SIMILAR PATTERNS OF AMINO ACIDS FOR 5UUN_A_ACTA303_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		3 GLU A 104
TYR A 105
ARG A 109
 None
 0.62A 5uunA-1epxA:
0.0		 5uunA-1epxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE

(Escherichia
coli) 		PF00881
(Nitroreductase) 		3 GLU A 198
TYR A 199
ARG A 203
 None
 0.71A 5uunA-1f5vA:
0.0		 5uunA-1f5vA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g01 ENDOGLUCANASE

(Bacillus sp.
KSM-635) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 GLU A 562
TYR A 563
ARG A 567
 None
 0.84A 5uunA-1g01A:
0.0		 5uunA-1g01A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1t E-SELECTIN

(Homo sapiens) 		PF00008
(EGF)
PF00059
(Lectin_C) 		3 GLU A  14
TYR A  18
ARG A  22
 None
 0.66A 5uunA-1g1tA:
0.0		 5uunA-1g1tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 GLU A 713
TYR A 719
ARG A 722
 None
 0.72A 5uunA-1ileA:
1.7		 5uunA-1ileA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome) 		3 GLU H  62
TYR H  66
ARG H  70
 None
 0.66A 5uunA-1j2qH:
0.1		 5uunA-1j2qH:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF06026
(Rib_5-P_isom_A) 		3 GLU A 155
TYR A 156
ARG A 140
 None
 0.74A 5uunA-1o8bA:
0.0		 5uunA-1o8bA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qah PERCHLORIC ACID
SOLUBLE PROTEIN

(Rattus
norvegicus) 		PF01042
(Ribonuc_L-PSP) 		3 GLU A  93
TYR A  95
ARG A 106
 None
 0.76A 5uunA-1qahA:
undetectable		 5uunA-1qahA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkt PROTEIN YFIR

(Bacillus
subtilis) 		PF00440
(TetR_N) 		3 GLU A 112
TYR A 113
ARG A 123
 None
 0.55A 5uunA-1rktA:
undetectable		 5uunA-1rktA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		3 GLU A 164
TYR A 163
ARG A 246
 None
 0.70A 5uunA-1tklA:
0.0		 5uunA-1tklA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugp NITRILE HYDRATASE
BETA SUBUNIT

(Pseudonocardia
thermophila) 		PF02211
(NHase_beta) 		3 GLU B 224
TYR B 222
ARG B 158
 None
 0.71A 5uunA-1ugpB:
undetectable		 5uunA-1ugpB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		3 GLU A1609
TYR A1610
ARG A1614
 None
 0.65A 5uunA-1uyvA:
undetectable		 5uunA-1uyvA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		3 GLU A  56
TYR A  53
ARG A 155
 None
 0.85A 5uunA-1yleA:
undetectable		 5uunA-1yleA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		3 GLU A 287
TYR A 288
ARG A 114
 None
 0.82A 5uunA-1z26A:
undetectable		 5uunA-1z26A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x INTEGRIN ALPHA-1
ANTIBODY AQC2 FAB

(Rattus
norvegicus;
Mus musculus) 		PF00092
(VWA)
PF07654
(C1-set)
PF07686
(V-set) 		3 GLU H  64
TYR H  58
ARG A 222
 None
 0.83A 5uunA-2b2xH:
undetectable		 5uunA-2b2xH:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu9 HISTONE CHAPERONE
CIA1

(Schizosaccharomyces
pombe) 		PF04729
(ASF1_hist_chap) 		3 GLU A  75
TYR A  22
ARG A 143
 None
 0.76A 5uunA-2cu9A:
undetectable		 5uunA-2cu9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 GLU A 172
TYR A 175
ARG A 212
 None
 0.80A 5uunA-2cxeA:
undetectable		 5uunA-2cxeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		3 GLU X 485
TYR X 487
ARG X 474
 None
 0.82A 5uunA-2f2lX:
undetectable		 5uunA-2f2lX:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLU A 379
TYR A 378
ARG A 383
 None
 0.66A 5uunA-2ihtA:
undetectable		 5uunA-2ihtA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijx DNA POLYMERASE
SLIDING CLAMP A

