SIMILAR PATTERNS OF AMINO ACIDS FOR 5UUN_B_ACTB309_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a99 PUTRESCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		3 TYR A  40
ALA A 136
TYR A 314
 PUT  A 371 (-3.7A)
None
PUT  A 371 (-4.9A)
 0.79A 5uunB-1a99A:
0.0		 5uunB-1a99A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		3 TYR A  17
ALA A 126
TYR A 125
 NA  A 621 (-4.6A)
None
None
 0.69A 5uunB-1bg4A:
0.0		 5uunB-1bg4A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 TYR A 307
ALA A 361
TYR A 349
 None
 0.79A 5uunB-1flgA:
0.0		 5uunB-1flgA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 TYR A 286
ALA A 339
TYR A 327
 None
 0.83A 5uunB-1kv9A:
0.0		 5uunB-1kv9A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 TYR A 294
ALA A 348
TYR A 336
 None
 0.87A 5uunB-1lrwA:
0.0		 5uunB-1lrwA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		3 TYR A 133
ALA A 102
TYR A  84
 None
 0.57A 5uunB-1mppA:
0.0		 5uunB-1mppA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Methanoculleus
thermophilus) 		PF00296
(Bac_luciferase) 		3 TYR A 230
ALA A  26
TYR A   7
 None
 0.84A 5uunB-1rhcA:
0.0		 5uunB-1rhcA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 TYR A 294
ALA A 348
TYR A 336
 None
 0.83A 5uunB-1w6sA:
undetectable		 5uunB-1w6sA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 TYR A 294
ALA A 348
TYR A 336
 None
 0.83A 5uunB-2d0vA:
0.0		 5uunB-2d0vA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		3 TYR A 119
ALA A  88
TYR A 100
 None
 0.83A 5uunB-2grvA:
undetectable		 5uunB-2grvA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 TYR A 371
ALA A 464
TYR A 465
 None
 0.77A 5uunB-2nlxA:
undetectable		 5uunB-2nlxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nna MHC CLASS II ANTIGEN

(Homo sapiens) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		3 TYR B   9
ALA B  38
TYR B  37
 None
 0.78A 5uunB-2nnaB:
undetectable		 5uunB-2nnaB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		3 TYR A 176
ALA A 112
TYR A 160
 None
 0.84A 5uunB-2nyfA:
1.4		 5uunB-2nyfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 TYR A 452
ALA A 252
TYR A 254
 None
 0.70A 5uunB-2qf7A:
undetectable		 5uunB-2qf7A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		3 TYR A 151
ALA A 109
TYR A  91
 None
 0.69A 5uunB-2rmpA:
undetectable		 5uunB-2rmpA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		3 TYR A 540
ALA A 492
TYR A 476
 None
 0.71A 5uunB-2vpjA:
undetectable		 5uunB-2vpjA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		3 TYR A 289
ALA A  15
TYR A 324
 None
 0.84A 5uunB-2w38A:
undetectable		 5uunB-2w38A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		3 TYR A 197
ALA A 262
TYR A 263
 None
 0.88A 5uunB-2w7yA:
undetectable		 5uunB-2w7yA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 TYR A 367
ALA A 233
TYR A 234
 None
PLP  A1429 ( 3.8A)
PLP  A1429 (-4.4A)
 0.84A 5uunB-2x5fA:
undetectable		 5uunB-2x5fA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		3 TYR A 447
ALA A 472
TYR A 451
 ZKD  A1569 (-4.0A)
None
None
 0.83A 5uunB-2xgoA:
undetectable		 5uunB-2xgoA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1p RIBOSOME MATURATION
FACTOR RIMM

