SIMILAR PATTERNS OF AMINO ACIDS FOR 5UUN_B_ACTB307_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao3 VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		3 LEU A  89
ALA A  88
LEU A 154
 None
 0.49A 5uunB-1ao3A:
0.0		 5uunB-1ao3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoy ARGININE REPRESSOR

(Escherichia
coli) 		PF01316
(Arg_repressor) 		3 LEU A  17
ALA A  16
LEU A  33
 LEU  A  17 ( 0.6A)
ALA  A  16 ( 0.0A)
LEU  A  33 ( 0.6A)
 0.54A 5uunB-1aoyA:
undetectable		 5uunB-1aoyA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		3 LEU A 248
ALA A 245
LEU A  14
 None
 0.55A 5uunB-1bjnA:
0.0		 5uunB-1bjnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		3 LEU A 235
ALA A 234
LEU A 273
 None
 0.45A 5uunB-1bxcA:
0.0		 5uunB-1bxcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		3 LEU A 329
ALA A 326
LEU A  30
 None
 0.53A 5uunB-1c3rA:
0.0		 5uunB-1c3rA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 LEU A 283
ALA A 282
LEU A 317
 None
 0.54A 5uunB-1d6hA:
0.0		 5uunB-1d6hA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddm NUMB PROTEIN

(Drosophila
melanogaster) 		PF00640
(PID) 		3 LEU A 178
ALA A 179
LEU A 106
 None
 0.53A 5uunB-1ddmA:
0.0		 5uunB-1ddmA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ete FLT3 LIGAND

(Homo sapiens) 		PF02947
(Flt3_lig) 		3 LEU A 115
ALA A 114
LEU A  50
 None
 0.52A 5uunB-1eteA:
0.0		 5uunB-1eteA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezi CMP-N-ACETYLNEURAMIN
IC ACID SYNTHETASE

(Neisseria
meningitidis) 		PF02348
(CTP_transf_3) 		3 LEU A  10
ALA A  11
LEU A 102
 None
 0.48A 5uunB-1eziA:
0.0		 5uunB-1eziA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LEU A 104
ALA A  84
LEU A  78
 None
 0.55A 5uunB-1fn4A:
undetectable		 5uunB-1fn4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE

(Saccharomyces
cerevisiae) 		PF03051
(Peptidase_C1_2) 		3 LEU A 452
ALA A 453
LEU A 288
 None
HG  A 904 (-4.8A)
None
 0.53A 5uunB-1gcbA:
undetectable		 5uunB-1gcbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqa CYTOCHROME C'

(Rhodobacter
sphaeroides) 		PF01322
(Cytochrom_C_2) 		3 LEU A  24
ALA A  25
LEU A  97
 None
 0.40A 5uunB-1gqaA:
undetectable		 5uunB-1gqaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 LEU A 489
ALA A 490
LEU A 267
 None
 0.45A 5uunB-1gytA:
undetectable		 5uunB-1gytA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 LEU A 560
ALA A 559
LEU A 581
 None
 0.37A 5uunB-1h39A:
2.5		 5uunB-1h39A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		3 LEU A 296
ALA A 293
LEU A  53
 None
 0.54A 5uunB-1h3eA:
undetectable		 5uunB-1h3eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34

(Pisum sativum) 		PF04548
(AIG1) 		3 LEU A 185
ALA A 184
LEU A 161
 None
 0.52A 5uunB-1h65A:
undetectable		 5uunB-1h65A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 LEU A 213
ALA A 214
LEU A 176
 None
 0.45A 5uunB-1h8lA:
undetectable		 5uunB-1h8lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hz4 MALT REGULATORY
PROTEIN

(Escherichia
coli) 		no annotation 3 LEU A 314
ALA A 310
LEU A 344
 None
 0.52A 5uunB-1hz4A:
1.7		 5uunB-1hz4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqp RFCS

(Pyrococcus
furiosus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 LEU A 317
ALA A 316
LEU A 273
 None
 0.48A 5uunB-1iqpA:
undetectable		 5uunB-1iqpA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LEU A 178
ALA A 177
LEU A 407
 None
 0.50A 5uunB-1iyxA:
undetectable		 5uunB-1iyxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 LEU A 271
ALA A 270
LEU A 233
 None
 0.46A 5uunB-1j6uA:
undetectable		 5uunB-1j6uA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE

(Neurospora
crassa) 		PF10282
(Lactonase) 		3 LEU A 210
ALA A 209
LEU A 238
 None
 0.46A 5uunB-1jofA:
undetectable		 5uunB-1jofA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr6 HELICASE NS3

(Hepacivirus C) 		PF00271
(Helicase_C) 		3 LEU A  88
ALA A  87
LEU A  39
 None
 0.47A 5uunB-1jr6A:
undetectable		 5uunB-1jr6A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		3 LEU A 129
ALA A 126
LEU A 186
 None
 0.52A 5uunB-1jvwA:
undetectable		 5uunB-1jvwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5p FERREDOXIN

(Trichomonas
vaginalis) 		PF00111
(Fer2) 		3 LEU A  76
ALA A  77
LEU A  67
 FES  A  94 ( 4.4A)
None
None
 0.36A 5uunB-1l5pA:
undetectable		 5uunB-1l5pA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhm S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Solanum
tuberosum) 		PF01536
(SAM_decarbox) 		3 LEU A 293
ALA A 292
LEU A 273
 None
 0.48A 5uunB-1mhmA:
undetectable		 5uunB-1mhmA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np3 KETOL-ACID
REDUCTOISOMERASE

(Pseudomonas
aeruginosa) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 LEU A 103
ALA A 104
LEU A  97
 None
 0.54A 5uunB-1np3A:
undetectable		 5uunB-1np3A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nqz COA PYROPHOSPHATASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		3 LEU A  93
ALA A  92
LEU A  51
 None
 0.49A 5uunB-1nqzA:
undetectable		 5uunB-1nqzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7x CITRATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00285
(Citrate_synt) 		3 LEU A 295
ALA A 292
LEU A 253
 None
 0.51A 5uunB-1o7xA:
undetectable		 5uunB-1o7xA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE

(Bacillus
subtilis) 		PF05448
(AXE1) 		3 LEU C 193
ALA C 190
LEU C  32
 None
 0.48A 5uunB-1odtC:
undetectable		 5uunB-1odtC:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 LEU A 306
ALA A 305
LEU A 267
 None
 0.53A 5uunB-1ogyA:
undetectable		 5uunB-1ogyA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on0 YYCN PROTEIN

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		3 LEU A 139
ALA A 136
LEU A 110
 None
 0.52A 5uunB-1on0A:
undetectable		 5uunB-1on0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		3 LEU A  69
ALA A  70
LEU A  10
 None
 0.51A 5uunB-1otkA:
undetectable		 5uunB-1otkA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Bacillus
subtilis) 		PF01070
(FMN_dh) 		3 LEU A 287
ALA A 286
LEU A  78
 None
 0.44A 5uunB-1p0nA:
undetectable		 5uunB-1p0nA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LEU A 183
ALA A 182
LEU A 413
 None
 0.50A 5uunB-1p43A:
undetectable		 5uunB-1p43A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		3 LEU X 245
ALA X 246
LEU X 266
 None
 0.46A 5uunB-1pp1X:
undetectable		 5uunB-1pp1X:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		3 LEU A 189
ALA A 190
LEU A 176
 None
 0.45A 5uunB-1pujA:
undetectable		 5uunB-1pujA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q56 AGRIN

(Gallus gallus) 		PF00054
(Laminin_G_1) 		3 LEU A 141
ALA A 140
LEU A  57
 None
 0.47A 5uunB-1q56A:
undetectable		 5uunB-1q56A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME
ALPHA-TYPE SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		3 LEU A  99
ALA A 100
LEU A  56
 None
 0.49A 5uunB-1q5qA:
undetectable		 5uunB-1q5qA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qac IMMUNOGLOBULIN LIGHT
CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		3 LEU A 104
ALA A  84
LEU A  78
 None
 0.51A 5uunB-1qacA:
undetectable		 5uunB-1qacA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 LEU A 138
ALA A 139
LEU A 221
 None
 0.48A 5uunB-1qo8A:
undetectable		 5uunB-1qo8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		3 LEU A 286
ALA A 285
LEU A 188
 None
 0.52A 5uunB-1qonA:
undetectable		 5uunB-1qonA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8o KUNITZ TRYPSIN
INHIBITOR

