SIMILAR PATTERNS OF AMINO ACIDS FOR 5UUN_A_ACTA310_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 GLU A 468
HIS A 467
ARG A 483
 API  A1499 (-3.1A)
None
None
 0.99A 5uunA-1e8cA:
0.5		 5uunA-1e8cA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fts FTSY

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 GLU A 396
HIS A 392
ARG A 386
 None
 0.87A 5uunA-1ftsA:
0.0		 5uunA-1ftsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Gallus gallus) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 GLU A 309
HIS A 307
ARG A 328
 None
SO4  A2104 (-3.8A)
None
 0.73A 5uunA-1ktcA:
0.0		 5uunA-1ktcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 GLU A 373
HIS A 372
ARG A 365
 None
 0.80A 5uunA-1llaA:
0.0		 5uunA-1llaA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lme PEPTIDE DEFORMYLASE

(Thermotoga
maritima) 		PF01327
(Pep_deformylase) 		3 GLU A 130
HIS A 129
ARG A 125
 None
OCS  A  87 ( 3.9A)
None
 0.97A 5uunA-1lmeA:
0.0		 5uunA-1lmeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 GLU A  20
HIS A  21
ARG A  25
 None
 0.76A 5uunA-1odoA:
0.0		 5uunA-1odoA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oij PUTATIVE
ALKYLSULFATASE ATSK

(Pseudomonas
putida) 		PF02668
(TauD) 		3 GLU C 207
HIS C 202
ARG C 200
 None
 0.91A 5uunA-1oijC:
0.0		 5uunA-1oijC:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		3 GLU A 300
HIS A 303
ARG A 313
 None
None
GDP  A1603 ( 3.4A)
 0.97A 5uunA-1p9bA:
0.0		 5uunA-1p9bA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrv GLYCOSYLTRANSFERASE
GTFD

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		3 GLU A 315
HIS A 316
ARG A 320
 GLU  A 315 ( 0.6A)
HIS  A 316 ( 1.0A)
ARG  A 320 ( 0.6A)
 0.91A 5uunA-1rrvA:
0.6		 5uunA-1rrvA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 269
HIS A 266
ARG A 267
 None
 0.96A 5uunA-1rvkA:
undetectable		 5uunA-1rvkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Escherichia
coli) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 GLU A 174
HIS A 171
ARG A 267
 None
 0.82A 5uunA-1t4bA:
undetectable		 5uunA-1t4bA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 GLU A 578
HIS A 577
ARG A 576
 None
SO4  A 771 (-3.6A)
SO4  A 771 (-4.8A)
 0.72A 5uunA-1u1hA:
undetectable		 5uunA-1u1hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3y PEPTIDE DEFORMYLASE

(Thermus
thermophilus) 		PF01327
(Pep_deformylase) 		3 GLU A 146
HIS A 145
ARG A 141
 None
OCS  A 102 ( 3.8A)
None
 0.95A 5uunA-1v3yA:
undetectable		 5uunA-1v3yA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A

(Homo sapiens) 		PF03770
(IPK) 		3 GLU A 304
HIS A 305
ARG A 308
 None
 0.80A 5uunA-1w2dA:
undetectable		 5uunA-1w2dA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws0 PEPTIDE DEFORMYLASE
1

(Bacillus cereus) 		PF01327
(Pep_deformylase) 		3 GLU A 133
HIS A 132
ARG A 128
 NI  A 200 ( 4.1A)
NI  A 200 (-3.2A)
None
 0.97A 5uunA-1ws0A:
undetectable		 5uunA-1ws0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycd HYPOTHETICAL 27.3
KDA PROTEIN IN
AAP1-SMF2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF03959
(FSH1) 		3 GLU A 154
HIS A 151
ARG A 156
 None
 0.97A 5uunA-1ycdA:
undetectable		 5uunA-1ycdA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF01327
(Pep_deformylase) 		3 GLU A 154
HIS A 153
ARG A 149
 ZN  A 198 ( 4.8A)
ZN  A 198 (-3.3A)
None
 0.99A 5uunA-1zy1A:
undetectable		 5uunA-1zy1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avd CATECHOL-O-METHYLTRA
NSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		3 GLU A 153
HIS A 154
ARG A 129
 None
 0.73A 5uunA-2avdA:
undetectable		 5uunA-2avdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904

