0.97A 5uxdA-4bhyA:
undetectable		 5uxdA-4bhyA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE L 102
ALA H  97
GLY H  99
TYR H  33
 None
 0.93A 5uxdA-4ht1L:
undetectable		 5uxdA-4ht1L:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 4 ALA A 224
GLY A 220
TYR A 221
TYR A 218
 None
 1.01A 5uxdA-4iegA:
undetectable		 5uxdA-4iegA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLU A  80
ALA A 302
GLY A 305
TYR A 306
 None
 0.65A 5uxdA-4l9rA:
undetectable		 5uxdA-4l9rA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 GLU B 381
ALA B 303
GLY B 305
TYR B 307
 None
 0.84A 5uxdA-4m69B:
4.4		 5uxdA-4m69B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt0 MTRE PROTEIN

(Neisseria
gonorrhoeae) 		PF02321
(OEP) 		4 ALA A 153
GLY A 150
TYR A 151
TYR A  91
 None
 1.01A 5uxdA-4mt0A:
undetectable		 5uxdA-4mt0A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE

(Alicyclobacillus
acidocaldarius) 		PF00016
(RuBisCO_large) 		4 GLU A 189
ALA A 231
GLY A 234
TYR A 212
 None
 1.08A 5uxdA-4nasA:
undetectable		 5uxdA-4nasA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI

(Staphylococcus
aureus) 		PF02976
(MutH) 		4 GLU A 117
TYR A  78
PHE A  70
GLY A  19
 None
 1.07A 5uxdA-4pxgA:
undetectable		 5uxdA-4pxgA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 TYR A 352
ALA A  81
GLY A  78
TYR A  77
 None
 1.07A 5uxdA-4qavA:
undetectable		 5uxdA-4qavA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		4 ALA A 243
GLY A 431
TYR A 432
TYR A 429
 None
 0.94A 5uxdA-4r12A:
undetectable		 5uxdA-4r12A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 GLU A 121
ALA A   6
GLY A 175
TYR A   5
 None
 0.80A 5uxdA-4x0oA:
undetectable		 5uxdA-4x0oA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo3 ACYLHOMOSERINE
LACTONASE

(Chryseobacterium
sp. StRB126) 		PF00753
(Lactamase_B) 		4 TYR A 255
PHE A 302
ALA A  94
GLY A  58
 None
 0.82A 5uxdA-4zo3A:
undetectable		 5uxdA-4zo3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 ALA A 397
GLY A 400
TYR A 399
TYR A 702
 None
 0.98A 5uxdA-4zr5A:
1.8		 5uxdA-4zr5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II) 		4 PHE A 195
ALA A 208
GLY A 174
TYR A 177
 None
 1.02A 5uxdA-5b47A:
undetectable		 5uxdA-5b47A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czv NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 3

(Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		4 TYR A1624
PHE A1622
ALA A1537
GLY A1494
 None
 0.91A 5uxdA-5czvA:
undetectable		 5uxdA-5czvA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmk BETA CHAIN OF MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS II,
I-AG7,H2-AB1 PROTEIN

(Mus musculus) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 GLU B  88
PHE B  18
ALA B  79
GLY B -24
 None
 1.09A 5uxdA-5dmkB:
undetectable		 5uxdA-5dmkB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqw PUTATIVE MAJOR COAT
PROTEIN

(Acidianus
tailed spindle
virus) 		no annotation 4 GLU A 125
ALA A  12
GLY A  14
TYR A  11
 None
 0.91A 5uxdA-5eqwA:
2.0		 5uxdA-5eqwA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1b GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		4 GLU A 178
PHE A 176
ALA A 152
GLY A  87
 None
 1.05A 5uxdA-5f1bA:
undetectable		 5uxdA-5f1bA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 4 ALA A 321
GLY A 324
TYR A 323
TYR A 302
 None
 0.72A 5uxdA-5gqfA:
undetectable		 5uxdA-5gqfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 TYR A 313
PHE A 314
ALA A 396
GLY A 394
 None
None
ZN  A1001 ( 4.5A)
None
 1.07A 5uxdA-5j6sA:
undetectable		 5uxdA-5j6sA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 PHE A 285
ALA A 273
GLY A 245
TYR A 247
 None
 1.08A 5uxdA-5jseA:
undetectable		 5uxdA-5jseA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0t METHIONINE--TRNA
LIGASE

(Brucella suis) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 PHE A 165
ALA A 124
GLY A 125
TYR A 127
 None
 0.90A 5uxdA-5k0tA:
2.0		 5uxdA-5k0tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kck ANTHRANILATE
SYNTHASE COMPONENT I