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 GLU A  58
TYR A  59
ARG A  53
 None
 0.86A 5uunA-2ijxA:
undetectable		 5uunA-2ijxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF05637
(Glyco_transf_34) 		3 GLU A 157
TYR A 158
ARG A 162
 None
 0.62A 5uunA-2p6wA:
undetectable		 5uunA-2p6wA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		3 GLU A  48
TYR A  49
ARG A  53
 None
 0.74A 5uunA-2q3oA:
undetectable		 5uunA-2q3oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		3 GLU A 319
TYR A 321
ARG A 176
 None
None
UNL  A   5 (-3.2A)
 0.85A 5uunA-2q83A:
undetectable		 5uunA-2q83A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tmk THYMIDYLATE KINASE

(Saccharomyces
cerevisiae) 		PF02223
(Thymidylate_kin) 		3 GLU A  51
TYR A  52
ARG A 150
 None
 0.43A 5uunA-2tmkA:
undetectable		 5uunA-2tmkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyk PROTEIN TDCF

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		3 GLU A  89
TYR A  91
ARG A 105
 None
 0.76A 5uunA-2uykA:
undetectable		 5uunA-2uykA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		3 GLU A 735
TYR A 736
ARG A 644
 None
 0.57A 5uunA-2vuwA:
undetectable		 5uunA-2vuwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		3 GLU A  55
TYR A 288
ARG A 290
 CA  A1298 (-3.9A)
None
None
 0.80A 5uunA-2vy0A:
undetectable		 5uunA-2vy0A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT

(Bacillus phage
SPP1) 		PF17288
(Terminase_3C) 		3 GLU A 314
TYR A 313
ARG A 278
 None
 0.63A 5uunA-2wbnA:
undetectable		 5uunA-2wbnA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		3 GLU A 181
TYR A 182
ARG A 186
 None
 0.59A 5uunA-2weuA:
undetectable		 5uunA-2weuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wj3 1-H-3-HYDROXY-4-OXOQ
UINALDINE
2,4-DIOXYGENASE

(Paenarthrobacter
nitroguajacolicus) 		PF00561
(Abhydrolase_1) 		3 GLU A  49
TYR A  45
ARG A 168
 None
 0.86A 5uunA-2wj3A:
undetectable		 5uunA-2wj3A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		3 GLU A 728
TYR A 729
ARG A 733
 None
 0.75A 5uunA-2znsA:
undetectable		 5uunA-2znsA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		3 GLU A 165
TYR A 166
ARG A 199
 None
 0.60A 5uunA-3bh1A:
undetectable		 5uunA-3bh1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bus METHYLTRANSFERASE

(Lechevalieria
aerocolonigenes) 		PF08241
(Methyltransf_11) 		3 GLU A 200
TYR A 199
ARG A 145
 None
 0.76A 5uunA-3busA:
undetectable		 5uunA-3busA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220

(Histophilus
somni) 		PF05114
(DUF692) 		3 GLU A 255
TYR A 256
ARG A 260
 None
 0.73A 5uunA-3bwwA:
undetectable		 5uunA-3bwwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLU A 571
TYR A 572
ARG A 576
 None
 0.45A 5uunA-3c4fA:
undetectable		 5uunA-3c4fA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0v GAG POLYPROTEIN

(Rous sarcoma
virus) 		PF00607
(Gag_p24) 		3 GLU A 217
TYR A 221
ARG A 225
 None
 0.76A 5uunA-3g0vA:
undetectable		 5uunA-3g0vA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLU A 188
TYR A 189
ARG A 300
 None
 0.86A 5uunA-3gazA:
undetectable		 5uunA-3gazA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7m SENSOR PROTEIN

(Geobacter
sulfurreducens) 		PF00497
(SBP_bac_3) 		3 GLU A 175
TYR A 176
ARG A 180
 None
 0.86A 5uunA-3h7mA:
undetectable		 5uunA-3h7mA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 GLU A 138
TYR A 139
ARG A 187
 None
 0.64A 5uunA-3h8fA:
undetectable		 5uunA-3h8fA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 GLU A 118
TYR A 117
ARG A 320
 None
 0.81A 5uunA-3hjeA:
undetectable		 5uunA-3hjeA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia7 CALG4

