SIMILAR PATTERNS OF AMINO ACIDS FOR 5UUN_B_ACTB308_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4i METHYLENETETRAHYDROF
OLATE DEHYDROGENASE
/
METHENYLTETRAHYDROFO
LATE CYCLOHYDROLASE

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 LEU A 155
ILE A 234
TYR A 258
 None
 0.68A 5uunB-1a4iA:
0.0		 5uunB-1a4iA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b48 PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 LEU A   7
ILE A  19
TYR A  79
 None
 0.58A 5uunB-1b48A:
12.5		 5uunB-1b48A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlj UDP-GLUCOSE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 LEU A 213
ILE A 283
TYR A 272
 None
 0.47A 5uunB-1dljA:
undetectable		 5uunB-1dljA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE

(Escherichia
coli) 		PF01817
(CM_2) 		3 LEU A  25
ILE A  80
TYR A  72
 None
 0.65A 5uunB-1ecmA:
undetectable		 5uunB-1ecmA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 LEU A 625
ILE A 471
TYR A 462
 None
 0.57A 5uunB-1jscA:
0.0		 5uunB-1jscA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		3 LEU A 396
ILE A 182
TYR A 384
 None
 0.53A 5uunB-1lfwA:
0.0		 5uunB-1lfwA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkb BETA-HYDROXYDECANOYL
THIOL ESTER
DEHYDRASE

(Escherichia
coli) 		PF07977
(FabA) 		3 LEU A  64
ILE A  60
TYR A 126
 None
 0.65A 5uunB-1mkbA:
undetectable		 5uunB-1mkbA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slj RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1) 		3 LEU A  70
ILE A  73
TYR A  82
 None
 0.64A 5uunB-1sljA:
undetectable		 5uunB-1sljA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tiq PROTEASE SYNTHASE
AND SPORULATION
NEGATIVE REGULATORY
PROTEIN PAI 1

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		3 LEU A  41
ILE A  21
TYR A  73
 None
 0.69A 5uunB-1tiqA:
undetectable		 5uunB-1tiqA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twl INORGANIC
PYROPHOSPHATASE

(Pyrococcus
furiosus) 		PF00719
(Pyrophosphatase) 		3 LEU A  33
ILE A  58
TYR A 170
 None
 0.63A 5uunB-1twlA:
undetectable		 5uunB-1twlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfz HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Caldanaerobacter
subterraneus) 		PF00156
(Pribosyltran) 		3 LEU A  60
ILE A  58
TYR A 145
 None
 0.70A 5uunB-1yfzA:
undetectable		 5uunB-1yfzA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1d LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF02217
(T_Ag_DNA_bind) 		3 LEU B  93
ILE B  33
TYR B  51
 None
 0.63A 5uunB-1z1dB:
undetectable		 5uunB-1z1dB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT

(Chlamydia
trachomatis) 		PF00268
(Ribonuc_red_sm) 		3 LEU A  20
ILE A 241
TYR A 189
 None
 0.67A 5uunB-2aniA:
undetectable		 5uunB-2aniA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2n HEXOKINASE

(Sulfurisphaera
tokodaii) 		PF01869
(BcrAD_BadFG) 		3 LEU A 105
ILE A 293
TYR A  19
 None
 0.68A 5uunB-2e2nA:
undetectable		 5uunB-2e2nA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2el7 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		3 LEU A   5
ILE A 137
TYR A 129
 None
 0.47A 5uunB-2el7A:
undetectable		 5uunB-2el7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6b FAMILY 11 XYLANASE

(Bacillus) 		PF00457
(Glyco_hydro_11) 		3 LEU A 199
ILE A  68
TYR A  95
 None
 0.62A 5uunB-2f6bA:
undetectable		 5uunB-2f6bA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqr PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Helicobacter
pylori) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 LEU A  47
ILE A 109
TYR A  99
 None
 0.47A 5uunB-2hqrA:
undetectable		 5uunB-2hqrA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 LEU A 871
ILE A 714
TYR A 723
 None
 0.69A 5uunB-2i75A:
undetectable		 5uunB-2i75A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		3 LEU A 193
ILE A 188
TYR A 180
 None
 0.66A 5uunB-2ixoA:
undetectable		 5uunB-2ixoA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN

(Saccharomyces
cerevisiae;
Aequorea
victoria) 		PF00462
(Glutaredoxin)
PF01353
(GFP) 		3 LEU A 201
ILE A 152
TYR A  92
 None
 0.67A 5uunB-2jadA:
3.9		 5uunB-2jadA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		3 LEU A  13
ILE A 221
TYR A  92
 None
 0.48A 5uunB-2masA:
undetectable		 5uunB-2masA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mi7 DE NOVO PROTEIN A3Y

(synthetic
construct) 		no annotation 3 LEU A   7
ILE A  41
TYR A  34
 None
 0.62A 5uunB-2mi7A:
undetectable		 5uunB-2mi7A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mp4 ACTIN-DEPOLYMERIZING
FACTOR 1, ISOFORMS
A/B

(Caenorhabditis
elegans) 		PF00241
(Cofilin_ADF) 		3 LEU A 158
ILE A 105
TYR A  27
 None
 0.69A 5uunB-2mp4A:
undetectable		 5uunB-2mp4A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		3 LEU A 339
ILE A 336
TYR A  14
 None
 0.54A 5uunB-2oryA:
undetectable		 5uunB-2oryA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Listeria
monocytogenes) 		PF06751
(EutB) 		3 LEU A 379
ILE A 342
TYR A 336
 None
 0.67A 5uunB-2qezA:
undetectable		 5uunB-2qezA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		3 LEU A 265
ILE A 478
TYR A 373
 None
 0.67A 5uunB-2r4gA:
undetectable		 5uunB-2r4gA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y1s MANNAN-BINDING
LECTIN

(Microcystis
aeruginosa) 		PF08881
(CVNH) 		3 LEU A  49
ILE A  92
TYR A  13
 None
 0.67A 5uunB-2y1sA:
undetectable		 5uunB-2y1sA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3

(Mus musculus) 		PF00621
(RhoGEF) 		3 LEU A  31
ILE A 148
TYR A 156
 None
 0.65A 5uunB-2z0qA:
undetectable		 5uunB-2z0qA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		3 LEU A  33
ILE A  20
TYR A  12
 None
 0.63A 5uunB-3bh1A:
undetectable		 5uunB-3bh1A:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		3 LEU A  50
ILE A  82
TYR A 167
 None
GSH  A 289 (-3.7A)
None
 0.31A 5uunB-3c8eA:
39.3		 5uunB-3c8eA:
59.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cos ALCOHOL
DEHYDROGENASE 4

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LEU A 337
ILE A 334
TYR A  95
 None
None
ACY  A 401 (-3.6A)
 0.70A 5uunB-3cosA:
undetectable		 5uunB-3cosA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		3 LEU A 212
ILE A 236
TYR A 222
 None
 0.52A 5uunB-3ed3A:
undetectable		 5uunB-3ed3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		3 LEU A 323
ILE A 404
TYR A 364
 None
 0.67A 5uunB-3focA:
undetectable		 5uunB-3focA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Clostridioides
difficile) 		PF01380
(SIS) 		3 LEU A 262
ILE A 218
TYR A 147
 None
 0.55A 5uunB-3g68A:
undetectable		 5uunB-3g68A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9q FERRICHROME-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		3 LEU A 222
ILE A 216
TYR A 287
 None
 0.69A 5uunB-3g9qA:
undetectable		 5uunB-3g9qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		3 LEU C  89
ILE C  76
TYR C  59
 None
 0.67A 5uunB-3gi8C:
undetectable		 5uunB-3gi8C:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 3 LEU B 767
ILE B 694
TYR B 637
 None
 0.63A 5uunB-3iz3B:
undetectable		 5uunB-3iz3B:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		3 LEU A 402
ILE A 207
TYR A 224
 None
 0.70A 5uunB-3j1eA:
undetectable		 5uunB-3j1eA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US2

(Plasmodium
falciparum) 		PF00318
(Ribosomal_S2) 		3 LEU C 120
ILE C  64
TYR C 174
 None
 0.61A 5uunB-3j7aC:
undetectable		 5uunB-3j7aC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		3 LEU A2344
ILE A2353
TYR A2396
 None
 0.58A 5uunB-3jbzA:
undetectable		 5uunB-3jbzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p PROTEIN TRANSPORT
PROTEIN SEC39

