SIMILAR PATTERNS OF AMINO ACIDS FOR 5UWC_G_EDTG407_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 TRP B 106
HIS B  75
SER B 110
ARG B 111
 None
None
None
BOG  B 450 (-3.6A)
 1.40A 5uwcG-1lpbB:
2.3		 5uwcG-1lpbB:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jzj INTERLEUKIN-3
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		5 TRP C 113
HIS C 115
SER C 121
LYS C 154
ARG C 165
 None
 0.69A 5uwcG-4jzjC:
24.4		 5uwcG-4jzjC:
98.96