SIMILAR PATTERNS OF AMINO ACIDS FOR 5UUN_B_ACTB305_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0r TRANSDUCIN (GAMMA
SUBUNIT)

(Bos taurus) 		PF00631
(G-gamma) 		3 GLU G  39
TYR G  43
ARG G  47
 None
 0.82A 5uunB-1a0rG:
undetectable		 5uunB-1a0rG:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		3 GLU A 104
TYR A 105
ARG A 109
 None
 0.57A 5uunB-1epxA:
0.0		 5uunB-1epxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE

(Escherichia
coli) 		PF00881
(Nitroreductase) 		3 GLU A 198
TYR A 199
ARG A 203
 None
 0.59A 5uunB-1f5vA:
0.0		 5uunB-1f5vA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g01 ENDOGLUCANASE

(Bacillus sp.
KSM-635) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 GLU A 562
TYR A 563
ARG A 567
 None
 0.83A 5uunB-1g01A:
0.0		 5uunB-1g01A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1t E-SELECTIN

(Homo sapiens) 		PF00008
(EGF)
PF00059
(Lectin_C) 		3 GLU A  14
TYR A  18
ARG A  22
 None
 0.65A 5uunB-1g1tA:
0.0		 5uunB-1g1tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1got GT-GAMMA

(Bos taurus) 		PF00631
(G-gamma) 		3 GLU G  39
TYR G  43
ARG G  47
 None
 0.73A 5uunB-1gotG:
undetectable		 5uunB-1gotG:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 GLU A 713
TYR A 719
ARG A 722
 None
 0.75A 5uunB-1ileA:
1.6		 5uunB-1ileA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome) 		3 GLU H  62
TYR H  66
ARG H  70
 None
 0.75A 5uunB-1j2qH:
0.0		 5uunB-1j2qH:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF06026
(Rib_5-P_isom_A) 		3 GLU A 155
TYR A 156
ARG A 140
 None
 0.80A 5uunB-1o8bA:
undetectable		 5uunB-1o8bA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qah PERCHLORIC ACID
SOLUBLE PROTEIN

(Rattus
norvegicus) 		PF01042
(Ribonuc_L-PSP) 		3 GLU A  93
TYR A  95
ARG A 106
 None
 0.83A 5uunB-1qahA:
undetectable		 5uunB-1qahA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkt PROTEIN YFIR

(Bacillus
subtilis) 		PF00440
(TetR_N) 		3 GLU A 112
TYR A 113
ARG A 123
 None
 0.53A 5uunB-1rktA:
undetectable		 5uunB-1rktA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		3 GLU A 164
TYR A 163
ARG A 246
 None
 0.53A 5uunB-1tklA:
0.0		 5uunB-1tklA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugp NITRILE HYDRATASE
BETA SUBUNIT

(Pseudonocardia
thermophila) 		PF02211
(NHase_beta) 		3 GLU B 224
TYR B 222
ARG B 158
 None
 0.67A 5uunB-1ugpB:
undetectable		 5uunB-1ugpB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		3 GLU A1609
TYR A1610
ARG A1614
 None
 0.59A 5uunB-1uyvA:
undetectable		 5uunB-1uyvA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		3 GLU A  56
TYR A  53
ARG A 155
 None
 0.78A 5uunB-1yleA:
undetectable		 5uunB-1yleA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		3 GLU A 287
TYR A 288
ARG A 114
 None
 0.75A 5uunB-1z26A:
undetectable		 5uunB-1z26A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu9 HISTONE CHAPERONE
CIA1

(Schizosaccharomyces
pombe) 		PF04729
(ASF1_hist_chap) 		3 GLU A  75
TYR A  22
ARG A 143
 None
 0.74A 5uunB-2cu9A:
undetectable		 5uunB-2cu9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 GLU A 172
TYR A 175
ARG A 212
 None
 0.78A 5uunB-2cxeA:
undetectable		 5uunB-2cxeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		3 GLU A 609
TYR A 611
ARG A 653
 None
 0.82A 5uunB-2ec5A:
undetectable		 5uunB-2ec5A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		3 GLU X 485
TYR X 487
ARG X 474
 None
 0.81A 5uunB-2f2lX:
undetectable		 5uunB-2f2lX:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLU A 379
TYR A 378
ARG A 383
 None
 0.66A 5uunB-2ihtA:
undetectable		 5uunB-2ihtA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijx DNA POLYMERASE
SLIDING CLAMP A