(Thermus
thermophilus) 		PF01782
(RimM)
PF05239
(PRC) 		3 TYR A  47
ALA A  14
TYR A  13
 None
 0.77A 5uunB-3a1pA:
undetectable		 5uunB-3a1pA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		3 TYR A 228
ALA A 357
TYR A 285
 None
 0.87A 5uunB-3aivA:
undetectable		 5uunB-3aivA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		3 TYR A 223
ALA A 298
TYR A  54
 GOL  A 384 (-4.6A)
GOL  A 384 (-3.8A)
GOL  A 384 (-4.6A)
 0.87A 5uunB-3allA:
undetectable		 5uunB-3allA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		3 TYR A 240
ALA A 422
TYR A 358
 LLP  A 271 ( 4.2A)
None
None
 0.83A 5uunB-3b46A:
undetectable		 5uunB-3b46A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		3 TYR A 286
ALA A 218
TYR A 219
 None
 0.86A 5uunB-3cf4A:
undetectable		 5uunB-3cf4A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3d LYSOZYME

(Escherichia
virus Lambda) 		PF00959
(Phage_lysozyme) 		3 TYR A  33
ALA A  95
TYR A  67
 None
 0.83A 5uunB-3d3dA:
undetectable		 5uunB-3d3dA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 TYR A  62
ALA A  78
TYR A  82
 None
 0.86A 5uunB-3e60A:
undetectable		 5uunB-3e60A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		3 TYR A 434
ALA A 233
TYR A 234
 None
 0.67A 5uunB-3i5gA:
undetectable		 5uunB-3i5gA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		3 TYR A 266
ALA A 434
TYR A 435
 None
 0.74A 5uunB-3i6dA:
undetectable		 5uunB-3i6dA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		3 TYR A 157
ALA A 340
TYR A  22
 None
 0.75A 5uunB-3if9A:
undetectable		 5uunB-3if9A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 TYR X 621
ALA X 440
TYR X 441
 None
 0.73A 5uunB-3jb9X:
undetectable		 5uunB-3jb9X:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		3 TYR A  58
ALA A 104
TYR A  82
 VAL  A 393 (-4.6A)
VAL  A 393 (-3.4A)
VAL  A 393 (-3.9A)
 0.86A 5uunB-3lkbA:
undetectable		 5uunB-3lkbA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lso PUTATIVE MEMBRANE
ANCHORED PROTEIN

(Corynebacterium
diphtheriae) 		PF16640
(Big_3_5) 		3 TYR B 104
ALA B  57
TYR B 190
 None
 0.86A 5uunB-3lsoB:
undetectable		 5uunB-3lsoB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nng UNCHARACTERIZED
PROTEIN

(Bacteroides
fragilis) 		PF00754
(F5_F8_type_C) 		3 TYR A 262
ALA A 208
TYR A 207
 None
 0.85A 5uunB-3nngA:
undetectable		 5uunB-3nngA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF06050
(HGD-D) 		3 TYR A 340
ALA A 361
TYR A 368
 None
 0.84A 5uunB-3o3oA:
undetectable		 5uunB-3o3oA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		3 TYR A 344
ALA A 296
TYR A 295
 None
 0.70A 5uunB-3pshA:
undetectable		 5uunB-3pshA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 TYR B 301
ALA B 243
TYR B 238
 None
 0.80A 5uunB-3sqgB:
undetectable		 5uunB-3sqgB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u07 UNCHARACTERIZED
PROTEIN VPA0106

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		3 TYR A 108
ALA A 314
TYR A 415
 None
 0.88A 5uunB-3u07A:
undetectable		 5uunB-3u07A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 TYR A 737
ALA A 606
TYR A 607
 None
 0.85A 5uunB-3wnpA:
undetectable		 5uunB-3wnpA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chb KELCH-LIKE PROTEIN 2

(Homo sapiens) 		PF01344
(Kelch_1) 		3 TYR A 469
ALA A 419
TYR A 403
 None
 0.68A 5uunB-4chbA:
undetectable		 5uunB-4chbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2s UREIDOGLYCINE
AMINOHYDROLASE

