SIMILAR PATTERNS OF AMINO ACIDS FOR 5UVM_B_ADNB207_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9y PROTEIN (PHOSDUCIN)

(Rattus
norvegicus) 		PF02114
(Phosducin) 		5 VAL C 137
PHE C 167
ASN C 222
LEU C 158
VAL C 165
 None
 0.89A 5uvmB-1b9yC:
undetectable		 5uvmB-1b9yC:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN

(Caenorhabditis
elegans) 		PF00795
(CN_hydrolase)
PF01230
(HIT) 		7 PHE A 301
ILE A 306
LEU A 333
THR A 387
VAL A 388
HIS A 392
HIS A 394
 None
None
None
None
None
None
NA  A 459 (-3.9A)
 0.60A 5uvmB-1emsA:
11.3		 5uvmB-1emsA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhi FRAGILE HISTIDINE
TRIAD PROTEIN

(Homo sapiens) 		PF01230
(HIT) 		7 PHE A   5
ILE A  10
LEU A  37
THR A  91
VAL A  92
HIS A  96
HIS A  98
 IB2  A 301 (-4.6A)
IB2  A 301 (-4.8A)
IB2  A 301 (-4.6A)
IB2  A 301 (-2.9A)
IB2  A 301 (-4.5A)
IB2  A 301 ( 3.9A)
IB2  A 301 ( 3.2A)
 0.46A 5uvmB-1fhiA:
10.9		 5uvmB-1fhiA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		5 VAL A  18
PHE A  64
ILE A  20
ILE A 318
VAL A  62
 None
 0.88A 5uvmB-1gr0A:
undetectable		 5uvmB-1gr0A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 ILE A  93
ILE A  54
ILE A  81
VAL A 137
HIS A 277
 None
 0.91A 5uvmB-1k32A:
undetectable		 5uvmB-1k32A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8d QA-2 ANTIGEN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 PHE A 116
ILE A 124
ASP A 156
ILE A 152
LEU A 114
 None
 0.83A 5uvmB-1k8dA:
undetectable		 5uvmB-1k8dA:
16.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)

(Homo sapiens) 		PF01230
(HIT) 		8 PHE A  19
ILE A  22
ASP A  43
ILE A  44
LEU A  53
VAL A 108
HIS A 112
HIS A 114
 None
 0.36A 5uvmB-1kpbA:
19.9		 5uvmB-1kpbA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A) 		PF00073
(Rhv) 		5 VAL 3  55
PHE 3  83
ILE 3  85
ILE 3 189
VAL 3  70
 None
 0.93A 5uvmB-1r1a3:
undetectable		 5uvmB-1r1a3:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE

(Salmonella
enterica) 		PF02525
(Flavodoxin_2) 		5 PHE A 109
ILE A 112
ILE A 164
ILE A  90
LEU A 161
 None
 0.96A 5uvmB-1t5bA:
undetectable		 5uvmB-1t5bA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uas ALPHA-GALACTOSIDASE

(Oryza sativa) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 ILE A  92
ILE A  76
ASN A  24
LEU A  79
THR A  31
 None
 1.00A 5uvmB-1uasA:
2.4		 5uvmB-1uasA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf8 NEURABIN-I

(Homo sapiens) 		PF00595
(PDZ) 		6 PHE A  94
ILE A  59
ILE A  24
ILE A  26
LEU A  22
VAL A  68
 None
 1.42A 5uvmB-1wf8A:
undetectable		 5uvmB-1wf8A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y23 HISTIDINE TRIAD
PROTEIN

(Bacillus
subtilis) 		PF01230
(HIT) 		8 PHE A   9
ILE A  12
ASP A  33
ILE A  34
LEU A  43
VAL A  98
HIS A 102
HIS A 104
 None
 0.48A 5uvmB-1y23A:
15.5		 5uvmB-1y23A:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7o ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Streptococcus
pneumoniae) 		PF00574
(CLP_protease) 		5 VAL A 100
ILE A 101
ILE A  75
ASP A  77
THR A 149
 None
 0.99A 5uvmB-1y7oA:
undetectable		 5uvmB-1y7oA:
32.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B