(Saccharomyces
cerevisiae) 		PF08314
(Sec39) 		3 LEU D 129
ILE D 182
TYR D 224
 None
 0.48A 5uunB-3k8pD:
undetectable		 5uunB-3k8pD:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkf PUTATIVE ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASE

(Bacteroides
thetaiotaomicron) 		PF03992
(ABM) 		3 LEU A  69
ILE A  56
TYR A  48
 ACT  A 203 ( 4.6A)
None
None
 0.62A 5uunB-3kkfA:
undetectable		 5uunB-3kkfA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Mentha x
piperita) 		PF00348
(polyprenyl_synt) 		3 LEU A 272
ILE A 284
TYR A   7
 None
 0.66A 5uunB-3krcA:
undetectable		 5uunB-3krcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK

(Methanothermobacter
thermautotrophicus) 		PF07885
(Ion_trans_2) 		3 LEU A  71
ILE A  41
TYR A  33
 None
 0.61A 5uunB-3lddA:
undetectable		 5uunB-3lddA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		3 LEU A 217
ILE A 406
TYR A 398
 None
 0.65A 5uunB-3mveA:
undetectable		 5uunB-3mveA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwn KINESIN-LIKE PROTEIN
KIF9

(Homo sapiens) 		PF00225
(Kinesin) 		3 LEU A 324
ILE A  35
TYR A  26
 None
 0.56A 5uunB-3nwnA:
undetectable		 5uunB-3nwnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or5 THIOL:DISULFIDE
INTERCHANGE PROTEIN,
THIOREDOXIN FAMILY
PROTEIN

(Chlorobaculum
tepidum) 		PF08534
(Redoxin) 		3 LEU A 123
ILE A  94
TYR A  58
 None
 0.60A 5uunB-3or5A:
undetectable		 5uunB-3or5A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 LEU A 206
ILE A 276
TYR A 265
 None
 0.61A 5uunB-3plrA:
undetectable		 5uunB-3plrA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q62 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Yersinia pestis) 		PF07977
(FabA) 		3 LEU A  65
ILE A  61
TYR A 127
 None
 0.60A 5uunB-3q62A:
undetectable		 5uunB-3q62A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA

(Homo sapiens) 		PF00183
(HSP90) 		3 LEU A 533
ILE A 449
TYR A 438
 None
 0.65A 5uunB-3q6mA:
undetectable		 5uunB-3q6mA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 221
ILE A 185
TYR A 395
 None
 0.60A 5uunB-3rcyA:
undetectable		 5uunB-3rcyA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7

(Sphingopyxis
macrogoltabida) 		PF00067
(p450) 		3 LEU A 178
ILE A 253
TYR A 245
 None
 0.60A 5uunB-3rwlA:
undetectable		 5uunB-3rwlA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		3 LEU A   7
ILE A 136
TYR A 128
 None
None
TRP  A 401 (-4.5A)
 0.57A 5uunB-3sz3A:
undetectable		 5uunB-3sz3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN

(Clostridioides
difficile) 		PF01408
(GFO_IDH_MocA) 		3 LEU A 261
ILE A  22
TYR A  91
 None
 0.53A 5uunB-3uuwA:
undetectable		 5uunB-3uuwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6o LEPTIN RECEPTOR

(Homo sapiens) 		no annotation 3 LEU A 603
ILE A 547
TYR A 574
 None
 0.69A 5uunB-3v6oA:
undetectable		 5uunB-3v6oA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		3 LEU A 208
ILE A 130
TYR A 168
 None
 0.70A 5uunB-3wkhA:
2.2		 5uunB-3wkhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		3 LEU A 526
ILE A 523
TYR A 365
 None
 0.70A 5uunB-3zuqA:
undetectable		 5uunB-3zuqA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		3 LEU A 524
ILE A 485
TYR A 447
 None
 0.64A 5uunB-4ag6A:
undetectable		 5uunB-4ag6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0i 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF07977
(FabA) 		3 LEU A  64
ILE A  60
TYR A 126
 None
 0.55A 5uunB-4b0iA:
undetectable		 5uunB-4b0iA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghb HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF15283
(DUF4595) 		3 LEU A 238
ILE A 188
TYR A 192
 None
None
GOL  A 406 (-4.8A)
 0.61A 5uunB-4ghbA:
undetectable		 5uunB-4ghbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyj RHODOPSIN

