SIMILAR PATTERNS OF AMINO ACIDS FOR 5UXC_A_ZITA306_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		4 THR A 149
PHE A  72
ASP A 179
LEU A 169
 None
 1.15A 5uxcA-1bsgA:
undetectable		 5uxcA-1bsgA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5w MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ARG A  81
PHE A  78
LEU A  29
SER A   6
 None
 1.15A 5uxcA-1e5wA:
0.0		 5uxcA-1e5wA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eh5 PALMITOYL PROTEIN
THIOESTERASE 1

(Bos taurus) 		PF02089
(Palm_thioest) 		4 THR A 234
PHE A 230
LEU A 290
SER A 138
 None
 1.30A 5uxcA-1eh5A:
undetectable		 5uxcA-1eh5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 THR A 149
PHE A  72
ASP A 179
LEU A 169
 None
 1.20A 5uxcA-1g68A:
0.0		 5uxcA-1g68A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7l SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSA

(Bacillus
subtilis) 		PF00535
(Glycos_transf_2) 		4 ARG A  59
PHE A  32
LEU A 107
SER A  23
 None
 1.16A 5uxcA-1h7lA:
0.0		 5uxcA-1h7lA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		4 THR A 246
ARG A 245
PHE A 244
LEU A 101
 None
 1.12A 5uxcA-1i5pA:
2.1		 5uxcA-1i5pA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		4 THR A 149
PHE A  72
ASP A 179
LEU A 169
 None
 1.24A 5uxcA-1n9bA:
0.0		 5uxcA-1n9bA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 THR A 173
ARG A 190
PHE A 171
LEU A 167
 None
 1.23A 5uxcA-1ps9A:
0.4		 5uxcA-1ps9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		4 THR B  31
ARG A 484
LEU B  24
SER B  70
 None
 1.11A 5uxcA-1r4nB:
undetectable		 5uxcA-1r4nB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rut FUSION PROTEIN OF
LMO4 PROTEIN AND LIM
DOMAIN-BINDING
PROTEIN 1

(Mus musculus) 		PF00412
(LIM) 		4 PHE X  81
ARG X  79
ASP X  76
LEU X  72
 None
None
ZN  X 602 (-3.0A)
None
 1.09A 5uxcA-1rutX:
undetectable		 5uxcA-1rutX:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1

(Mus musculus) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		4 ARG A 160
PHE A 124
ARG A 186
ASP A 156
 None
 1.31A 5uxcA-1xhbA:
undetectable		 5uxcA-1xhbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybd URIDYLATE KINASE

(Neisseria
meningitidis) 		PF00696
(AA_kinase) 		4 THR A 237
ARG A 183
PHE A 218
LEU A 162
 None
 1.17A 5uxcA-1ybdA:
undetectable		 5uxcA-1ybdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 THR A 149
PHE A  72
ASP A 179
LEU A 169
 None
 1.19A 5uxcA-1zg4A:
undetectable		 5uxcA-1zg4A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		4 THR A 336
PHE A 303
LEU A 307
SER A  69
 None
 1.04A 5uxcA-1zkdA:
undetectable		 5uxcA-1zkdA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN

(Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ARG A 106
PHE A  50
LEU A  89
SER A  97
 None
 1.15A 5uxcA-2be7A:
undetectable		 5uxcA-2be7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dl3 SORBIN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF07653
(SH3_2) 		4 THR A  57
ARG A  56
PHE A  54
LEU A  26
 None
 1.19A 5uxcA-2dl3A:
undetectable		 5uxcA-2dl3A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 THR A   6
ARG A   9
LEU A  52
SER A  27
 None
 1.26A 5uxcA-2fbqA:
undetectable		 5uxcA-2fbqA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx5 HYPOTHETICAL PROTEIN

(Prochlorococcus
marinus) 		PF13279
(4HBT_2) 		4 ARG A 118
PHE A  99
LEU A 140
SER A  40
 None
 1.11A 5uxcA-2hx5A:
undetectable		 5uxcA-2hx5A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7m HYALURONIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 THR A 673
ARG A 740
ASP A 742
SER A 746
 None
 1.31A 5uxcA-2j7mA:
undetectable		 5uxcA-2j7mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		4 THR A 282
PHE A 274
ASP A 278
LEU A 239
 None
 1.17A 5uxcA-2jakA:
undetectable		 5uxcA-2jakA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l10 TALIN-1