(Rattus
norvegicus) 		no annotation 5 PHE B 399
ILE B 378
ILE B 348
LEU B 360
VAL B 394
 None
 0.93A 5uvmB-2dwzB:
undetectable		 5uvmB-2dwzB:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF01230
(HIT) 		7 PHE A   3
ILE A   6
ILE A  25
ASP A  27
LEU A  37
HIS A  96
HIS A  98
 None
None
None
None
None
PO4  A 202 ( 3.7A)
PO4  A 202 ( 4.0A)
 0.46A 5uvmB-2eo4A:
13.7		 5uvmB-2eo4A:
33.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga8 HYPOTHETICAL 39.9
KDA PROTEIN

(Saccharomyces
cerevisiae) 		PF07728
(AAA_5) 		5 VAL A 239
ILE A 134
ILE A 201
LEU A 202
VAL A 159
 None
 1.00A 5uvmB-2ga8A:
undetectable		 5uvmB-2ga8A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzf GLUTAREDOXIN-1

(Ectromelia
virus) 		PF00462
(Glutaredoxin) 		5 PHE A  75
ILE A  98
ILE A  89
LEU A  86
VAL A  15
 None
 0.98A 5uvmB-2hzfA:
undetectable		 5uvmB-2hzfA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mmo THIOREDOXIN

(Plasmodium
falciparum) 		PF00085
(Thioredoxin) 		5 VAL A  55
ILE A  53
ILE A  14
ASP A  12
VAL A  60
 None
 0.97A 5uvmB-2mmoA:
undetectable		 5uvmB-2mmoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2moq IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B

(Staphylococcus
aureus) 		PF05031
(NEAT) 		5 VAL A 200
PHE A 198
ILE A 209
ILE A 223
ILE A 185
 None
 0.94A 5uvmB-2moqA:
undetectable		 5uvmB-2moqA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o90 DIHYDRONEOPTERIN
ALDOLASE

(Escherichia
coli) 		PF02152
(FolB) 		6 PHE A  30
ILE A  32
ILE A  94
ASN A 107
LEU A  96
VAL A  11
 None
 1.47A 5uvmB-2o90A:
undetectable		 5uvmB-2o90A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE

(Escherichia
coli) 		PF02611
(CDH) 		7 ILE A  37
ASP A  69
ASN A  71
LEU A  77
THR A 135
HIS A 140
HIS A 142
 None
 0.95A 5uvmB-2pofA:
8.1		 5uvmB-2pofA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbg PUTATIVE
UNCHARACTERIZED
PROTEIN ST0493

(Sulfurisphaera
tokodaii) 		no annotation 6 PHE A  17
ILE A  53
ILE A  38
ASN A  39
LEU A  49
VAL A  12
 None
 1.43A 5uvmB-2rbgA:
undetectable		 5uvmB-2rbgA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbg PUTATIVE
UNCHARACTERIZED
PROTEIN ST0493

(Sulfurisphaera
tokodaii) 		no annotation 5 PHE A  17
ILE A  53
ILE A  38
ASN A  39
VAL A  12
 None
 0.96A 5uvmB-2rbgA:
undetectable		 5uvmB-2rbgA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2trc PHOSDUCIN

(Rattus
norvegicus) 		PF02114
(Phosducin) 		5 VAL P 137
PHE P 167
ASN P 222
LEU P 158
VAL P 165
 None
 0.87A 5uvmB-2trcP:
undetectable		 5uvmB-2trcP:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Bacillus
subtilis) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		5 ILE A 161
ILE A  91
ASP A 118
ILE A 119
ASN A 120
 None
None
NAD  A1210 (-2.8A)
NAD  A1210 (-4.0A)
None
 0.93A 5uvmB-2vt2A:
undetectable		 5uvmB-2vt2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2i 2-OXOGLUTARATE
OXYGENASE

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		6 VAL A  95
PHE A 179
ILE A  68
ILE A 137
LEU A 177
HIS A 202
 None
 1.33A 5uvmB-2w2iA:
undetectable		 5uvmB-2w2iA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvx CHELATASE, PUTATIVE

(Desulfovibrio
vulgaris) 		PF06180
(CbiK) 		5 ILE A 122
ILE A  90
ASP A 161
ILE A 162
VAL A 180
 None
 0.94A 5uvmB-2xvxA:
undetectable		 5uvmB-2xvxA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bal ACETYLACETONE-CLEAVI
NG ENZYME