(Micromonospora
echinospora) 		PF00201
(UDPGT) 		3 GLU A 179
TYR A 180
ARG A 116
 None
 0.67A 5uunA-3ia7A:
undetectable		 5uunA-3ia7A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llm ATP-DEPENDENT RNA
HELICASE A

(Homo sapiens) 		PF00270
(DEAD) 		3 GLU A 553
TYR A 554
ARG A 528
 None
 0.74A 5uunA-3llmA:
undetectable		 5uunA-3llmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm4 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus
jostii) 		PF00903
(Glyoxalase) 		3 GLU A  98
TYR A 103
ARG A  13
 None
 0.84A 5uunA-3lm4A:
undetectable		 5uunA-3lm4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		3 GLU A 151
TYR A 152
ARG A 156
 None
 0.65A 5uunA-3lovA:
undetectable		 5uunA-3lovA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC

(Pisum sativum) 		PF00175
(NAD_binding_1) 		3 GLU A 208
TYR A 206
ARG A 172
 None
 0.82A 5uunA-3mhpA:
undetectable		 5uunA-3mhpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzs PYRIDOXAMINE KINASE

(Yersinia pestis) 		PF08543
(Phos_pyr_kin) 		3 GLU A 262
TYR A 263
ARG A 216
 BME  A 289 (-3.9A)
None
None
 0.77A 5uunA-3pzsA:
undetectable		 5uunA-3pzsA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qay ENDOLYSIN

(Clostridium
virus phiCD27) 		PF01520
(Amidase_3) 		3 GLU A  63
TYR A  67
ARG A  71
 None
 0.80A 5uunA-3qayA:
undetectable		 5uunA-3qayA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rku OXIDOREDUCTASE
YMR226C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		3 GLU A  32
TYR A 238
ARG A 242
 None
 0.80A 5uunA-3rkuA:
1.2		 5uunA-3rkuA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLU A 571
TYR A 572
ARG A 576
 07J  A   1 (-3.9A)
None
None
 0.57A 5uunA-3tt0A:
undetectable		 5uunA-3tt0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		3 GLU A 328
TYR A 331
ARG A 317
 None
 0.79A 5uunA-3ttlA:
undetectable		 5uunA-3ttlA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvf INTRON-ENCODED DNA
ENDONUCLEASE I-HJEMI

(Trichoderma
reesei) 		PF00961
(LAGLIDADG_1) 		3 GLU A 119
TYR A 120
ARG A 102
 None
 0.85A 5uunA-3uvfA:
2.3		 5uunA-3uvfA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		3 GLU A 476
TYR A 474
ARG A 523
 None
 0.76A 5uunA-3vr1A:
undetectable		 5uunA-3vr1A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w79 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		3 GLU A 179
TYR A 180
ARG A 163
 None
 0.60A 5uunA-3w79A:
undetectable		 5uunA-3w79A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wic GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		3 GLU A 289
TYR A 293
ARG A 297
 None
 0.81A 5uunA-3wicA:
undetectable		 5uunA-3wicA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjs NADH OXIDASE

(Gluconobacter
oxydans) 		PF00724
(Oxidored_FMN) 		3 GLU A  41
TYR A  42
ARG A  46
 None
 0.83A 5uunA-3wjsA:
undetectable		 5uunA-3wjsA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		3 GLU A  41
TYR A  42
ARG A  46
 None
 0.77A 5uunA-4a3uA:
undetectable		 5uunA-4a3uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ab4 XENOBIOTIC REDUCTASE
B

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		3 GLU A  41
TYR A  42
ARG A  46
 None
 0.74A 5uunA-4ab4A:
undetectable		 5uunA-4ab4A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 GLU A 147
TYR A 378
ARG A 380
 CA  A 400 (-3.5A)
None
None
 0.78A 5uunA-4bpzA:
undetectable		 5uunA-4bpzA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxx TRANSCRIPTION FACTOR
BYE1

