SIMILAR PATTERNS OF AMINO ACIDS FOR 5UXC_A_ZITA307

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ASP A 585
GLU A 559
ARG A 547
THR A 589
 None
 1.45A 5uxcA-1amoA:
0.0		 5uxcA-1amoA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1d L-PHENYLALANINE
DEHYDROGENASE

(Rhodococcus sp.) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ASP A 329
GLU A 268
ARG A 338
THR A 332
 None
 1.17A 5uxcA-1c1dA:
0.0		 5uxcA-1c1dA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		4 ASP A  87
PRO A 106
GLU A 110
ARG A  84
 None
 1.43A 5uxcA-1fp9A:
0.0		 5uxcA-1fp9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fqt RIESKE-TYPE
FERREDOXIN OF
BIPHENYL DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00355
(Rieske) 		4 ASP A  47
PRO A  82
GLU A  84
THR A  44
 None
FES  A1001 ( 4.4A)
GOL  A 901 (-4.0A)
None
 1.48A 5uxcA-1fqtA:
0.0		 5uxcA-1fqtA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ASP A  30
PRO A  22
GLU A  55
THR A  25
 None
 1.10A 5uxcA-1gvhA:
undetectable		 5uxcA-1gvhA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE
TRPG

(Serratia
marcescens) 		PF00117
(GATase)
PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ASP B  19
PRO B  57
ARG A 375
THR B  14
 None
GLU  B1401 (-3.8A)
None
None
 1.02A 5uxcA-1i7qB:
0.0		 5uxcA-1i7qB:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr6 HELICASE NS3

(Hepacivirus C) 		PF00271
(Helicase_C) 		4 ASP A 106
PRO A 135
GLU A 137
THR A 104
 None
 1.35A 5uxcA-1jr6A:
0.0		 5uxcA-1jr6A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ASP A 343
PRO A 231
GLU A 334
THR A 338
 None
 1.38A 5uxcA-1jx2A:
1.1		 5uxcA-1jx2A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		4 PRO A 372
GLU A 407
ARG A 393
THR A 389
 None
 1.34A 5uxcA-1sh2A:
undetectable		 5uxcA-1sh2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		4 ASP A 397
PRO A 389
GLU A 326
THR A 392
 None
 1.22A 5uxcA-1szqA:
0.9		 5uxcA-1szqA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t11 TRIGGER FACTOR

(Vibrio cholerae) 		PF00254
(FKBP_C)
PF05697
(Trigger_N)
PF05698
(Trigger_C) 		4 PRO A 303
GLU A 142
ARG A 145
THR A 143
 None
 1.50A 5uxcA-1t11A:
undetectable		 5uxcA-1t11A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 ASP A 409
PRO A 561
ARG A 411
THR A 634
 None
 1.27A 5uxcA-1u1hA:
undetectable		 5uxcA-1u1hA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		4 ASP A 392
GLU A 345
ARG A 346
THR A 356
 None
 1.41A 5uxcA-1uwiA:
undetectable		 5uxcA-1uwiA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 ASP A 581
PRO A 628
GLU A 629
THR A 627
 None
 1.35A 5uxcA-1yiqA:
undetectable		 5uxcA-1yiqA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]

(Yellow fever
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 PRO A 450
GLU A 480
ARG A 431
THR A 432
 None
 1.49A 5uxcA-1yksA:
undetectable		 5uxcA-1yksA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		4 ASP A 214
PRO A 154
GLU A 178
ARG A 231
 None
 1.32A 5uxcA-2br4A:
undetectable		 5uxcA-2br4A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ASP A 429
PRO A 456
GLU A 543
THR A 541
 None
 1.08A 5uxcA-2cfmA:
undetectable		 5uxcA-2cfmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ASP A 538
GLU A 543
ARG A 544
THR A 541
 None
 1.37A 5uxcA-2cfmA:
undetectable		 5uxcA-2cfmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 PRO A 456
GLU A 543
ARG A 544
THR A 541
 None
 1.47A 5uxcA-2cfmA:
undetectable		 5uxcA-2cfmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1h TRANSCRIPTION
ELONGATION FACTOR
S-II

