SIMILAR PATTERNS OF AMINO ACIDS FOR 5UUN_A_ACTA312

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aba GLUTAREDOXIN

(Escherichia
virus T4) 		PF00462
(Glutaredoxin) 		3 ILE A  76
VAL A  68
PRO A  66
 None
 0.62A 5uunA-1abaA:
5.5		 5uunA-1abaA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4q PROTEIN (HUMAN
THIOLTRANSFERASE)

(Homo sapiens) 		PF00462
(Glutaredoxin) 		3 ILE A  79
VAL A  72
PRO A  70
 None
None
GSH  A 106 ( 4.3A)
 0.59A 5uunA-1b4qA:
5.8		 5uunA-1b4qA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)

(Ochrobactrum
anthropi) 		PF03576
(Peptidase_S58) 		3 ILE A 111
VAL A 142
PRO A 140
 None
 0.73A 5uunA-1b65A:
undetectable		 5uunA-1b65A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)

(Amycolatopsis
mediterranei) 		PF01041
(DegT_DnrJ_EryC1) 		3 ILE A 355
VAL A 107
PRO A  84
 None
 0.71A 5uunA-1b9hA:
0.0		 5uunA-1b9hA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ILE A 541
VAL A 551
PRO A 554
 None
 0.69A 5uunA-1dedA:
0.0		 5uunA-1dedA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00106
(adh_short) 		3 ILE A 257
VAL A 221
PRO A 224
 None
 0.69A 5uunA-1e6wA:
0.9		 5uunA-1e6wA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		3 ILE A 265
VAL A 282
PRO A  44
 None
 0.69A 5uunA-1eepA:
undetectable		 5uunA-1eepA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		3 ILE A 385
VAL A 295
PRO A 292
 None
 0.62A 5uunA-1eyyA:
0.0		 5uunA-1eyyA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF01180
(DHO_dh) 		3 ILE A 298
VAL A 315
PRO A  57
 None
 0.70A 5uunA-1f76A:
undetectable		 5uunA-1f76A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnh PROTEIN
(FIBRONECTIN)

(Homo sapiens) 		PF00041
(fn3) 		3 ILE A 240
VAL A 227
PRO A 231
 None
 0.63A 5uunA-1fnhA:
undetectable		 5uunA-1fnhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		3 ILE B 280
VAL B 333
PRO B 331
 None
 0.66A 5uunA-1gydB:
undetectable		 5uunA-1gydB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hk6 EXOCYST COMPLEX
COMPONENT SEC5

(Mus musculus) 		PF01833
(TIG) 		3 ILE A  74
VAL A  10
PRO A   8
 None
 0.72A 5uunA-1hk6A:
undetectable		 5uunA-1hk6A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 ILE A 107
VAL A 249
PRO A 247
 None
 0.70A 5uunA-1i7oA:
undetectable		 5uunA-1i7oA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ILE A 367
VAL A 384
PRO A  64
 None
 0.64A 5uunA-1jcnA:
undetectable		 5uunA-1jcnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ILE A 367
VAL A 384
PRO A  64
 None
 0.63A 5uunA-1jr1A:
undetectable		 5uunA-1jr1A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzo THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBC

(Escherichia
coli) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		3 ILE A  90
VAL A  92
PRO A 183
 None
 0.68A 5uunA-1jzoA:
3.2		 5uunA-1jzoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 ILE A 264
VAL A 274
PRO A 272
 None
 0.55A 5uunA-1kcxA:
undetectable		 5uunA-1kcxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kte THIOLTRANSFERASE

(Sus scrofa) 		PF00462
(Glutaredoxin) 		3 ILE A  79
VAL A  72
PRO A  70
 None
 0.55A 5uunA-1kteA:
5.9		 5uunA-1kteA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT

(Homo sapiens) 		no annotation 3 ILE B  90
VAL B 119
PRO B 122
 None
 0.70A 5uunA-1l1oB:
undetectable		 5uunA-1l1oB:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9l GRANULYSIN

(Homo sapiens) 		no annotation 3 ILE A  57
VAL A  26
PRO A  21
 None
None
EOH  A 101 ( 4.2A)
 0.71A 5uunA-1l9lA:
undetectable		 5uunA-1l9lA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqy PEPTIDE DEFORMYLASE
2