(Mus musculus) 		PF08913
(VBS) 		4 PHE A1274
ASP A1277
LEU A1249
SER A1309
 None
 1.06A 5uxcA-2l10A:
2.7		 5uxcA-2l10A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		4 THR A   4
PHE A   6
LEU A 121
SER A  66
 None
 1.21A 5uxcA-2nwqA:
undetectable		 5uxcA-2nwqA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE

(Thermus
thermophilus) 		PF01370
(Epimerase) 		4 ARG A  60
PHE A  62
LEU A 100
SER A  71
 None
 1.14A 5uxcA-2p5uA:
undetectable		 5uxcA-2p5uA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7j PUTATIVE SENSORY
BOX/GGDEF FAMILY
PROTEIN

(Vibrio
parahaemolyticus) 		PF02743
(dCache_1) 		4 ARG A  82
PHE A  83
LEU A  49
SER A 158
 SO4  A 501 (-3.2A)
None
None
None
 1.06A 5uxcA-2p7jA:
undetectable		 5uxcA-2p7jA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 ARG A 960
PHE A 959
LEU A1152
SER A1011
 None
 1.25A 5uxcA-2rhpA:
undetectable		 5uxcA-2rhpA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		4 THR A 393
ARG A 392
LEU A 483
SER A 417
 None
 1.12A 5uxcA-2vrkA:
undetectable		 5uxcA-2vrkA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ARG A 235
PHE A 236
LEU A 265
SER A 222
 None
None
KCX  A 262 ( 4.4A)
UAG  A1498 (-2.6A)
 1.16A 5uxcA-2wtzA:
undetectable		 5uxcA-2wtzA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A  64
ASP A  58
LEU A 116
SER A 241
 None
GOL  A1726 (-3.1A)
GOL  A1726 ( 4.8A)
None
 0.99A 5uxcA-2x40A:
undetectable		 5uxcA-2x40A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ARG B1405
PHE B1439
LEU B1364
SER B1384
 None
 1.24A 5uxcA-2xwbB:
undetectable		 5uxcA-2xwbB:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 PHE A  84
ARG A 122
ASP A  85
SER A  93
 None
 1.22A 5uxcA-2zpaA:
2.4		 5uxcA-2zpaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		4 ARG A 413
PHE A 246
LEU A 401
SER A 243
 None
 1.30A 5uxcA-2zu0A:
undetectable		 5uxcA-2zu0A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 ARG A 387
PHE A 508
LEU A 395
SER A 465
 None
 1.11A 5uxcA-3a9sA:
undetectable		 5uxcA-3a9sA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 ARG A  51
ASP A  45
LEU A  99
SER A 224
 GOL  A5001 ( 4.7A)
GOL  A5001 (-3.1A)
GOL  A5001 ( 3.9A)
None
 1.25A 5uxcA-3abzA:
undetectable		 5uxcA-3abzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		4 THR A 154
PHE A 152
LEU A 148
SER A 222
 None
 1.08A 5uxcA-3bc8A:
undetectable		 5uxcA-3bc8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1l PUTATIVE ANTIOXIDANT
DEFENSE PROTEIN
MLR4105

(Mesorhizobium
japonicum) 		PF02627
(CMD) 		4 ARG A 145
PHE A 149
ASP A 156
LEU A  64
 None
 1.03A 5uxcA-3c1lA:
undetectable		 5uxcA-3c1lA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwz BETA-LACTAMASE

(Mycobacterium
tuberculosis) 		PF13354
(Beta-lactamase2) 		4 THR A 165
PHE A  86
ASP A 195
LEU A 185
 None
 1.22A 5uxcA-3dwzA:
undetectable		 5uxcA-3dwzA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ARG A 435
PHE A 466
LEU A 480
SER A  51
 None
 1.30A 5uxcA-3eh2A:
undetectable		 5uxcA-3eh2A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE

(Azospirillum
brasilense) 		PF00701
(DHDPS) 		4 THR A  34
ARG A 288
PHE A  31
LEU A  37
 None
PO4  A 405 (-3.9A)
None
None
 1.25A 5uxcA-3fkrA:
undetectable		 5uxcA-3fkrA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 THR A 392
PHE A 345
LEU A 369
SER A 378
 FMT  A 510 ( 3.9A)
None
None
None
 1.30A 5uxcA-3ll7A:
undetectable		 5uxcA-3ll7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		4 THR A 177
PHE A 138
LEU A 146
SER A 115
 None
 1.19A 5uxcA-3lrkA:
2.2		 5uxcA-3lrkA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1k PROTEIN STWHY2