(Acinetobacter
johnsonii) 		no annotation 6 PHE A 125
ILE A 136
LEU A 123
THR A 107
HIS A  62
HIS A  64
 None
None
None
None
ZN  A 154 (-3.4A)
ZN  A 154 (-3.3A)
 1.23A 5uvmB-3balA:
undetectable		 5uvmB-3balA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		6 VAL A 176
ILE A 179
ILE A 203
ASP A 205
HIS A 277
HIS A 279
 None
None
DD2  A 901 ( 4.2A)
DD2  A 901 (-3.2A)
None
None
 1.18A 5uvmB-3bl9A:
9.9		 5uvmB-3bl9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A2128
ILE A3017
LEU A3014
THR A2089
VAL A2138
 None
 0.99A 5uvmB-3cmtA:
undetectable		 5uvmB-3cmtA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvz S-LAYER PROTEIN

(Clostridioides
difficile) 		PF12211
(LMWSLP_N) 		5 VAL A  36
PHE A  83
ILE A  34
ASN A  69
VAL A  81
 None
 0.75A 5uvmB-3cvzA:
undetectable		 5uvmB-3cvzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		5 VAL A  33
PHE A  70
ILE A  48
ASN A  83
LEU A  71
 None
 1.01A 5uvmB-3e49A:
undetectable		 5uvmB-3e49A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f11 IRON TRANSPORT
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 VAL A 128
ILE A 123
ILE A 296
THR A 143
VAL A 317
 None
 0.97A 5uvmB-3f11A:
undetectable		 5uvmB-3f11A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		5 VAL A   3
PHE A   7
ILE A 239
LEU A 295
VAL A 257
 None
 0.90A 5uvmB-3fqdA:
undetectable		 5uvmB-3fqdA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		5 VAL A  55
ILE A  24
ILE A 197
ASN A 164
VAL A  13
 None
 0.79A 5uvmB-3fs2A:
undetectable		 5uvmB-3fs2A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		5 VAL A  31
ILE A  34
ILE A  50
LEU A  53
THR A  25
 None
 0.85A 5uvmB-3fz0A:
undetectable		 5uvmB-3fz0A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpu DNA GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 VAL A  26
PHE A  98
ILE A  23
LEU A  71
VAL A  96
 None
 0.97A 5uvmB-3gpuA:
undetectable		 5uvmB-3gpuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gux PUTATIVE
ZN-DEPENDENT
EXOPEPTIDASE

(Bacteroides
vulgatus) 		PF04389
(Peptidase_M28) 		5 VAL A 322
ILE A 160
ILE A 220
LEU A 157
VAL A 225
 None
 0.95A 5uvmB-3guxA:
undetectable		 5uvmB-3guxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		6 VAL A 208
PHE A 116
ILE A  72
ASN A 191
LEU A 120
HIS A 121
 None
None
None
GOL  A 301 (-4.9A)
None
None
 1.26A 5uvmB-3hamA:
undetectable		 5uvmB-3hamA:
17.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3imi HIT FAMILY PROTEIN

(Bacillus
anthracis) 		PF01230
(HIT) 		9 PHE A  10
ILE A  13
ASP A  34
ILE A  35
LEU A  44
THR A  98
VAL A  99
HIS A 103
HIS A 105
 None
None
None
None
None
SO4  A 145 (-2.8A)
SO4  A 145 (-4.4A)
SO4  A 145 (-3.8A)
SO4  A 145 (-4.1A)
 0.48A 5uvmB-3imiA:
16.4		 5uvmB-3imiA:
32.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kea K1L

(Vaccinia virus) 		PF12796
(Ank_2) 		6 VAL A 136
PHE A 132
ILE A 159
ILE A 164
LEU A 157
VAL A 144
 None
 1.21A 5uvmB-3keaA:
undetectable		 5uvmB-3keaA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ksv UNCHARACTERIZED
PROTEIN

(Leishmania
major) 		PF01230
(HIT) 		6 ASP A  31
ILE A  32
ASN A  33
LEU A  41
HIS A 100
HIS A 102
 None
 1.05A 5uvmB-3ksvA:
15.8		 5uvmB-3ksvA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ksv UNCHARACTERIZED
PROTEIN

(Leishmania
major) 		PF01230
(HIT) 		8 PHE A   7
ILE A  10
ASP A  31
ILE A  32
LEU A  41
VAL A  96
HIS A 100
HIS A 102
 None
 0.54A 5uvmB-3ksvA:
15.8		 5uvmB-3ksvA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION

(Streptococcus
mutans) 		PF01230
(HIT) 		8 PHE A   6
ILE A   9
ASP A  30
ILE A  31
LEU A  40
VAL A  95
HIS A  99
HIS A 101
 None
None
None
None
None
None
NA  A 141 (-3.7A)
NA  A 141 (-4.1A)
 0.63A 5uvmB-3l7xA:
15.0		 5uvmB-3l7xA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l7x PUTATIVE HIT-LIKE
PROTEIN INVOLVED IN
CELL-CYCLE
REGULATION

(Streptococcus
mutans) 		PF01230
(HIT) 		8 PHE A   6
ILE A   9
ASP A  30
LEU A  40
THR A  94
VAL A  95
HIS A  99
HIS A 101
 None
None
None
None
None
None
NA  A 141 (-3.7A)
NA  A 141 (-4.1A)
 0.52A 5uvmB-3l7xA:
15.0		 5uvmB-3l7xA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION

(Bartonella
henselae) 		PF01230
(HIT) 		8 PHE A  11
ASP A  35
ILE A  36
LEU A  45
THR A  99
VAL A 100
HIS A 104
HIS A 106
 None
UNL  A 141 ( 4.2A)
UNL  A 141 ( 4.0A)
None
None
None
None
None
 0.48A 5uvmB-3lb5A:
15.2		 5uvmB-3lb5A:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n1t HIT-LIKE PROTEIN
HINT

(Escherichia
coli) 		PF01230
(HIT) 		7 PHE A   7
ILE A  10
ASP A  31
ILE A  32
LEU A  41
VAL A  97
HIS A 103
 None
None
5GP  A 200 (-2.3A)
5GP  A 200 (-3.6A)
5GP  A 200 (-4.2A)
5GP  A 200 (-3.6A)
5GP  A 200 (-4.1A)
 0.37A 5uvmB-3n1tA:
20.1		 5uvmB-3n1tA:
37.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01230
(HIT) 		6 PHE A   5
ILE A   8
ILE A  30
THR A  94
VAL A  95
HIS A  99
 None
None
AMP  A 155 (-3.8A)
AMP  A 155 (-3.7A)
AMP  A 155 (-4.5A)
AMP  A 155 (-3.7A)
 1.42A 5uvmB-3o0mA:
15.1		 5uvmB-3o0mA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01230
(HIT) 		11 VAL A   4
PHE A   5
ILE A   8
ILE A  27
ASP A  29
ILE A  30
LEU A  39
THR A  94
VAL A  95
HIS A  99
HIS A 101
 AMP  A 155 (-4.7A)
None
None
None
AMP  A 155 (-2.7A)
AMP  A 155 (-3.8A)
AMP  A 155 (-4.8A)
AMP  A 155 (-3.7A)
AMP  A 155 (-4.5A)
AMP  A 155 (-3.7A)
AMP  A 155 (-3.8A)
 0.44A 5uvmB-3o0mA:
15.1		 5uvmB-3o0mA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01230
(HIT) 		5 VAL A  95
ILE A  41
LEU A  39
HIS A 101
HIS A  37
 AMP  A 155 (-4.5A)
None
AMP  A 155 (-4.8A)
AMP  A 155 (-3.8A)
None
 1.00A 5uvmB-3o0mA:
15.1		 5uvmB-3o0mA:
28.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oxk PUTATIVE HISTIDINE
TRIAD FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01230
(HIT) 		10 PHE A   7
ILE A  10
ASP A  31
ILE A  32
ASN A  33
LEU A  41
THR A  94
VAL A  95
HIS A  99
HIS A 101
 5GP  A 125 (-4.9A)
None
5GP  A 125 (-2.6A)
5GP  A 125 (-3.7A)
None
5GP  A 125 (-4.7A)
5GP  A 125 (-3.4A)
None
5GP  A 125 (-3.9A)
5GP  A 125 (-4.1A)
 0.49A 5uvmB-3oxkA:
18.0		 5uvmB-3oxkA:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p0t UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF01230
(HIT) 		6 PHE A   5
ILE A   8
LEU A  39
VAL A  89
HIS A  93
HIS A  95
 None
EDO  A 201 ( 4.8A)
None
SO4  A 150 (-4.2A)
SO4  A 150 (-3.8A)
SO4  A 150 (-4.1A)
 1.13A 5uvmB-3p0tA:
11.6		 5uvmB-3p0tA:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p0t UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF01230
(HIT) 		6 PHE A   5
ILE A   9
LEU A  39
VAL A  89
HIS A  93
HIS A  95
 None
None
None
SO4  A 150 (-4.2A)
SO4  A 150 (-3.8A)
SO4  A 150 (-4.1A)
 1.40A 5uvmB-3p0tA:
11.6		 5uvmB-3p0tA:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p0t UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF01230
(HIT) 		6 PHE A   5
ILE A  30
LEU A  39
VAL A  89
HIS A  93
HIS A  95
 None
EDO  A 200 (-3.9A)
None
SO4  A 150 (-4.2A)
SO4  A 150 (-3.8A)
SO4  A 150 (-4.1A)
 0.98A 5uvmB-3p0tA:
11.6		 5uvmB-3p0tA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes) 		PF01212
(Beta_elim_lyase) 		5 VAL A 279
PHE A 295
ILE A 305
LEU A 306
VAL A 293
 None
 0.88A 5uvmB-3pj0A:
undetectable		 5uvmB-3pj0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqy ALPHA CHAIN OF THE
6218-TCR