(Streptococcus
pneumoniae) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 GLU A 383
GLY A 386
TYR A  97
TYR A 388
 None
 0.94A 5uxdA-5kckA:
undetectable		 5uxdA-5kckA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 GLU A 657
ALA A 789
GLY A 792
TYR A 796
 None
 0.54A 5uxdA-5lewA:
undetectable		 5uxdA-5lewA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		4 PHE A 267
ALA A 256
GLY A 235
TYR A 234
 None
 1.05A 5uxdA-5m60A:
undetectable		 5uxdA-5m60A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi PLASTID RIBOSOMAL
PROTEIN UL5C

(Spinacia
oleracea) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		4 PHE F  73
ALA F 213
GLY F 179
TYR F 181
 None
 0.87A 5uxdA-5mmiF:
undetectable		 5uxdA-5mmiF:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3

(Saccharomyces
cerevisiae) 		PF05327
(RRN3) 		4 PHE O 491
ALA O 429
GLY O 425
TYR O 427
 None
 1.04A 5uxdA-5n5zO:
undetectable		 5uxdA-5n5zO:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 4 GLU A  34
TYR A 253
ALA A  60
GLY A  58
 None
None
MG  A1002 ( 4.7A)
SAH  A1001 (-3.3A)
 1.06A 5uxdA-5njuA:
undetectable		 5uxdA-5njuA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns3 50S RIBOSOMAL
PROTEIN L5

(Thermus
thermophilus) 		no annotation 4 PHE A  23
ALA A 163
GLY A 129
TYR A 131
 None
 0.94A 5uxdA-5ns3A:
undetectable		 5uxdA-5ns3A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L5

(Mycolicibacterium
smegmatis) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		4 PHE F  27
ALA F 167
GLY F 133
TYR F 135
 None
 0.87A 5uxdA-5o60F:
undetectable		 5uxdA-5o60F:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		4 PHE A 734
ALA A 685
GLY A 457
TYR A 687
 None
 1.04A 5uxdA-5szsA:
undetectable		 5uxdA-5szsA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 GLU A 375
ALA A 287
GLY A 127
TYR A 128
 None
 0.98A 5uxdA-5t8tA:
undetectable		 5uxdA-5t8tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tws HUMAN DNA POLYMERASE
MU

(Homo sapiens) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 GLU A 165
TYR A 234
ALA A 251
GLY A 247
 None
None
None
NA  A 508 ( 4.7A)
 1.06A 5uxdA-5twsA:
undetectable		 5uxdA-5twsA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz HEMAGGLUTININ HA1
HEMAGGLUTININ HA2

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ALA B 536
GLY B 523
TYR B 522
TYR A  11
 None
 1.10A 5uxdA-5ujzB:
undetectable		 5uxdA-5ujzB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor) 		no annotation 4 TYR A  82
ALA A 106
GLY A 159
TYR A 157
 None
 0.94A 5uxdA-5ukgA:
undetectable		 5uxdA-5ukgA:
18.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		5 GLU A 196
TYR A 198
ALA A 268
GLY A 271
TYR A 275
 None
 0.56A 5uxdA-5uxbA:
41.8		 5uxdA-5uxbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7o NOSK

(Streptomyces
actuosus) 		PF12697
(Abhydrolase_6) 		4 PHE A 244
ALA A 101
GLY A 106
TYR A 103
 None
 1.05A 5uxdA-5v7oA:
undetectable		 5uxdA-5v7oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 4 GLU A   7
PHE A   9
GLY A 330
TYR A 334
 None
 0.98A 5uxdA-5w19A:
undetectable		 5uxdA-5w19A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 4 GLU M 124
TYR M 126
ALA M 141
GLY M 145
 None
 1.06A 5uxdA-5wc8M:
undetectable		 5uxdA-5wc8M:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 4 TYR B 918
PHE B 922
ALA B 869
GLY B 873
 None
 1.09A 5uxdA-5wfcB:
undetectable		 5uxdA-5wfcB:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 TYR A1277
ALA A 447
GLY A 449
TYR A 453
 A  B  -3 ( 4.7A)
None
None
None
 0.97A 5uxdA-5wlhA:
2.9		 5uxdA-5wlhA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 4 GLU A 178
PHE A 176
ALA A 152
GLY A  87
 None
 1.05A 5uxdA-6f5uA:
undetectable		 5uxdA-6f5uA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f6s ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 4 GLU A 178
PHE A 176
ALA A 152
GLY A  87
 GOL  A 506 (-4.0A)
None
None
None
 1.06A 5uxdA-6f6sA:
undetectable		 5uxdA-6f6sA:
14.19