(Arabidopsis
thaliana) 		PF07883
(Cupin_2) 		3 TYR A 152
ALA A 215
TYR A 216
 None
 0.62A 5uunB-4e2sA:
undetectable		 5uunB-4e2sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 TYR A  27
ALA A  99
TYR A  44
 None
 0.88A 5uunB-4ev0A:
undetectable		 5uunB-4ev0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora) 		PF02171
(Piwi) 		3 TYR A1160
ALA A 220
TYR A 222
 None
 0.85A 5uunB-4f1nA:
undetectable		 5uunB-4f1nA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flm S-FORMYLGLUTATHIONE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF00756
(Esterase) 		3 TYR A 119
ALA A 201
TYR A 205
 None
 0.85A 5uunB-4flmA:
undetectable		 5uunB-4flmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guc PROTEIN BA_2500

(Bacillus
anthracis) 		PF16723
(DUF5065) 		3 TYR A 136
ALA A 130
TYR A 131
 None
 0.86A 5uunB-4gucA:
undetectable		 5uunB-4gucA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1

(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		no annotation 3 TYR B 135
ALA B 129
TYR B 132
 None
G5A  B 402 (-3.6A)
None
 0.82A 5uunB-4h2xB:
undetectable		 5uunB-4h2xB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		3 TYR A 263
ALA A 299
TYR A 302
 None
 0.80A 5uunB-4h3sA:
undetectable		 5uunB-4h3sA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica) 		PF02917
(Pertussis_S1) 		3 TYR G 225
ALA G  81
TYR G  82
 None
 0.88A 5uunB-4k6lG:
undetectable		 5uunB-4k6lG:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfz LMO-2
ANTI-LMO2 VH

(Homo sapiens;
Homo sapiens) 		PF00412
(LIM)
PF07686
(V-set) 		3 TYR C  59
ALA A 103
TYR A 104
 None
 0.86A 5uunB-4kfzC:
undetectable		 5uunB-4kfzC:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR B 129
ALA B 220
TYR B 224
 None
 0.85A 5uunB-4l37B:
undetectable		 5uunB-4l37B:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR A 126
ALA A 217
TYR A 221
 None
SCN  A 711 ( 4.4A)
None
 0.81A 5uunB-4l37A:
undetectable		 5uunB-4l37A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		3 TYR A 421
ALA A 529
TYR A 533
 None
 0.84A 5uunB-4l9mA:
undetectable		 5uunB-4l9mA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		3 TYR A 290
ALA A 343
TYR A 331
 None
 0.71A 5uunB-4maeA:
undetectable		 5uunB-4maeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		3 TYR A 919
ALA A 929
TYR A 928
 None
 0.84A 5uunB-4n1aA:
undetectable		 5uunB-4n1aA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A 540
ALA A 509
TYR A 517
 None
 0.78A 5uunB-4n5aA:
undetectable		 5uunB-4n5aA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5q GLUTATHIONE
S-TRANSFERASE

(Dermatophagoides
pteronyssinus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 TYR A 162
ALA A 219
TYR A 218
 None
 0.85A 5uunB-4q5qA:
15.5		 5uunB-4q5qA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdg PUTATIVE ADHESIN

(Bacteroides
thetaiotaomicron) 		PF08842
(Mfa2) 		3 TYR A 155
ALA A  58
TYR A  49
 None
 0.71A 5uunB-4qdgA:
undetectable		 5uunB-4qdgA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm9 EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 TYR A 146
ALA A 177
TYR A 137
 None
 0.41A 5uunB-4rm9A:
undetectable		 5uunB-4rm9A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rma EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 TYR A 146
ALA A 177
TYR A 137
 None
 0.48A 5uunB-4rmaA:
undetectable		 5uunB-4rmaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 3 TYR A 384
ALA A 438
TYR A 413
 None
 0.78A 5uunB-4ru5A:
undetectable		 5uunB-4ru5A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		3 TYR A 750
ALA A 703
TYR A 702
 None
 0.87A 5uunB-4sliA:
undetectable		 5uunB-4sliA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 3 TYR B 322
ALA B 375
TYR B 363
 None
 0.80A 5uunB-4tqoB:
undetectable		 5uunB-4tqoB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqt U2 SNRNP COMPONENT
IST3

