SIMILAR PATTERNS OF AMINO ACIDS FOR 5UTU_F_ADNF503_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvp HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE

(Drosophila
melanogaster) 		PF00790
(VHS)
PF01363
(FYVE) 		4 GLU A  88
THR A 129
GLU A  95
HIS A  99
 None
 1.32A 5utuF-1dvpA:
0.0		 5utuF-1dvpA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		4 GLU A 101
THR A 105
GLU A  51
HIS A  57
 None
None
None
GRG  A 500 ( 4.2A)
 1.45A 5utuF-2q80A:
0.0		 5utuF-2q80A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd9 BH0186 PROTEIN

(Bacillus
halodurans) 		PF12867
(DinB_2) 		4 GLU A  38
THR A  39
GLU A  44
HIS A  81
 None
None
GOL  A 304 (-3.5A)
None
 1.45A 5utuF-2rd9A:
0.1		 5utuF-2rd9A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLU A  94
THR A  91
GLU A  88
HIS A 120
 None
 1.49A 5utuF-3anxA:
4.2		 5utuF-3anxA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bze HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHA CHAIN
E

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLU A 232
THR A 233
GLU A 212
HIS A   3
 None
 1.21A 5utuF-3bzeA:
0.0		 5utuF-3bzeA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S27,
MITOCHONDRIAL

(Bos taurus) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 GLU e 321
THR e 323
GLU e 235
HIS e 245
 None
 1.09A 5utuF-3jd5e:
undetectable		 5utuF-3jd5e:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE

(Nitrosomonas
europaea) 		PF13447
(Multi-haem_cyto) 		4 GLU A 179
THR A 322
GLU A 186
HIS A  38
 HEC  A 604 (-3.7A)
None
None
None
 1.24A 5utuF-4fasA:
0.0		 5utuF-4fasA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 GLU A  47
THR A  46
GLU A 661
HIS A 656
 None
 1.50A 5utuF-4hvtA:
1.6		 5utuF-4hvtA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd4 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 GLU A 125
THR A 124
GLU A  64
HIS A  56
 None
 1.31A 5utuF-4wd4A:
0.0		 5utuF-4wd4A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		4 GLU B 203
THR B 190
GLU B  77
HIS B  80
 None
None
None
GOL  B 802 ( 4.6A)
 1.18A 5utuF-4yg8B:
undetectable		 5utuF-4yg8B:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mnw GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1

(Homo sapiens) 		no annotation 4 GLU A 161
THR A 160
GLU A 185
HIS A 192
 None
 1.32A 5utuF-5mnwA:
undetectable		 5utuF-5mnwA:
10.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLU A  63
THR A  64
GLU A 197
HIS A 342
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 4.9A)
 0.28A 5utuF-5v96A:
56.2		 5utuF-5v96A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avf HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-7 ALPHA
CHAIN

(Homo sapiens) 		no annotation 4 GLU H 232
THR H 233
GLU H 212
HIS H   3
 None
 1.43A 5utuF-6avfH:
undetectable		 5utuF-6avfH:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gru ADP-SUGAR
PYROPHOSPHATASE

(Homo sapiens) 		no annotation 4 GLU A 114
THR A 117
GLU A 112
HIS A 142
 None
None
MG  A 302 (-2.5A)
None
 1.36A 5utuF-6gruA:
undetectable		 5utuF-6gruA:
10.02