SIMILAR PATTERNS OF AMINO ACIDS FOR 5US8_B_ADNB503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyw GLUTATHIONE
S-TRANSFERASE

(Nilaparvata
lugens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 GLU A 197
GLU A 201
ARG A  15
LYS A 204
GLU A 200
 None
 1.40A 5us8A-3wywA:
0.0
5us8B-3wywA:
0.0		 5us8A-3wywA:
18.78
5us8B-3wywA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 5 ARG A1065
GLU A1067
ARG A1069
GLU A1070
ARG A1066
 None
 1.29A 5us8A-5yimA:
0.0
5us8B-5yimA:
0.0		 5us8A-5yimA:
11.01
5us8B-5yimA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 5 ARG A1069
GLU A1070
ARG A1066
ARG A1065
GLU A1067
 None
 1.34A 5us8A-5yimA:
0.0
5us8B-5yimA:
0.0		 5us8A-5yimA:
11.01
5us8B-5yimA:
11.01