(Enterococcus
faecalis) 		PF12706
(Lactamase_B_2) 		3 GLU A 237
HIS A 193
ARG A 197
 None
 0.96A 5uunA-2az4A:
undetectable		 5uunA-2az4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		3 GLU A 200
HIS A 203
ARG A 230
 None
None
IPA  A6001 (-3.0A)
 0.82A 5uunA-2fwrA:
undetectable		 5uunA-2fwrA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lh0 HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		no annotation 3 GLU A  48
HIS A  49
ARG A  46
 None
 0.81A 5uunA-2lh0A:
undetectable		 5uunA-2lh0A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5f PUTATIVE NUDIX
HYDROLASE DR_0079

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		3 GLU A 143
HIS A 144
ARG A 148
 None
 0.85A 5uunA-2o5fA:
undetectable		 5uunA-2o5fA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb7 E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF02182
(SAD_SRA) 		3 GLU A 438
HIS A 445
ARG A 433
 None
 0.87A 5uunA-2pb7A:
undetectable		 5uunA-2pb7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		3 GLU A 126
HIS A 129
ARG A 269
 None
 1.00A 5uunA-2qa2A:
undetectable		 5uunA-2qa2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsk HEMAGGLUTININ-NEURAM
INIDASE

(Hendra
henipavirus) 		PF00423
(HN) 		3 GLU A 235
HIS A 233
ARG A 248
 None
 0.99A 5uunA-2vskA:
undetectable		 5uunA-2vskA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsm HEMAGGLUTININ-NEURAM
INIDASE

(Nipah
henipavirus) 		PF00423
(HN) 		3 GLU A 235
HIS A 233
ARG A 248
 None
 0.93A 5uunA-2vsmA:
undetectable		 5uunA-2vsmA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 GLU B 172
HIS B 173
ARG B 269
 BA  B1779 (-3.2A)
BA  B1779 (-4.3A)
None
 0.92A 5uunA-2w55B:
undetectable		 5uunA-2w55B:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE

(Rhodospirillum
rubrum) 		PF03747
(ADP_ribosyl_GH) 		3 GLU A 112
HIS A 111
ARG A 107
 None
 0.92A 5uunA-2wocA:
1.2		 5uunA-2wocA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		3 GLU A 288
HIS A 467
ARG A 468
 None
 0.80A 5uunA-2wzgA:
undetectable		 5uunA-2wzgA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)

(Saccharomyces
cerevisiae) 		PF09110
(HAND)
PF09111
(SLIDE) 		3 GLU A 938
HIS A 807
ARG A 936
 None
 0.99A 5uunA-2y9yA:
undetectable		 5uunA-2y9yA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygo WNT INHIBITORY
FACTOR 1

(Homo sapiens) 		PF02019
(WIF) 		3 GLU A 194
HIS A  85
ARG A 195
 None
 0.97A 5uunA-2ygoA:
undetectable		 5uunA-2ygoA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfw PEX

(Synechococcus
sp.) 		PF03551
(PadR) 		3 GLU A  56
HIS A  55
ARG A  54
 None
 0.99A 5uunA-2zfwA:
undetectable		 5uunA-2zfwA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Mus musculus) 		PF02182
(SAD_SRA) 		3 GLU A 443
HIS A 450
ARG A 438
 None
 0.76A 5uunA-2zkgA:
undetectable		 5uunA-2zkgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnh HYDROLASE FAMILY
PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		3 GLU A 158
HIS A 179
ARG A 174
 None
 0.98A 5uunA-3cnhA:
undetectable		 5uunA-3cnhA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eco MEPR

(Staphylococcus
aureus) 		PF12802
(MarR_2) 		3 GLU A  15
HIS A  14
ARG A  10
 None
 0.86A 5uunA-3ecoA:
2.2		 5uunA-3ecoA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5k PEPTIDE DEFORMYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01327
(Pep_deformylase) 		3 GLU A 157
HIS A 156
ARG A 152
 BB2  A1001 (-2.6A)
CO  A1002 ( 3.2A)
None
 0.94A 5uunA-3g5kA:
undetectable		 5uunA-3g5kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5l PUTATIVE
S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF13649
(Methyltransf_25) 		3 GLU A 175
HIS A 191
ARG A 171
 None
 0.96A 5uunA-3g5lA:
undetectable		 5uunA-3g5lA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge9 THYMIDYLATE SYNTHASE
THYX

