SIMILAR PATTERNS OF AMINO ACIDS FOR 5UUN_B_ACTB311_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		4 PHE A  46
PRO A 155
TYR A 356
TYR A 228
 None
 1.00A 5uunB-2fv0A:
0.0		 5uunB-2fv0A:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 PHE A  22
PRO A  53
TYR A 167
TYR A 225
 GSH  A 290 ( 3.9A)
None
None
None
 0.42A 5uunB-3c8eA:
39.3		 5uunB-3c8eA:
59.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PHE A 378
PRO A 496
TYR A 306
TYR A 324
 None
 1.27A 5uunB-3i4gA:
1.9		 5uunB-3i4gA:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mzw GLUTATHIONE
S-TRANSFERASE

(Streptococcus
sanguinis) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 PHE A  19
PRO A  50
TYR A 164
TYR A 222
 GDS  A 301 (-3.6A)
None
None
None
 0.28A 5uunB-4mzwA:
36.0		 5uunB-4mzwA:
48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pua GLUTATHIONE
S-TRANSFERASE

(Streptococcus
pneumoniae) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 PHE A  20
PRO A  51
TYR A 165
TYR A 223
 GSH  A 301 (-3.4A)
None
None
None
 0.67A 5uunB-4puaA:
36.0		 5uunB-4puaA:
49.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aie GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 4

(Saccharomyces
cerevisiae) 		PF14570
(zf-RING_4) 		4 PHE A  47
PRO A  51
TYR A  61
TYR A  81
 None
 1.43A 5uunB-5aieA:
undetectable		 5uunB-5aieA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 4 PHE B  26
PRO B  57
TYR B 171
TYR B 229
 GSH  B 302 (-2.8A)
None
EDO  B 313 (-3.4A)
EDO  B 313 (-4.7A)
 0.33A 5uunB-5uuoB:
46.9		 5uunB-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 PHE A 544
PRO A 364
TYR A 575
TYR A  58
 None
 1.37A 5uunB-6eonA:
0.0		 5uunB-6eonA:
17.20