(Trypanosoma
brucei) 		PF00855
(PWWP) 		4 ASP A  88
PRO A  77
GLU A  97
ARG A  94
 None
 1.40A 5uxcA-2m1hA:
undetectable		 5uxcA-2m1hA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyu INOSINE TRIPHOSPHATE
PYROPHOSPHATASE RDGB

(Escherichia
coli) 		PF01725
(Ham1p_like) 		4 ASP A 157
GLU A 175
ARG A 174
THR A 173
 IMP  A3036 (-2.9A)
None
None
None
 1.21A 5uxcA-2pyuA:
undetectable		 5uxcA-2pyuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		4 ASP A 338
PRO A 308
ARG A 333
THR A 334
 None
 1.33A 5uxcA-2q01A:
1.3		 5uxcA-2q01A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF11934
(DUF3452) 		4 ASP A 111
PRO A  67
GLU A  72
ARG A  73
 None
 1.49A 5uxcA-2qdjA:
1.1		 5uxcA-2qdjA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		4 ASP A 103
PRO A 481
GLU A 167
THR A 108
 None
 1.30A 5uxcA-2vroA:
undetectable		 5uxcA-2vroA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A  40
PRO A 111
GLU A 113
THR A 110
 None
 1.48A 5uxcA-2w4oA:
3.7		 5uxcA-2w4oA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 PRO A 165
GLU A 464
ARG A 463
THR A 469
 None
GOL  A1491 (-4.3A)
None
None
 1.27A 5uxcA-2xdrA:
undetectable		 5uxcA-2xdrA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01083
(Cutinase) 		4 ASP A 160
PRO A 126
GLU A 149
THR A 153
 None
 1.42A 5uxcA-3ajaA:
undetectable		 5uxcA-3ajaA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01083
(Cutinase) 		4 PRO A 126
GLU A 149
ARG A 152
THR A 153
 None
 1.15A 5uxcA-3ajaA:
undetectable		 5uxcA-3ajaA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8y ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		4 ASP A 223
PRO A 306
GLU A 310
ARG A 252
 None
None
None
ADA  A 901 ( 3.7A)
 1.36A 5uxcA-3b8yA:
undetectable		 5uxcA-3b8yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 ASP A 124
PRO A  70
GLU A  74
THR A 119
 None
 1.42A 5uxcA-3e53A:
undetectable		 5uxcA-3e53A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebj POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 ASP A 111
PRO A 103
GLU A 141
THR A 143
 None
 1.00A 5uxcA-3ebjA:
undetectable		 5uxcA-3ebjA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ASP A  50
PRO A 278
GLU A  57
THR A  47
 None
 1.28A 5uxcA-3g1zA:
undetectable		 5uxcA-3g1zA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 384
PRO A  43
GLU A  40
ARG A 401
 None
 1.17A 5uxcA-3gyrA:
undetectable		 5uxcA-3gyrA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9i LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		4 PRO A  69
GLU A  16
ARG A  85
THR A  72
 None
 1.43A 5uxcA-3m9iA:
undetectable		 5uxcA-3m9iA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p39 NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		4 ASP A  87
GLU A  91
ARG A 143
THR A  89
 None
 1.42A 5uxcA-3p39A:
undetectable		 5uxcA-3p39A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 ASP A 185
GLU A 138
ARG A 180
THR A 182
 None
 1.15A 5uxcA-3pkjA:
undetectable		 5uxcA-3pkjA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuc GALECTIN

(Xenopus laevis) 		PF00337
(Gal-bind_lectin) 		4 ASP A  96
PRO A 109
GLU A 107
THR A  99
 None
 1.41A 5uxcA-3wucA:
undetectable		 5uxcA-3wucA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 ASP A 185
GLU A 138
ARG A 180
THR A 182
 None
 1.05A 5uxcA-3zg6A:
undetectable		 5uxcA-3zg6A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyt ESTERASE A