(Corynebacterium
glutamicum) 		PF02511
(Thy1) 		3 GLU A  92
HIS A  91
ARG A  87
 None
 0.78A 5uunA-3ge9A:
undetectable		 5uunA-3ge9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLU A 172
HIS A 176
ARG A 131
 None
 0.82A 5uunA-3h1lA:
undetectable		 5uunA-3h1lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h51 PUTATIVE
CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II
ASSOCIATION DOMAIN

(Xanthomonas
campestris) 		PF08332
(CaMKII_AD) 		3 GLU A  89
HIS A  57
ARG A  81
 None
 0.94A 5uunA-3h51A:
undetectable		 5uunA-3h51A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		3 GLU A 534
HIS A 536
ARG A 300
 None
 0.99A 5uunA-3kxwA:
1.2		 5uunA-3kxwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
horikoshii) 		PF03833
(PolC_DP2) 		3 GLU X 185
HIS X 233
ARG X 186
 None
 0.98A 5uunA-3o59X:
undetectable		 5uunA-3o59X:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		3 GLU A 203
HIS A  18
ARG A  55
 None
 0.96A 5uunA-3qk8A:
undetectable		 5uunA-3qk8A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1j ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Mycobacterium
avium) 		PF02668
(TauD) 		3 GLU A 196
HIS A 191
ARG A 189
 None
 0.86A 5uunA-3r1jA:
undetectable		 5uunA-3r1jA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD

(Mycobacterium
marinum) 		PF02668
(TauD) 		3 GLU A 198
HIS A 193
ARG A 191
 None
 0.86A 5uunA-3swtA:
undetectable		 5uunA-3swtA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 GLU A2908
HIS A2907
ARG A2903
 None
 0.90A 5uunA-3vkgA:
undetectable		 5uunA-3vkgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuy NITRILASE

(Synechocystis
sp. PCC 6803) 		PF00795
(CN_hydrolase) 		3 GLU A 171
HIS A 172
ARG A 178
 None
 1.00A 5uunA-3wuyA:
undetectable		 5uunA-3wuyA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvy DIOXYGENASE
RV3406/MT3514

(Mycobacterium
tuberculosis) 		PF02668
(TauD) 		3 GLU A 194
HIS A 189
ARG A 187
 None
 0.77A 5uunA-4cvyA:
undetectable		 5uunA-4cvyA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr9 PEPTIDE DEFORMYLASE

(Synechococcus
elongatus) 		PF01327
(Pep_deformylase) 		3 GLU A 152
HIS A 151
ARG A 147
 BB2  A 203 (-2.6A)
ZN  A 201 ( 3.3A)
None
 0.95A 5uunA-4dr9A:
undetectable		 5uunA-4dr9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		3 GLU A 273
HIS A 272
ARG A 275
 None
 0.97A 5uunA-4eqmA:
undetectable		 5uunA-4eqmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fq3 FUSION (INVOLVED IN
T(12
16) IN MALIGNANT
LIPOSARCOMA)

(Homo sapiens) 		no annotation 3 GLU B 516
HIS B 517
ARG B 521
 None
 0.91A 5uunA-4fq3B:
undetectable		 5uunA-4fq3B:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE

(Burkholderia
thailandensis) 		PF00121
(TIM) 		3 GLU A  81
HIS A  73
ARG A 119
 None
 0.87A 5uunA-4g1kA:
undetectable		 5uunA-4g1kA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP2

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 GLU B  59
HIS B 207
ARG B 102
 None
 0.93A 5uunA-4gh4B:
undetectable		 5uunA-4gh4B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		3 GLU A  96
HIS A 100
ARG A  99
 None
 0.97A 5uunA-4iwnA:
undetectable		 5uunA-4iwnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		3 GLU A 196
HIS A 221
ARG A 193
 None
 0.94A 5uunA-4k22A:
undetectable		 5uunA-4k22A:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLU A 729
HIS A 732
ARG A 712
 None
 0.97A 5uunA-4k33A:
undetectable		 5uunA-4k33A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nle ADENYLOSUCCINATE
LYASE

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 GLU A 391
HIS A 390
ARG A 386
 None
 0.74A 5uunA-4nleA:
2.2		 5uunA-4nleA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6k INTERLEUKIN 22