(Solanum
tuberosum) 		PF08536
(Whirly) 		4 THR A  98
PHE A 116
LEU A 118
SER A 135
 None
 1.11A 5uxcA-3n1kA:
undetectable		 5uxcA-3n1kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 THR A 122
ARG A 121
ARG A 157
ASP A 192
 None
 1.24A 5uxcA-3nvlA:
undetectable		 5uxcA-3nvlA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 363
ARG A 202
ASP A 322
SER A 276
 SO4  A   4 (-4.1A)
SO4  A   4 (-3.8A)
None
None
 1.29A 5uxcA-3q4tA:
3.9		 5uxcA-3q4tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syx SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00568
(WH1) 		4 ARG A 114
PHE A 112
LEU A 101
SER A  41
 None
 1.29A 5uxcA-3syxA:
undetectable		 5uxcA-3syxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u07 UNCHARACTERIZED
PROTEIN VPA0106

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 ARG A 156
PHE A 138
LEU A  89
SER A  99
 None
 0.97A 5uxcA-3u07A:
undetectable		 5uxcA-3u07A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzv ANTI-DENGUE MAB 4E11
ENVELOPE PROTEIN

(Dengue virus;
Mus musculus) 		PF02832
(Flavi_glycop_C)
PF07686
(V-set) 		4 THR B  33
ARG A 323
ARG B  99
SER A 331
 EOH  B 254 (-3.2A)
None
None
None
 1.28A 5uxcA-3uzvB:
undetectable		 5uxcA-3uzvB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4q BETA-LACTAMASE

(Burkholderia
multivorans) 		PF13354
(Beta-lactamase2) 		4 THR A 149
PHE A  72
ASP A 179
LEU A 169
 None
 1.25A 5uxcA-3w4qA:
undetectable		 5uxcA-3w4qA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		4 THR A 103
PHE A 100
ARG A  98
ASP A  96
 None
 1.02A 5uxcA-3wecA:
undetectable		 5uxcA-3wecA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 THR A 149
PHE A  72
ASP A 179
LEU A 169
 None
 1.26A 5uxcA-3zdjA:
undetectable		 5uxcA-3zdjA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akv SORTING NEXIN-33

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		4 THR A 380
ARG A 377
LEU A 527
SER A 285
 None
 1.07A 5uxcA-4akvA:
4.3		 5uxcA-4akvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		4 PHE A 354
ASP A 350
LEU A 346
SER A 341
 None
 0.96A 5uxcA-4aurA:
2.4		 5uxcA-4aurA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 THR B2777
ARG B2772
PHE B2773
LEU B2654
 None
 1.30A 5uxcA-4bedB:
undetectable		 5uxcA-4bedB:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 THR A 560
ARG A 239
ASP A 237
LEU A 273
 None
 0.84A 5uxcA-4bjpA:
undetectable		 5uxcA-4bjpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ARG C 140
PHE C 155
LEU C 114
SER C 170
 None
 1.14A 5uxcA-4bujC:
2.1		 5uxcA-4bujC:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 THR A 149
PHE A  72
ASP A 179
LEU A 169
 None
 1.29A 5uxcA-4c6yA:
undetectable		 5uxcA-4c6yA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 THR A 149
PHE A  72
ASP A 179
LEU A 169
 None
 1.21A 5uxcA-4c75A:
undetectable		 5uxcA-4c75A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czd PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY

(Desulfovibrio
desulfuricans) 		PF13404
(HTH_AsnC-type)
no annotation 		4 THR A  36
ARG B  56
PHE B  57
LEU A  40
 None
 1.19A 5uxcA-4czdA:
undetectable		 5uxcA-4czdA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 THR A 505
PHE A 428
ASP A 535
LEU A 525
 None
 1.14A 5uxcA-4dxbA:
undetectable		 5uxcA-4dxbA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola) 		PF13354
(Beta-lactamase2) 		4 THR A 149
PHE A  72
ASP A 179
LEU A 169
 None
 1.14A 5uxcA-4ev4A:
undetectable		 5uxcA-4ev4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 THR A 150
ARG A 148
PHE A 181
LEU A 280
 None
 1.31A 5uxcA-4fspA:
undetectable		 5uxcA-4fspA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7v VOLTAGE-SENSOR
CONTAINING
PHOSPHATASE

