SIMILAR PATTERNS OF AMINO ACIDS FOR 5UUN_A_ACTA305

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6c TOBACCO RINGSPOT
VIRUS CAPSID PROTEIN

(Tobacco
ringspot virus) 		PF03391
(Nepo_coat)
PF03688
(Nepo_coat_C)
PF03689
(Nepo_coat_N) 		3 THR A  13
MET A 162
HIS A 163
 None
 0.95A 5uunA-1a6cA:
undetectable		 5uunA-1a6cA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4t PROTEIN
(DIHYDROLIPOAMIDE
SUCCINYLTRANSFERASE)

(Escherichia
coli) 		PF00198
(2-oxoacid_dh) 		3 THR A 323
MET A 347
HIS A 348
 None
 0.98A 5uunA-1c4tA:
0.0		 5uunA-1c4tA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de4 HEMOCHROMATOSIS
PROTEIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 THR A  82
MET A  84
HIS A  87
 None
 1.01A 5uunA-1de4A:
0.0		 5uunA-1de4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 THR A 133
MET A 131
HIS A 111
 None
None
NAD  A 500 (-4.1A)
 0.89A 5uunA-1evjA:
0.5		 5uunA-1evjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gka CRUSTACYANIN A2
SUBUNIT

(Homarus
gammarus) 		PF00061
(Lipocalin) 		3 THR B  83
MET B  91
HIS B  90
 None
 0.98A 5uunA-1gkaB:
0.0		 5uunA-1gkaB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 THR A 185
MET A 183
HIS A 163
 None
None
NDP  A 500 (-3.9A)
 0.88A 5uunA-1h6dA:
0.5		 5uunA-1h6dA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		3 THR A 236
MET A 269
HIS A 268
 None
 0.95A 5uunA-1mpoA:
0.0		 5uunA-1mpoA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 THR A 753
MET A 759
HIS A 723
 None
 0.75A 5uunA-1ogyA:
0.8		 5uunA-1ogyA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		3 THR A 197
MET A 199
HIS A 192
 None
 0.94A 5uunA-1przA:
0.0		 5uunA-1przA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1u FIBROBLAST GROWTH
FACTOR HOMOLOGOUS
FACTOR 1

(Homo sapiens) 		PF00167
(FGF) 		3 THR A  42
MET A  25
HIS A  26
 None
 0.96A 5uunA-1q1uA:
undetectable		 5uunA-1q1uA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfj PROTEIN (FLAVIN
REDUCTASE)

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 THR A 134
MET A 105
HIS A 195
 None
 0.72A 5uunA-1qfjA:
undetectable		 5uunA-1qfjA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		3 THR A 131
MET A  87
HIS A  86
 None
NAD  A 360 (-4.8A)
None
 0.74A 5uunA-1rkxA:
undetectable		 5uunA-1rkxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR B  68
MET B  82
HIS B  83
 None
None
ZN  B 308 (-3.2A)
 0.68A 5uunA-1t4kB:
undetectable		 5uunA-1t4kB:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur1 ENDOXYLANASE

(Cellvibrio
mixtus) 		PF00331
(Glyco_hydro_10) 		3 THR A  65
MET A 101
HIS A 100
 None
 0.89A 5uunA-1ur1A:
undetectable		 5uunA-1ur1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		3 THR A 206
MET A 208
HIS A 249
 None
 0.86A 5uunA-1uz4A:
undetectable		 5uunA-1uz4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpq HYPOTHETICAL PROTEIN
TM1631