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		5 PHE D 150
ILE D 169
ASN D 203
THR D 211
VAL D 134
 None
 0.97A 5uvmB-3pqyD:
undetectable		 5uvmB-3pqyD:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q87 N6 ADENINE SPECIFIC
DNA METHYLASE

(Encephalitozoon
cuniculi) 		PF05175
(MTS) 		5 VAL B 111
PHE B 110
ILE B 107
ILE B 159
VAL B 114
 None
 0.91A 5uvmB-3q87B:
undetectable		 5uvmB-3q87B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6f HIT FAMILY PROTEIN

(Encephalitozoon
cuniculi) 		PF01230
(HIT) 		6 PHE A   6
ASP A  28
LEU A  38
VAL A  87
HIS A  91
HIS A  93
 MPD  A 134 ( 4.9A)
MPD  A 134 (-3.3A)
None
SO4  A 133 (-4.4A)
SO4  A 133 (-3.6A)
SO4  A 133 (-4.3A)
 0.40A 5uvmB-3r6fA:
14.7		 5uvmB-3r6fA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6f HIT FAMILY PROTEIN

(Encephalitozoon
cuniculi) 		PF01230
(HIT) 		5 VAL A  87
ILE A  40
LEU A  38
HIS A  93
HIS A  36
 SO4  A 133 (-4.4A)
None
None
SO4  A 133 (-4.3A)
None
 0.90A 5uvmB-3r6fA:
14.7		 5uvmB-3r6fA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3th1 CHLOROCATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 VAL A 121
PHE A 191
ILE A 119
LEU A 240
VAL A 189
 None
 0.86A 5uvmB-3th1A:
undetectable		 5uvmB-3th1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 RAS-RELATED PROTEIN
RAB-35

(Homo sapiens) 		PF00071
(Ras) 		5 VAL B  86
ILE B  14
ILE B  73
ILE B 106
ASN B 107
 None
 0.90A 5uvmB-3tw8B:
undetectable		 5uvmB-3tw8B:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE

(Staphylococcus
aureus) 		PF03167
(UDG) 		5 VAL A  54
PHE A 154
ILE A 141
VAL A 152
HIS A 173
 None
 0.94A 5uvmB-3wdgA:
undetectable		 5uvmB-3wdgA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		5 PHE A 367
ILE A 427
ILE A 247
LEU A 291
HIS A 338
 None
 1.01A 5uvmB-3zmrA:
undetectable		 5uvmB-3zmrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6s PROBABLE WRKY
TRANSCRIPTION FACTOR
52

(Arabidopsis
thaliana) 		no annotation 5 VAL A  11
ILE A  36
ASP A 141
ILE A 138
HIS A 146
 None
 0.98A 5uvmB-4c6sA:
undetectable		 5uvmB-4c6sA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5r A49

(Vaccinia virus) 		PF06489
(Orthopox_A49R) 		6 PHE A  64
ILE A 150
ILE A 109
ASN A 108
LEU A 153
VAL A  68
 None
 1.30A 5uvmB-4d5rA:
undetectable		 5uvmB-4d5rA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4egu HISTIDINE TRIAD
(HIT) PROTEIN