(Ciona
intestinalis) 		PF00520
(Ion_trans) 		4 THR S 193
ARG S 226
ASP S 129
LEU S 157
 None
 1.08A 5uxcA-4g7vS:
2.2		 5uxcA-4g7vS:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbf PHIKZ131

(Pseudomonas
virus phiKZ) 		no annotation 4 THR A 656
PHE A 594
ARG A 651
SER A 617
 None
 1.24A 5uxcA-4gbfA:
3.2		 5uxcA-4gbfA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A 104
ASP A  98
LEU A 148
SER A 272
 BGC  A 901 ( 4.9A)
BGC  A 901 (-2.9A)
BGC  A 901 ( 4.1A)
None
 1.02A 5uxcA-4i3gA:
undetectable		 5uxcA-4i3gA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		4 THR A 266
ASP A 229
LEU A 205
SER A 244
 None
 1.15A 5uxcA-4injA:
undetectable		 5uxcA-4injA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Mus musculus) 		PF00106
(adh_short) 		4 THR A 211
ARG A 198
LEU A 116
SER A 146
 None
 1.25A 5uxcA-4k26A:
undetectable		 5uxcA-4k26A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Brugia malayi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 187
ARG A 239
ASP A 203
LEU A 200
 None
 1.19A 5uxcA-4k9dA:
undetectable		 5uxcA-4k9dA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kop SINGLE-STRANDED
DNA-BINDING PROTEIN
WHY2, MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF08536
(Whirly) 		4 THR A  95
PHE A 113
LEU A 115
SER A 132
 None
MPO  A 301 (-4.2A)
None
None
 1.17A 5uxcA-4kopA:
undetectable		 5uxcA-4kopA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		4 THR A 456
PHE A 453
LEU A 483
SER A 450
 None
 1.07A 5uxcA-4mhcA:
undetectable		 5uxcA-4mhcA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt0 MTRE PROTEIN

(Neisseria
gonorrhoeae) 		PF02321
(OEP) 		4 THR A  22
PHE A 137
ARG A 141
ASP A 135
 None
 1.24A 5uxcA-4mt0A:
undetectable		 5uxcA-4mt0A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bos taurus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR O 179
ARG O 231
ASP O 195
LEU O 192
 NAD  O 401 ( 4.9A)
None
None
None
 1.23A 5uxcA-4o59O:
undetectable		 5uxcA-4o59O:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 4 THR A  64
PHE A  68
LEU A 326
SER A 223
 None
 1.31A 5uxcA-4ofzA:
undetectable		 5uxcA-4ofzA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		4 THR A 188
PHE A 180
LEU A 163
SER A 227
 None
 1.27A 5uxcA-4ovtA:
undetectable		 5uxcA-4ovtA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		4 PHE A 220
ASP A 211
LEU A 208
SER A  95
 None
 1.25A 5uxcA-4p1cA:
undetectable		 5uxcA-4p1cA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ARG A 664
PHE A 666
LEU A 682
SER A 593
 None
 1.26A 5uxcA-4tweA:
2.5		 5uxcA-4tweA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		4 ARG A  38
PHE A  39
ARG A 334
ASP A  32
 EPE  A1341 (-3.0A)
None
None
None
 1.25A 5uxcA-4us5A:
undetectable		 5uxcA-4us5A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ARG A 438
PHE A 436
LEU A 394
SER A 537
 None
 1.06A 5uxcA-4xmvA:
undetectable		 5uxcA-4xmvA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo sapiens) 		PF05889
(SepSecS) 		4 THR A 154
PHE A 152
LEU A 148
SER A 222
 None
 1.10A 5uxcA-4zdlA:
undetectable		 5uxcA-4zdlA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 PHE A 490
ARG A 485
ASP A 491
SER A 499
 None
 1.17A 5uxcA-5a2rA:
0.7		 5uxcA-5a2rA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ARG A 588
ASP A 589
LEU A  76
SER A 103
 None
 1.00A 5uxcA-5a31A:
2.2		 5uxcA-5a31A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 THR A1717
PHE A1721
LEU A1711
SER A1342
 None
 1.28A 5uxcA-5amqA:
undetectable		 5uxcA-5amqA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		4 THR A 279
PHE A 202
ASP A 309
LEU A 299
 None
 1.18A 5uxcA-5aqaA:
undetectable		 5uxcA-5aqaA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum) 		PF13354
(Beta-lactamase2) 		4 THR A 150
PHE A  72
ASP A 180
LEU A 170
 None
 1.20A 5uxcA-5e43A:
undetectable		 5uxcA-5e43A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 THR A 142
PHE A  64
ASP A 172
LEU A 162
 None
 1.20A 5uxcA-5eoeA:
undetectable		 5uxcA-5eoeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flv HOMEOBOX PROTEIN
NKX-2.5, T-BOX
TRANSCRIPTION FACTOR
TBX5