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		3 TYR A  76
ALA A  31
TYR A  32
 None
 0.87A 5uunB-4uqtA:
undetectable		 5uunB-4uqtA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usr MONOOXYGENASE

(Pseudomonas
stutzeri) 		PF13738
(Pyr_redox_3) 		3 TYR A  91
ALA A  62
TYR A  21
 None
 0.77A 5uunB-4usrA:
undetectable		 5uunB-4usrA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 TYR A 501
ALA A 424
TYR A 476
 None
 0.87A 5uunB-4uzsA:
undetectable		 5uunB-4uzsA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzv HEMOGLOBIN

(Thermobifida
fusca) 		PF01152
(Bac_globin) 		3 TYR A 143
ALA A 150
TYR A 146
 None
 0.79A 5uunB-4uzvA:
undetectable		 5uunB-4uzvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N)
PF12796
(Ank_2) 		3 TYR A 188
ALA A 100
TYR A 101
 None
 0.77A 5uunB-4xd0A:
undetectable		 5uunB-4xd0A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		3 TYR A 469
ALA A 548
TYR A 547
 None
 0.73A 5uunB-4xnuA:
undetectable		 5uunB-4xnuA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C

(Aspergillus
niger) 		PF00331
(Glyco_hydro_10) 		3 TYR A  42
ALA A 151
TYR A 150
 None
 0.70A 5uunB-4xuyA:
undetectable		 5uunB-4xuyA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xx6 BETA-XYLANASE

(Gloeophyllum
trabeum) 		PF00331
(Glyco_hydro_10) 		3 TYR A  42
ALA A 155
TYR A 154
 None
None
P6G  A 426 (-4.4A)
 0.71A 5uunB-4xx6A:
undetectable		 5uunB-4xx6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 TYR A 172
ALA A 325
TYR A 330
 None
 0.82A 5uunB-4z0vA:
undetectable		 5uunB-4z0vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgc KELCH PROTEIN

(Plasmodium
falciparum) 		PF01344
(Kelch_1)
PF02214
(BTB_2)
PF13418
(Kelch_4) 		3 TYR A 604
ALA A 557
TYR A 541
 None
 0.67A 5uunB-4zgcA:
undetectable		 5uunB-4zgcA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnb UBIQUITIN-CONJUGATIN
G ENZYME E2 S

(Homo sapiens) 		PF00179
(UQ_con) 		3 TYR A 141
ALA A 148
TYR A 144
 None
 0.81A 5uunB-5bnbA:
undetectable		 5uunB-5bnbA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Mus musculus) 		PF01344
(Kelch_1) 		3 TYR A 396
ALA A 344
TYR A 329
 None
 0.60A 5uunB-5fnuA:
undetectable		 5uunB-5fnuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq8 BT_2262
(UNCHARACTERISED
LIPOPROTEIN)

(Bacteroides
thetaiotaomicron) 		PF16403
(DUF5011)
PF16404
(DUF5012) 		3 TYR G 141
ALA G 201
TYR G 200
 None
 0.86A 5uunB-5fq8G:
undetectable		 5uunB-5fq8G:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		3 TYR A 570
ALA A 486
TYR A 487
 None
 0.88A 5uunB-5i6zA:
undetectable		 5uunB-5i6zA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 TYR A 593
ALA A 469
TYR A 470
 None
 0.67A 5uunB-5jp0A:
undetectable		 5uunB-5jp0A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks5 EUKARYOTIC
ELONGATION FACTOR 2
KINASE

(Homo sapiens) 		no annotation 3 TYR A 641
ALA A 716
TYR A 713
 None
 0.87A 5uunB-5ks5A:
undetectable		 5uunB-5ks5A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 3 TYR B 176
ALA B 112
TYR B 160
 None
 0.80A 5uunB-5ltmB:
undetectable		 5uunB-5ltmB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lva NAD(P)H-FMN
OXIDOREDUCTASE