(Thermotoga
maritima) 		PF01904
(DUF72) 		3 THR A 234
MET A   1
HIS A   0
 None
 1.01A 5uunA-1vpqA:
undetectable		 5uunA-1vpqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		3 THR A 133
MET A  89
HIS A  88
 None
APR  A 400 (-4.9A)
None
 0.80A 5uunA-1wvgA:
undetectable		 5uunA-1wvgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 THR A  93
MET A 130
HIS A 129
 None
 1.02A 5uunA-1xjeA:
undetectable		 5uunA-1xjeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		3 THR A 284
MET A 234
HIS A 235
 None
 0.86A 5uunA-1yjkA:
undetectable		 5uunA-1yjkA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		3 THR A 250
MET A 222
HIS A 223
 None
 0.96A 5uunA-1zoiA:
undetectable		 5uunA-1zoiA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		3 THR A 273
MET A 275
HIS A 278
 None
 0.89A 5uunA-2bwgA:
undetectable		 5uunA-2bwgA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 THR A 176
MET A 245
HIS A 244
 None
 0.94A 5uunA-2ep5A:
undetectable		 5uunA-2ep5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2

(Pseudomonas
syringae) 		PF05721
(PhyH) 		3 THR A 232
MET A 234
HIS A 235
 DSU  A 896 (-2.9A)
CL  A 903 ( 4.4A)
FE2  A 900 (-3.4A)
 0.83A 5uunA-2fctA:
undetectable		 5uunA-2fctA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		3 THR A 125
MET A  79
HIS A  81
 None
 0.99A 5uunA-2fvmA:
undetectable		 5uunA-2fvmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		3 THR A 470
MET A 472
HIS A  68
 None
 0.82A 5uunA-2gq3A:
2.0		 5uunA-2gq3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		3 THR A 197
MET A 199
HIS A 192
 None
 0.92A 5uunA-2istA:
undetectable		 5uunA-2istA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lj8 COFILIN/ACTIN
DEPOLYMERIZING
FACTOR, PUTATIVE

(Trypanosoma
brucei) 		PF00241
(Cofilin_ADF) 		3 THR A  49
MET A  37
HIS A  38
 None
 0.45A 5uunA-2lj8A:
undetectable		 5uunA-2lj8A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpd UNCHARACTERIZED
PROTEIN

(Burkholderia
pseudomallei) 		PF03621
(MbtH) 		3 THR A  11
MET A   9
HIS A   8
 None
 0.72A 5uunA-2lpdA:
undetectable		 5uunA-2lpdA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		3 THR A  53
MET A  55
HIS A  56
 None
None
CL  A 232 ( 4.7A)
 0.81A 5uunA-2no5A:
undetectable		 5uunA-2no5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		3 THR A 174
MET A 172
HIS A 167
 None
 0.98A 5uunA-2p1rA:
undetectable		 5uunA-2p1rA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 THR A  30
MET A  36
HIS A  39
 None
 0.89A 5uunA-2qkxA:
undetectable		 5uunA-2qkxA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 THR A 473
MET A 471
HIS A 455
 None
 0.85A 5uunA-2x50A:
undetectable		 5uunA-2x50A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyl POSSIBLE
OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF00355
(Rieske) 		3 THR A 177
MET A 179
HIS A 181
 None
None
FE2  A 452 (-3.3A)
 0.83A 5uunA-2zylA:
undetectable		 5uunA-2zylA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a64 CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		3 THR A 157
MET A 159
HIS A 160
 None
 0.81A 5uunA-3a64A:
undetectable		 5uunA-3a64A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		3 THR A  25
MET A  31
HIS A  30
 None
 1.02A 5uunA-3ayxA:
undetectable		 5uunA-3ayxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		3 THR A 364
MET A 327
HIS A 361
 None
 1.00A 5uunA-3cv2A:
undetectable		 5uunA-3cv2A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 THR A  30
MET A  36
HIS A  39
 None
 1.03A 5uunA-3dj4A:
undetectable		 5uunA-3dj4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiz INORGANIC
PYROPHOSPHATASE

(Burkholderia
pseudomallei) 		PF00719
(Pyrophosphatase) 		3 THR A -10
MET A -12
HIS A -13
 None
 0.98A 5uunA-3eizA:
undetectable		 5uunA-3eizA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjy PROBABLE MUTT1
PROTEIN