(Geobacillus
stearothermophilus) 		PF01327
(Pep_deformylase) 		3 ILE A 127
VAL A 129
PRO A  92
 None
 0.71A 5uunA-1lqyA:
undetectable		 5uunA-1lqyA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli) 		PF00004
(AAA) 		3 ILE A 297
VAL A 191
PRO A 188
 None
 0.63A 5uunA-1lv7A:
undetectable		 5uunA-1lv7A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		3 ILE A 322
VAL A 320
PRO A  59
 None
 0.56A 5uunA-1m1cA:
0.1		 5uunA-1m1cA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ILE B 787
VAL B 756
PRO B 754
 None
 0.70A 5uunA-1m2vB:
undetectable		 5uunA-1m2vB:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2

(Salmonella
virus PRD1) 		PF09214
(Prd1-P2) 		3 ILE A 283
VAL A 263
PRO A 276
 None
 0.69A 5uunA-1n7uA:
undetectable		 5uunA-1n7uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		3 ILE H  51
VAL H 100
PRO H 102
 None
 0.72A 5uunA-1q5qH:
undetectable		 5uunA-1q5qH:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qas PHOSPHOLIPASE C
DELTA-1

(Rattus
norvegicus) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 ILE A 635
VAL A 656
PRO A 654
 None
 0.71A 5uunA-1qasA:
undetectable		 5uunA-1qasA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Mycobacterium
tuberculosis) 		PF01513
(NAD_kinase) 		3 ILE A 241
VAL A 220
PRO A 222
 None
 0.62A 5uunA-1u0tA:
undetectable		 5uunA-1u0tA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1

(Homo sapiens) 		PF07679
(I-set) 		3 ILE A  41
VAL A  43
PRO A  20
 None
 0.70A 5uunA-1u2hA:
undetectable		 5uunA-1u2hA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3m PRION-LIKE PROTEIN

(Gallus gallus) 		PF00377
(Prion) 		3 ILE A 227
VAL A 191
PRO A 198
 None
 0.53A 5uunA-1u3mA:
undetectable		 5uunA-1u3mA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ILE B 208
VAL B 257
PRO B 289
 None
 0.68A 5uunA-1umbB:
undetectable		 5uunA-1umbB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3y PEPTIDE DEFORMYLASE

(Thermus
thermophilus) 		PF01327
(Pep_deformylase) 		3 ILE A 119
VAL A 121
PRO A  87
 None
 0.68A 5uunA-1v3yA:
undetectable		 5uunA-1v3yA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ILE A 337
VAL A 354
PRO A  39
 None
 0.54A 5uunA-1vrdA:
undetectable		 5uunA-1vrdA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965

(Mycobacterium
tuberculosis) 		PF01068
(DNA_ligase_A_M)
PF04679
(DNA_ligase_A_C) 		3 ILE A 667
VAL A 756
PRO A 753
 None
 0.72A 5uunA-1vs0A:
undetectable		 5uunA-1vs0A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		3 ILE A 197
VAL A 186
PRO A 184
 None
 0.44A 5uunA-1w5dA:
undetectable		 5uunA-1w5dA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ILE B 192
VAL B 145
PRO B 147
 None
 0.60A 5uunA-1w85B:
undetectable		 5uunA-1w85B:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w94 PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN

(Methanothermobacter
thermautotrophicus) 		no annotation 3 ILE A  60
VAL A  50
PRO A  57
 None
 0.70A 5uunA-1w94A:
undetectable		 5uunA-1w94A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wft 1700129L13RIK
PROTEIN

(Mus musculus) 		no annotation 3 ILE A 109
VAL A  14
PRO A  11
 None
 0.67A 5uunA-1wftA:
undetectable		 5uunA-1wftA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wj3 KIAA1496 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		3 ILE A 104
VAL A  25
PRO A  22
 None
 0.65A 5uunA-1wj3A:
undetectable		 5uunA-1wj3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws0 PEPTIDE DEFORMYLASE
1

(Bacillus cereus) 		PF01327
(Pep_deformylase) 		3 ILE A 106
VAL A 108
PRO A  75
 None
 0.66A 5uunA-1ws0A:
undetectable		 5uunA-1ws0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 ILE A 147
VAL A 124
PRO A 121
 None
 0.68A 5uunA-1xj5A:
undetectable		 5uunA-1xj5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xte SERINE/THREONINE-PRO
TEIN KINASE SGK3