(Saccharomyces
cerevisiae) 		PF07500
(TFIIS_M) 		3 GLU X 285
TYR X 287
ARG X 238
 None
 0.81A 5uunA-4bxxX:
undetectable		 5uunA-4bxxX:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmw DITERPENE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 3 GLU A 196
TYR A 197
ARG A 187
 None
 0.71A 5uunA-4cmwA:
undetectable		 5uunA-4cmwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		3 GLU A 312
TYR A 313
ARG A 317
 None
 0.75A 5uunA-4fmcA:
undetectable		 5uunA-4fmcA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE

(Oenococcus oeni) 		PF00465
(Fe-ADH) 		3 GLU A 294
TYR A 295
ARG A 372
 None
 0.80A 5uunA-4fr2A:
1.0		 5uunA-4fr2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		3 GLU A 506
TYR A 507
ARG A 511
 None
 0.70A 5uunA-4g3fA:
undetectable		 5uunA-4g3fA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Methylobacillus
flagellatus) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 GLU A  68
TYR A  69
ARG A  73
 None
 0.74A 5uunA-4gltA:
19.1		 5uunA-4gltA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hym TOPOISOMERASE IV,
SUBUNIT B

(Francisella
tularensis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 GLU A  60
TYR A  59
ARG A 165
 None
 0.78A 5uunA-4hymA:
undetectable		 5uunA-4hymA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 GLU A 377
TYR A 378
ARG A 313
 None
 0.71A 5uunA-4i5jA:
undetectable		 5uunA-4i5jA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kz1 VIRB8 PROTEIN

(Bartonella
grahamii) 		PF04335
(VirB8) 		3 GLU A 164
TYR A 165
ARG A  52
 None
 0.72A 5uunA-4kz1A:
undetectable		 5uunA-4kz1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lso TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Bartonella
quintana) 		PF04335
(VirB8) 		3 GLU A 225
TYR A 226
ARG A 113
 None
 0.85A 5uunA-4lsoA:
undetectable		 5uunA-4lsoA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN

(Pseudomonas
putida) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 GLU A 177
TYR A 178
ARG A 220
 None
 0.57A 5uunA-4naxA:
26.9		 5uunA-4naxA:
34.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLU A 688
TYR A 689
ARG A 638
 None
2TT  A1201 (-4.0A)
None
 0.80A 5uunA-4oliA:
undetectable		 5uunA-4oliA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		3 GLU A 266
TYR A 267
ARG A 250
 None
 0.81A 5uunA-4ovyA:
undetectable		 5uunA-4ovyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		3 GLU A 154
TYR A 155
ARG A 159
 None
 0.83A 5uunA-4rnwA:
undetectable		 5uunA-4rnwA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		3 GLU A 453
TYR A 451
ARG A 474
 None
 0.76A 5uunA-4uwaA:
undetectable		 5uunA-4uwaA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE

(Burkholderia
cenocepacia) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLU A 155
TYR A 156
ARG A 160
 None
 0.70A 5uunA-4wjbA:
undetectable		 5uunA-4wjbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		3 GLU A  82
TYR A  83
ARG A  56
 None
 0.76A 5uunA-4yj5A:
undetectable		 5uunA-4yj5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		3 GLU A  55
TYR A  56
ARG A  60
 None
 0.81A 5uunA-4yncA:
undetectable		 5uunA-4yncA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLU A 571
TYR A 572
ARG A 576
 38O  A1769 ( 3.7A)
None
None
 0.54A 5uunA-5a46A:
undetectable		 5uunA-5a46A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A
TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Homo sapiens;
Homo sapiens) 		PF08704
(GCD14)
PF04189
(Gcd10p) 		3 GLU A   7
TYR A   6
ARG B 395
 None
 0.77A 5uunA-5ccxA:
undetectable		 5uunA-5ccxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		3 GLU A1609
TYR A1610
ARG A1614
 None
 0.67A 5uunA-5cslA:
5.1		 5uunA-5cslA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkp ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Neisseria
meningitidis) 		PF00574
(CLP_protease) 		3 GLU A 185
TYR A 189
ARG A 166
 None
 0.86A 5uunA-5dkpA:
undetectable		 5uunA-5dkpA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Cryptococcus
neoformans) 		PF02358
(Trehalose_PPase) 		3 GLU A 116
TYR A 120
ARG A 124
 None
 0.74A 5uunA-5dx9A:
undetectable		 5uunA-5dx9A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7s LON PROTEASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C) 		3 GLU A 533
TYR A 583
ARG A 536
 None
 0.82A 5uunA-5e7sA:
undetectable		 5uunA-5e7sA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 GLU A 362
TYR A 363
ARG A 367
 EDO  A 623 ( 4.9A)
None
None
 0.86A 5uunA-5ecuA:
undetectable		 5uunA-5ecuA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		3 GLU A 646
TYR A 647
ARG A 651
 None
 0.71A 5uunA-5ezrA:
undetectable		 5uunA-5ezrA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g53 ADENOSINE RECEPTOR
A2A
ENGINEERED DOMAIN OF
HUMAN G ALPHA S LONG
ISOFORM