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 GLU A  58
TYR A  59
ARG A  53
 None
 0.79A 5uunB-2ijxA:
undetectable		 5uunB-2ijxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4s PURINE NUCLEOSIDE
PHOSPHORYLASE

(Anopheles
gambiae) 		PF01048
(PNP_UDP_1) 		3 GLU A  97
TYR A 101
ARG A 105
 None
 0.83A 5uunB-2p4sA:
undetectable		 5uunB-2p4sA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF05637
(Glyco_transf_34) 		3 GLU A 157
TYR A 158
ARG A 162
 None
 0.52A 5uunB-2p6wA:
undetectable		 5uunB-2p6wA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		3 GLU A  48
TYR A  49
ARG A  53
 None
 0.80A 5uunB-2q3oA:
undetectable		 5uunB-2q3oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qeq FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT

(West Nile virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		3 GLU A 354
TYR A 355
ARG A 422
 None
 0.83A 5uunB-2qeqA:
undetectable		 5uunB-2qeqA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tmk THYMIDYLATE KINASE

(Saccharomyces
cerevisiae) 		PF02223
(Thymidylate_kin) 		3 GLU A  51
TYR A  52
ARG A 150
 None
 0.38A 5uunB-2tmkA:
undetectable		 5uunB-2tmkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyk PROTEIN TDCF

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		3 GLU A  89
TYR A  91
ARG A 105
 None
 0.80A 5uunB-2uykA:
undetectable		 5uunB-2uykA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		3 GLU A 735
TYR A 736
ARG A 644
 None
 0.47A 5uunB-2vuwA:
undetectable		 5uunB-2vuwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT

(Bacillus phage
SPP1) 		PF17288
(Terminase_3C) 		3 GLU A 314
TYR A 313
ARG A 278
 None
 0.67A 5uunB-2wbnA:
undetectable		 5uunB-2wbnA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		3 GLU A 181
TYR A 182
ARG A 186
 None
 0.48A 5uunB-2weuA:
undetectable		 5uunB-2weuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgp DUAL SPECIFICITY
PROTEIN PHOSPHATASE
14

(Homo sapiens) 		PF00782
(DSPc) 		3 GLU A 186
TYR A 185
ARG A 149
 None
 0.77A 5uunB-2wgpA:
undetectable		 5uunB-2wgpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1

(Saccharomyces
cerevisiae) 		PF12697
(Abhydrolase_6) 		3 GLU A  69
TYR A  70
ARG A  74
 None
 0.72A 5uunB-2y6vA:
undetectable		 5uunB-2y6vA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		3 GLU A 165
TYR A 166
ARG A 199
 None
 0.49A 5uunB-3bh1A:
undetectable		 5uunB-3bh1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bus METHYLTRANSFERASE

(Lechevalieria
aerocolonigenes) 		PF08241
(Methyltransf_11) 		3 GLU A 200
TYR A 199
ARG A 145
 None
 0.71A 5uunB-3busA:
undetectable		 5uunB-3busA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220

(Histophilus
somni) 		PF05114
(DUF692) 		3 GLU A 255
TYR A 256
ARG A 260
 None
 0.71A 5uunB-3bwwA:
undetectable		 5uunB-3bwwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLU A 571
TYR A 572
ARG A 576
 None
 0.41A 5uunB-3c4fA:
undetectable		 5uunB-3c4fA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 GLU A 280
TYR A 279
ARG A 298
 None
 0.78A 5uunB-3e77A:
undetectable		 5uunB-3e77A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0v GAG POLYPROTEIN

(Rous sarcoma
virus) 		PF00607
(Gag_p24) 		3 GLU A 217
TYR A 221
ARG A 225
 None
 0.65A 5uunB-3g0vA:
undetectable		 5uunB-3g0vA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLU A 188
TYR A 189
ARG A 300
 None
 0.77A 5uunB-3gazA:
undetectable		 5uunB-3gazA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00239
(Resolvase) 		3 GLU A  48
TYR A  47
ARG A  65
 None
 0.83A 5uunB-3guvA:
undetectable		 5uunB-3guvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7m SENSOR PROTEIN