(Mus musculus) 		PF00787
(PX) 		3 ILE A  92
VAL A  10
PRO A   8
 None
 0.59A 5uunA-1xteA:
undetectable		 5uunA-1xteA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtn SERINE/THREONINE-PRO
TEIN KINASE SGK3

(Mus musculus) 		PF00787
(PX) 		3 ILE A  92
VAL A  10
PRO A   8
 None
 0.62A 5uunA-1xtnA:
undetectable		 5uunA-1xtnA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2

(Homo sapiens) 		PF00179
(UQ_con) 		3 ILE A  84
VAL A  67
PRO A  65
 None
 0.69A 5uunA-1y6lA:
undetectable		 5uunA-1y6lA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypf GMP REDUCTASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		3 ILE A 210
VAL A 227
PRO A  39
 None
 0.65A 5uunA-1ypfA:
undetectable		 5uunA-1ypfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypz T CELL RECEPTOR
DELTA

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ILE E 151
VAL E 141
PRO E 126
 None
 0.66A 5uunA-1ypzE:
undetectable		 5uunA-1ypzE:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		3 ILE A  10
VAL A 229
PRO A   5
 None
 0.69A 5uunA-1z9dA:
undetectable		 5uunA-1z9dA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ILE A 346
VAL A 363
PRO A  47
 None
 0.66A 5uunA-1zfjA:
undetectable		 5uunA-1zfjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1f URIDYLATE KINASE

(Haemophilus
influenzae) 		PF00696
(AA_kinase) 		3 ILE A   9
VAL A 227
PRO A   4
 None
 0.62A 5uunA-2a1fA:
undetectable		 5uunA-2a1fA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284

(Homo sapiens) 		PF00179
(UQ_con) 		3 ILE A  90
VAL A  71
PRO A  69
 None
 0.73A 5uunA-2a7lA:
undetectable		 5uunA-2a7lA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aak UBIQUITIN
CONJUGATING ENZYME

(Arabidopsis
thaliana) 		PF00179
(UQ_con) 		3 ILE A  87
VAL A  70
PRO A  68
 None
 0.73A 5uunA-2aakA:
undetectable		 5uunA-2aakA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayv UBIQUITIN-CONJUGATIN
G ENZYME E2

(Toxoplasma
gondii) 		PF00179
(UQ_con) 		3 ILE A  84
VAL A  67
PRO A  65
 None
 0.62A 5uunA-2ayvA:
undetectable		 5uunA-2ayvA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 ILE A 760
VAL A 227
PRO A 229
 None
 0.60A 5uunA-2b39A:
3.6		 5uunA-2b39A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bep UBIQUITIN-CONJUGATIN
G ENZYME E2-25 KDA

(Bos taurus) 		PF00179
(UQ_con) 		3 ILE A  91
VAL A  73
PRO A  71
 None
 0.67A 5uunA-2bepA:
undetectable		 5uunA-2bepA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2brt LEUCOANTHOCYANIDIN
DIOXYGENASE

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		3 ILE A  67
VAL A 189
PRO A 195
 None
 0.71A 5uunA-2brtA:
undetectable		 5uunA-2brtA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ILE A 337
VAL A 354
PRO A  49
 None
 0.50A 5uunA-2cu0A:
undetectable		 5uunA-2cu0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195

(Thermus
thermophilus) 		PF03746
(LamB_YcsF) 		3 ILE A  91
VAL A 108
PRO A 110
 None
 0.68A 5uunA-2dfaA:
undetectable		 5uunA-2dfaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlh RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Homo sapiens) 		PF00041
(fn3) 		3 ILE A 108
VAL A  25
PRO A  22
 None
 0.72A 5uunA-2dlhA:
undetectable		 5uunA-2dlhA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee2 CONTACTIN-1

(Homo sapiens) 		PF00041
(fn3) 		3 ILE A 106
VAL A  25
PRO A  22
 None
 0.72A 5uunA-2ee2A:
undetectable		 5uunA-2ee2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eke SUMO-CONJUGATING
ENZYME UBC9

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		3 ILE A  92
VAL A  75
PRO A  73
 None
 0.70A 5uunA-2ekeA:
undetectable		 5uunA-2ekeA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2

(Homo sapiens) 		PF00179
(UQ_con) 		3 ILE A  84
VAL A  67
PRO A  65
 None
 0.69A 5uunA-2espA:
undetectable		 5uunA-2espA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4w UBIQUITIN-CONJUGATIN
G ENZYME E2, J2