(Mus musculus) 		PF00046
(Homeobox)
PF00907
(T-box) 		4 THR A1203
ARG A1182
ASP A1105
LEU A1135
 None
 0.90A 5uxcA-5flvA:
undetectable		 5uxcA-5flvA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxv HISTONE DEMETHYLASE
UTY

(Homo sapiens) 		PF02373
(JmjC) 		4 ARG A 896
ASP A 897
LEU A 892
SER A 889
 None
 1.30A 5uxcA-5fxvA:
undetectable		 5uxcA-5fxvA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggk PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF15711
(ILEI) 		4 THR A 176
PHE A 212
LEU A 173
SER A 195
 None
 1.27A 5uxcA-5ggkA:
undetectable		 5uxcA-5ggkA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis) 		PF13354
(Beta-lactamase2) 		4 THR A 149
PHE A  72
ASP A 179
LEU A 169
 None
 1.21A 5uxcA-5gl9A:
undetectable		 5uxcA-5gl9A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1q INNEXIN-6

(Caenorhabditis
elegans) 		PF00876
(Innexin) 		4 THR A 211
PHE A 277
LEU A 280
SER A  43
 None
 1.08A 5uxcA-5h1qA:
undetectable		 5uxcA-5h1qA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		4 ARG A 210
PHE A 212
LEU A 229
SER A 198
 None
None
None
SAM  A 301 (-2.5A)
 0.84A 5uxcA-5hfjA:
undetectable		 5uxcA-5hfjA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jja SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		4 THR A 282
PHE A 274
ASP A 278
LEU A 239
 THR  A 282 ( 0.8A)
PHE  A 274 ( 1.3A)
ASP  A 278 ( 0.6A)
LEU  A 239 ( 0.6A)
 1.25A 5uxcA-5jjaA:
undetectable		 5uxcA-5jjaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ARG A 588
ASP A 589
LEU A  76
SER A 103
 None
 1.09A 5uxcA-5lcwA:
1.8		 5uxcA-5lcwA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 THR A 149
PHE A  72
ASP A 179
LEU A 169
 EDO  A 303 ( 4.9A)
None
None
None
 1.16A 5uxcA-5ll7A:
undetectable		 5uxcA-5ll7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 THR B  46
ARG B  40
ASP B  37
LEU B  33
 None
 0.98A 5uxcA-5ltmB:
1.4		 5uxcA-5ltmB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE

(Escherichia
coli) 		PF01977
(UbiD) 		4 THR A 369
PHE A 354
LEU A 344
SER A 387
 None
 1.14A 5uxcA-5m1bA:
undetectable		 5uxcA-5m1bA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		5 THR A  23
PHE A  37
ASP A  45
LEU A  93
SER A  97
 None
 0.78A 5uxcA-5uxbA:
41.6		 5uxcA-5uxbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 4 ARG A 129
PHE A 133
LEU A  81
SER A  57
 None
 1.12A 5uxcA-5xepA:
undetectable		 5uxcA-5xepA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 THR B 484
ARG B 478
ASP B 189
SER B 167
 None
 1.09A 5uxcA-5xogB:
undetectable		 5uxcA-5xogB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0q UPF0348 PROTEIN
B4417_3650

(Bacillus
subtilis) 		no annotation 4 ARG A 187
PHE A 100
LEU A  98
SER A 172
 APC  A1001 (-2.8A)
None
None
None
 0.90A 5uxcA-5y0qA:
undetectable		 5uxcA-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 4 ARG A 231
ASP A 277
LEU A 259
SER A 287
 None
 1.16A 5uxcA-5y4gA:
undetectable		 5uxcA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 4 THR A 379
ARG A 251
ASP A 244
SER A 264
 None
 1.27A 5uxcA-6et9A:
undetectable		 5uxcA-6et9A:
13.67