(Copaifera
langsdorffii) 		PF00197
(Kunitz_legume) 		3 LEU A  32
ALA A  33
LEU A  55
 None
 0.55A 5uunB-1r8oA:
undetectable		 5uunB-1r8oA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 LEU A  67
ALA A  68
LEU A  25
 None
 0.52A 5uunB-1re5A:
undetectable		 5uunB-1re5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfs RIESKE PROTEIN

(Spinacia
oleracea) 		PF00355
(Rieske) 		3 LEU A  98
ALA A  99
LEU A  69
 None
 0.32A 5uunB-1rfsA:
undetectable		 5uunB-1rfsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE

(Cryptococcus
neoformans) 		PF00475
(IGPD) 		3 LEU A 177
ALA A 176
LEU A 145
 None
 0.50A 5uunB-1rhyA:
undetectable		 5uunB-1rhyA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica;
Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
PF00111
(Fer2)
PF01799
(Fer2_2) 		3 LEU C  64
ALA C  65
LEU B  37
 None
 0.54A 5uunB-1sb3C:
undetectable		 5uunB-1sb3C:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 LEU A 388
ALA A 389
LEU A 165
 None
 0.47A 5uunB-1serA:
undetectable		 5uunB-1serA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A

(Rattus
norvegicus) 		PF00625
(Guanylate_kin) 		3 LEU B 403
ALA B 400
LEU B 315
 None
 0.54A 5uunB-1t0hB:
undetectable		 5uunB-1t0hB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida;
Pseudomonas
putida) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 LEU A  71
ALA A  72
LEU C  37
 None
 0.46A 5uunB-1t3qA:
undetectable		 5uunB-1t3qA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 LEU A 813
ALA A 814
LEU A 723
 None
 0.53A 5uunB-1taqA:
undetectable		 5uunB-1taqA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdh NEI ENDONUCLEASE
VIII-LIKE 1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		3 LEU A 165
ALA A 164
LEU A 183
 None
 0.54A 5uunB-1tdhA:
undetectable		 5uunB-1tdhA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 LEU A 198
ALA A 197
LEU A 125
 LEU  A 198 ( 0.6A)
ALA  A 197 ( 0.0A)
LEU  A 125 ( 0.6A)
 0.53A 5uunB-1tedA:
undetectable		 5uunB-1tedA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2

(Homo sapiens) 		PF10275
(Peptidase_C65) 		3 LEU A 191
ALA A 190
LEU A  56
 None
 0.47A 5uunB-1tffA:
undetectable		 5uunB-1tffA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		3 LEU A1341
ALA A1342
LEU A1324
 None
 0.49A 5uunB-1ug3A:
undetectable		 5uunB-1ug3A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhr SWI/SNF RELATED,
MATRIX ASSOCIATED,
ACTIN DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
D MEMBER 1

(Mus musculus) 		PF02201
(SWIB) 		3 LEU A  36
ALA A  35
LEU A  78
 None
 0.49A 5uunB-1uhrA:
undetectable		 5uunB-1uhrA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Deinococcus
radiodurans) 		PF02566
(OsmC) 		3 LEU B 113
ALA B 110
LEU B  62
 None
GOL  B1140 (-3.6A)
None
 0.54A 5uunB-1uspB:
undetectable		 5uunB-1uspB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		3 LEU A 203
ALA A 204
LEU A  28
 None
 0.55A 5uunB-1v9cA:
undetectable		 5uunB-1v9cA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		3 LEU A 104
ALA A 105
LEU A 400
 None
 0.52A 5uunB-1vb3A:
undetectable		 5uunB-1vb3A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Nostoc sp. PCC
7120) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 LEU A 165
ALA A 164
LEU A 208
 None
 0.46A 5uunB-1vquA:
undetectable		 5uunB-1vquA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		3 LEU A 353
ALA A 350
LEU A 266
 None
 0.51A 5uunB-1vytA:
undetectable		 5uunB-1vytA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		3 LEU A 161
ALA A 158
LEU A  64
 None
 0.53A 5uunB-1w27A:
2.2		 5uunB-1w27A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		3 LEU C 766
ALA C 763
LEU C 782
 None
 0.50A 5uunB-1wa5C:
1.6		 5uunB-1wa5C:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 LEU A 227
ALA A 228
LEU A 220
 LEU  A 227 ( 0.6A)
ALA  A 228 ( 0.0A)
LEU  A 220 ( 0.6A)
 0.54A 5uunB-1wsvA:
undetectable		 5uunB-1wsvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN

(Thermus
thermophilus) 		PF02615
(Ldh_2) 		3 LEU A  15
ALA A  14
LEU A  49
 None
 0.55A 5uunB-1x0aA:
undetectable		 5uunB-1x0aA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		3 LEU A 293
ALA A 292
LEU A 328
 None
 0.54A 5uunB-1x2gA:
undetectable		 5uunB-1x2gA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0k HYPOTHETICAL PROTEIN
PA4535

(Pseudomonas
aeruginosa) 		PF08682
(DUF1780) 		3 LEU A 118
ALA A 119
LEU A 172
 None
 0.53A 5uunB-1y0kA:
undetectable		 5uunB-1y0kA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y60 FORMALDEHYDE-ACTIVAT
ING ENZYME FAE

(Methylobacterium
extorquens) 		PF08714
(Fae) 		3 LEU A  53
ALA A  54
LEU A  42
 None
 0.55A 5uunB-1y60A:
undetectable		 5uunB-1y60A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y89 DEVB PROTEIN

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		3 LEU A  17
ALA A  18
LEU A 136
 None
 0.42A 5uunB-1y89A:
undetectable		 5uunB-1y89A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LEU L 104
ALA L  84
LEU L  78
 None
 0.55A 5uunB-1zanL:
undetectable		 5uunB-1zanL:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 LEU A 975
ALA A 972
LEU A 981
 None
 0.53A 5uunB-1zy4A:
undetectable		 5uunB-1zy4A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 LEU A 371
ALA A 367
LEU A 464
 None
 0.54A 5uunB-2aaaA:
undetectable		 5uunB-2aaaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afe PROTEIN ASL1650

(Nostoc sp. PCC
7120) 		PF00550
(PP-binding) 		3 LEU A  83
ALA A  80
LEU A  61
 None
 0.50A 5uunB-2afeA:
undetectable		 5uunB-2afeA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		3 LEU A 244
ALA A 241
LEU A 322
 None
 0.50A 5uunB-2amcA:
undetectable		 5uunB-2amcA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 LEU B 313
ALA B 314
LEU B 293
 None
 0.55A 5uunB-2amcB:
undetectable		 5uunB-2amcB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		3 LEU A 276
ALA A 275
LEU A 252
 None
 0.52A 5uunB-2b81A:
undetectable		 5uunB-2b81A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 LEU A 383
ALA A 384
LEU A 374
 None
 0.51A 5uunB-2b9eA:
undetectable		 5uunB-2b9eA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN

(Homo sapiens) 		PF02036
(SCP2) 		3 LEU B 131
ALA B 128
LEU B 103
 None
 0.45A 5uunB-2c0lB:
undetectable		 5uunB-2c0lB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE

(Homo sapiens) 		PF01648
(ACPS) 		3 LEU A 189
ALA A 188
LEU A 212
 None
 0.54A 5uunB-2cg5A:
undetectable		 5uunB-2cg5A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 LEU A 318
ALA A 317
LEU A 307
 None
 0.54A 5uunB-2cgjA:
undetectable		 5uunB-2cgjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 309
ALA A 308
LEU A 339
 None
 0.40A 5uunB-2chrA:
undetectable		 5uunB-2chrA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crn UBASH3A PROTEIN