(Paenarthrobacter
nitroguajacolicus) 		PF00144
(Beta-lactamase) 		4 ASP A 333
PRO A 273
ARG A  36
THR A 263
 None
 1.45A 5uxcA-3zytA:
undetectable		 5uxcA-3zytA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Escherichia
coli) 		PF04378
(RsmJ) 		4 ASP A 123
GLU A 140
ARG A 128
THR A 117
 None
 1.48A 5uxcA-4bluA:
undetectable		 5uxcA-4bluA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cog KYNURENINE
FORMAMIDASE

(Burkholderia
cenocepacia) 		PF04199
(Cyclase) 		4 ASP A 145
PRO A  16
GLU A 117
ARG A 113
 None
 1.30A 5uxcA-4cogA:
undetectable		 5uxcA-4cogA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3l BMAL1B
CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		4 ASP A 317
PRO B 426
GLU B 432
ARG B 343
 None
 1.14A 5uxcA-4f3lA:
undetectable		 5uxcA-4f3lA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea) 		PF00230
(MIP) 		4 PRO A 102
GLU A  44
ARG A 118
THR A 105
 None
 1.33A 5uxcA-4ia4A:
0.8		 5uxcA-4ia4A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj0 VP1 CAPSID PROTEIN

(Human
polyomavirus 1) 		PF00718
(Polyoma_coat) 		4 ASP A  74
PRO A  80
GLU A 206
THR A 170
 None
 1.49A 5uxcA-4mj0A:
undetectable		 5uxcA-4mj0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nef AQUAPORIN-2

(Homo sapiens) 		PF00230
(MIP) 		4 PRO A  69
GLU A  16
ARG A  85
THR A  72
 None
 1.35A 5uxcA-4nefA:
undetectable		 5uxcA-4nefA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		4 ASP A 307
PRO A 312
ARG A 208
THR A 309
 None
None
UDP  A 401 ( 3.2A)
None
 1.38A 5uxcA-4nesA:
undetectable		 5uxcA-4nesA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opa NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		no annotation 4 ASP B  87
GLU B  91
ARG B 143
THR B  89
 None
 1.30A 5uxcA-4opaB:
undetectable		 5uxcA-4opaB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u36 SEED LECTIN

(Vatairea
macrocarpa) 		PF00139
(Lectin_legB) 		4 ASP A  87
PRO A  42
GLU A  78
THR A 220
 TNR  A 303 (-2.7A)
None
None
None
 1.37A 5uxcA-4u36A:
undetectable		 5uxcA-4u36A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ASP A 526
PRO A 256
GLU A 257
THR A 262
 None
 1.45A 5uxcA-4z2aA:
undetectable		 5uxcA-4z2aA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 ASP A 102
GLU A 116
ARG A 125
THR A 128
 None
 1.38A 5uxcA-5a0tA:
undetectable		 5uxcA-5a0tA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5x AQUAPORIN-5

(Homo sapiens) 		PF00230
(MIP) 		4 PRO A  70
GLU A  17
ARG A  86
THR A  73
 None
 1.36A 5uxcA-5c5xA:
undetectable		 5uxcA-5c5xA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ca5 NONO-1