(Bifidobacterium
adolescentis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		3 THR A 239
MET A 300
HIS A 301
 None
None
GOL  A 400 (-4.3A)
 0.91A 5uunA-3fjyA:
undetectable		 5uunA-3fjyA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 THR A 187
MET A 189
HIS A 192
 None
 0.99A 5uunA-3igoA:
undetectable		 5uunA-3igoA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg5 B-CELL ANTIGEN
RECEPTOR
COMPLEX-ASSOCIATED
PROTEIN BETA CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 THR A 108
MET A  63
HIS A  64
 None
 0.94A 5uunA-3kg5A:
undetectable		 5uunA-3kg5A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD

(Bacillus
subtilis) 		PF07451
(SpoVAD) 		3 THR A 112
MET A 114
HIS A 327
 None
 0.94A 5uunA-3lm6A:
undetectable		 5uunA-3lm6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)

(Bacillus
licheniformis) 		PF07451
(SpoVAD) 		3 THR A 112
MET A 114
HIS A 327
 None
 0.97A 5uunA-3lmaA:
undetectable		 5uunA-3lmaA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mh9 LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		no annotation 3 THR C 220
MET C  60
HIS C  59
 None
 0.92A 5uunA-3mh9C:
undetectable		 5uunA-3mh9C:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mha LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		PF07161
(LppX_LprAFG) 		3 THR A 220
MET A  60
HIS A  59
 None
Z69  A   1 (-3.0A)
None
 0.89A 5uunA-3mhaA:
undetectable		 5uunA-3mhaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5

(Thermotoga
petrophila) 		PF00150
(Cellulase) 		3 THR A 189
MET A 191
HIS A 228
 None
 0.82A 5uunA-3pz9A:
undetectable		 5uunA-3pz9A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2i DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 THR A 108
MET A 106
HIS A  86
 None
None
NAI  A 500 (-3.9A)
 0.62A 5uunA-3q2iA:
undetectable		 5uunA-3q2iA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 THR A 107
MET A 105
HIS A  85
 None
None
NAI  A 500 (-3.9A)
 0.59A 5uunA-3q2kA:
undetectable		 5uunA-3q2kA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 THR A  82
MET A  58
HIS A  57
 None
 0.79A 5uunA-3qdqA:
undetectable		 5uunA-3qdqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF11838
(ERAP1_C) 		3 THR A 534
MET A 544
HIS A 543
 None
 0.89A 5uunA-3rjoA:
1.7		 5uunA-3rjoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 3 THR A 119
MET A 121
HIS A 123
 None
None
CA  A 501 (-3.5A)
 0.94A 5uunA-3s4lA:
undetectable		 5uunA-3s4lA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 THR A 147
MET A 158
HIS A 151
 FDA  A 400 (-3.3A)
None
None
 1.02A 5uunA-3sf6A:
1.1		 5uunA-3sf6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqx 2-AMINO-3-KETOBUTYRA
TE COENZYME A LIGASE

(Coxiella
burnetii) 		PF00155
(Aminotran_1_2) 		3 THR A 338
MET A 340
HIS A 343
 None
 0.86A 5uunA-3tqxA:
undetectable		 5uunA-3tqxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 THR A 287
MET A 289
HIS A 337
 None
 0.84A 5uunA-3ttsA:
undetectable		 5uunA-3ttsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wau 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Bacteroides
fragilis) 		PF04041
(Glyco_hydro_130) 		3 THR A  42
MET A 347
HIS A 348
 None
 0.88A 5uunA-3wauA:
undetectable		 5uunA-3wauA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 THR A 914
MET A 916
HIS A 917
 None
 1.02A 5uunA-4aygA:
undetectable		 5uunA-4aygA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 THR A 128
MET A 130
HIS A 131
 None
CL  A 401 ( 3.9A)
None
 1.02A 5uunA-4eclA:
undetectable		 5uunA-4eclA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		3 THR A 475
MET A 477
HIS A  68
 None
 0.84A 5uunA-4ex4A:
undetectable		 5uunA-4ex4A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmv GLUCURONOARABINOXYLA
N
ENDO-1,4-BETA-XYLANA
SE