(Geobacter
sulfurreducens) 		PF00497
(SBP_bac_3) 		3 GLU A 175
TYR A 176
ARG A 180
 None
 0.81A 5uunB-3h7mA:
undetectable		 5uunB-3h7mA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 GLU A 138
TYR A 139
ARG A 187
 None
 0.55A 5uunB-3h8fA:
undetectable		 5uunB-3h8fA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia7 CALG4

(Micromonospora
echinospora) 		PF00201
(UDPGT) 		3 GLU A 179
TYR A 180
ARG A 116
 None
 0.76A 5uunB-3ia7A:
undetectable		 5uunB-3ia7A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llm ATP-DEPENDENT RNA
HELICASE A

(Homo sapiens) 		PF00270
(DEAD) 		3 GLU A 553
TYR A 554
ARG A 528
 None
 0.58A 5uunB-3llmA:
undetectable		 5uunB-3llmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm4 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus
jostii) 		PF00903
(Glyoxalase) 		3 GLU A  98
TYR A 103
ARG A  13
 None
 0.70A 5uunB-3lm4A:
undetectable		 5uunB-3lm4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		3 GLU A 151
TYR A 152
ARG A 156
 None
 0.62A 5uunB-3lovA:
undetectable		 5uunB-3lovA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II

(Bacillus
anthracis) 		PF01116
(F_bP_aldolase) 		3 GLU A 125
TYR A 126
ARG A 130
 None
 0.79A 5uunB-3q94A:
undetectable		 5uunB-3q94A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qay ENDOLYSIN

(Clostridium
virus phiCD27) 		PF01520
(Amidase_3) 		3 GLU A  63
TYR A  67
ARG A  71
 None
 0.78A 5uunB-3qayA:
undetectable		 5uunB-3qayA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rku OXIDOREDUCTASE
YMR226C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		3 GLU A  32
TYR A 238
ARG A 242
 None
 0.72A 5uunB-3rkuA:
undetectable		 5uunB-3rkuA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLU A 571
TYR A 572
ARG A 576
 07J  A   1 (-3.9A)
None
None
 0.50A 5uunB-3tt0A:
undetectable		 5uunB-3tt0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		3 GLU A 328
TYR A 331
ARG A 317
 None
 0.71A 5uunB-3ttlA:
undetectable		 5uunB-3ttlA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty9 POLYNUCLEOTIDE
2',3'-CYCLIC
PHOSPHATE
PHOSPHODIESTERASE /
POLYNUCLEOTIDE
5'-HYDROXYL-KINASE /
POLYNUCLEOTIDE
3'-PHOSPHATASE

(Ruminiclostridium
thermocellum) 		PF16536
(PNKP-ligase_C)
PF16542
(PNKP_ligase) 		3 GLU A 513
TYR A 517
ARG A 521
 None
 0.79A 5uunB-3ty9A:
undetectable		 5uunB-3ty9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvf INTRON-ENCODED DNA
ENDONUCLEASE I-HJEMI

(Trichoderma
reesei) 		PF00961
(LAGLIDADG_1) 		3 GLU A 119
TYR A 120
ARG A 102
 None
 0.76A 5uunB-3uvfA:
undetectable		 5uunB-3uvfA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		3 GLU A 244
TYR A 243
ARG A 220
 None
 0.76A 5uunB-3w4rA:
undetectable		 5uunB-3w4rA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w79 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		3 GLU A 179
TYR A 180
ARG A 163
 None
 0.66A 5uunB-3w79A:
undetectable		 5uunB-3w79A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		3 GLU A 244
TYR A 243
ARG A 220
 None
 0.77A 5uunB-3wl1A:
undetectable		 5uunB-3wl1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		3 GLU A  41
TYR A  42
ARG A  46
 None
 0.83A 5uunB-4a3uA:
undetectable		 5uunB-4a3uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ab4 XENOBIOTIC REDUCTASE
B

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		3 GLU A  41
TYR A  42
ARG A  46
 None
 0.77A 5uunB-4ab4A:
undetectable		 5uunB-4ab4A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxx TRANSCRIPTION FACTOR
BYE1