(Homo sapiens;
Homo sapiens) 		PF00001
(7tm_1)
PF00503
(G-alpha) 		3 GLU C 392
TYR C 391
ARG A 102
 None
 0.65A 5uunA-5g53C:
undetectable		 5uunA-5g53C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		3 GLU A 323
TYR A 325
ARG A 292
 None
 0.81A 5uunA-5ghsA:
2.2		 5uunA-5ghsA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6y NUCLEOSOME-REMODELIN
G FACTOR SUBUNIT
BPTF

(Homo sapiens) 		no annotation 3 GLU A  75
TYR A  74
ARG A 125
 None
 0.86A 5uunA-5h6yA:
2.1		 5uunA-5h6yA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		3 GLU B 954
TYR B1026
ARG B1099
 None
 0.83A 5uunA-5hb4B:
undetectable		 5uunA-5hb4B:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfn CEPHALOSPORIN-C
DEACETYLASE

(Thermotoga
maritima) 		PF05448
(AXE1) 		3 GLU A  21
TYR A  19
ARG A 218
 None
 0.54A 5uunA-5hfnA:
undetectable		 5uunA-5hfnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2

(Homo sapiens) 		PF00400
(WD40) 		3 GLU A 449
TYR A 450
ARG A 706
 None
 0.64A 5uunA-5igqA:
undetectable		 5uunA-5igqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kku POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		3 GLU A 118
TYR A 115
ARG A  58
 None
 0.77A 5uunA-5kkuA:
undetectable		 5uunA-5kkuA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npt TELOMERASE REVERSE
TRANSCRIPTASE

(Ogataea
polymorpha) 		no annotation 3 GLU A  73
TYR A  72
ARG A  43
 None
 0.66A 5uunA-5nptA:
undetectable		 5uunA-5nptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 3 GLU A 256
TYR A 219
ARG A 206
 None
PEG  A 407 (-4.2A)
None
 0.84A 5uunA-5o25A:
undetectable		 5uunA-5o25A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		3 GLU A 163
TYR A 164
ARG A 168
 None
 0.68A 5uunA-5thwA:
undetectable		 5uunA-5thwA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9k ARYL HYDROCARBON
RECEPTOR-INTERACTING
PROTEIN-LIKE 1
(AIPL1)

(Homo sapiens) 		PF00254
(FKBP_C) 		3 GLU A 135
TYR A 134
ARG A 105
 None
 0.82A 5uunA-5u9kA:
undetectable		 5uunA-5u9kA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 3 GLU B 208
TYR B 209
ARG B 254
 None
 0.21A 5uunA-5uuoB:
45.5		 5uunA-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7z DNA POLYMERASE III
SUBUNIT BETA

(Rickettsia
conorii) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 GLU A 338
TYR A 336
ARG A 176
 None
 0.62A 5uunA-5w7zA:
undetectable		 5uunA-5w7zA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG

(Saccharomyces
cerevisiae) 		PF10345
(Cohesin_load) 		3 GLU A 563
TYR A 565
ARG A 601
 None
 0.77A 5uunA-5w94A:
1.7		 5uunA-5w94A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 3 GLU A 280
TYR A 279
ARG A 629
 None
 0.78A 5uunA-5wugA:
undetectable		 5uunA-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd5 -

(-) 		no annotation 3 GLU A 180
TYR A 179
ARG A  27
 None
 0.87A 5uunA-6fd5A:
undetectable		 5uunA-6fd5A:
undetectable