([Clostridium]
papyrosolvens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 THR A 256
MET A 254
HIS A 251
 None
 0.90A 5uunA-4fmvA:
undetectable		 5uunA-4fmvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf2 ERYTHROCYTE BINDING
ANTIGEN 140

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 THR A 209
MET A 294
HIS A 293
 None
None
GOL  A 814 (-3.2A)
 0.92A 5uunA-4gf2A:
2.4		 5uunA-4gf2A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqt HEAT SHOCK PROTEIN
90

(Caenorhabditis
elegans) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 THR A  78
MET A 176
HIS A 177
 None
None
ZN  A 502 (-3.1A)
 1.00A 5uunA-4gqtA:
undetectable		 5uunA-4gqtA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Rickettsia
bellii) 		PF02350
(Epimerase_2) 		3 THR A 144
MET A 115
HIS A 114
 None
 0.75A 5uunA-4hwgA:
undetectable		 5uunA-4hwgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxa 13D9 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  52
MET H  34
HIS H  35
 None
 0.98A 5uunA-4hxaH:
undetectable		 5uunA-4hxaH:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it5 CO-CHAPERONE PROTEIN
HSCB HOMOLOG

(Vibrio cholerae) 		PF00226
(DnaJ)
PF07743
(HSCB_C) 		3 THR A 123
MET A 125
HIS A 128
 None
 0.90A 5uunA-4it5A:
4.1		 5uunA-4it5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		3 THR A  46
MET A 318
HIS A 293
 None
 1.00A 5uunA-4j6cA:
undetectable		 5uunA-4j6cA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		3 THR A 441
MET A 443
HIS A 445
 None
 0.87A 5uunA-4jeuA:
undetectable		 5uunA-4jeuA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		3 THR A  10
MET A 269
HIS A 299
 None
None
ATP  A 602 (-4.6A)
 1.01A 5uunA-4qreA:
3.1		 5uunA-4qreA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6k SOLUTE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF13416
(SBP_bac_8) 		3 THR A 249
MET A 174
HIS A 175
 None
 0.99A 5uunA-4r6kA:
undetectable		 5uunA-4r6kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		3 THR A 395
MET A 424
HIS A 423
 None
TRS  A 803 (-4.4A)
None
 1.03A 5uunA-4rhhA:
undetectable		 5uunA-4rhhA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsw HOPA1

(Pseudomonas
syringae) 		no annotation 3 THR A 250
MET A 252
HIS A 255
 None
 1.02A 5uunA-4rswA:
undetectable		 5uunA-4rswA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		3 THR A 493
MET A 495
HIS A 498
 None
 0.93A 5uunA-4u1rA:
undetectable		 5uunA-4u1rA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		3 THR A 485
MET A 487
HIS A 489
 None
VFV  A 580 (-3.6A)
None
 0.81A 5uunA-4uhiA:
undetectable		 5uunA-4uhiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 THR A  58
MET A  81
HIS A  84
 None
 0.89A 5uunA-4uplA:
undetectable		 5uunA-4uplA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC

(Escherichia
coli) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 THR A 125
MET A 127
HIS A 128
 None
SO4  A1002 ( 4.9A)
None
 1.01A 5uunA-4wr3A:
undetectable		 5uunA-4wr3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 THR A 344
MET A 346
HIS A 349
 None
 1.02A 5uunA-4xoxA:
undetectable		 5uunA-4xoxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 THR A 134
MET A  89
HIS A 131
 None
 0.88A 5uunA-4zo6A:
undetectable		 5uunA-4zo6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		3 THR A 323
MET A 325
HIS A 373
 None
 0.86A 5uunA-4zpxA:
undetectable		 5uunA-4zpxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		3 THR A  60
MET A  63
HIS A  64
 None
 0.81A 5uunA-5a2oA:
undetectable		 5uunA-5a2oA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 THR A 708
MET A 703
HIS A 704
 None
 1.01A 5uunA-5cioA:
undetectable		 5uunA-5cioA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		3 THR A 161
MET A 152
HIS A 154
 None
 0.93A 5uunA-5dmhA:
1.7		 5uunA-5dmhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 THR A 359
MET A 326
HIS A 327
 None
 0.80A 5uunA-5dmyA:
undetectable		 5uunA-5dmyA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 THR A 294
MET A 296
HIS A 344
 None
 0.82A 5uunA-5e9aA:
undetectable		 5uunA-5e9aA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epv BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE

(Brucella
abortus) 		PF07536
(HWE_HK) 		3 THR A 405
MET A 419
HIS A 418
 None
 0.96A 5uunA-5epvA:
3.7		 5uunA-5epvA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1m PHOSPHORYLATED
PROTEIN PHOSPHATASE

(Staphylococcus
aureus) 		PF13672
(PP2C_2) 		3 THR A 170
MET A  99
HIS A  42
 None
 1.00A 5uunA-5f1mA:
undetectable		 5uunA-5f1mA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g1d SYNTENIN-1

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 THR A 268
MET A 203
HIS A 204
 None
 0.92A 5uunA-5g1dA:
undetectable		 5uunA-5g1dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		3 THR A 120
MET A 124
HIS A 125
 None
 0.76A 5uunA-5j7zA:
undetectable		 5uunA-5j7zA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb1 MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		3 THR A 170
MET A 208
HIS A 168
 None
 0.84A 5uunA-5jb1A:
undetectable		 5uunA-5jb1A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Aspergillus
fumigatus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 THR A 180
MET A 252
HIS A 251
 None
 1.00A 5uunA-5jw6A:
undetectable		 5uunA-5jw6A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 3 THR A 468
MET A 470
HIS A  68
 None
 0.86A 5uunA-5oasA:
1.9		 5uunA-5oasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujd SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNI

(Staphylococcus
pseudintermedius) 		no annotation 3 THR A 122
MET A 176
HIS A  90
 None
 0.85A 5uunA-5ujdA:
undetectable		 5uunA-5ujdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz SCFV

(Homo sapiens) 		PF07686
(V-set) 		3 THR G 177
MET G 159
HIS G 160
 None
 0.97A 5uunA-5ujzG:
undetectable		 5uunA-5ujzG:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 3 THR B 234
MET B 238
HIS B 239
 None
EDO  B 312 (-4.8A)
None
 0.14A 5uunA-5uuoB:
45.5		 5uunA-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		3 THR A  81
MET A 386
HIS A 388
 None
 0.94A 5uunA-5vemA:
undetectable		 5uunA-5vemA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vh6 ELONGATION FACTOR G

(Bacillus
subtilis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		3 THR A  68
MET A 357
HIS A 358
 None
 0.94A 5uunA-5vh6A:
undetectable		 5uunA-5vh6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vye L-THREONINE ALDOLASE

(Pseudomonas
putida) 		no annotation 3 THR A 143
MET A 173
HIS A 172
 PLR  A 401 ( 3.3A)
None
None
 1.03A 5uunA-5vyeA:
undetectable		 5uunA-5vyeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		no annotation 3 THR A 284
MET A 234
HIS A 235
 None
 0.87A 5uunA-5wm0A:
undetectable		 5uunA-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		3 THR A 474
MET A 476
HIS A  68
 None
 0.84A 5uunA-6axeA:
undetectable		 5uunA-6axeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 3 THR A 922
MET A 932
HIS A 933
 None
 0.88A 5uunA-6bfuA:
undetectable		 5uunA-6bfuA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 3 THR A  68
MET A 357
HIS A 358
 None
 0.87A 5uunA-6bk7A:
undetectable		 5uunA-6bk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 3 THR A 223
MET A 245
HIS A 244
 None
 1.02A 5uunA-6c43A:
undetectable		 5uunA-6c43A:
undetectable