(Clostridioides
difficile) 		PF01230
(HIT) 		5 ASP A  32
ASN A  34
LEU A  42
HIS A 102
HIS A 104
 5GP  A 201 (-2.2A)
5GP  A 201 (-3.1A)
5GP  A 201 (-3.7A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.88A 5uvmB-4eguA:
20.2		 5uvmB-4eguA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4egu HISTIDINE TRIAD
(HIT) PROTEIN

(Clostridioides
difficile) 		PF01230
(HIT) 		7 PHE A   8
ILE A  11
ASP A  32
LEU A  42
VAL A  98
HIS A 102
HIS A 104
 5GP  A 201 (-4.4A)
None
5GP  A 201 (-2.2A)
5GP  A 201 (-3.7A)
5GP  A 201 (-3.8A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.34A 5uvmB-4eguA:
20.2		 5uvmB-4eguA:
36.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 VAL A  85
ILE A  89
ILE A 120
ASP A 188
THR A  79
 None
None
None
None
CL  A 403 ( 4.3A)
 0.86A 5uvmB-4faiA:
undetectable		 5uvmB-4faiA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fu0 D-ALANINE--D-ALANINE
LIGASE 7

(Enterococcus
faecalis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 VAL A   8
PHE A 102
ILE A   6
ASN A  30
VAL A 104
 None
 0.90A 5uvmB-4fu0A:
undetectable		 5uvmB-4fu0A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fu0 D-ALANINE--D-ALANINE
LIGASE 7

(Enterococcus
faecalis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		6 VAL A   8
PHE A 102
ILE A   6
ILE A 344
LEU A 340
VAL A 104
 None
 1.30A 5uvmB-4fu0A:
undetectable		 5uvmB-4fu0A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuu LEUCINE
AMINOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF04389
(Peptidase_M28) 		5 VAL A 319
ILE A 160
ILE A 220
LEU A 157
VAL A 225
 None
 0.92A 5uvmB-4fuuA:
undetectable		 5uvmB-4fuuA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 VAL A 124
ILE A  98
ILE A 267
ASN A 231
VAL A  88
 None
 0.83A 5uvmB-4grsA:
undetectable		 5uvmB-4grsA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		6 VAL A  98
PHE A 182
ILE A  71
ILE A 140
LEU A 180
HIS A 205
 None
 1.37A 5uvmB-4hooA:
undetectable		 5uvmB-4hooA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k68 GH10 XYLANASE

(soil metagenome) 		PF00331
(Glyco_hydro_10) 		5 VAL A 125
PHE A 126
ILE A 134
ILE A 182
VAL A 121
 None
 0.92A 5uvmB-4k68A:
undetectable		 5uvmB-4k68A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		6 VAL A  95
PHE A 179
ILE A  68
ILE A 137
LEU A 177
HIS A 202
 None
 1.34A 5uvmB-4lxlA:
undetectable		 5uvmB-4lxlA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		6 VAL A 307
ILE A 334
ILE A 338
LEU A 349
THR A 120
VAL A 119
 None
 1.43A 5uvmB-4n0qA:
undetectable		 5uvmB-4n0qA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		6 VAL A  22
PHE A  39
ILE A  24
ILE A  35
ASN A 198
HIS A  17
 None
 1.40A 5uvmB-4nbrA:
undetectable		 5uvmB-4nbrA:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL

(Homo sapiens) 		PF01230
(HIT) 		7 PHE A  56
ILE A  59
ASP A  80
LEU A  90
VAL A 145
HIS A 149
HIS A 151
 None
None
SO4  A 201 (-2.8A)
None
None
None
SO4  A 201 (-4.8A)
 0.32A 5uvmB-4njzA:
20.4		 5uvmB-4njzA:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		5 VAL A 148
ILE A 145
ILE A 131
LEU A 127
VAL A 151
 None
 0.96A 5uvmB-4o0mA:
undetectable		 5uvmB-4o0mA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdv M7GPPPX
DIPHOSPHATASE

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		6 VAL A 176
ILE A 179
ILE A 203
ASP A 205
HIS A 277
HIS A 279
 None
None
30U  A 401 ( 4.0A)
30U  A 401 (-2.4A)
PO4  A 402 (-3.7A)
PO4  A 402 (-4.0A)
 1.26A 5uvmB-4qdvA:
10.6		 5uvmB-4qdvA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		5 VAL A 190
ILE A 228
ILE A 176
ASN A 175
VAL A 158
 None
 0.92A 5uvmB-4wr2A:
undetectable		 5uvmB-4wr2A:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zgl UNCHARACTERIZED
HIT-LIKE PROTEIN
HP_0404