(Danio rerio) 		no annotation 3 GLU A  87
HIS A  84
ARG A  85
 None
 0.56A 5uunA-4o6kA:
undetectable		 5uunA-4o6kA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 GLU A 149
HIS A 148
ARG A 147
 None
 0.87A 5uunA-4pd3A:
3.8		 5uunA-4pd3A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF02182
(SAD_SRA) 		3 GLU A 467
HIS A 474
ARG A 462
 None
 0.86A 5uunA-4pw5A:
undetectable		 5uunA-4pw5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmg STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase) 		3 GLU A 253
HIS A 201
ARG A 203
 None
 1.00A 5uunA-4qmgA:
undetectable		 5uunA-4qmgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		3 GLU A 126
HIS A 130
ARG A 135
 None
 0.93A 5uunA-4r33A:
undetectable		 5uunA-4r33A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		3 GLU A 205
HIS A 200
ARG A 198
 None
MPD  A 402 (-4.5A)
None
 0.76A 5uunA-4y0eA:
undetectable		 5uunA-4y0eA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN

(Homo sapiens) 		PF00533
(BRCT) 		3 GLU A1731
HIS A1732
ARG A1753
 None
 0.82A 5uunA-4y18A:
undetectable		 5uunA-4y18A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 GLU A 740
HIS A 741
ARG A 839
 None
None
BCT  A3006 (-4.0A)
 0.93A 5uunA-4yswA:
undetectable		 5uunA-4yswA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzy EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		no annotation 3 GLU A 265
HIS A 263
ARG A 240
 None
 0.84A 5uunA-4yzyA:
undetectable		 5uunA-4yzyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5

(Homo sapiens) 		PF00307
(CH) 		3 GLU A  94
HIS A 101
ARG A 102
 None
 0.93A 5uunA-4z6gA:
undetectable		 5uunA-4z6gA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8s RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00161
(RIP) 		3 GLU A 144
HIS A 142
ARG A  81
 None
 0.97A 5uunA-4z8sA:
0.5		 5uunA-4z8sA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		3 GLU A  35
HIS A  36
ARG A 227
 None
 0.92A 5uunA-4zasA:
undetectable		 5uunA-4zasA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		3 GLU A 210
HIS A 206
ARG A 199
 None
 0.76A 5uunA-5afuA:
undetectable		 5uunA-5afuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B

(Mus musculus) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		3 GLU A 203
HIS A 202
ARG A 198
 None
 0.97A 5uunA-5axiA:
undetectable		 5uunA-5axiA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chh ARAC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF12625
(Arabinose_bd)
PF12833
(HTH_18) 		3 GLU A  64
HIS A  65
ARG A  67
 None
 0.73A 5uunA-5chhA:
undetectable		 5uunA-5chhA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		3 GLU A 639
HIS A 638
ARG A 640
 None
 0.63A 5uunA-5cjuA:
0.0		 5uunA-5cjuA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx0 PEPTIDE DEFORMYLASE

(Xanthomonas
oryzae) 		PF01327
(Pep_deformylase) 		3 GLU A 142
HIS A 141
ARG A 137
 56L  A 205 (-3.3A)
CD  A 201 ( 3.5A)
None
 0.94A 5uunA-5cx0A:
undetectable		 5uunA-5cx0A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG

(Homo sapiens) 		PF02724
(CDC45) 		3 GLU A 388
HIS A 396
ARG A 462
 None
None
EDO  A 605 (-3.7A)
 0.99A 5uunA-5dgoA:
undetectable		 5uunA-5dgoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5d PEPTIDE DEFORMYLASE

(Xanthomonas
oryzae) 		PF01327
(Pep_deformylase) 		3 GLU A 142
HIS A 141
ARG A 137
 CD  A 202 ( 4.2A)
CD  A 202 (-3.4A)
None
 0.98A 5uunA-5e5dA:
undetectable		 5uunA-5e5dA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 GLU A 749
HIS A 750
ARG A 848
 None
 0.92A 5uunA-5epgA:
undetectable		 5uunA-5epgA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd5 FERRIC UPTAKE
REGULATION PROTEIN

(Rhizobium
leguminosarum) 		PF01475
(FUR) 		3 GLU A  84
HIS A  36
ARG A  82
 None
 0.64A 5uunA-5fd5A:
undetectable		 5uunA-5fd5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh3 OXYA PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		3 GLU A  56
HIS A 296
ARG A 292
 None
 0.88A 5uunA-5hh3A:
undetectable		 5uunA-5hh3A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		3 GLU A 207
HIS A 202
ARG A 200
 None
 0.93A 5uunA-5hsxA:
undetectable		 5uunA-5hsxA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2b PEPTIDE DEFORMYLASE