(Exiguobacterium
sibiricum) 		PF01036
(Bac_rhodopsin) 		3 LEU A 202
ILE A 133
TYR A  83
 None
 0.70A 5uunB-4hyjA:
undetectable		 5uunB-4hyjA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 3 LEU D 146
ILE D 559
TYR D 123
 None
 0.59A 5uunB-4jf7D:
undetectable		 5uunB-4jf7D:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE

(Staphylococcus
aureus) 		PF01656
(CbiA) 		3 LEU A1206
ILE A1044
TYR A1071
 None
 0.67A 5uunB-4jmpA:
undetectable		 5uunB-4jmpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 3 LEU A 737
ILE A 702
TYR A 778
 None
 0.68A 5uunB-4jzaA:
undetectable		 5uunB-4jzaA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		3 LEU A  21
ILE A  47
TYR A 357
 None
 0.69A 5uunB-4lisA:
undetectable		 5uunB-4lisA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		3 LEU A 152
ILE A 175
TYR A 130
 None
 0.52A 5uunB-4madA:
undetectable		 5uunB-4madA:
19.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mzw GLUTATHIONE
S-TRANSFERASE

(Streptococcus
sanguinis) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		3 LEU A  47
ILE A  79
TYR A 164
 None
GDS  A 301 ( 3.8A)
None
 0.30A 5uunB-4mzwA:
36.0		 5uunB-4mzwA:
48.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		3 LEU A 618
ILE A 455
TYR A 443
 None
 0.65A 5uunB-4n78A:
undetectable		 5uunB-4n78A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nex ACETYLGLUTAMATE
KINASE

(Xylella
fastidiosa) 		PF04768
(NAT) 		3 LEU A 329
ILE A 343
TYR A 338
 None
 0.69A 5uunB-4nexA:
undetectable		 5uunB-4nexA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf1 ACETYLGLUTAMATE
KINASE

(Xylella
fastidiosa) 		PF04768
(NAT) 		3 LEU A 329
ILE A 343
TYR A 338
 None
 0.66A 5uunB-4nf1A:
undetectable		 5uunB-4nf1A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrd UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF16255
(Lipase_GDSL_lke) 		3 LEU A 145
ILE A 105
TYR A 191
 None
 0.69A 5uunB-4nrdA:
undetectable		 5uunB-4nrdA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		3 LEU A  60
ILE A  85
TYR A 142
 None
 0.69A 5uunB-4ovqA:
undetectable		 5uunB-4ovqA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pba UNCHARACTERIZED
PROTEIN ABASI

(Acinetobacter
baumannii) 		no annotation 3 LEU B 290
ILE B 270
TYR B 314
 None
 0.55A 5uunB-4pbaB:
undetectable		 5uunB-4pbaB:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pua GLUTATHIONE
S-TRANSFERASE

(Streptococcus
pneumoniae) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		3 LEU A  48
ILE A  80
TYR A 165
 None
GSH  A 302 ( 3.8A)
None
 0.35A 5uunB-4puaA:
36.0		 5uunB-4puaA:
49.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50

(Saccharomyces
cerevisiae) 		no annotation 3 LEU D 351
ILE D 307
TYR D 232
 None
 0.65A 5uunB-4qqfD:
undetectable		 5uunB-4qqfD:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8l UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF00710
(Asparaginase) 		3 LEU A  20
ILE A 113
TYR A  74
 None
 0.66A 5uunB-4r8lA:
undetectable		 5uunB-4r8lA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj1 ANTIGEN MTB48,
MYCOBACTERIAL
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 3 LEU A  46
ILE A 272
TYR A 266
 None
 0.59A 5uunB-4wj1A:
undetectable		 5uunB-4wj1A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN

(Plasmodium
falciparum;
Aequorea
victoria) 		PF01353
(GFP)
PF02861
(Clp_N) 		3 LEU A 350
ILE A 301
TYR A 241
 None
 0.69A 5uunB-4xbiA:
undetectable		 5uunB-4xbiA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 LEU A 193
ILE A 310
TYR A 318
 None
 0.69A 5uunB-4xh9A:
undetectable		 5uunB-4xh9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkb YCF53-LIKE PROTEIN