(Caenorhabditis
elegans) 		PF00076
(RRM_1)
PF08075
(NOPS) 		4 ASP A 158
GLU A 235
ARG A 160
THR A 113
 None
 1.35A 5uxcA-5ca5A:
undetectable		 5uxcA-5ca5A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckq MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Rattus
norvegicus) 		PF00431
(CUB)
PF14670
(FXa_inhibition) 		4 ASP A  57
PRO A  83
GLU A  75
ARG A  74
 CA  A 305 (-2.7A)
None
None
None
 1.04A 5uxcA-5ckqA:
undetectable		 5uxcA-5ckqA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckq MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Rattus
norvegicus) 		PF00431
(CUB)
PF14670
(FXa_inhibition) 		4 PRO A  83
GLU A  75
ARG A  74
THR A  82
 None
 1.09A 5uxcA-5ckqA:
undetectable		 5uxcA-5ckqA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ASP A 800
PRO A 761
GLU A 838
ARG A 795
 None
 1.29A 5uxcA-5i2gA:
1.3		 5uxcA-5i2gA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 ASP A 262
PRO A 258
GLU A 246
ARG A 219
 None
 1.50A 5uxcA-5i2hA:
1.0		 5uxcA-5i2hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE

(Thermobifida
fusca) 		PF03807
(F420_oxidored) 		4 ASP A  91
PRO A 127
GLU A 129
ARG A  94
 None
 1.49A 5uxcA-5n2iA:
undetectable		 5uxcA-5n2iA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 4 ASP A 294
PRO A  43
ARG A 260
THR A 263
 None
 1.47A 5uxcA-5o9wA:
undetectable		 5uxcA-5o9wA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy9 GLYCOPROTEIN G
LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens;
Indiana
vesiculovirus) 		no annotation 4 ASP A 334
GLU D 119
ARG A 354
THR A 352
 None
CA  D1001 (-2.9A)
None
None
 0.87A 5uxcA-5oy9A:
undetectable		 5uxcA-5oy9A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 4 ASP B 315
PRO B 152
GLU B 322
ARG B  81
 None
 1.35A 5uxcA-5thzB:
undetectable		 5uxcA-5thzB:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Desulfovibrio
vulgaris) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASP A 139
GLU A 143
ARG A 115
THR A 141
 None
 1.44A 5uxcA-5tx7A:
undetectable		 5uxcA-5tx7A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8e ARGININE KINASE

(Polybetes
pythagoricus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ASP A 174
PRO A 205
GLU A 149
THR A 171
 None
 1.30A 5uxcA-5u8eA:
0.2		 5uxcA-5u8eA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 4 ASP A 209
PRO A 149
ARG A 146
THR A 147
 None
PHB  A 602 (-4.7A)
None
PHB  A 602 (-4.5A)
 1.39A 5uxcA-5w1eA:
undetectable		 5uxcA-5w1eA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybl MULTIFUNCTIONAL
DIOXYGENASE AUSE

(Aspergillus
nidulans) 		no annotation 4 ASP A 204
GLU A 119
ARG A 226
THR A 158
 None
None
AKG  A 302 (-3.0A)
None
 1.44A 5uxcA-5yblA:
undetectable		 5uxcA-5yblA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN DEPDC5

(Homo sapiens) 		no annotation 4 ASP D 297
GLU D 344
ARG D 223
THR D 300
 None
 1.41A 5uxcA-6cetD:
undetectable		 5uxcA-6cetD:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 4 PRO M 150
GLU M 162
ARG M 160
THR M 152
 None
 1.49A 5uxcA-6criM:
undetectable		 5uxcA-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgk -

(-) 		no annotation 4 ASP A  92
GLU A  96
ARG A 148
THR A  94
 None
 1.27A 5uxcA-6dgkA:
undetectable		 5uxcA-6dgkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 4 PRO A 122
GLU A 118
ARG A 114
THR A 117
 None
 1.48A 5uxcA-6enzA:
undetectable		 5uxcA-6enzA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-4

(Rattus
norvegicus) 		no annotation 4 ASP 7  69
GLU 7 244
ARG 7  88
THR 7 237
 None
 1.05A 5uxcA-6epd7:
undetectable		 5uxcA-6epd7:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esb CAPSID PROTEIN VP1

(Human
polyomavirus 1) 		no annotation 4 ASP 1  74
PRO 1  80
GLU 1 206
THR 1 170
 None
 1.49A 5uxcA-6esb1:
undetectable		 5uxcA-6esb1:
13.22