(Bacillus
subtilis) 		PF02525
(Flavodoxin_2) 		3 TYR A  69
ALA A 113
TYR A 114
 FMN  A 201 (-3.3A)
None
FMN  A 201 (-4.9A)
 0.79A 5uunB-5lvaA:
undetectable		 5uunB-5lvaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 TYR B 306
ALA B 248
TYR B 243
 None
 0.86A 5uunB-5n28B:
undetectable		 5uunB-5n28B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkp KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF01344
(Kelch_1) 		3 TYR A 463
ALA A 413
TYR A 397
 None
 0.62A 5uunB-5nkpA:
undetectable		 5uunB-5nkpA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oee LARGE SUBUNIT
TERMINASE

(Phage D6E) 		no annotation 3 TYR A 379
ALA A 358
TYR A 238
 None
 0.85A 5uunB-5oeeA:
undetectable		 5uunB-5oeeA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 3 TYR A  58
ALA A 444
TYR A 473
 None
 0.83A 5uunB-5oglA:
undetectable		 5uunB-5oglA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 TYR T 418
ALA T 391
TYR T 392
 None
 0.84A 5uunB-5ojsT:
undetectable		 5uunB-5ojsT:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
INTERAPTIN

(Homo sapiens;
Legionella
pneumophila) 		no annotation
no annotation 		3 TYR A 163
ALA C 174
TYR C 166
 None
 0.81A 5uunB-5oshA:
undetectable		 5uunB-5oshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 3 TYR B 128
ALA B 285
TYR B 277
 None
 0.84A 5uunB-5swiB:
undetectable		 5uunB-5swiB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 TYR A 950
ALA A 927
TYR A 952
 None
 0.80A 5uunB-5tuyA:
undetectable		 5uunB-5tuyA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u22 N2152

(Neocallimastix
frontalis) 		PF01229
(Glyco_hydro_39) 		3 TYR A 427
ALA A 347
TYR A 349
 None
 0.80A 5uunB-5u22A:
undetectable		 5uunB-5u22A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 3 TYR A 187
ALA A 150
TYR A 156
 None
 0.86A 5uunB-5ub6A:
undetectable		 5uunB-5ub6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 TYR A 958
ALA A 653
TYR A 962
 None
 0.86A 5uunB-5ur2A:
undetectable		 5uunB-5ur2A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 3 TYR B 171
ALA B 228
TYR B 229
 EDO  B 313 (-3.4A)
None
EDO  B 313 (-4.7A)
 0.31A 5uunB-5uuoB:
46.9		 5uunB-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 CAPSID VERTEX
PROTEIN GP24

(Escherichia
virus T4) 		PF07068
(Gp23) 		3 TYR a 342
ALA a 207
TYR a  36
 None
 0.86A 5uunB-5vf3a:
undetectable		 5uunB-5vf3a:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 TYR A1038
ALA A1015
TYR A1040
 None
 0.84A 5uunB-5vsdA:
undetectable		 5uunB-5vsdA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE

(Brucella
melitensis) 		PF00551
(Formyl_trans_N) 		3 TYR A 199
ALA A 113
TYR A 114
 None
 0.86A 5uunB-5vysA:
undetectable		 5uunB-5vysA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 3 TYR A 563
ALA A 581
TYR A 584
 None
 0.86A 5uunB-5wvgA:
undetectable		 5uunB-5wvgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6a ENDOGLUCANASE,
PUTATIVE

(Aspergillus
fumigatus) 		no annotation 3 TYR A 154
ALA A 189
TYR A 149
 None
 0.84A 5uunB-5x6aA:
undetectable		 5uunB-5x6aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9e CYSTEINE DESULFURASE

(Legionella
pneumophila) 		no annotation 3 TYR A 228
ALA A 181
TYR A 180
 None
 0.86A 5uunB-6c9eA:
undetectable		 5uunB-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza B
virus) 		no annotation 3 TYR A 536
ALA A 281
TYR A 279
 None
 0.85A 5uunB-6f5oA:
undetectable		 5uunB-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-) 		no annotation 3 TYR A 396
ALA A 344
TYR A 329
 None
 0.58A 5uunB-6fmqA:
undetectable		 5uunB-6fmqA:
undetectable