SIMILAR PATTERNS OF AMINO ACIDS FOR 5UUN_A_ACTA304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwu FIBRINOGEN BETA
CHAIN

(Petromyzon
marinus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ARG B 285
THR B 289
GLY B 295
PHE B 294
 None
 1.39A 5uunA-1lwuB:
0.0		 5uunA-1lwuB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ARG A 354
THR A 501
GLY A 330
PHE A 312
 None
 1.27A 5uunA-1y9gA:
0.0		 5uunA-1y9gA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		4 ARG A 201
THR A 217
GLY A 212
PHE A 215
 None
 1.37A 5uunA-2g29A:
0.8		 5uunA-2g29A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 ARG A 207
THR A 385
GLY A 105
PHE A 155
 A2G  A1428 (-3.3A)
None
A2G  A1428 (-3.8A)
GAL  A1429 ( 4.5A)
 1.05A 5uunA-2w7yA:
0.2		 5uunA-2w7yA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ARG A 391
THR A 386
GLY A 164
PHE A 388
 None
 1.01A 5uunA-4dnsA:
0.0		 5uunA-4dnsA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 ARG A 399
THR A 352
GLY A 401
PHE A 422
 None
 1.29A 5uunA-4dxbA:
0.1		 5uunA-4dxbA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ARG A 391
THR A 386
GLY A 162
PHE A 388
 None
 1.10A 5uunA-4pveA:
0.0		 5uunA-4pveA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		4 ARG A 246
THR A 153
GLY A  53
PHE A  52
 None
 1.43A 5uunA-4r12A:
0.0		 5uunA-4r12A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9j FICOLIN-2

(Homo sapiens) 		no annotation 4 ARG G 132
THR G 136
GLY G 142
PHE G 141
 SO4  G 305 (-4.8A)
SO4  G 305 (-3.5A)
None
None
 1.33A 5uunA-4r9jG:
0.0		 5uunA-4r9jG:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwa ORNITHINE
DECARBOXYLASE

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ARG A 270
THR A  63
GLY A  86
PHE A  65
 None
 1.33A 5uunA-5bwaA:
undetectable		 5uunA-5bwaA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ARG A 282
THR A 237
GLY A 235
PHE A 231
 None
 1.30A 5uunA-5dmyA:
undetectable		 5uunA-5dmyA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP2

(Deformed wing
virus) 		PF00073
(Rhv) 		4 ARG B 208
THR B 138
GLY B 157
PHE B 158
 None
 1.45A 5uunA-5g52B:
undetectable		 5uunA-5g52B:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 4 ARG A 309
THR A 329
GLY A 381
PHE A 310
 None
 1.22A 5uunA-5znnA:
undetectable		 5uunA-5znnA:
undetectable