(Homo sapiens) 		PF00179
(UQ_con) 		3 ILE A  32
VAL A  48
PRO A  51
 None
 0.68A 5uunA-2f4wA:
undetectable		 5uunA-2f4wA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f86 HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF08332
(CaMKII_AD) 		3 ILE B 353
VAL B 429
PRO B 417
 None
 0.73A 5uunA-2f86B:
undetectable		 5uunA-2f86B:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		3 ILE A  86
VAL A  69
PRO A  67
 None
 0.57A 5uunA-2gmiA:
undetectable		 5uunA-2gmiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		3 ILE A 328
VAL A 368
PRO A 350
 None
 0.64A 5uunA-2gqwA:
undetectable		 5uunA-2gqwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq9 MLL6688 PROTEIN

(Mesorhizobium
loti) 		PF12900
(Pyridox_ox_2) 		3 ILE A  55
VAL A 132
PRO A 130
 None
 0.62A 5uunA-2hq9A:
undetectable		 5uunA-2hq9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqi HYPOTHETICAL PROTEIN
XCC0632

(Xanthomonas
campestris) 		PF03886
(ABC_trans_aux) 		3 ILE A  65
VAL A 129
PRO A  59
 None
 0.68A 5uunA-2iqiA:
undetectable		 5uunA-2iqiA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1) 		3 ILE A 168
VAL A 180
PRO A 182
 None
 0.73A 5uunA-2l4oA:
undetectable		 5uunA-2l4oA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnm PROTEIN TIC 40,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 3 ILE A   8
VAL A   4
PRO A   1
 None
 0.61A 5uunA-2lnmA:
undetectable		 5uunA-2lnmA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2z NON-SPECIFIC
LIPID-TRANSFER
PROTEIN

(Anethum
graveolens) 		PF00234
(Tryp_alpha_amyl) 		3 ILE A  79
VAL A  77
PRO A  72
 None
 0.68A 5uunA-2n2zA:
undetectable		 5uunA-2n2zA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 ILE A 103
VAL A  59
PRO A  57
 None
 0.73A 5uunA-2nsmA:
undetectable		 5uunA-2nsmA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 ILE A 200
VAL A 186
PRO A 197
 None
 0.55A 5uunA-2obvA:
undetectable		 5uunA-2obvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ILE A 403
VAL A 408
PRO A 344
 None
 0.71A 5uunA-2oejA:
undetectable		 5uunA-2oejA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2os1 PEPTIDE DEFORMYLASE

(Enterococcus
faecalis) 		PF01327
(Pep_deformylase) 		3 ILE A 131
VAL A 133
PRO A  96
 None
 0.67A 5uunA-2os1A:
undetectable		 5uunA-2os1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00581
(Rhodanese) 		3 ILE A 175
VAL A 255
PRO A 251
 None
 0.71A 5uunA-2oucA:
undetectable		 5uunA-2oucA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 ILE A 143
VAL A 120
PRO A 117
 None
 0.66A 5uunA-2pt6A:
undetectable		 5uunA-2pt6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg8 ACYL CARRIER PROTEIN
SYNTHASE PY06285

(Plasmodium
yoelii) 		PF01648
(ACPS) 		3 ILE A 145
VAL A 127
PRO A 125
 None
 0.72A 5uunA-2qg8A:
undetectable		 5uunA-2qg8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgx UBIQUITIN-CONJUGATIN
G ENZYME E2 Q1

(Homo sapiens) 		PF00179
(UQ_con) 		3 ILE A 103
VAL A  85
PRO A  83
 None
 0.67A 5uunA-2qgxA:
undetectable		 5uunA-2qgxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0j UBIQUITIN CARRIER
PROTEIN

