SIMILAR PATTERNS OF AMINO ACIDS FOR 5UUN_B_ACTB310_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1be4 NUCLEOSIDE
DIPHOSPHATE
TRANSFERASE

(Bos taurus) 		PF00334
(NDK) 		4 GLY A  71
PRO A  72
VAL A  73
ARG A  42
 None
 1.11A 5uunA-1be4A:
0.0
5uunB-1be4A:
0.0		 5uunA-1be4A:
20.15
5uunB-1be4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az3 NUCLEOSIDE
DIPHOSPHATE KINASE

(Halobacterium
salinarum) 		PF00334
(NDK) 		4 GLY A  72
PRO A  73
VAL A  74
ARG A  43
 None
 1.37A 5uunA-2az3A:
0.0
5uunB-2az3A:
0.0		 5uunA-2az3A:
22.97
5uunB-2az3A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLY A 535
PRO A 536
VAL A 502
ARG A 270
 None
 0.88A 5uunA-2cfmA:
0.0
5uunB-2cfmA:
0.0		 5uunA-2cfmA:
18.60
5uunB-2cfmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 GLY A 303
PRO A 302
VAL A 299
ARG A 279
 None
None
None
DHK  A9241 (-2.7A)
 1.25A 5uunA-2o7qA:
0.0
5uunB-2o7qA:
0.0		 5uunA-2o7qA:
20.88
5uunB-2o7qA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbx EPHRIN TYPE-B
RECEPTOR 2

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		4 GLY A 175
PRO A 176
VAL A 177
ARG A  93
 None
 1.49A 5uunA-2qbxA:
0.0
5uunB-2qbxA:
0.0		 5uunA-2qbxA:
23.13
5uunB-2qbxA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		4 GLY A 806
PRO A 807
VAL A 817
ARG A 815
 None
 1.24A 5uunA-2vf8A:
0.0
5uunB-2vf8A:
0.0		 5uunA-2vf8A:
17.79
5uunB-2vf8A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x11 EPHRIN-A5

(Homo sapiens) 		PF00812
(Ephrin) 		4 GLY B 137
PRO B 136
VAL B 163
ARG B 138
 None
 1.42A 5uunA-2x11B:
0.0
5uunB-2x11B:
0.0		 5uunA-2x11B:
18.46
5uunB-2x11B:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 254
PRO A 255
VAL A 286
ARG A 282
 None
 1.30A 5uunA-3i6eA:
0.0
5uunB-3i6eA:
0.0		 5uunA-3i6eA:
22.14
5uunB-3i6eA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js3 3-DEHYDROQUINATE
DEHYDRATASE

(Clostridioides
difficile) 		PF01487
(DHquinase_I) 		4 GLY A 236
PRO A 235
VAL A 232
ARG A 214
 None
None
None
DHS  A 301 (-2.8A)
 1.21A 5uunA-3js3A:
0.0
5uunB-3js3A:
0.0		 5uunA-3js3A:
20.77
5uunB-3js3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwc UNCHARACTERIZED
PROTEIN

(Rhizobium
leguminosarum) 		PF06249
(EutQ) 		4 GLY A  94
PRO A  95
VAL A  77
ARG A  81
 None
None
None
SO4  A   1 (-3.9A)
 1.12A 5uunA-3lwcA:
undetectable
5uunB-3lwcA:
undetectable		 5uunA-3lwcA:
18.45
5uunB-3lwcA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		4 GLY A 113
PRO A 114
VAL A 117
ARG A 111
 None
 1.20A 5uunA-3wsuA:
undetectable
5uunB-3wsuA:
undetectable		 5uunA-3wsuA:
22.10
5uunB-3wsuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLY A 547
PRO A 548
VAL A 514
ARG A 282
 None
 1.26A 5uunA-4eq5A:
undetectable
5uunB-4eq5A:
undetectable		 5uunA-4eq5A:
20.32
5uunB-4eq5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLY A 508
PRO A 509
VAL A 548
ARG A 567
 None
None
None
MAN  A1141 ( 4.0A)
 1.36A 5uunA-4iugA:
0.2
5uunB-4iugA:
undetectable		 5uunA-4iugA:
15.24
5uunB-4iugA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		4 GLY A 493
PRO A 494
VAL A 465
ARG A 471
 None
 1.19A 5uunA-4xbrA:
undetectable
5uunB-4xbrA:
undetectable		 5uunA-4xbrA:
21.41
5uunB-4xbrA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		4 GLY A 252
PRO A 253
VAL A 336
ARG A 268
 None
 1.24A 5uunA-5cg0A:
0.0
5uunB-5cg0A:
undetectable		 5uunA-5cg0A:
20.72
5uunB-5cg0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 GLY A 624
PRO A 623
VAL A 627
ARG A 490
 None
 1.21A 5uunA-5ksdA:
1.0
5uunB-5ksdA:
undetectable		 5uunA-5ksdA:
19.25
5uunB-5ksdA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m43 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00782
(DSPc) 		4 GLY A 154
PRO A 155
VAL A 111
ARG A 147
 None
 1.12A 5uunA-5m43A:
undetectable
5uunB-5m43A:
undetectable		 5uunA-5m43A:
21.57
5uunB-5m43A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 4 GLY A 493
PRO A 494
VAL A 465
ARG A 471
 None
 1.15A 5uunA-5vefA:
undetectable
5uunB-5vefA:
undetectable		 5uunA-5vefA:
23.63
5uunB-5vefA:
23.63