(Helicobacter
pylori) 		PF01230
(HIT) 		10 VAL A   3
PHE A   4
ILE A   7
ASP A  28
ILE A  29
ASN A  30
LEU A  38
VAL A  91
HIS A  95
HIS A  97
 None
 0.43A 5uvmB-4zglA:
17.2		 5uvmB-4zglA:
37.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs2 HISTIDINE TRIAD
PROTEIN

(Plasmodium
falciparum) 		PF01230
(HIT) 		7 PHE A  24
ILE A  29
LEU A  56
THR A 110
VAL A 111
HIS A 115
HIS A 117
 None
None
None
None
CL  A1000 ( 3.9A)
None
None
 0.39A 5uvmB-5cs2A:
10.3		 5uvmB-5cs2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1z IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B

(Staphylococcus
aureus) 		PF05031
(NEAT) 		6 VAL I 200
PHE I 198
ILE I 209
ILE I 223
LEU I 189
THR I 252
 None
 1.38A 5uvmB-5d1zI:
undetectable		 5uvmB-5d1zI:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		5 VAL A 388
PHE A 519
ILE A 390
ILE A 504
VAL A 517
 None
 0.94A 5uvmB-5e26A:
undetectable		 5uvmB-5e26A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkf ENDONUCLEASE ENDOMS

(Thermococcus
kodakarensis) 		PF01939
(NucS) 		5 VAL A  58
PHE A  64
ILE A  66
ILE A  33
VAL A  84
 None
 0.98A 5uvmB-5gkfA:
2.1		 5uvmB-5gkfA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 VAL A 167
ILE A 179
ILE A 149
VAL A 126
HIS A 108
 None
 1.00A 5uvmB-5h1kA:
undetectable		 5uvmB-5h1kA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf2 PREDICTED
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00583
(Acetyltransf_1) 		5 ILE A  20
ILE A  82
ASP A  84
ILE A  85
LEU A  15
 None
ACO  A 402 (-4.4A)
None
EDO  A 403 (-4.7A)
None
 0.95A 5uvmB-5kf2A:
2.0		 5uvmB-5kf2A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6c HEMOLYSIN-RELATED
PROTEIN

(Vibrio cholerae) 		no annotation 5 PHE A 953
ILE A 855
ILE A 941
ILE A 879
VAL A 889
 None
 0.96A 5uvmB-5v6cA:
undetectable		 5uvmB-5v6cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN

(Staphylococcus
aureus) 		no annotation 6 VAL E 200
PHE E 198
ILE E 209
ILE E 223
LEU E 189
THR E 252
 None
 1.30A 5uvmB-5vmmE:
undetectable		 5uvmB-5vmmE:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN

(Staphylococcus
aureus) 		no annotation 6 VAL H 200
PHE H 198
ILE H 209
ILE H 223
LEU H 189
THR H 252
 None
 1.36A 5uvmB-5vmmH:
undetectable		 5uvmB-5vmmH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		5 VAL A 815
ILE A 813
ILE A 781
ASN A 782
VAL A 801
 None
 0.94A 5uvmB-5wveA:
undetectable		 5uvmB-5wveA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cvq APRATAXIN

(Homo sapiens) 		no annotation 5 ILE A 191
ASP A 193
LEU A 203
HIS A 260
HIS A 262
 AMP  A 401 ( 4.3A)
AMP  A 401 (-2.2A)
AMP  A 401 ( 4.7A)
AMP  A 401 (-3.8A)
AMP  A 401 (-4.0A)
 0.29A 5uvmB-6cvqA:
10.6		 5uvmB-6cvqA:
24.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6d6j HIT FAMILY HYDROLASE

(Legionella
pneumophila) 		no annotation 8 PHE A   5
ILE A   8
ASP A  29
ILE A  30
LEU A  39
VAL A  95
HIS A  99
HIS A 101
 None
 0.57A 5uvmB-6d6jA:
20.1		 5uvmB-6d6jA:
33.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A 670
ILE A 668
ILE A 632
ILE A 652
VAL A 658
 None
 0.82A 5uvmB-6eojA:
undetectable		 5uvmB-6eojA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 6 VAL A 370
ILE A 374
ILE A 378
ASP A 475
LEU A 379
VAL A 364
 None
 1.37A 5uvmB-6gctA:
undetectable		 5uvmB-6gctA:
20.25