(Synechocystis
sp. PCC 6803) 		PF05419
(GUN4)
PF16416
(GUN4_N) 		3 LEU A 152
ILE A  82
TYR A  41
 None
 0.69A 5uunB-4xkbA:
undetectable		 5uunB-4xkbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycz NUP120

(Thermothelomyces
thermophila) 		no annotation 3 LEU C1002
ILE C1033
TYR C1055
 None
 0.54A 5uunB-4yczC:
undetectable		 5uunB-4yczC:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		3 LEU A 377
ILE A 365
TYR A 331
 None
 0.67A 5uunB-4zcfA:
undetectable		 5uunB-4zcfA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Pseudomonas
aeruginosa;
Aquifex
aeolicus) 		PF06557
(DUF1122) 		3 LEU A  42
ILE A  22
TYR A  87
 None
 0.69A 5uunB-4zsxA:
undetectable		 5uunB-4zsxA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmt UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		no annotation 3 LEU A 133
ILE A 142
TYR A 112
 None
 0.64A 5uunB-5bmtA:
undetectable		 5uunB-5bmtA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1z D4-10 HEAVY CHAIN
IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B

(Homo sapiens;
Staphylococcus
aureus) 		PF07654
(C1-set)
PF07686
(V-set)
PF05031
(NEAT) 		3 LEU D  73
ILE D  53
TYR I 165
 None
 0.70A 5uunB-5d1zD:
undetectable		 5uunB-5d1zD:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 242
ILE A 200
TYR A 210
 LEU  A 242 ( 0.6A)
ILE  A 200 ( 0.7A)
TYR  A 210 ( 1.3A)
 0.63A 5uunB-5d7aA:
undetectable		 5uunB-5d7aA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ

(Salmonella
enterica) 		PF01832
(Glucosaminidase) 		3 LEU A 246
ILE A 177
TYR A 280
 None
 0.69A 5uunB-5dn5A:
undetectable		 5uunB-5dn5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		3 LEU A  20
ILE A 113
TYR A  74
 None
 0.63A 5uunB-5dneA:
undetectable		 5uunB-5dneA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dok TELOMERASE
ASSOCIATED PROTEIN
P45

(Tetrahymena
thermophila) 		no annotation 3 LEU A 242
ILE A 192
TYR A 287
 None
 0.66A 5uunB-5dokA:
undetectable		 5uunB-5dokA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		3 LEU A 165
ILE A  82
TYR A 304
 None
 0.56A 5uunB-5evjA:
undetectable		 5uunB-5evjA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 3 LEU A 260
ILE A 208
TYR A 185
 None
 0.69A 5uunB-5f0oA:
1.4		 5uunB-5f0oA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		3 LEU A 187
ILE A 224
TYR A 231
 None
 0.66A 5uunB-5f7uA:
undetectable		 5uunB-5f7uA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff5 PAAA

(Pantoea
agglomerans) 		PF00899
(ThiF) 		3 LEU A 159
ILE A 195
TYR A 178
 None
 0.68A 5uunB-5ff5A:
undetectable		 5uunB-5ff5A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D

(Streptococcus
pyogenes;
Aequorea
victoria) 		PF01353
(GFP)
PF13930
(Endonuclea_NS_2) 		3 LEU A 201
ILE A 152
TYR A  92
 None
 0.67A 5uunB-5fguA:
undetectable		 5uunB-5fguA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		3 LEU A 111
ILE A 107
TYR A 383
 None
 0.69A 5uunB-5fw4A:
undetectable		 5uunB-5fw4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		3 LEU A  95
ILE A  66
TYR A  32
 None
 0.70A 5uunB-5hfjA:
undetectable		 5uunB-5hfjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kew VTRA PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 3 LEU A 189
ILE A 178
TYR A 175
 None
 0.66A 5uunB-5kewA:
undetectable		 5uunB-5kewA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 3 LEU A 516
ILE A 481
TYR A 470
 None
 0.61A 5uunB-5lewA:
undetectable		 5uunB-5lewA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly6 PNEUMOLYSIN

(Streptococcus
pneumoniae) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 LEU B 292
ILE B 329
TYR B  71
 None
 0.57A 5uunB-5ly6B:
undetectable		 5uunB-5ly6B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		3 LEU A 258
ILE A  23
TYR A 138
 None
 0.58A 5uunB-5tprA:
undetectable		 5uunB-5tprA:
20.18