(Burkholderia
ambifaria) 		PF01327
(Pep_deformylase) 		3 GLU A 142
HIS A 141
ARG A 137
 BB2  A 202 (-2.2A)
BB2  A 202 ( 2.4A)
None
 0.93A 5uunA-5i2bA:
undetectable		 5uunA-5i2bA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 GLU A 529
HIS A 530
ARG A 527
 None
 0.97A 5uunA-5i67A:
undetectable		 5uunA-5i67A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		3 GLU A  60
HIS A  63
ARG A  62
 OCD  A 500 (-3.2A)
None
None
 0.96A 5uunA-5k52A:
undetectable		 5uunA-5k52A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		3 GLU B2181
HIS B2211
ARG B2320
 None
 0.91A 5uunA-5k8dB:
undetectable		 5uunA-5k8dB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5keu TAURINE DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		3 GLU A 207
HIS A 202
ARG A 200
 None
 0.89A 5uunA-5keuA:
undetectable		 5uunA-5keuA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kob PEPTIDE DEFORMYLASE

(Paraburkholderia
xenovorans) 		PF01327
(Pep_deformylase) 		3 GLU A 142
HIS A 141
ARG A 137
 FE2  A 201 ( 4.2A)
FE2  A 201 (-3.3A)
None
 0.95A 5uunA-5kobA:
undetectable		 5uunA-5kobA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 GLU A 936
HIS A 928
ARG A 926
 None
 0.96A 5uunA-5ldnA:
undetectable		 5uunA-5ldnA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nri D-ALANINE--D-ALANINE
LIGASE

(Burkholderia
pseudomallei) 		no annotation 3 GLU A 173
HIS A 177
ARG A 126
 None
None
EDO  A 408 (-3.7A)
 0.76A 5uunA-5nriA:
undetectable		 5uunA-5nriA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S2

(Mycolicibacterium
smegmatis) 		PF00318
(Ribosomal_S2) 		3 GLU V  59
HIS V  63
ARG V 228
 None
 0.92A 5uunA-5o5jV:
undetectable		 5uunA-5o5jV:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnu DNA-DEPENDENT ATPASE
XPBII

(Sulfurisphaera
tokodaii) 		no annotation 3 GLU A 175
HIS A 178
ARG A 205
 None
None
CL  A 511 ( 3.8A)
 0.92A 5uunA-5tnuA:
undetectable		 5uunA-5tnuA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 3 GLU B 242
HIS B 243
ARG B 246
 None
 0.06A 5uunA-5uuoB:
45.5		 5uunA-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		3 GLU A 190
HIS A 185
ARG A 183
 None
 0.95A 5uunA-5vn6A:
undetectable		 5uunA-5vn6A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0h SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		no annotation 3 GLU A 306
HIS A 259
ARG A 334
 None
 0.79A 5uunA-5w0hA:
undetectable		 5uunA-5w0hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 3 GLU A 168
HIS A  83
ARG A 155
 None
 0.96A 5uunA-5w21A:
undetectable		 5uunA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x83 NETRIN RECEPTOR DCC

(Homo sapiens) 		PF00041
(fn3) 		3 GLU A 810
HIS A 733
ARG A 735
 None
 0.90A 5uunA-5x83A:
undetectable		 5uunA-5x83A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF10588
(NADH-G_4Fe-4S_3)
PF13459
(Fer4_15)
PF13510
(Fer2_4) 		3 GLU B  47
HIS B  45
ARG B 161
 None
 0.89A 5uunA-5xfaB:
undetectable		 5uunA-5xfaB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv5 CONSERVED PROTEIN

(Methanosarcina
mazei) 		no annotation 3 GLU A  39
HIS A  43
ARG A  72
 None
 0.89A 5uunA-5xv5A:
undetectable		 5uunA-5xv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 3 GLU A 259
HIS A 257
ARG A  49
 None
None
YCP  A 403 ( 3.5A)
 0.84A 5uunA-5yu1A:
undetectable		 5uunA-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvi RNA-BINDING PROTEIN
FUS

(Homo sapiens) 		no annotation 3 GLU B 516
HIS B 517
ARG B 521
 None
 0.84A 5uunA-5yviB:
undetectable		 5uunA-5yviB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 3 GLU A 421
HIS A 422
ARG A 427
 None
 0.83A 5uunA-6fyvA:
undetectable		 5uunA-6fyvA:
undetectable