(Saccharomyces
cerevisiae) 		PF07500
(TFIIS_M) 		3 GLU X 285
TYR X 287
ARG X 238
 None
 0.71A 5uunB-4bxxX:
undetectable		 5uunB-4bxxX:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmw DITERPENE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 3 GLU A 196
TYR A 197
ARG A 187
 None
 0.71A 5uunB-4cmwA:
undetectable		 5uunB-4cmwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		3 GLU A 312
TYR A 313
ARG A 317
 None
 0.70A 5uunB-4fmcA:
undetectable		 5uunB-4fmcA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE

(Oenococcus oeni) 		PF00465
(Fe-ADH) 		3 GLU A 294
TYR A 295
ARG A 372
 None
 0.59A 5uunB-4fr2A:
undetectable		 5uunB-4fr2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		3 GLU A 506
TYR A 507
ARG A 511
 None
 0.70A 5uunB-4g3fA:
undetectable		 5uunB-4g3fA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Methylobacillus
flagellatus) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 GLU A  68
TYR A  69
ARG A  73
 None
 0.69A 5uunB-4gltA:
19.2		 5uunB-4gltA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 GLU A 377
TYR A 378
ARG A 313
 None
 0.81A 5uunB-4i5jA:
undetectable		 5uunB-4i5jA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kz1 VIRB8 PROTEIN

(Bartonella
grahamii) 		PF04335
(VirB8) 		3 GLU A 164
TYR A 165
ARG A  52
 None
 0.73A 5uunB-4kz1A:
undetectable		 5uunB-4kz1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		3 GLU A 251
TYR A  43
ARG A  51
 None
 0.82A 5uunB-4lctA:
undetectable		 5uunB-4lctA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lso TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Bartonella
quintana) 		PF04335
(VirB8) 		3 GLU A 225
TYR A 226
ARG A 113
 None
 0.68A 5uunB-4lsoA:
undetectable		 5uunB-4lsoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		3 GLU A  81
TYR A  85
ARG A  89
 None
 0.80A 5uunB-4m9dA:
undetectable		 5uunB-4m9dA:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN

(Pseudomonas
putida) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 GLU A 177
TYR A 178
ARG A 220
 None
 0.58A 5uunB-4naxA:
27.2		 5uunB-4naxA:
34.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		3 GLU A 266
TYR A 267
ARG A 250
 None
 0.80A 5uunB-4ovyA:
undetectable		 5uunB-4ovyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnw CHANOCLAVINE-I
ALDEHYDE REDUCTASE

(Aspergillus
fumigatus) 		PF00724
(Oxidored_FMN) 		3 GLU A  47
TYR A  48
ARG A  52
 None
 0.80A 5uunB-4qnwA:
undetectable		 5uunB-4qnwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		3 GLU A 154
TYR A 155
ARG A 159
 None
 0.84A 5uunB-4rnwA:
undetectable		 5uunB-4rnwA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		3 GLU A 453
TYR A 451
ARG A 474
 None
 0.71A 5uunB-4uwaA:
undetectable		 5uunB-4uwaA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE

(Burkholderia
cenocepacia) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLU A 155
TYR A 156
ARG A 160
 None
 0.73A 5uunB-4wjbA:
undetectable		 5uunB-4wjbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y81 PROTEASOME SUBUNIT
BETA TYPE-6

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		3 GLU L 218
TYR L 217
ARG L 185
 None
 0.78A 5uunB-4y81L:
undetectable		 5uunB-4y81L:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		3 GLU A  55
TYR A  56
ARG A  60
 None
 0.83A 5uunB-4yncA:
undetectable		 5uunB-4yncA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLU A 571
TYR A 572
ARG A 576
 38O  A1769 ( 3.7A)
None
None
 0.45A 5uunB-5a46A:
undetectable		 5uunB-5a46A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A
TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Homo sapiens;
Homo sapiens) 		PF08704
(GCD14)
PF04189
(Gcd10p) 		3 GLU A   7
TYR A   6
ARG B 395
 None
 0.73A 5uunB-5ccxA:
undetectable		 5uunB-5ccxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		3 GLU A1609
TYR A1610
ARG A1614
 None
 0.57A 5uunB-5cslA:
undetectable		 5uunB-5cslA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkp ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Neisseria
meningitidis) 		PF00574
(CLP_protease) 		3 GLU A 185
TYR A 189
ARG A 166
 None
 0.84A 5uunB-5dkpA:
undetectable		 5uunB-5dkpA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Cryptococcus
neoformans) 		PF02358
(Trehalose_PPase) 		3 GLU A 116
TYR A 120
ARG A 124
 None
 0.82A 5uunB-5dx9A:
undetectable		 5uunB-5dx9A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7s LON PROTEASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C) 		3 GLU A 533
TYR A 583
ARG A 536
 None
 0.74A 5uunB-5e7sA:
undetectable		 5uunB-5e7sA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		3 GLU A 646
TYR A 647
ARG A 651
 None
 0.75A 5uunB-5ezrA:
undetectable		 5uunB-5ezrA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g53 ADENOSINE RECEPTOR
A2A
ENGINEERED DOMAIN OF
HUMAN G ALPHA S LONG
ISOFORM

