SIMILAR PATTERNS OF AMINO ACIDS FOR 5UOC_C_H4BC502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 ARG A 438
TRP A 440
TRP A 270
PHE A 338
 None
PQQ  A1608 (-4.1A)
PQQ  A1608 (-3.3A)
None
 1.49A 5uocC-4cvcA:
0.0
5uocD-4cvcA:
0.0		 5uocC-4cvcA:
22.09
5uocD-4cvcA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		4 ARG A 385
TRP A 387
TRP A 218
PHE A 286
 None
 1.42A 5uocC-4mh1A:
undetectable
5uocD-4mh1A:
0.0		 5uocC-4mh1A:
22.80
5uocD-4mh1A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 VAL A 341
TRP A 323
TRP A 347
PHE A 290
 None
 1.17A 5uocC-5jseA:
0.0
5uocD-5jseA:
0.0		 5uocC-5jseA:
18.54
5uocD-5jseA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n77 MAGNESIUM TRANSPORT
PROTEIN CORA

(Escherichia
coli) 		PF01544
(CorA) 		4 VAL A  32
ARG A  14
TRP A  28
PHE A   5
 None
 1.43A 5uocC-5n77A:
0.0
5uocD-5n77A:
0.0		 5uocC-5n77A:
21.06
5uocD-5n77A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 VAL A 538
ARG A 205
TRP A 599
PHE A 606
 None
 1.45A 5uocC-5no8A:
0.0
5uocD-5no8A:
0.0		 5uocC-5no8A:
21.46
5uocD-5no8A:
21.46