(Plasmodium
falciparum) 		PF00179
(UQ_con) 		3 ILE A  84
VAL A  67
PRO A  65
 None
 0.62A 5uunA-2r0jA:
undetectable		 5uunA-2r0jA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
graminearum) 		PF02458
(Transferase) 		3 ILE A 137
VAL A 167
PRO A 306
 None
 0.67A 5uunA-2rkvA:
undetectable		 5uunA-2rkvA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4y URIDYLATE KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		3 ILE A  12
VAL A 230
PRO A   7
 None
 0.69A 5uunA-2v4yA:
undetectable		 5uunA-2v4yA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		3 ILE A 324
VAL A 319
PRO A 380
 None
 0.65A 5uunA-2xfsA:
undetectable		 5uunA-2xfsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		3 ILE A  26
VAL A   5
PRO A 255
 None
 0.68A 5uunA-2xsbA:
undetectable		 5uunA-2xsbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		3 ILE A  97
VAL A 114
PRO A 116
 None
 0.67A 5uunA-2xu2A:
undetectable		 5uunA-2xu2A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Candidatus
Cloacimonas
acidaminovorans) 		PF05853
(BKACE) 		3 ILE A 169
VAL A 142
PRO A 140
 None
 0.62A 5uunA-2y7dA:
undetectable		 5uunA-2y7dA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yew E1 ENVELOPE
GLYCOPROTEIN

(Barmah Forest
virus) 		PF01589
(Alpha_E1_glycop) 		3 ILE B 330
VAL B 369
PRO B 294
 None
 0.65A 5uunA-2yewB:
undetectable		 5uunA-2yewB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		3 ILE A 326
VAL A 278
PRO A 280
 None
 0.62A 5uunA-2z00A:
undetectable		 5uunA-2z00A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a45 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Acanthamoeba
polyphaga
mimivirus) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		3 ILE A 270
VAL A 158
PRO A 187
 None
 0.59A 5uunA-3a45A:
undetectable		 5uunA-3a45A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a58 EXOCYST COMPLEX
COMPONENT SEC3

(Saccharomyces
cerevisiae) 		PF15277
(Sec3-PIP2_bind) 		3 ILE A 210
VAL A 178
PRO A 226
 None
 0.70A 5uunA-3a58A:
undetectable		 5uunA-3a58A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5f DIHYDRODIPICOLINATE
SYNTHASE

(Clostridium
botulinum) 		PF00701
(DHDPS) 		3 ILE A  40
VAL A   9
PRO A 212
 None
 0.71A 5uunA-3a5fA:
undetectable		 5uunA-3a5fA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjr PUTATIVE
CARBOXYLESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		3 ILE A 118
VAL A  37
PRO A 109
 None
 0.70A 5uunA-3bjrA:
undetectable		 5uunA-3bjrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzh UBIQUITIN-CONJUGATIN
G ENZYME E2 E1

(Homo sapiens) 		PF00179
(UQ_con) 		3 ILE A 130
VAL A 113
PRO A 111
 GOL  A 200 (-3.7A)
GOL  A 200 ( 4.3A)
None
 0.70A 5uunA-3bzhA:
undetectable		 5uunA-3bzhA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckm YRAM (HI1655)

(Haemophilus
influenzae) 		PF04348
(LppC) 		3 ILE A 412
VAL A 383
PRO A 381
 None
 0.67A 5uunA-3ckmA:
undetectable		 5uunA-3ckmA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 ILE A 291
VAL A 305
PRO A 199
 None
 0.70A 5uunA-3cp8A:
undetectable		 5uunA-3cp8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctf GLUTAREDOXIN-2

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		3 ILE A 119
VAL A 112
PRO A 110
 None
 0.69A 5uunA-3ctfA:
5.7		 5uunA-3ctfA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3b 30S RIBOSOMAL
PROTEIN S10

(Escherichia
coli) 		PF00338
(Ribosomal_S10) 		3 ILE J  55
VAL J  36
PRO J  39
 None
 0.70A 5uunA-3d3bJ:
undetectable		 5uunA-3d3bJ:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4m GLUTAREDOXIN-2,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		3 ILE A  85
VAL A  78
PRO A  76
 None
 0.69A 5uunA-3d4mA:
6.0		 5uunA-3d4mA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus) 		PF01979
(Amidohydro_1) 		3 ILE A 324
VAL A 277
PRO A 279
 None
FLC  A 424 ( 3.8A)
None
 0.65A 5uunA-3d6nA:
undetectable		 5uunA-3d6nA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanocaldococcus
jannaschii) 		PF03201
(HMD) 		3 ILE A 119
VAL A  74
PRO A  71
 None
 0.58A 5uunA-3dafA:
undetectable		 5uunA-3dafA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daq DIHYDRODIPICOLINATE
SYNTHASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		3 ILE A  41
VAL A  10
PRO A 214
 None
 0.72A 5uunA-3daqA:
undetectable		 5uunA-3daqA:
21.66