(Homo sapiens) 		PF00627
(UBA) 		3 LEU A  30
ALA A  29
LEU A  13
 None
 0.51A 5uunB-2crnA:
undetectable		 5uunB-2crnA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu6 DTDP-4-KETO-L-RHAMNO
SE REDUCTASE-RELATED
PROTEIN

(Thermus
thermophilus) 		PF01883
(FeS_assembly_P) 		3 LEU A  14
ALA A  13
LEU A  71
 None
 0.55A 5uunB-2cu6A:
undetectable		 5uunB-2cu6A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuw PURS

(Thermus
thermophilus) 		PF02700
(PurS) 		3 LEU A  67
ALA A  68
LEU A  44
 None
 0.47A 5uunB-2cuwA:
undetectable		 5uunB-2cuwA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cve HYPOTHETICAL PROTEIN
TTHA1053

(Thermus
thermophilus) 		PF01205
(UPF0029)
PF09186
(DUF1949) 		3 LEU A 166
ALA A 165
LEU A 146
 None
 0.48A 5uunB-2cveA:
undetectable		 5uunB-2cveA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 LEU A 176
ALA A 173
LEU A 277
 None
 0.47A 5uunB-2cvzA:
undetectable		 5uunB-2cvzA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		3 LEU A 120
ALA A 121
LEU A  72
 None
 0.50A 5uunB-2cyaA:
undetectable		 5uunB-2cyaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		3 LEU A 107
ALA A 106
LEU A 123
 None
 0.52A 5uunB-2eaeA:
1.7		 5uunB-2eaeA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		3 LEU A 183
ALA A 182
LEU A 199
 None
 0.37A 5uunB-2ej0A:
undetectable		 5uunB-2ej0A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erx GTP-BINDING PROTEIN
DI-RAS2

(Homo sapiens) 		PF00071
(Ras) 		3 LEU A 139
ALA A 138
LEU A  94
 None
 0.31A 5uunB-2erxA:
undetectable		 5uunB-2erxA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 LEU A 244
ALA A 245
LEU A 296
 None
 0.41A 5uunB-2fvlA:
undetectable		 5uunB-2fvlA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		3 LEU A 116
ALA A 112
LEU A 150
 None
 0.42A 5uunB-2g37A:
undetectable		 5uunB-2g37A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		3 LEU A 286
ALA A 287
LEU A 270
 None
 0.40A 5uunB-2ghpA:
undetectable		 5uunB-2ghpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqb CONSERVED
HYPOTHETICAL PROTEIN

(Rhodopseudomonas
palustris) 		PF12200
(DUF3597) 		3 LEU A  89
ALA A  85
LEU A 109
 None
 0.46A 5uunB-2gqbA:
undetectable		 5uunB-2gqbA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt2 GDP-MANNOSE MANNOSYL
HYDROLASE

(Escherichia
coli) 		PF00293
(NUDIX) 		3 LEU A 150
ALA A 151
LEU A 136
 None
 0.21A 5uunB-2gt2A:
undetectable		 5uunB-2gt2A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h01 2-CYS PEROXIREDOXIN

(Plasmodium
yoelii) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		3 LEU A 154
ALA A 153
LEU A 123
 None
 0.50A 5uunB-2h01A:
undetectable		 5uunB-2h01A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti) 		PF00285
(Citrate_synt) 		3 LEU A 351
ALA A 348
LEU A 308
 None
None
CMX  A5001 (-4.9A)
 0.45A 5uunB-2h12A:
undetectable		 5uunB-2h12A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hy5 PUTATIVE
SULFURTRANSFERASE
DSRE

(Allochromatium
vinosum) 		PF02635
(DrsE) 		3 LEU A  28
ALA A  27
LEU A  67
 None
 0.54A 5uunB-2hy5A:
undetectable		 5uunB-2hy5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		3 LEU A 197
ALA A 198
LEU A  86
 None
 0.44A 5uunB-2hyjA:
undetectable		 5uunB-2hyjA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9c HYPOTHETICAL PROTEIN
RPA1889

(Rhodopseudomonas
palustris) 		PF09450
(DUF2019) 		3 LEU A  82
ALA A  83
LEU A 115
 None
 0.52A 5uunB-2i9cA:
undetectable		 5uunB-2i9cA:
18.40