(Homo sapiens;
Homo sapiens) 		PF00001
(7tm_1)
PF00503
(G-alpha) 		3 GLU C 392
TYR C 391
ARG A 102
 None
 0.78A 5uunB-5g53C:
undetectable		 5uunB-5g53C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		3 GLU A 323
TYR A 325
ARG A 292
 None
 0.72A 5uunB-5ghsA:
undetectable		 5uunB-5ghsA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6y NUCLEOSOME-REMODELIN
G FACTOR SUBUNIT
BPTF

(Homo sapiens) 		no annotation 3 GLU A  75
TYR A  74
ARG A 125
 None
 0.74A 5uunB-5h6yA:
undetectable		 5uunB-5h6yA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfn CEPHALOSPORIN-C
DEACETYLASE

(Thermotoga
maritima) 		PF05448
(AXE1) 		3 GLU A  21
TYR A  19
ARG A 218
 None
 0.70A 5uunB-5hfnA:
undetectable		 5uunB-5hfnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmm EXODEOXYRIBONUCLEASE

(Escherichia
virus T5) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		3 GLU A 210
TYR A 242
ARG A 216
 None
EDO  A 301 (-4.6A)
EDO  A 301 (-3.8A)
 0.80A 5uunB-5hmmA:
undetectable		 5uunB-5hmmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2

(Homo sapiens) 		PF00400
(WD40) 		3 GLU A 449
TYR A 450
ARG A 706
 None
 0.61A 5uunB-5igqA:
undetectable		 5uunB-5igqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npt TELOMERASE REVERSE
TRANSCRIPTASE

(Ogataea
polymorpha) 		no annotation 3 GLU A  73
TYR A  72
ARG A  43
 None
 0.64A 5uunB-5nptA:
undetectable		 5uunB-5nptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		3 GLU A 163
TYR A 164
ARG A 168
 None
 0.69A 5uunB-5thwA:
undetectable		 5uunB-5thwA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9k ARYL HYDROCARBON
RECEPTOR-INTERACTING
PROTEIN-LIKE 1
(AIPL1)

(Homo sapiens) 		PF00254
(FKBP_C) 		3 GLU A 135
TYR A 134
ARG A 105
 None
 0.79A 5uunB-5u9kA:
undetectable		 5uunB-5u9kA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 3 GLU B 208
TYR B 209
ARG B 254
 None
 0.21A 5uunB-5uuoB:
46.9		 5uunB-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7z DNA POLYMERASE III
SUBUNIT BETA

(Rickettsia
conorii) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 GLU A 338
TYR A 336
ARG A 176
 None
 0.56A 5uunB-5w7zA:
undetectable		 5uunB-5w7zA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG

(Saccharomyces
cerevisiae) 		PF10345
(Cohesin_load) 		3 GLU A 563
TYR A 565
ARG A 601
 None
 0.59A 5uunB-5w94A:
undetectable		 5uunB-5w94A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 3 GLU A 280
TYR A 279
ARG A 629
 None
 0.80A 5uunB-5wugA:
undetectable		 5uunB-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		3 GLU A 345
TYR A 347
ARG A 340
 None
None
C  B  40 ( 3.4A)
 0.81A 5uunB-5xblA:
undetectable		 5uunB-5xblA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 3 GLU A 129
TYR A 131
ARG A 199
 None
 0.82A 5uunB-6ap6A:
undetectable		 5uunB-6ap6A:
undetectable